Morika Williams

Works (12)

Updated: July 15th, 2023 21:13

2022 journal article

Pilot comparison of outcome measures across chemical and surgical experimental models of chronic osteoarthritis in the rat (Rattus norvegicus)

PLOS ONE, 17(11).

By: M. Williams n , R. Meyers n, L. Braxton n, B. Diekman n & B. Lascelles  n

Ed(s): A. Wijnen

MeSH headings : Rats; Animals; Rats, Sprague-Dawley; Lameness, Animal; Disease Models, Animal; Osteoarthritis / complications; Pain / complications; Models, Anatomic; Outcome Assessment, Health Care
TL;DR: The pilot data suggest both the ACL+DMM and MIA models are equal in terms of clinically relevant pain behaviors, but the MIA model is associated with more severe histological changes over time potentially making it more suitable for screening disease modifying agents. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 22, 2022

2020 review

Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life

[Review of ]. FRONTIERS IN PEDIATRICS, 8.

By: M. Williams n  & B. Lascelles  n

author keywords: neonatal pain; early life; consequences; neurobiology; mechanisms; animal models; chronic pain
TL;DR: A narrative review of the literature pertaining to the idea that early life pain has significant long-term effects on neurosensory, cognition, behavior, pain processing, and health outcomes that persist into childhood and even adulthood is provided. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 23, 2020

2019 journal article

A novel device to measure static hindlimb weight-bearing forces in pronograde rodents

Journal of Neuroscience Methods, 328, 108405.

By: M. Williams n , S. Sommer n, R. Meyers n, J. Valdivia *, M. Nolan n  & B. Lascelles  n

author keywords: Inflammatory pain; Spontaneous; pain; Weight-bearing; Incapacitance meter; Non-reflexive assay
MeSH headings : Animals; Behavior, Animal / physiology; Biomechanical Phenomena / physiology; Disease Models, Animal; Hindlimb / physiology; Inflammation / chemically induced; Mice; Neurosciences / instrumentation; Neurosciences / methods; Pain / chemically induced; Pain / physiopathology; Posture / physiology; Rats; Weight-Bearing / physiology
TL;DR: A Static Horizontal Incapacitance Meter (SHIM) is designed to measure bodyweight distribution in pronograde standing rodents and successfully detected asymmetric weight-bearing in acute and sub-chronic pain models and the analgesic effects of meloxicam. (via Semantic Scholar)
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Source: ORCID
Added: August 27, 2019

2017 journal article

Oral Transmucosal Detomidine Gel in New Zealand White Rabbits (Oryctolagus cuniculus).

Journal of the American Association for Laboratory Animal Science : JAALAS. http://europepmc.org/articles/PMC5517333

Morika Williams

europepmc.org
Source: ORCID
Added: September 21, 2019

2017 journal article

Oral transmucosal detomidine gel in New Zealand white rabbits (Oryctolagus cuniculus)

Journal of the American Association for Laboratory Animal Science, 56(4), 436–442.

By: M. Williams , C. Long, J. Durrant, G. McKeon, H. Shive, E. Griffith , K. Messenger, R. Fish

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

A necessary consideration

Lab Animal, 45(2), 58–58.

By: M. Williams  & R. Fish

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Response to Protocol Review Scenario: A necessary consideration

Lab Animal, 45(2), 58–58.

By: M. Williams n  & R. Fish n

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Sources: ORCID, Crossref
Added: September 21, 2019

2015 journal article

Probable primary polydipsia in a domestic shorthair cat

Journal of Feline Medicine and Surgery Open Reports, 1(2), 205511691561537.

By: C. Long n, M. Williams n , M. Savage  n, J. Fogle n, R. Meeker * & L. Hudson n

TL;DR: Findings provide strong evidence that primary polydipsia was the underlying etiology of the cat’s condition and exemplifies the challenges faced when a cat presents for polyuria and polyDipsia without an obvious cause identified on routine diagnostics. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Crossref
Added: July 20, 2019

2013 journal article

Feasibility and repeatability of cold and mechanical quantitative sensory testing in normal dogs

VETERINARY JOURNAL, 199(2), 245–250.

