Yoshiaki Tsuji

Works (54)

Updated: March 2nd, 2025 17:18

2024 journal article

Modulation of iron metabolism by new chemicals interacting with the iron regulatory system

REDOX BIOLOGY, 79.

By: Y. Tsuji n , J. Ninomiya-Tsuji n , M. Shen & B. Difrancesco

author keywords: Iron metabolism; IRP2; Reactive oxygen species; Oxidative stress; Ferritin; Transferrin receptor
Sources: Web Of Science, NC State University Libraries
Added: January 13, 2025

2023 journal article

LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 11.

By: M. Simmers n, D. Jima n, Y. Tsuji n  & M. Cowley n 

author keywords: lncRNA; Tuna; placental insufficiency; fetal growth restriction (FGR); Cadmium; Nrf2; oxidative stress
TL;DR: The lncRNA Tuna is identified as a potential novel player in Cd-induced placental insufficiency and increases NRF2/NRF2 both at the transcript and protein levels, confirming that Tuna activates oxidative stress response genes through this pathway. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 3, 2023

2023 journal article

Optimization of Biotinylated RNA or DNA Pull-Down Assays for Detection of Binding Proteins: Examples of IRP1, IRP2, HuR, AUF1, and Nrf2

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(4).

By: Y. Tsuji n 

author keywords: RNA pull-down; DNA pull-down; biotin; streptavidin; IRP2; HuR; AUF1; Nrf2; ferritin; IRP-IRE
MeSH headings : Humans; Carrier Proteins / chemistry; DNA / chemistry; Iron / metabolism; Iron Regulatory Protein 1 / chemistry; Iron Regulatory Protein 2 / chemistry; NF-E2-Related Factor 2 / chemistry; RNA / chemistry; Streptavidin / metabolism; Biotinylation; Chromatography, Affinity / methods
TL;DR: The step-by step optimization of pull-down for IRP with a 5′-biotinylated stem-loop IRE (iron-responsive element) RNA, HuR, and AUF1 with an AU-rich RNA element and Nrf2 binding to an antioxidant- responsive element (ARE) enhancer in the human ferritin H gene is demonstrated. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 20, 2023

2020 journal article

Transmembrane protein western blotting: Impact of sample preparation on detection of SLC11A2 (DMT1) and SLC40A1 (ferroportin)

PLOS ONE, 15(7).

By: Y. Tsuji n 

MeSH headings : A549 Cells; Antibodies / immunology; Blotting, Western / methods; Caco-2 Cells; Cation Transport Proteins / analysis; Cation Transport Proteins / immunology; Cell Fractionation / methods; HEK293 Cells; HeLa Cells; Hep G2 Cells; Humans; Jurkat Cells; Limit of Detection; MCF-7 Cells
TL;DR: It is shown here the case that even excellent primary antibodies failed to detect a specific protein of interest due to a routine heating practice of protein samples, suggesting the similar cases for thousands of other transmembrane and heat-sensitive proteins. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 17, 2020

2019 journal article

Iron-induced transferrin receptor-1 mRNA destabilization: A response to "Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation"

RNA, 25(11), 1416–1420.

By: M. Miyazawa*, A. Bogdan*, K. Hashimoto* & Y. Tsuji n 

MeSH headings : Iron; MicroRNAs; RNA Stability; RNA, Messenger; Receptors, Transferrin
TL;DR: There are several critical issues contained in the article by Connell and colleagues that require further consideration and the opportunity to reply here. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 28, 2019

2019 journal article

Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2

CELL CHEMICAL BIOLOGY, 26(1), 85-+.

By: M. Miyazawa n, A. Bogdan n & Y. Tsuji n 

MeSH headings : Adolescent; Adult; Aged; Animals; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Cell Proliferation / drug effects; Cell Survival / drug effects; Cells, Cultured; Cisplatin / metabolism; Cisplatin / pharmacology; Drug Screening Assays, Antitumor; Female; Fetus; Humans; Iron / metabolism; Iron Deficiencies; Iron Regulatory Protein 2 / antagonists & inhibitors; Iron Regulatory Protein 2 / genetics; Iron Regulatory Protein 2 / metabolism; Male; Mice; Middle Aged; Molecular Structure; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / metabolism; Neoplasms, Experimental / pathology
TL;DR: Cisplatin is an inhibitor of IRP2 that induces intracellular iron deficiency and combination of cisplatin and the iron chelator desferrioxamine enhanced cytotoxicity through augmented iron depletion in culture and xenograft mouse model. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019

2018 journal article

Regulation of transferrin receptor-1 mRNA by the interplay between IRE-binding proteins and miR-7/miR-141 in the 3′-IRE stem–loops

RNA, 24(4), 468–479.

