Works Published in 2012
Displaying works 1 - 20 of 112 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas
Cancer, 118(23), 5878–5887.
author keywords: angiosarcoma; p53; phosphoinositide-3-kinase; catalytic; alpha polypeptide; phosphatase and tensin homolog; complex karyotype
MeSH headings : Adult; Aged; Aged, 80 and over; Class I Phosphatidylinositol 3-Kinases; Female; Genes, p53; Genomics; Hemangiosarcoma / etiology; Hemangiosarcoma / genetics; Humans; Male; Middle Aged; Mutation; PTEN Phosphohydrolase / genetics; Phosphatidylinositol 3-Kinases / physiology; Proto-Oncogene Proteins B-raf / genetics; Proto-Oncogene Proteins c-akt / physiology; Proto-Oncogene Proteins c-mdm2 / analysis; Signal Transduction / physiology; TOR Serine-Threonine Kinases / physiology
TL;DR:
The p53 and phosphoinositide‐3‐kinase, catalytic, alpha polypeptide/v‐akt murine thymoma viral oncogene homolog/mechanistic target of rapamycin (PIK3CA/AKT/mTOR) pathways frequently are altered in sarcoma with complex genomics, such as leiomyosarcoma (LMS) or undifferentiated pleomorphic sarcomA (UPS).
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: August 14, 2021
2012 journal article
A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations
Cancer Genetics, 205(11), 572–587.
author keywords: Osteosarcoma; oligo-aCGH; canine; comparative oncology
MeSH headings : Adolescent; Adult; Algorithms; Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Child; Chromosome Aberrations; Comparative Genomic Hybridization / methods; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Genome, Human; Genomics / methods; Humans; Male; Osteosarcoma / genetics; Osteosarcoma / veterinary; Species Specificity
TL;DR:
These findings support and build upon the high level of cytogenetic complexity, through the identification of shared regions of microaberration and functional analysis of possible orthologous OS-associated genes to pinpoint the cellular processes most commonly affected by aberration in human and canine OS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 14, 2021
2012 journal article
Failure to amplify bartonella koehlerae dna from blood of cats and their fleas in the united states
Journal of Veterinary Internal Medicine, 26(3), 791–792.
Event: ACVIM at New Orleans, LA on May 30 - June 2, 2012
Source: NC State University Libraries
Added: March 7, 2021
2012 journal article
Performance of the new in-clinic snap (R) 4dx (R) plus test for the detection of ehrlichia ewingii (granulocytic ehrlichiosis) and anaplasma platys (thrombocytotropic anaplasmosis) antibodies in dogs
Journal of Veterinary Internal Medicine, 26(3), 795–796.
Event: 2012 ACVIM Forum at New Orleans, LA on May 30 - June 2, 2012
Source: NC State University Libraries
Added: March 7, 2021
2012 journal article
Bartonella bacteremia detected in non-lesional skin with laser scanning confocal microscopy
Journal of Investigative Dermatology, 132, S49.
Source: NC State University Libraries
Added: March 7, 2021
2012 journal article
Candidatus Bartonella merieuxii, a Potential New Zoonotic Bartonella Species in Canids from Iraq
PLoS Neglected Tropical Diseases, 6(9), e1843.
Ed(s): J. Vinetz
MeSH headings : Animals; Bartonella / classification; Bartonella / genetics; Bartonella / isolation & purification; Bartonella Infections / veterinary; Cluster Analysis; DNA, Bacterial / blood; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; DNA, Intergenic / chemistry; DNA, Intergenic / genetics; DNA-Directed RNA Polymerases / genetics; Dogs; Female; Foxes; Iraq; Jackals; Male; Molecular Sequence Data; Phylogeny; Sequence Analysis, DNA; Seroepidemiologic Studies
TL;DR:
Seroprevalence in Iraqi dog owners and bacteremia in Iraqi people with unexplained fever or culture negative endocarditis requires further investigation as well as in United States military personnel who were stationed in Iraq.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 20, 2021
2012 journal article
Bartonella henselaeInfection Detected in Patients with Inflammatory Breast Cancer.
Cancer Research, 72(24 Supplement), P3–10-03.
