Works (3)
Updated: July 5th, 2023 15:49
2011 journal article
Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki-Miyaura cross-coupling
ORGANIC & BIOMOLECULAR CHEMISTRY, 9(8), 3041–3049.
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / physiology; Biofilms; Imidazoles / chemistry; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / physiology; Molecular Structure; Triazoles / chemical synthesis; Triazoles / pharmacology
TL;DR:
A pilot library of 2-aminoimidazole triazoles (2-AITs) was synthesized and assayed against Acinetobacter baumannii and methicillin-resistant Staphylococus aureus and they are found to possess biofilm inhibition capabilities at low micromolar concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii
BIOORGANIC & MEDICINAL CHEMISTRY, 18(2), 663–674.
author keywords: 2-Aminobenzimidazole; Chemical library synthesis; Antibiotic; Multidrug-resistant bacteria; Staphylococcus aureus; Acinetobacter baumannii
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Benzimidazoles / chemical synthesis; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Drug Resistance, Multiple, Bacterial; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Molecular Conformation; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
TL;DR:
These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity
JOURNAL OF MEDICINAL CHEMISTRY, 52(15), 4582–4585.
MeSH headings : Amides / chemical synthesis; Amides / pharmacology; Amides / toxicity; Animals; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Caenorhabditis elegans / drug effects; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / physiology; Pyrroles / chemical synthesis; Pyrroles / pharmacology; Pyrroles / toxicity; Structure-Activity Relationship; Sulfonamides / chemical synthesis; Sulfonamides / pharmacology; Thiourea / chemical synthesis; Thiourea / pharmacology; Urea / chemical synthesis; Urea / pharmacology
TL;DR:
The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described and the most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.