By: J. Briley n , M. Williams n , M. Freire  n, E. Griffith n  & B. Lascelles  n

author keywords: Canine; Quantitative sensory testing; Pressure algometer; Electronic von Frey anesthesiometer
MeSH headings : Animals; Cold Temperature; Dogs / physiology; Electrical Equipment and Supplies / veterinary; Feasibility Studies; Female; Male; Mechanoreceptors / physiology; Pain Measurement / methods; Reproducibility of Results; Sensation / physiology; Sensory Thresholds / physiology
TL;DR: Both mechanical QST devices tested provided repeatable, reliable sensory threshold measurements in normal, client-owned dogs and contribute to the validation of the EVF and PA as tools to obtain repeated QST data over time in dogs to assess somatosensory processing changes. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Feasibility and repeatability of thermal quantitative sensory testing in normal dogs and dogs with hind limb osteoarthritis-associated pain

VETERINARY JOURNAL, 199(1), 63–67.

By: M. Williams n , A. Kirkpatrick n, E. Griffith n , J. Benito  n, J. Hash n & B. Lascelles  n

author keywords: Canine; Quantitative sensory testing; Osteoarthritis; Thermal threshold
MeSH headings : Animals; Differential Threshold / physiology; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Hindlimb / pathology; Hot Temperature / adverse effects; Neurologic Examination; Osteoarthritis / diagnosis; Osteoarthritis / pathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / pathology; Pain / veterinary; Pain Threshold
TL;DR: In conclusion, thermal thresholds can be measured in client owned dogs with no prior training and are repeatable from week to week. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Dietary Beta-glucan Leads to Increased TNF-alpha Production in the Lung

American Journal of Animal and Veterinary Sciences.

Morika Williams

TL;DR: It is suggested that dietary β-glucan may promote inflammatory responses after exposure to chitin and therefore could be contributing factor to lung inflammation particularly in animals prone to airway inflammatory diseases. (via Semantic Scholar)
Source: ORCID
Added: September 21, 2019

2012 journal article

Morphologic and Molecular Analysis of 39 Spontaneous Feline Pulmonary Carcinomas

VETERINARY PATHOLOGY, 49(6), 971–978.

By: . S. D'Costa, B. Yoon n, D. Kim*, A. Motsinger-Reif  n, M. Williams n  & Y. Kim n

author keywords: cat; lung cancer; immunohistochemistry; thyroid transcription factor-1; surfactant protein a; epidermal growth factor receptor; p53
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Adenocarcinoma / veterinary; Adenocarcinoma, Bronchiolo-Alveolar / metabolism; Adenocarcinoma, Bronchiolo-Alveolar / pathology; Adenocarcinoma, Bronchiolo-Alveolar / veterinary; Animals; Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Carcinoma, Adenosquamous / metabolism; Carcinoma, Adenosquamous / pathology; Carcinoma, Adenosquamous / veterinary; Cat Diseases / genetics; Cat Diseases / metabolism; Cat Diseases / pathology; Cats; DNA, Neoplasm / chemistry; DNA, Neoplasm / genetics; ErbB Receptors / genetics; ErbB Receptors / metabolism; Female; Immunohistochemistry / veterinary; Incidence; Lung Neoplasms / metabolism; Lung Neoplasms / pathology; Lung Neoplasms / veterinary; Male; Neoplasm Metastasis; North Carolina; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Pulmonary Surfactant-Associated Protein A / genetics; Pulmonary Surfactant-Associated Protein A / metabolism; Sequence Analysis, DNA / veterinary; Thyroid Nuclear Factor 1; Transcription Factors / genetics; Transcription Factors / metabolism; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR: Results indicate that primary lung carcinomas are rare but aggressive tumors in cats, thereby warranting further studies on molecular carcinogenesis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: August 6, 2018

Employment

Updated: September 17th, 2020 12:21

2020 - present

University of North Carolina at Chapel Hill Chapel Hill, NC, US
Clinical Fellow Pathology and Laboratory Medicine

2016 - 2020

North Carolina State University Raleigh, NC, US
Clinician Scientist Comparative Biomedical Sciences

Education

Updated: September 17th, 2020 12:24

2016 - 2020

North Carolina State University Raleigh, NC, US
PhD Comparative Biomedical Sciences (Pharmacology)

2010 - 2014

North Carolina State University Raleigh, NC, US
DVM College of Veterinary Medicine

2006 - 2010

North Carolina Agricultural and Technical State University Greensboro, NC, US
BS in Laboratory Animal Science, BS in Animal Science Agriculture and Environmental Sciences

Funding History

Funding history based on the linked ORCID record. Updated: September 17th, 2020 14:27

grant April 1, 2018 - March 31, 2023
Sex- and Age-dependent ACL Function in the Growing Knee Joint
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant April 1, 2015 - March 31, 2019
Age-Dependent ACL Function During Growth: Guiding Injury Treatment in Children
National Institute of Arthritis and Musculoskeletal and Skin Diseases

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