By: M. Miyazawa  n, A. Bogdan  n, K. Hashimoto  n & Y. Tsuji n 

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Sources: NC State University Libraries, Crossref
Added: February 24, 2025

2017 journal article

Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis

JOURNAL OF MOLECULAR BIOLOGY, 429(1), 64–78.

By: K. Hashimoto n & Y. Tsuji n 

author keywords: ATF1; HIPK1; CCNA1; CBP; TAF4
MeSH headings : Arsenic / metabolism; Carrier Proteins / metabolism; Cell Line; Cyclic AMP Response Element-Binding Protein / metabolism; Gene Expression Profiling; Humans; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / metabolism; Serine / metabolism; Transcriptional Activation
TL;DR: The results suggest that the HIPK2-phospho-Ser271 CREB axis is a new arsenic-responsive CREB activation mechanism in parallel with the PKA-ph phosphate-based activation mechanism of Ser133 CREB. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Nuclear lamins and progerin are dispensable for antioxidant Nrf2 response to arsenic and cadmium

CELLULAR SIGNALLING, 33, 69–78.

By: K. Hashimoto n, R. Majumdar n & Y. Tsuji n 

author keywords: HGPS; Nrf2; Lamin; Progerin; Arsenic; Cadmium
MeSH headings : Antioxidants / metabolism; Arsenic / toxicity; Cadmium / toxicity; Cell Line, Tumor; Cell Nucleus / metabolism; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Profiling; Gene Knockdown Techniques; Heme Oxygenase-1 / metabolism; Humans; Kelch-Like ECH-Associated Protein 1 / metabolism; Lamin Type A / metabolism; Lamins / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Oxidative Stress / genetics; Phosphorylation / drug effects; Progeria / metabolism; Progeria / pathology; Sequestosome-1 Protein / metabolism
TL;DR: The results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 response to arsenic and cadmium. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 review

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

[Review of ]. TRENDS IN BIOCHEMICAL SCIENCES, 41(3), 274–286.

By: A. Bogdan n, M. Miyazawa n, K. Hashimoto n & Y. Tsuji n 

MeSH headings : Cell Death; Homeostasis; Humans; Iron / metabolism
TL;DR: New regulators of iron metabolism are highlighted, including iron-trafficking proteins [solute carrier family 39, SLC39, also known as ZRT/IRT-like protein, ZIP; and poly-(rC)-binding protein, PCBP] and a cargo receptor (NCOA4) that is crucial for release of ferritin-bound iron. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 review

Siderophores in Iron Metabolism: From Mechanism to Therapy Potential

[Review of ]. TRENDS IN MOLECULAR MEDICINE, 22(12), 1077–1090.

By: B. Wilson  n, A. Bogdan n, M. Miyazawa n, K. Hashimoto n & Y. Tsuji n 

MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / immunology; Bacteria / metabolism; Bacterial Infections / drug therapy; Bacterial Infections / immunology; Bacterial Infections / metabolism; Drug Discovery; Host-Pathogen Interactions / drug effects; Humans; Iron / immunology; Iron / metabolism; Lipocalin-2 / immunology; Lipocalin-2 / metabolism; Siderophores / immunology; Siderophores / metabolism
TL;DR: This review discusses the recently described molecular mechanisms of siderophore iron trafficking between host and bacteria, highlighting the therapeutic potential of exploiting pathogen sidersophore machinery for the treatment of antibiotic-resistant bacterial infections. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

ANTIOXIDANTS & REDOX SIGNALING, 25(17), 953–964.

