Works (12)
Updated: July 15th, 2023 21:13
2022 journal article
Pilot comparison of outcome measures across chemical and surgical experimental models of chronic osteoarthritis in the rat (Rattus norvegicus)
PLOS ONE, 17(11).
Ed(s): A. Wijnen
MeSH headings : Rats; Animals; Rats, Sprague-Dawley; Lameness, Animal; Disease Models, Animal; Osteoarthritis / complications; Pain / complications; Models, Anatomic; Outcome Assessment, Health Care
TL;DR:
The pilot data suggest both the ACL+DMM and MIA models are equal in terms of clinically relevant pain behaviors, but the MIA model is associated with more severe histological changes over time potentially making it more suitable for screening disease modifying agents.
(via Semantic Scholar)
open access via journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 22, 2022
2020 review
Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life
[Review of ]. FRONTIERS IN PEDIATRICS, 8.
author keywords: neonatal pain; early life; consequences; neurobiology; mechanisms; animal models; chronic pain
TL;DR:
A narrative review of the literature pertaining to the idea that early life pain has significant long-term effects on neurosensory, cognition, behavior, pain processing, and health outcomes that persist into childhood and even adulthood is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 23, 2020
2019 journal article
A novel device to measure static hindlimb weight-bearing forces in pronograde rodents
Journal of Neuroscience Methods, 328, 108405.
author keywords: Inflammatory pain; Spontaneous; pain; Weight-bearing; Incapacitance meter; Non-reflexive assay
MeSH headings : Animals; Behavior, Animal / physiology; Biomechanical Phenomena / physiology; Disease Models, Animal; Hindlimb / physiology; Inflammation / chemically induced; Mice; Neurosciences / instrumentation; Neurosciences / methods; Pain / chemically induced; Pain / physiopathology; Posture / physiology; Rats; Weight-Bearing / physiology
TL;DR:
A Static Horizontal Incapacitance Meter (SHIM) is designed to measure bodyweight distribution in pronograde standing rodents and successfully detected asymmetric weight-bearing in acute and sub-chronic pain models and the analgesic effects of meloxicam.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 27, 2019
2017 journal article
Oral Transmucosal Detomidine Gel in New Zealand White Rabbits (Oryctolagus cuniculus).
Journal of the American Association for Laboratory Animal Science : JAALAS. http://europepmc.org/articles/PMC5517333
Source: ORCID
Added: September 21, 2019
2017 journal article
Oral transmucosal detomidine gel in New Zealand white rabbits (Oryctolagus cuniculus)
Journal of the American Association for Laboratory Animal Science, 56(4), 436–442.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
A necessary consideration
Lab Animal, 45(2), 58–58.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Response to Protocol Review Scenario: A necessary consideration
Lab Animal, 45(2), 58–58.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref
Added: September 21, 2019
2015 journal article
Probable primary polydipsia in a domestic shorthair cat
Journal of Feline Medicine and Surgery Open Reports, 1(2), 205511691561537.
TL;DR:
Findings provide strong evidence that primary polydipsia was the underlying etiology of the cat’s condition and exemplifies the challenges faced when a cat presents for polyuria and polyDipsia without an obvious cause identified on routine diagnostics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, Crossref
Added: July 20, 2019
2013 journal article
Feasibility and repeatability of cold and mechanical quantitative sensory testing in normal dogs
VETERINARY JOURNAL, 199(2), 245–250.
author keywords: Canine; Quantitative sensory testing; Pressure algometer; Electronic von Frey anesthesiometer
MeSH headings : Animals; Cold Temperature; Dogs / physiology; Electrical Equipment and Supplies / veterinary; Feasibility Studies; Female; Male; Mechanoreceptors / physiology; Pain Measurement / methods; Reproducibility of Results; Sensation / physiology; Sensory Thresholds / physiology
TL;DR:
Both mechanical QST devices tested provided repeatable, reliable sensory threshold measurements in normal, client-owned dogs and contribute to the validation of the EVF and PA as tools to obtain repeated QST data over time in dogs to assess somatosensory processing changes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Feasibility and repeatability of thermal quantitative sensory testing in normal dogs and dogs with hind limb osteoarthritis-associated pain
VETERINARY JOURNAL, 199(1), 63–67.