Event: Poster Session at the Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium at San Antonio, TX on December 4-8, 2012
TL;DR:
It is suggested that bacteria infections such as the one produced by Bartonella henselae might contribute to the clinical and pathological characteristics of IBC, associated with rapid spread of the breast tumor cells through the lymphatic system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 13, 2021
2012 journal article
Bartonella spp. Bacteremia and Rheumatic Symptoms in Patients from Lyme Disease–endemic Region
Emerging Infectious Diseases, 18(11), 1919b–1921.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 13, 2021
2012 journal article
Granulomatous hepatitis due to Bartonella henselae infection in an immunocompetent patient
BMC Infectious Diseases, 12(1), 17.
author keywords: Granulomatous hepatitis; Bartonella henselae; Diagnosis; Treatment
MeSH headings : Adult; Bartonella Infections / diagnosis; Bartonella Infections / microbiology; Bartonella Infections / pathology; Bartonella Infections / surgery; Bartonella henselae / isolation & purification; Blood / microbiology; Female; Granuloma / microbiology; Granuloma / pathology; Hepatitis / diagnosis; Hepatitis / microbiology; Hepatitis / pathology; Hepatitis / surgery; Histocytochemistry; Humans; Liver / microbiology; Liver / pathology; Microscopy; Polymerase Chain Reaction; Radiography, Abdominal; Tomography, X-Ray Computed
TL;DR:
The diagnosis of hepatic bartonellosis is exceedingly difficult to establish and requires a high degree of clinical suspicion, and recently developed, PCR-based approaches may be required in select patients to make the diagnosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 13, 2021
2012 journal article
Bartonellaspp. Infection in Healthy and Sick Horses and Foals from the Southeastern United States
Journal of Veterinary Internal Medicine, 26(6), 1408–1412.
author keywords: Bartonella vinsonii; coinfection; foals; lameness
MeSH headings : Animals; Antibodies, Bacterial; Bacteremia / blood; Bacteremia / veterinary; Bartonella / isolation & purification; Bartonella Infections / epidemiology; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Female; Fluorescent Antibody Technique, Indirect / veterinary; Horse Diseases / epidemiology; Horse Diseases / microbiology; Horses; Male; Polymerase Chain Reaction / veterinary; Serologic Tests; Southeastern United States
TL;DR:
Horses in the southeastern United States are naturally infected with B. berkhofii genotypes I and III, and a bacteria most similar to Candidatus Bartonella volans, and further investigation into the pathogenic potential of Bart onella spp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 24, 2021
2012 journal article
Isolation of a Novel Strain of Mycobacterium iranicum from a Woman in the United States
Journal of Clinical Microbiology, 51(2), 705–707.
MeSH headings : Female; Genes, Bacterial; Humans; Lung / diagnostic imaging; Lung / pathology; Middle Aged; Mycobacterium / classification; Mycobacterium / genetics; Mycobacterium / isolation & purification; Mycobacterium Infections, Nontuberculous / diagnosis; Mycobacterium Infections, Nontuberculous / transmission; Radiography; Sputum / microbiology; United States
TL;DR:
A novel strain of Mycobacterium iranicum, a recently described nontuberculous Myc Cobacterium species, was isolated from the sputum of a woman and fomite transmission of inhaled aerosolized secretions from her husband's sleep apnea equipment was historically possible.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 21, 2021
2012 journal article
Infection of human brain vascular pericytes (HBVPs) by Bartonella henselae
Medical Microbiology and Immunology, 202(2), 143–151.
author keywords: Blood vessels; Bacteria; Cytokines; Vascular endothelial growth factor; Pericyte coverage
MeSH headings : Angiomatosis, Bacillary / metabolism; Angiomatosis, Bacillary / microbiology; Apoptosis; Bartonella henselae / physiology; Brain / metabolism; Brain / microbiology; Brain / pathology; Cell Proliferation; Cells, Cultured; Humans; Pericytes / metabolism; Pericytes / microbiology; Pericytes / ultrastructure; Vascular Endothelial Growth Factor A / biosynthesis
TL;DR:
After infecting human brain vascular pericytes with Bartonella henselae, it was found that these bacteria were able to invade HBVPs and that bacterial infection resulted in decreased pericyte proliferation and increased pericyter production of vascular endothelial growth factor (VEGF) when compared to the uninfected control cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 21, 2021
2012 journal article
Bartonella henselae infection in a man with hypergammaglobulinaemia, splenomegaly and polyclonal plasmacytosis
Journal of Medical Microbiology, 62(Pt_2), 338–341.
MeSH headings : Aged; Bartonella Infections / complications; Bartonella Infections / diagnosis; Bartonella Infections / microbiology; Bartonella henselae / isolation & purification; Cat-Scratch Disease / diagnosis; Cat-Scratch Disease / microbiology; Humans; Hypergammaglobulinemia / complications; Male; Splenomegaly / complications
TL;DR:
Clinicians should remain cognizant of the heterogeneous clinical presentations associated with bartonellosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: January 21, 2021
2012 journal article
Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior
Proceedings of the National Academy of Sciences, 110(3), 1017–1022.