By: K. Hashimoto n, A. Simmons*, R. Kajino-Sakamoto*, Y. Tsuji n  & J. Ninomiya-Tsuji n 

Contributors: K. Hashimoto n, A. Simmons*, R. Kajino-Sakamoto*, Y. Tsuji n  & J. Ninomiya-Tsuji n 

author keywords: intestine; TAK1; Nrf2; Keap1; p62/SQSTM
MeSH headings : Animals; Antioxidants / metabolism; Cell Line; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Kelch-Like ECH-Associated Protein 1 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Models, Biological; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress; Protein Binding; Proteolysis; Reactive Oxygen Species / metabolism; Sequestosome-1 Protein / metabolism
TL;DR: The results identify for the first time that TAK1 is a modulator of p62/SQSTM1-dependent Keap1 degradation and maintains the steady state-level of Nrf2, important for homeostatic antioxidant protection in the intestinal epithelium. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2015 journal article

Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1849(10), 1277–1288.

By: P. Ray n, B. Huang n & Y. Tsuji n 

author keywords: Nrf2; Histone; Epigenetic; Arsenic; HO-1; Antioxidant response element
MeSH headings : Animals; Antioxidant Response Elements / genetics; Arsenites / pharmacology; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1 / biosynthesis; Heme Oxygenase-1 / genetics; Heme Oxygenase-1 / metabolism; Histones / genetics; Histones / metabolism; Humans; Keratinocytes / metabolism; Mice; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / genetics; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Signal Transduction; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR: It is proposed that Nrf2 may influence H3S10 phosphorylation at the HO-1 ARE and additional promoter regions, which highlights the complex interplay between NRF2 and H 3S10osphorylation in arsenite-activatedHO-1 transcription. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels

CELLULAR SIGNALLING, 26(12), 2702–2709.

By: B. Huang n, M. Miyazawa n & Y. Tsuji n 

author keywords: Hypoxia; Cobalt chloride; Hypoxia inducible factor (HIF); Iron regulatory protein (IRP); Nrf2; Ferritin
MeSH headings : Apoferritins / genetics; Cell Line, Tumor; Cobalt / pharmacology; Ferritins / genetics; Gene Expression Regulation / genetics; Humans; Hypoxia / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Iron-Regulatory Proteins / genetics; Protein Processing, Post-Translational / drug effects; Protein Processing, Post-Translational / genetics; RNA, Messenger / genetics; Transcription, Genetic / drug effects; Transcription, Genetic / genetics; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR: It is demonstrated that hypoxia and cobalt chloride regulate ferritin heavy chain (ferritin H) expression by two distinct mechanisms through the interplay between DNA and mRNA elements at the transcriptional and post-transcriptional levels. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene

MOLECULAR BIOLOGY OF THE CELL, 25(13), 2116–2127.

By: M. Miyazawa n & Y. Tsuji n 

MeSH headings : Antioxidants / physiology; Apoptosis; Cell Differentiation; Erythroid Cells / metabolism; Hemin / pharmacology; Humans; K562 Cells; Mitochondria / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress; Phosphorylation; Protein Isoforms / physiology; Protein Processing, Post-Translational; Protein Transport; Reactive Oxygen Species / metabolism; Response Elements; Shc Signaling Adaptor Proteins / physiology; Src Homology 2 Domain-Containing, Transforming Protein 1; Transcription, Genetic; Transcriptional Activation
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Role of AMP-Activated Protein Kinase in Ferritin H Gene Expression by Resveratrol in Human T Cells

BIOCHEMISTRY, 52(30), 5075–5083.

By: K. Iwasaki *, P. Ray n, B. Huang n, K. Sakamoto  n, T. Kobayashi * & Y. Tsuji n 

