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Works (28)
Updated: April 3rd, 2024 18:06
2023 journal article
LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 11.
author keywords: lncRNA; Tuna; placental insufficiency; fetal growth restriction (FGR); Cadmium; Nrf2; oxidative stress
TL;DR:
The lncRNA Tuna is identified as a potential novel player in Cd-induced placental insufficiency and increases NRF2/NRF2 both at the transcript and protein levels, confirming that Tuna activates oxidative stress response genes through this pathway.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 3, 2023
2023 journal article
Optimization of Biotinylated RNA or DNA Pull-Down Assays for Detection of Binding Proteins: Examples of IRP1, IRP2, HuR, AUF1, and Nrf2
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(4).
author keywords: RNA pull-down; DNA pull-down; biotin; streptavidin; IRP2; HuR; AUF1; Nrf2; ferritin; IRP-IRE
MeSH headings : Humans; Carrier Proteins / chemistry; DNA / chemistry; Iron / metabolism; Iron Regulatory Protein 1 / chemistry; Iron Regulatory Protein 2 / chemistry; NF-E2-Related Factor 2 / chemistry; RNA / chemistry; Streptavidin / metabolism; Biotinylation; Chromatography, Affinity / methods
TL;DR:
The step-by step optimization of pull-down for IRP with a 5′-biotinylated stem-loop IRE (iron-responsive element) RNA, HuR, and AUF1 with an AU-rich RNA element and Nrf2 binding to an antioxidant- responsive element (ARE) enhancer in the human ferritin H gene is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: March 20, 2023
2020 journal article
Transmembrane protein western blotting: Impact of sample preparation on detection of SLC11A2 (DMT1) and SLC40A1 (ferroportin)
PLOS ONE, 15(7).
MeSH headings : A549 Cells; Antibodies / immunology; Blotting, Western / methods; Caco-2 Cells; Cation Transport Proteins / analysis; Cation Transport Proteins / immunology; Cell Fractionation / methods; HEK293 Cells; HeLa Cells; Hep G2 Cells; Humans; Jurkat Cells; Limit of Detection; MCF-7 Cells
TL;DR:
It is shown here the case that even excellent primary antibodies failed to detect a specific protein of interest due to a routine heating practice of protein samples, suggesting the similar cases for thousands of other transmembrane and heat-sensitive proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 17, 2020
2019 journal article
Iron-induced transferrin receptor-1 mRNA destabilization: A response to "Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation"
RNA, 25(11), 1416–1420.
MeSH headings : Iron; MicroRNAs; RNA Stability; RNA, Messenger; Receptors, Transferrin
TL;DR:
There are several critical issues contained in the article by Connell and colleagues that require further consideration and the opportunity to reply here.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 28, 2019
2019 journal article
Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2
CELL CHEMICAL BIOLOGY, 26(1), 85-+.
MeSH headings : Adolescent; Adult; Aged; Animals; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Cell Proliferation / drug effects; Cell Survival / drug effects; Cells, Cultured; Cisplatin / metabolism; Cisplatin / pharmacology; Drug Screening Assays, Antitumor; Female; Fetus; Humans; Iron / metabolism; Iron Deficiencies; Iron Regulatory Protein 2 / antagonists & inhibitors; Iron Regulatory Protein 2 / genetics; Iron Regulatory Protein 2 / metabolism; Male; Mice; Middle Aged; Molecular Structure; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / metabolism; Neoplasms, Experimental / pathology
TL;DR:
Cisplatin is an inhibitor of IRP2 that induces intracellular iron deficiency and combination of cisplatin and the iron chelator desferrioxamine enhanced cytotoxicity through augmented iron depletion in culture and xenograft mouse model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 4, 2019
2017 journal article
Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis
JOURNAL OF MOLECULAR BIOLOGY, 429(1), 64–78.
author keywords: ATF1; HIPK1; CCNA1; CBP; TAF4
MeSH headings : Arsenic / metabolism; Carrier Proteins / metabolism; Cell Line; Cyclic AMP Response Element-Binding Protein / metabolism; Gene Expression Profiling; Humans; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / metabolism; Serine / metabolism; Transcriptional Activation
TL;DR:
The results suggest that the HIPK2-phospho-Ser271 CREB axis is a new arsenic-responsive CREB activation mechanism in parallel with the PKA-ph phosphate-based activation mechanism of Ser133 CREB.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Nuclear lamins and progerin are dispensable for antioxidant Nrf2 response to arsenic and cadmium
CELLULAR SIGNALLING, 33, 69–78.