author keywords: genetic architecture; chemosensation; behavioral genetics
MeSH headings : Animals; Behavior, Animal / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene Regulatory Networks; Genes, Insect; Genetic Association Studies; Genetic Variation; Genetics, Behavioral; Genome-Wide Association Study; Humans; Male; Models, Genetic; Models, Neurological; Neurogenesis / genetics; Neurogenesis / physiology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Smell / genetics; Smell / physiology
TL;DR:
The results suggest that fully understanding the genotype–phenotype relationship requires a paradigm shift from a focus on single SNPs to pathway associations, and the lack of replication between the GWA analyses, small marginal SNP effects, and convergence on common cellular networks were likely attributable to epistasis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 5, 2021
2012 journal article
Stable Synthetic Bacteriochlorins for Photodynamic Therapy: Role of Dicyano Peripheral Groups, Central Metal Substitution (2H, Zn, Pd), and Cremophor EL Delivery
ChemMedChem, 7(12), 2155–2167.
author keywords: antitumor agents; Cremophor EL micelles; photodynamic therapy; photostability; reactive oxygen species; synthetic bacteriochlorins
MeSH headings : Animals; Coordination Complexes / administration & dosage; Coordination Complexes / chemistry; Coordination Complexes / pharmacology; Glycerol / analogs & derivatives; Glycerol / chemistry; HeLa Cells; Humans; Neoplasms / drug therapy; Palladium / administration & dosage; Palladium / chemistry; Palladium / pharmacology; Pharmaceutical Vehicles / chemistry; Photochemotherapy; Photosensitizing Agents / administration & dosage; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology; Porphyrins / administration & dosage; Porphyrins / chemistry; Porphyrins / pharmacology; Zinc / administration & dosage; Zinc / chemistry; Zinc / pharmacology
TL;DR:
The incorporation of cyano substituents provides an excellent motif for the enhancement of the photoactivity and photostability of bacteriochlorins as PDT photosensitizers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 6, 2020
2012 journal article
Invasion of canine erythrocytes by Bartonella vinsonii subsp. berkhoffii
Veterinary Microbiology, 156(1-2), 213–216.
author keywords: Bartonella vinsonii subsp berkhoffii; Erythrocyte; Canine; Invasion
MeSH headings : Animals; Bacteremia / microbiology; Bacteremia / veterinary; Bartonella / genetics; Bartonella / immunology; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Dog Diseases / microbiology; Dogs; Female; Humans; Middle Aged
TL;DR:
It is suggested that canine erythrocytes may serve in the maintenance of bacteremia due to B. vinsonii subsp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 2, 2020
2012 journal article
Extensive epistasis for olfactory behaviour, sleep and waking activity in Drosophila melanogaster
Genetics Research, 94(1), 9–20.
MeSH headings : Animals; Benzaldehydes; Calreticulin / genetics; Calreticulin / physiology; Chromosomes, Insect; DNA Transposable Elements; Drosophila Proteins / genetics; Drosophila Proteins / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Female; Genes, Insect; Genetic Pleiotropy; Male; Membrane Glycoproteins / genetics; Membrane Glycoproteins / physiology; Mutagenesis, Insertional; Mutation; Odorants; Phenotype; Quantitative Trait, Heritable; Reflex, Startle / genetics; Semaphorins / genetics; Semaphorins / physiology; Sleep / genetics; Smell / genetics; Wakefulness / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2012 journal article
A Semi-nonparametric Approach to Joint Modeling of A Primary Binary Outcome and Longitudinal Data Measured at Discrete Informative Times
Statistics in Biosciences, 4(2), 213–234.
author keywords: EM algorithm; Informative observation times; IVF; Joint model; Longitudinal data; Maximum likelihood estimation; SNP density
TL;DR:
This work proposes to introduce a third model in the joint model for the informative β-hCG observation times, and relax the normality distributional assumption of random effects using the semi-nonparametric (SNP) approach of Gallant and Nychka (Econometrica 55:363–390, 1987).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Epistasis dominates the genetic architecture of Drosophila quantitative traits
Proceedings of the National Academy of Sciences, 109(39), 15553–15559.
author keywords: chill coma recovery; genetic interaction networks; genome-wide association studies; startle response; starvation resistance
MeSH headings : Animals; Drosophila melanogaster; Epistasis, Genetic / physiology; Genes, Insect / physiology; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable
TL;DR:
The analysis underscores the importance of epistasis as a principal factor that determines variation for quantitative traits and provides a means to uncover genetic networks affecting these traits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2012 journal article
The Drosophila melanogaster Genetic Reference Panel
Nature, 482(7384), 173–178.
MeSH headings : Alleles; Animals; Centromere / genetics; Chromosomes, Insect / genetics; Drosophila melanogaster / genetics; Genome-Wide Association Study; Genomics; Genotype; Phenotype; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics; Selection, Genetic / genetics; Starvation / genetics; Telomere / genetics; X Chromosome / genetics
TL;DR:
The Drosophila melanogaster Genetic Reference Panel is described, a community resource for analysis of population genomics and quantitative traits, which reveals reduced polymorphism in centromeric autosomal regions and the X chromosomes, evidence for positive and negative selection, and rapid evolution of the X chromosome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
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