MeSH headings : AMP-Activated Protein Kinases / antagonists & inhibitors; AMP-Activated Protein Kinases / chemistry; AMP-Activated Protein Kinases / genetics; AMP-Activated Protein Kinases / metabolism; Antioxidants / chemistry; Antioxidants / pharmacology; Apoferritins / genetics; Apoferritins / metabolism; Enzyme Activation / drug effects; Gene Expression Regulation / drug effects; Glycogen Synthase Kinase 3 / antagonists & inhibitors; Glycogen Synthase Kinase 3 / genetics; Glycogen Synthase Kinase 3 / metabolism; Glycogen Synthase Kinase 3 beta; Humans; Jurkat Cells; K562 Cells; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Phosphorylation / drug effects; Protein Processing, Post-Translational / drug effects; RNA Interference; Response Elements / drug effects; Resveratrol; Serine / metabolism; Stilbenes / antagonists & inhibitors; Stilbenes / pharmacology; T-Lymphocytes / drug effects; T-Lymphocytes / metabolism
TL;DR: It is found that AMP-activated protein kinase (AMPK) plays a key role in the activation of nuclear factor E2-related factor (Nrf2) and subsequent ARE-dependent ferritin H gene transcription by resveratrol. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4

FASEB JOURNAL, 27(9), 3763–3774.

By: B. Huang*, P. Ray*, K. Iwasaki & Y. Tsuji* 

author keywords: arsenic; histone methylation; antioxidant; oxidative stress
MeSH headings : Antioxidants / metabolism; Arsenic / toxicity; Cell Line; Cells, Cultured; Ferritins / genetics; Fibroblasts / cytology; Fibroblasts / metabolism; Histones / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Methylation; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Oxidative Stress / genetics; Protein-Arginine N-Methyltransferases / genetics; Protein-Arginine N-Methyltransferases / metabolism; Repressor Proteins / genetics; Repressor Proteins / metabolism; Transcription, Genetic / drug effects; Transcription, Genetic / genetics
TL;DR: To test the hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, PRMT1 and PRMT4 regulate the ARE and cellular antioxidant response to arsenic, and focused microarray characterized several oxidative stress response genes are subject toPRMT1 orPRMT4 regulation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 review

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

[Review of ]. CELLULAR SIGNALLING, 24(5), 981–990.

By: P. Ray n, B. Huang n & Y. Tsuji n 

author keywords: Reactive oxygen species; MAPK; Shc; Nrf2; ATM; Iron
MeSH headings : Amino Acid Sequence; Animals; Gene Expression Regulation; Homeostasis; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Molecular Sequence Data; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species / metabolism; Signal Transduction
TL;DR: This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival, ROS homeostasis and antioxidant gene regulation, mitochondrial oxidative stress, apoptosis, and aging. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Regulation of Genotoxic Stress Response by Homeodomain-interacting Protein Kinase 2 through Phosphorylation of Cyclic AMP Response Element-binding Protein at Serine 271

MOLECULAR BIOLOGY OF THE CELL, 21(16), 2966–2974.

By: K. Sakamoto  n, B. Huang  n, K. Iwasaki  n, K. Hailemariam n, J. Ninomiya-Tsuji n  & Y. Tsuji n 

Contributors: K. Sakamoto  n, B. Huang  n, K. Iwasaki  n, K. Hailemariam n, J. Ninomiya-Tsuji n  & Y. Tsuji n 

MeSH headings : Animals; Antineoplastic Agents, Phytogenic / pharmacology; Blotting, Western; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; CREB-Binding Protein / genetics; CREB-Binding Protein / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Line, Tumor; Cells, Cultured; Cyclic AMP Response Element-Binding Protein / genetics; Cyclic AMP Response Element-Binding Protein / metabolism; DNA Damage; Embryo, Mammalian / cytology; Etoposide / pharmacology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; HEK293 Cells; Humans; K562 Cells; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; RNA Interference; Serine / genetics; Serine / metabolism; Transcription, Genetic / drug effects; Two-Hybrid System Techniques
TL;DR: Homeodomain-interacting protein kinase 2 is a new CREB kinase for phosphorylation at Ser-271 but not Ser-133 in genotoxic stress and activates CREB transactivation function including brain-derived neurotrophic factor (BDNF) mRNA expression. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 journal article

Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress

JOURNAL OF CELL SCIENCE, 123(22), 3863–3871.