author keywords: HGPS; Nrf2; Lamin; Progerin; Arsenic; Cadmium
MeSH headings : Antioxidants / metabolism; Arsenic / toxicity; Cadmium / toxicity; Cell Line, Tumor; Cell Nucleus / metabolism; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Profiling; Gene Knockdown Techniques; Heme Oxygenase-1 / metabolism; Humans; Kelch-Like ECH-Associated Protein 1 / metabolism; Lamin Type A / metabolism; Lamins / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Oxidative Stress / genetics; Phosphorylation / drug effects; Progeria / metabolism; Progeria / pathology; Sequestosome-1 Protein / metabolism
TL;DR:
The results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 response to arsenic and cadmium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 review
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease
[Review of ]. TRENDS IN BIOCHEMICAL SCIENCES, 41(3), 274–286.
MeSH headings : Cell Death; Homeostasis; Humans; Iron / metabolism
TL;DR:
New regulators of iron metabolism are highlighted, including iron-trafficking proteins [solute carrier family 39, SLC39, also known as ZRT/IRT-like protein, ZIP; and poly-(rC)-binding protein, PCBP] and a cargo receptor (NCOA4) that is crucial for release of ferritin-bound iron.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 review
Siderophores in Iron Metabolism: From Mechanism to Therapy Potential
[Review of ]. TRENDS IN MOLECULAR MEDICINE, 22(12), 1077–1090.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / immunology; Bacteria / metabolism; Bacterial Infections / drug therapy; Bacterial Infections / immunology; Bacterial Infections / metabolism; Drug Discovery; Host-Pathogen Interactions / drug effects; Humans; Iron / immunology; Iron / metabolism; Lipocalin-2 / immunology; Lipocalin-2 / metabolism; Siderophores / immunology; Siderophores / metabolism
TL;DR:
This review discusses the recently described molecular mechanisms of siderophore iron trafficking between host and bacteria, highlighting the therapeutic potential of exploiting pathogen sidersophore machinery for the treatment of antibiotic-resistant bacterial infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1
ANTIOXIDANTS & REDOX SIGNALING, 25(17), 953–964.
author keywords: intestine; TAK1; Nrf2; Keap1; p62/SQSTM
MeSH headings : Animals; Antioxidants / metabolism; Cell Line; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Kelch-Like ECH-Associated Protein 1 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Models, Biological; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress; Protein Binding; Proteolysis; Reactive Oxygen Species / metabolism; Sequestosome-1 Protein / metabolism
TL;DR:
The results identify for the first time that TAK1 is a modulator of p62/SQSTM1-dependent Keap1 degradation and maintains the steady state-level of Nrf2, important for homeostatic antioxidant protection in the intestinal epithelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1849(10), 1277–1288.
author keywords: Nrf2; Histone; Epigenetic; Arsenic; HO-1; Antioxidant response element
MeSH headings : Animals; Antioxidant Response Elements / genetics; Arsenites / pharmacology; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1 / biosynthesis; Heme Oxygenase-1 / genetics; Heme Oxygenase-1 / metabolism; Histones / genetics; Histones / metabolism; Humans; Keratinocytes / metabolism; Mice; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / genetics; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Signal Transduction; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR:
It is proposed that Nrf2 may influence H3S10 phosphorylation at the HO-1 ARE and additional promoter regions, which highlights the complex interplay between NRF2 and H 3S10osphorylation in arsenite-activatedHO-1 transcription.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels
CELLULAR SIGNALLING, 26(12), 2702–2709.
author keywords: Hypoxia; Cobalt chloride; Hypoxia inducible factor (HIF); Iron regulatory protein (IRP); Nrf2; Ferritin
MeSH headings : Apoferritins / genetics; Cell Line, Tumor; Cobalt / pharmacology; Ferritins / genetics; Gene Expression Regulation / genetics; Humans; Hypoxia / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Iron-Regulatory Proteins / genetics; Protein Processing, Post-Translational / drug effects; Protein Processing, Post-Translational / genetics; RNA, Messenger / genetics; Transcription, Genetic / drug effects; Transcription, Genetic / genetics; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR:
It is demonstrated that hypoxia and cobalt chloride regulate ferritin heavy chain (ferritin H) expression by two distinct mechanisms through the interplay between DNA and mRNA elements at the transcriptional and post-transcriptional levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene
MOLECULAR BIOLOGY OF THE CELL, 25(13), 2116–2127.