author keywords: Canine; Quantitative sensory testing; Osteoarthritis; Thermal threshold
MeSH headings : Animals; Differential Threshold / physiology; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Hindlimb / pathology; Hot Temperature / adverse effects; Neurologic Examination; Osteoarthritis / diagnosis; Osteoarthritis / pathology; Osteoarthritis / veterinary; Pain / diagnosis; Pain / pathology; Pain / veterinary; Pain Threshold
TL;DR:
In conclusion, thermal thresholds can be measured in client owned dogs with no prior training and are repeatable from week to week.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Dietary Beta-glucan Leads to Increased TNF-alpha Production in the Lung
American Journal of Animal and Veterinary Sciences.
TL;DR:
It is suggested that dietary β-glucan may promote inflammatory responses after exposure to chitin and therefore could be contributing factor to lung inflammation particularly in animals prone to airway inflammatory diseases.
(via Semantic Scholar)
Source: ORCID
Added: September 21, 2019
2011 journal article
Morphologic and Molecular Analysis of 39 Spontaneous Feline Pulmonary Carcinomas
VETERINARY PATHOLOGY, 49(6), 971–978.
author keywords: cat; lung cancer; immunohistochemistry; thyroid transcription factor-1; surfactant protein a; epidermal growth factor receptor; p53
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Adenocarcinoma / veterinary; Adenocarcinoma, Bronchiolo-Alveolar / metabolism; Adenocarcinoma, Bronchiolo-Alveolar / pathology; Adenocarcinoma, Bronchiolo-Alveolar / veterinary; Animals; Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Carcinoma, Adenosquamous / metabolism; Carcinoma, Adenosquamous / pathology; Carcinoma, Adenosquamous / veterinary; Cat Diseases / genetics; Cat Diseases / metabolism; Cat Diseases / pathology; Cats; DNA, Neoplasm / chemistry; DNA, Neoplasm / genetics; ErbB Receptors / genetics; ErbB Receptors / metabolism; Female; Immunohistochemistry / veterinary; Incidence; Lung Neoplasms / metabolism; Lung Neoplasms / pathology; Lung Neoplasms / veterinary; Male; Neoplasm Metastasis; North Carolina; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Pulmonary Surfactant-Associated Protein A / genetics; Pulmonary Surfactant-Associated Protein A / metabolism; Sequence Analysis, DNA / veterinary; Thyroid Nuclear Factor 1; Transcription Factors / genetics; Transcription Factors / metabolism; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR:
Results indicate that primary lung carcinomas are rare but aggressive tumors in cats, thereby warranting further studies on molecular carcinogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: August 6, 2018
Employment
Updated: September 17th, 2020 12:21
2020 - present
University of North Carolina at Chapel Hill Chapel Hill, NC, US
Clinical Fellow
Pathology and Laboratory Medicine
2016 - 2020
North Carolina State University Raleigh, NC, US
Clinician Scientist
Comparative Biomedical Sciences
Education
Updated: September 17th, 2020 12:24
2016 - 2020
North Carolina State University Raleigh, NC, US
PhD
Comparative Biomedical Sciences (Pharmacology)
2010 - 2014
North Carolina State University Raleigh, NC, US
DVM
College of Veterinary Medicine
2006 - 2010
North Carolina Agricultural and Technical State University Greensboro, NC, US
BS in Laboratory Animal Science, BS in Animal Science
Agriculture and Environmental Sciences
Funding History
Funding history based on the linked ORCID record. Updated: September 17th, 2020 14:27
grant
April 1, 2018 - March 31, 2023
Sex- and Age-dependent ACL Function in the Growing Knee Joint
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
April 1, 2015 - March 31, 2019
Age-Dependent ACL Function During Growth: Guiding Injury Treatment in Children
National Institute of Arthritis and Musculoskeletal and Skin Diseases
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