By: K. Hailemariam n, K. Iwasaki  n, B. Huang n, K. Sakamoto  n & Y. Tsuji n 

author keywords: HIPK2; ATF1; Phosphorylation; Ferritin; Genotoxic stress; Transcription
MeSH headings : Activating Transcription Factor 1 / genetics; Activating Transcription Factor 1 / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Growth Processes / genetics; Cell Survival / genetics; DNA Damage; Ferritins / genetics; Ferritins / metabolism; Gene Expression Regulation; Humans; Phosphorylation; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: HIPK2 (homeodomain-interacting protein kinase 2), a DNA-damage-responsive nuclear kinase, is a new ATF1 kinase involved in the regulation of ferritin H and other antioxidant detoxification genes in genotoxic stress conditions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Role of the Tumor Suppressor PTEN in Antioxidant Responsive Element-mediated Transcription and Associated Histone Modifications

MOLECULAR BIOLOGY OF THE CELL, 20(6), 1606–1617.

By: K. Sakamoto  n, K. Iwasaki  n, H. Sugiyama * & Y. Tsuji n 

MeSH headings : Antioxidants / metabolism; Apoptosis / drug effects; Cell Line; Ferritins / genetics; Ferritins / metabolism; Histones / metabolism; Humans; Hydrogen Peroxide / pharmacology; Hydroquinones / pharmacology; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism; PTEN Phosphohydrolase / genetics; PTEN Phosphohydrolase / metabolism; Protein Binding; Proto-Oncogene Proteins c-akt / metabolism; RNA, Messenger / genetics; Response Elements / genetics; Transcription, Genetic / drug effects; Transcription, Genetic / genetics; Transcriptional Activation / genetics
TL;DR: It is demonstrated that the status of PTEN determines cellular susceptibility to oxidative stress through antioxidant-responsive element (ARE)-mediated transcription of detoxification genes and ferritin H transcription was robustly induced in tert-butylhydroquinone (t-BHQ)-treated Jurkat cells via an ARE, and it was due to PTEN deficiency. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization

BIOCHEMICAL JOURNAL, 411, 107–113.

By: E. Mackenzie n & Y. Tsuji n 

author keywords: antioxidant-responsive element (ARE); calcineurin; calcium; ferritin; ionomycin; nuclear factor of activated T-cells (NFAT)
MeSH headings : 3T3 Cells; Animals; Apoferritins / genetics; Calcineurin / metabolism; Calcium / physiology; Gene Expression Regulation; Humans; Ionomycin / pharmacology; Jurkat Cells; Mice; NFATC Transcription Factors / metabolism; RNA Stability; Response Elements
TL;DR: The results suggest that ionomycin-mediated induction of ferritin H may occur in an NFAT-independent manner but through post-transcriptional stabilization of the ferritine H mRNA half-life. (via Semantic Scholar)
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Added: August 6, 2018

2008 review

Intracellular iron transport and storage: From molecular mechanisms to health implications

[Review of ]. ANTIOXIDANTS & REDOX SIGNALING, 10(6), 997–1030.

By: E. Mackenzie n, K. Iwasaki  n & Y. Tsuji n 

MeSH headings : Animals; Biological Transport; Humans; Iron / metabolism; Iron Overload / genetics; Iron-Binding Proteins / metabolism; Mice; Oxidative Stress; Transferrin / metabolism
TL;DR: The molecular mechanisms responsible for regulation of iron absorption, transport, and storage through the roles of key regulatory proteins, including ferroportin, hepcidin, ferritin, and frataxin are highlighted. (via Semantic Scholar)
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7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Post-transcriptional Modulation of Iron Homeostasis during p53-dependent Growth Arrest

Journal of Biological Chemistry, 283(49), 33911–33918.

By: F. Zhang *, W. Wang *, Y. Tsuji* , S. Torti * & F. Torti *

MeSH headings : Antigens, CD / chemistry; Apoferritins / chemistry; Cation Transport Proteins / biosynthesis; Cation Transport Proteins / chemistry; Cell Cycle; Cell Line, Tumor; Ferritins / chemistry; Homeostasis; Humans; Iron / chemistry; Models, Biological; Protein Binding; Protein Structure, Tertiary; RNA Processing, Post-Transcriptional; Receptors, Transferrin / chemistry; Transcription, Genetic; Tumor Suppressor Protein p53 / metabolism
TL;DR: The results suggest that p53 may induce cell cycle arrest not only by well described mechanisms involving the induction of cyclin-dependent kinase inhibitors but also by the recruitment of pathways that reduce the availability of intracellular iron. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2008 journal article

Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress

FREE RADICAL BIOLOGY AND MEDICINE, 44(9), 1762–1771.