MeSH headings : Antioxidants / physiology; Apoptosis; Cell Differentiation; Erythroid Cells / metabolism; Hemin / pharmacology; Humans; K562 Cells; Mitochondria / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress; Phosphorylation; Protein Isoforms / physiology; Protein Processing, Post-Translational; Protein Transport; Reactive Oxygen Species / metabolism; Response Elements; Shc Signaling Adaptor Proteins / physiology; Src Homology 2 Domain-Containing, Transforming Protein 1; Transcription, Genetic; Transcriptional Activation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Role of AMP-Activated Protein Kinase in Ferritin H Gene Expression by Resveratrol in Human T Cells
BIOCHEMISTRY, 52(30), 5075–5083.
MeSH headings : AMP-Activated Protein Kinases / antagonists & inhibitors; AMP-Activated Protein Kinases / chemistry; AMP-Activated Protein Kinases / genetics; AMP-Activated Protein Kinases / metabolism; Antioxidants / chemistry; Antioxidants / pharmacology; Apoferritins / genetics; Apoferritins / metabolism; Enzyme Activation / drug effects; Gene Expression Regulation / drug effects; Glycogen Synthase Kinase 3 / antagonists & inhibitors; Glycogen Synthase Kinase 3 / genetics; Glycogen Synthase Kinase 3 / metabolism; Glycogen Synthase Kinase 3 beta; Humans; Jurkat Cells; K562 Cells; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Phosphorylation / drug effects; Protein Processing, Post-Translational / drug effects; RNA Interference; Response Elements / drug effects; Resveratrol; Serine / metabolism; Stilbenes / antagonists & inhibitors; Stilbenes / pharmacology; T-Lymphocytes / drug effects; T-Lymphocytes / metabolism
TL;DR:
It is found that AMP-activated protein kinase (AMPK) plays a key role in the activation of nuclear factor E2-related factor (Nrf2) and subsequent ARE-dependent ferritin H gene transcription by resveratrol.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4
FASEB JOURNAL, 27(9), 3763–3774.
author keywords: arsenic; histone methylation; antioxidant; oxidative stress
MeSH headings : Antioxidants / metabolism; Arsenic / toxicity; Cell Line; Cells, Cultured; Ferritins / genetics; Fibroblasts / cytology; Fibroblasts / metabolism; Histones / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Methylation; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Oxidative Stress / genetics; Protein-Arginine N-Methyltransferases / genetics; Protein-Arginine N-Methyltransferases / metabolism; Repressor Proteins / genetics; Repressor Proteins / metabolism; Transcription, Genetic / drug effects; Transcription, Genetic / genetics
TL;DR:
To test the hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, PRMT1 and PRMT4 regulate the ARE and cellular antioxidant response to arsenic, and focused microarray characterized several oxidative stress response genes are subject toPRMT1 orPRMT4 regulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 review
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
[Review of ]. CELLULAR SIGNALLING, 24(5), 981–990.
author keywords: Reactive oxygen species; MAPK; Shc; Nrf2; ATM; Iron
MeSH headings : Amino Acid Sequence; Animals; Gene Expression Regulation; Homeostasis; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Molecular Sequence Data; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species / metabolism; Signal Transduction
TL;DR:
This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival, ROS homeostasis and antioxidant gene regulation, mitochondrial oxidative stress, apoptosis, and aging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Regulation of Genotoxic Stress Response by Homeodomain-interacting Protein Kinase 2 through Phosphorylation of Cyclic AMP Response Element-binding Protein at Serine 271
MOLECULAR BIOLOGY OF THE CELL, 21(16), 2966–2974.
