Samuel Reyes

Works (3)

Updated: July 5th, 2023 15:49

2011 article

Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki–Miyaura cross-coupling

Reyes, S., Huigens, R. W., III, Su, Z., Simon, M. L., & Melander, C. (2011, January 1). Organic & Biomolecular Chemistry.

By: S. Reyes n, R. Huigens n, Z. Su n, M. Simon n & C. Melander  n

MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / physiology; Biofilms; Imidazoles / chemistry; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / physiology; Molecular Structure; Triazoles / chemical synthesis; Triazoles / pharmacology
topics (OpenAlex): Phenothiazines and Benzothiazines Synthesis and Activities; Click Chemistry and Applications; Bacterial biofilms and quorum sensing
TL;DR: A pilot library of 2-aminoimidazole triazoles (2-AITs) was synthesized and assayed against Acinetobacter baumannii and methicillin-resistant Staphylococus aureus and they are found to possess biofilm inhibition capabilities at low micromolar concentrations. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity

Richards, J. J., Reyes, S., Stowe, S. D., Tucker, A. T., Ballard, T. E., Mathies, L. D., … Melander, C. (2009, July 9). Journal of Medicinal Chemistry.

By: J. Richards n, S. Reyes n, S. Stowe n, A. Tucker n, T. Ballard n, L. Mathies n, J. Cavanagh n, C. Melander n

MeSH headings : Amides / chemical synthesis; Amides / pharmacology; Amides / toxicity; Animals; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Caenorhabditis elegans / drug effects; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / physiology; Pyrroles / chemical synthesis; Pyrroles / pharmacology; Pyrroles / toxicity; Structure-Activity Relationship; Sulfonamides / chemical synthesis; Sulfonamides / pharmacology; Thiourea / chemical synthesis; Thiourea / pharmacology; Urea / chemical synthesis; Urea / pharmacology
topics (OpenAlex): Bacterial biofilms and quorum sensing; Biocrusts and Microbial Ecology; Fungal Biology and Applications
TL;DR: The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described and the most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans. (via Semantic Scholar)
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Added: August 6, 2018

2009 article

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

Huigens, R. W., Reyes, S., Reed, C. S., Bunders, C., Rogers, S. A., Steinhauer, A. T., & Melander, C. (2009, December 7). Bioorganic & Medicinal Chemistry.

By: R. Huigens n, S. Reyes n, C. Reed n, C. Bunders n, S. Rogers n, A. Steinhauer n, C. Melander n

author keywords: 2-Aminobenzimidazole; Chemical library synthesis; Antibiotic; Multidrug-resistant bacteria; Staphylococcus aureus; Acinetobacter baumannii
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Benzimidazoles / chemical synthesis; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Drug Resistance, Multiple, Bacterial; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Molecular Conformation; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
topics (OpenAlex): Synthesis and biological activity; Phenothiazines and Benzothiazines Synthesis and Activities; Antimicrobial Peptides and Activities
TL;DR: These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains. (via Semantic Scholar)
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Added: August 6, 2018

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