By: E. MacKenzie n, P. Ray n & Y. Tsuji n 

author keywords: ferritin; rotenone; mitochondria; iron; oxidative stress; free radicals
MeSH headings : Animals; Antioxidants / metabolism; Apoferritins / chemistry; Cell Line, Tumor; Gene Expression Regulation; Humans; Mice; Mitochondria / metabolism; Models, Biological; NF-E2-Related Factor 2 / metabolism; NIH 3T3 Cells; Oxidative Stress; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins c-jun; Rotenone / pharmacology; Uncoupling Agents / pharmacology
TL;DR: Results suggest that ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to ARE activation and may be critically important to protect cells from mitochondrial dysfunction and oxidative stress. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element

JOURNAL OF BIOLOGICAL CHEMISTRY, 282(31), 22335–22343.

By: K. Iwasaki  n, K. Hailemariam n & Y. Tsuji n 

MeSH headings : Activating Transcription Factor 1 / metabolism; Animals; Antioxidants / metabolism; Apoferritins / genetics; DNA-Binding Proteins / metabolism; Humans; K562 Cells; Mice; Molecular Chaperones / metabolism; NF-E2-Related Factor 2 / metabolism; NIH 3T3 Cells; Nuclear Proteins / metabolism; Protein Binding; Protein Inhibitors of Activated STAT / metabolism; RNA, Small Interfering / metabolism; Regulatory Factor X Transcription Factors; SUMO-1 Protein; Small Ubiquitin-Related Modifier Proteins / metabolism; Transcription Factors
TL;DR: PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene, which is a major intracellular iron storage protein involved in iron homeostasis. (via Semantic Scholar)
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Added: August 6, 2018

2007 other

Regulation and Polymorphisms in Phase II Genes

By: Y. Tsuji n 

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

2006 journal article

Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats

International Journal of Oncology, 29(4), 829–838.

By: G. Jia*, R. Takahashi*, Z. Zhang *, Y. Tsuji n  & H. Sone *

TL;DR: The results indicate conclusively that in LEC rat liver, akr1b7 might be up-regulated by oxidative stress mediated through NF-kappaB, but not that mediated directly by copper. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2006 journal article

Coordinate Inhibition of Cytokine-mediated Induction of Ferritin H, Manganese Superoxide Dismutase, and Interleukin-6 by the Adenovirus E1A Oncogene

Journal of Biological Chemistry, 281(24), 16428–16435.

By: J. Jennings-Gee*, Y. Tsuji* , E. Pietsch *, E. Moran*, J. Mymryk *, F. Torti *, S. Torti *

TL;DR: The results suggest that p300/CBP is a critical control point in NF-κB-dependent transcriptional regulation of cytoprotective genes by cytokines. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2006 journal article

Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells

MOLECULAR AND CELLULAR BIOLOGY, 26(7), 2845–2856.

By: K. Iwasaki  n, E. MacKenzie n, K. Hailemariam n, K. Sakamoto  n & Y. Tsuji n 

MeSH headings : Antioxidants / metabolism; Antioxidants / pharmacology; Basic-Leucine Zipper Transcription Factors / metabolism; Cell Differentiation; Cells, Cultured; DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism; Erythroid Cells / cytology; Ferritins / genetics; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Glutathione S-Transferase pi / metabolism; Hemin / pharmacology; Humans; K562 Cells; NAD(P)H Dehydrogenase (Quinone) / metabolism; Protein Binding; RNA, Messenger / genetics; RNA, Messenger / metabolism; Response Elements / genetics; Transcriptional Activation / genetics
TL;DR: Results suggest that hemin activates the transcription of the ferritin H gene during K562 erythroid differentiation by Ref-1-mediated activation of these b-zip transcription factors to the ARE. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress

ONCOGENE, 24(51), 7567–7578.