MeSH headings : Animals; Antineoplastic Agents, Phytogenic / pharmacology; Blotting, Western; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; CREB-Binding Protein / genetics; CREB-Binding Protein / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Line, Tumor; Cells, Cultured; Cyclic AMP Response Element-Binding Protein / genetics; Cyclic AMP Response Element-Binding Protein / metabolism; DNA Damage; Embryo, Mammalian / cytology; Etoposide / pharmacology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; HEK293 Cells; Humans; K562 Cells; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; RNA Interference; Serine / genetics; Serine / metabolism; Transcription, Genetic / drug effects; Two-Hybrid System Techniques
TL;DR:
Homeodomain-interacting protein kinase 2 is a new CREB kinase for phosphorylation at Ser-271 but not Ser-133 in genotoxic stress and activates CREB transactivation function including brain-derived neurotrophic factor (BDNF) mRNA expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress
JOURNAL OF CELL SCIENCE, 123(22), 3863–3871.
author keywords: HIPK2; ATF1; Phosphorylation; Ferritin; Genotoxic stress; Transcription
MeSH headings : Activating Transcription Factor 1 / genetics; Activating Transcription Factor 1 / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Growth Processes / genetics; Cell Survival / genetics; DNA Damage; Ferritins / genetics; Ferritins / metabolism; Gene Expression Regulation; Humans; Phosphorylation; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
HIPK2 (homeodomain-interacting protein kinase 2), a DNA-damage-responsive nuclear kinase, is a new ATF1 kinase involved in the regulation of ferritin H and other antioxidant detoxification genes in genotoxic stress conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Role of the Tumor Suppressor PTEN in Antioxidant Responsive Element-mediated Transcription and Associated Histone Modifications
MOLECULAR BIOLOGY OF THE CELL, 20(6), 1606–1617.
MeSH headings : Antioxidants / metabolism; Apoptosis / drug effects; Cell Line; Ferritins / genetics; Ferritins / metabolism; Histones / metabolism; Humans; Hydrogen Peroxide / pharmacology; Hydroquinones / pharmacology; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism; PTEN Phosphohydrolase / genetics; PTEN Phosphohydrolase / metabolism; Protein Binding; Proto-Oncogene Proteins c-akt / metabolism; RNA, Messenger / genetics; Response Elements / genetics; Transcription, Genetic / drug effects; Transcription, Genetic / genetics; Transcriptional Activation / genetics
TL;DR:
It is demonstrated that the status of PTEN determines cellular susceptibility to oxidative stress through antioxidant-responsive element (ARE)-mediated transcription of detoxification genes and ferritin H transcription was robustly induced in tert-butylhydroquinone (t-BHQ)-treated Jurkat cells via an ARE, and it was due to PTEN deficiency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization
BIOCHEMICAL JOURNAL, 411, 107–113.
author keywords: antioxidant-responsive element (ARE); calcineurin; calcium; ferritin; ionomycin; nuclear factor of activated T-cells (NFAT)
MeSH headings : 3T3 Cells; Animals; Apoferritins / genetics; Calcineurin / metabolism; Calcium / physiology; Gene Expression Regulation; Humans; Ionomycin / pharmacology; Jurkat Cells; Mice; NFATC Transcription Factors / metabolism; RNA Stability; Response Elements
TL;DR:
The results suggest that ionomycin-mediated induction of ferritin H may occur in an NFAT-independent manner but through post-transcriptional stabilization of the ferritine H mRNA half-life.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 review
Intracellular iron transport and storage: From molecular mechanisms to health implications
[Review of ]. ANTIOXIDANTS & REDOX SIGNALING, 10(6), 997–1030.
MeSH headings : Animals; Biological Transport; Humans; Iron / metabolism; Iron Overload / genetics; Iron-Binding Proteins / metabolism; Mice; Oxidative Stress; Transferrin / metabolism
TL;DR:
The molecular mechanisms responsible for regulation of iron absorption, transport, and storage through the roles of key regulatory proteins, including ferroportin, hepcidin, ferritin, and frataxin are highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Post-transcriptional Modulation of Iron Homeostasis during p53-dependent Growth Arrest
Journal of Biological Chemistry, 283(49), 33911–33918.