By: Y. Tsuji n 

author keywords: ferritin; oxidative stress; JunD; AP1; ARE; iron
MeSH headings : Antioxidants / physiology; Carcinoma, Hepatocellular / pathology; Ferritins / biosynthesis; Ferritins / physiology; Humans; Iron / metabolism; Leukemia, Erythroblastic, Acute / pathology; Liver Neoplasms / pathology; Oxidative Stress; Protein Isoforms; Proto-Oncogene Proteins c-jun / physiology; Response Elements; Transcription Factor AP-1 / physiology; Transcription, Genetic; Tumor Cells, Cultured
TL;DR: Results suggest that JunD is another ARE regulatory protein for transcriptional activation of the human ferritin H gene and probably other antioxidant genes containing the conserved ARE sequences by which JunD may confer cytoprotection during oxidative stress. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Ferritin and the response to oxidative stress

Biochemical Journal, 357(1), 241.

By: K. Orino*, L. Lehman*, Y. Tsuji* , H. Ayaki*, S. Torti * & F. Torti *

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

2000 journal article

Coordinate Transcriptional and Translational Regulation of Ferritin in Response to Oxidative Stress

Molecular and Cellular Biology, 20(16), 5818–5827.

By: Y. Tsuji* , H. Ayaki*, S. Whitman*, C. Morrow*, S. Torti * & F. Torti *

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1999 journal article

Adenovirus E1A blocks oxidant‐dependent ferritin induction and sensitizes cells to pro‐oxidant cytotoxicity

FEBS Letters, 461(3), 334–338.

By: K. Orino*, Y. Tsuji* , F. Torti * & S. Torti *

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1999 journal article

Transcriptional Regulation of the Mouse Ferritin H Gene

Journal of Biological Chemistry, 274(11), 7501–7507.

By: Y. Tsuji* , E. Moran*, S. Torti * & F. Torti *

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1995 journal article

FER-1, an Enhancer of the Ferritin H Gene and a Target of E1A-Mediated Transcriptional Repression

Molecular and Cellular Biology, 15(9), 5152–5164.

By: Y. Tsuji* , N. Akebi*, T. Lam*, Y. Nakabeppu *, S. Torti * & F. Torti *

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1993 journal article

Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1.

Journal of Clinical Investigation, 92(1), 179–185.

By: M. Mohtai*, R. Smith*, D. Schurman*, Y. Tsuji* , F. Torti *, N. Hutchinson*, W. Stetler-Stevenson, G. Goldberg*

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1993 journal article

Preferential repression of the H subunit of ferritin by adenovirus E1A in NIH-3T3 mouse fibroblasts.

Journal of Biological Chemistry, 268(10), 7270–7275.

By: Y. Tsuji* , E. Kwak*, T. Saika*, S. Torti * & F. Torti *

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1991 journal article

Antitumor Activity of a Novel Chimera Tumor Necrosis Factor (TNF-STH) Constructed by Connecting rTNF-S with Thymosin β4 Against Murine Syngeneic Tumors

Journal of Immunotherapy, 10(2), 105–111.

By: K. Noguchi*, H. Inagawa *, Y. Tsuji* , A. Morikawa*, D. Mizuno* & G. Soma*

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3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 4, 2025

1991 journal article

Iron-independent induction of ferritin H chain by tumor necrosis factor.

Proceedings of the National Academy of Sciences, 88(11), 4946–4950.

By: L. Miller*, S. Miller *, S. Torti *, Y. Tsuji*  & F. Torti *

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1990 journal article

Interleukin 1 induces ferritin heavy chain in human muscle cells

Biochemical and Biophysical Research Communications, 169(1), 289–296.

By: Y. Wei *, S. Miller *, Y. Tsuji* , S. Torti * & F. Torti *

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1988 journal article

Biological Activities of Novel Recombinant Tumor Necrosis Factor Having N-Terminal Amino Acid Sequences Derived from Cytotoxic Factors Produced by THP-1 Cells

Journal of Biological Response Modifiers, 7(6), 587–595.

By: G. Soma, Y. Tsuji , Y. Tanabe, K. Noguchi, N. Kitahara-Tanabe, T. Gatanaga, H. Inagawa, M. Kawakami, D. Mizuno

Source: NC State University Libraries
Added: February 10, 2025

1987 journal article

Colchicine activates cell cycle-dependent genes in growth-arrested rat 3Y1 cells

Experimental Cell Research, 173(1), 294–298.

By: M. Miura*, J. Ninomiya-Tsuji* , Y. Tsuji* , S. Ishibashi* & T. Ide*

Contributors: M. Miura*, J. Ninomiya-Tsuji* , Y. Tsuji* , S. Ishibashi* & T. Ide*

Sources: Crossref, NC State University Libraries, ORCID
Added: September 1, 2024

1986 journal article

Events blocked in prereplicative phase in senescent human diploid cells, TIG-1, following serum stimulation

Mechanisms of Ageing and Development, 37(2), 103–117.

By: F. Kihara*, Y. Tsuji* , M. Miura*, S. Ishibashi* & T. Ide*

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1986 journal article

Induction of heat shock proteins in young and senescent human diploid fibroblasts

Mechanisms of Ageing and Development, 36(2), 155–160.

By: Y. Tsuji* , S. Ishibashi* & T. Ide*

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1984 journal article

Induction of host DNA synthesis in senescent human diploid fibroblasts by infection with human cytomegalovirus

Mechanisms of Ageing and Development, 25(1-2), 227–235.

By: T. Ide*, Y. Tsuji* , S. Ishibashi*, Y. Mitsui* & M. Toba*

Sources: Crossref, NC State University Libraries
Added: February 4, 2025

1984 journal article

Loss of responsiveness in senescent human TIG-1 cells to the DNA synthesis-inducing effect of various growth factors

Mechanisms of Ageing and Development, 27(2), 219–232.

By: Y. Tsuji* , T. Ide*, S. Ishibashi* & K. Nishikawa*

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1984 journal article

Progress of aging in human diploid cells transformed with a tsA mutant of simian virus 40

Experimental Cell Research, 150(2), 321–328.

By: T. Ide*, Y. Tsuji* , T. Nakashima* & S. Ishibashi*

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1983 journal article

Correlation between the presence of T-antigen and the reinitiation of host DNA synthesis in senescent human diploid fibroblasts after SV40 infection

Experimental Cell Research, 144(1), 165–169.

By: Y. Tsuji* , T. Ide* & S. Ishibashi*

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

1983 journal article

Reinitiation of host DNA synthesis in senescent human diploid cells by infection with simian virus 40

Experimental Cell Research, 143(2), 343–349.

By: T. Ide*, Y. Tsuji* , S. Ishibashi* & Y. Mitsui*

Sources: NC State University Libraries, Crossref
Added: February 24, 2025

journal article

Activation of the Ferritin H Enhancer, FER-1, by the Cooperative Action of Members of the AP1 and Sp1 Transcription Factor Families

Journal of Biological Chemistry, 273(5), 2984–2992.

By: Y. Tsuji , S. Torti & F. Torti

Source: Crossref
Added: March 2, 2025

journal article

Augmentation by IL-1 alpha of tumor necrosis factor-alpha cytotoxicity in cells transfected with adenovirus E1A.

The Journal of Immunology, 150(5), 1897–1907.

By: Y. Tsuji , J. Ninomiya-Tsuji, S. Torti & F. Torti

Source: Crossref
Added: March 2, 2025

journal article

Improvement of cytotoxicity of tumor necorosis factor (TNF) by increase in basicity of its N-terminal region

Biochemical and Biophysical Research Communications, 148(2), 629–635.

By: G. Soma, N. Kitahara, Y. Tsuji , M. Kato, H. Oshima, T. Gatanaga, H. Inagawa, K. Noguchi, Y. Tanabe, D. Mizuno

Source: Crossref
Added: March 2, 2025

journal article

Selective Loss of CDC2 and CDK2 Induction by Tumor Necrosis Factor-α in Senescent Human Diploid Fibroblasts

Experimental Cell Research, 209(2), 175–182.

By: Y. Tsuji , J. Ninomiya-Tsuji, S. Torti & F. Torti

Source: Crossref
Added: March 2, 2025

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