MeSH headings : Antigens, CD / chemistry; Apoferritins / chemistry; Cation Transport Proteins / biosynthesis; Cation Transport Proteins / chemistry; Cell Cycle; Cell Line, Tumor; Ferritins / chemistry; Homeostasis; Humans; Iron / chemistry; Models, Biological; Protein Binding; Protein Structure, Tertiary; RNA Processing, Post-Transcriptional; Receptors, Transferrin / chemistry; Transcription, Genetic; Tumor Suppressor Protein p53 / metabolism
TL;DR:
The results suggest that p53 may induce cell cycle arrest not only by well described mechanisms involving the induction of cyclin-dependent kinase inhibitors but also by the recruitment of pathways that reduce the availability of intracellular iron.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2008 journal article
Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress
FREE RADICAL BIOLOGY AND MEDICINE, 44(9), 1762–1771.
author keywords: ferritin; rotenone; mitochondria; iron; oxidative stress; free radicals
MeSH headings : Animals; Antioxidants / metabolism; Apoferritins / chemistry; Cell Line, Tumor; Gene Expression Regulation; Humans; Mice; Mitochondria / metabolism; Models, Biological; NF-E2-Related Factor 2 / metabolism; NIH 3T3 Cells; Oxidative Stress; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins c-jun; Rotenone / pharmacology; Uncoupling Agents / pharmacology
TL;DR:
Results suggest that ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to ARE activation and may be critically important to protect cells from mitochondrial dysfunction and oxidative stress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element
JOURNAL OF BIOLOGICAL CHEMISTRY, 282(31), 22335–22343.
MeSH headings : Activating Transcription Factor 1 / metabolism; Animals; Antioxidants / metabolism; Apoferritins / genetics; DNA-Binding Proteins / metabolism; Humans; K562 Cells; Mice; Molecular Chaperones / metabolism; NF-E2-Related Factor 2 / metabolism; NIH 3T3 Cells; Nuclear Proteins / metabolism; Protein Binding; Protein Inhibitors of Activated STAT / metabolism; RNA, Small Interfering / metabolism; Regulatory Factor X Transcription Factors; SUMO-1 Protein; Small Ubiquitin-Related Modifier Proteins / metabolism; Transcription Factors
TL;DR:
PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene, which is a major intracellular iron storage protein involved in iron homeostasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats
International Journal of Oncology, 29(4), 829–838.
TL;DR:
The results indicate conclusively that in LEC rat liver, akr1b7 might be up-regulated by oxidative stress mediated through NF-kappaB, but not that mediated directly by copper.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Coordinate Inhibition of Cytokine-mediated Induction of Ferritin H, Manganese Superoxide Dismutase, and Interleukin-6 by the Adenovirus E1A Oncogene
Journal of Biological Chemistry, 281(24), 16428–16435.
TL;DR:
The results suggest that p300/CBP is a critical control point in NF-κB-dependent transcriptional regulation of cytoprotective genes by cytokines.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2006 journal article
Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells
MOLECULAR AND CELLULAR BIOLOGY, 26(7), 2845–2856.
MeSH headings : Antioxidants / metabolism; Antioxidants / pharmacology; Basic-Leucine Zipper Transcription Factors / metabolism; Cell Differentiation; Cells, Cultured; DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism; Erythroid Cells / cytology; Ferritins / genetics; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Glutathione S-Transferase pi / metabolism; Hemin / pharmacology; Humans; K562 Cells; NAD(P)H Dehydrogenase (Quinone) / metabolism; Protein Binding; RNA, Messenger / genetics; RNA, Messenger / metabolism; Response Elements / genetics; Transcriptional Activation / genetics
TL;DR:
Results suggest that hemin activates the transcription of the ferritin H gene during K562 erythroid differentiation by Ref-1-mediated activation of these b-zip transcription factors to the ARE.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress
ONCOGENE, 24(51), 7567–7578.
author keywords: ferritin; oxidative stress; JunD; AP1; ARE; iron
MeSH headings : Antioxidants / physiology; Carcinoma, Hepatocellular / pathology; Ferritins / biosynthesis; Ferritins / physiology; Humans; Iron / metabolism; Leukemia, Erythroblastic, Acute / pathology; Liver Neoplasms / pathology; Oxidative Stress; Protein Isoforms; Proto-Oncogene Proteins c-jun / physiology; Response Elements; Transcription Factor AP-1 / physiology; Transcription, Genetic; Tumor Cells, Cultured
TL;DR:
Results suggest that JunD is another ARE regulatory protein for transcriptional activation of the human ferritin H gene and probably other antioxidant genes containing the conserved ARE sequences by which JunD may confer cytoprotection during oxidative stress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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