Seema Nandi

Works (14)

Updated: April 27th, 2024 05:01

2024 journal article

Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma

Science Translational Medicine, 16(742).

By: K. Nellenbach n, E. Mihalko n, S. Nandi n, D. Koch n, J. Shetty *, L. Moretti *, J. Sollinger n, N. Moiseiwitsch n ...

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Added: April 22, 2024

2021 journal article

Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma

SCIENCE ADVANCES, 7(41).

By: E. Ogunnaike  n, A. Valdivia *, M. Yazdimamaghani *, E. Leon *, S. Nandi n, H. Hudson *, H. Du*, S. Khagi * ...

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Added: October 26, 2021

2021 journal article

Platelet‐like</scp> particles reduce <scp>coagulopathy‐related</scp> and neuroinflammatory pathologies <scp>post‐experimental</scp> traumatic brain injury

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 109(12), 2268–2278.

By: J. Todd*, V. Bharadwaj *, K. Nellenbach n, S. Nandi n, E. Mihalko n, C. Copeland*, A. Brown n , S. Stabenfeldt *

author keywords: blood-brain barrier; coagulopathy; neuroinflammation; permeability; platelet-like particles; traumatic brain injury
MeSH headings : Animals; Blood Platelets / metabolism; Blood-Brain Barrier / metabolism; Brain Injuries, Traumatic / complications; Brain Injuries, Traumatic / drug therapy; Brain Injuries, Traumatic / metabolism; Disease Models, Animal; Mice; Microglia / metabolism
TL;DR: Results suggest that PLP-treatment addressed acute hypocoagulation and decreased BBB permeability followed by decreased neuroinflammation and fold-change tissue loss by 7 days post-injury, indicating that PLPs could be a potential therapeutic modality for TBI. (via Semantic Scholar)
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Added: June 21, 2021

2021 journal article

Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses

Advanced Therapeutics, 4(5).

By: S. Nandi n, E. Mihalko n, K. Nellenbach n, M. Castaneda  n, J. Schneible n, M. Harp*, H. Deal n, M. Daniele n  ...

author keywords: bleeding; Clotting; fibrin; hemostasis; microgel
TL;DR: Soft microgels decorated with the peptide AHRPYAAK are found to significantly increase clot density in vitro and decrease bleeding in a rodent trauma model in vivo, indicating that FAMCYs are capable of recapitulating the platelet‐mimetic properties of previous designs while utilizing a less costly, more translational design. (via Semantic Scholar)
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Added: April 5, 2021

2020 journal article

Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet‐like particles

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108(6), 2599–2609.

By: E. Chee n, S. Nandi n, K. Nellenbach n, E. Mihalko n, D. Snider  n, L. Morrill n, A. Bond  n, E. Sproul n ...

Contributors: E. Chee n, S. Nandi n, K. Nellenbach n, E. Mihalko n, D. Snider  n, L. Morrill n, A. Bond  n, E. Sproul n ...

author keywords: antimicrobial; microgels; nanosilver; platelet-mimetic; wound healing
MeSH headings : Acrylic Resins / chemistry; Animals; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Blood Platelets; Clot Retraction; Colony-Forming Units Assay; Fibrin / chemistry; Fibrin / immunology; Gels; Hemorrhage / drug therapy; Hemostasis / drug effects; Liver / injuries; Male; Metal Nanoparticles; Mice; Mice, Inbred C57BL; Microgels; Silver / administration & dosage; Silver / chemistry; Wound Healing
TL;DR: It is found that nanosilver incorporation does not affect base PLP performance while bestowing significant antimicrobial activity and enhancing infected wound healing outcomes, and Ag-PLPs have great promise for treating hemorrhage and improving healing following trauma. (via Semantic Scholar)
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Added: March 16, 2020

2020 journal article

Neonatal Fibrin Scaffolds Promote Enhanced Cell Adhesion, Migration, and Wound Healing In Vivo Compared to Adult Fibrin Scaffolds

Cellular and Molecular Bioengineering, 13(5), 393–404.

By: K. Nellenbach n, S. Nandi n, C. Peeler  n, A. Kyu  n & A. Brown n 

TL;DR: In vivo significantly smaller wound areas and greater epidermal thickness were observed when wounds were treated with neonatal fibrin compared to adultfibrin or a saline control, indicating that fibr in scaffolds sourced from neonatal plasma could improve healing outcomes compared to scaffoldsourced from adult plasma. (via Semantic Scholar)
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Added: June 15, 2020

2020 journal article

Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects

Journal of Colloid and Interface Science, 577, 406–418.

By: S. Nandi n, L. Sommerville *, K. Nellenbach n, E. Mihalko n, M. Erb n, D. Freytes n, M. Hoffman *, D. Monroe *, A. Brown n 

author keywords: Fibrin; Biomimetic; Platelet; Hemophilia; Biomaterials
MeSH headings : Blood Coagulation; Blood Platelets; Fibrin; Plasma; Wound Healing
TL;DR: PLPs improved clot network density, force generation, and stiffness, and promoted fibroblast migration within an in vitro model of early wound healing under hemophilic conditions, indicating that PLPs could provide a biomimetic platform for improving wound healing events in disease conditions that cause deficient fibrin network formation. (via Semantic Scholar)
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Added: August 24, 2020

2020 journal article

Ultrasound Enhanced Synthetic Platelet Therapy for Augmented Wound Repair

ACS Biomaterials Science & Engineering, 6(5), 3026–3036.

By: S. Nandi n, K. Mohanty n, K. Nellenbach n, M. Erb n, M. Muller n  & A. Brown n 

author keywords: biomimetic; fibrin; wound healing clot retraction; artificial platelet
MeSH headings : Blood Coagulation; Blood Platelets; Clot Retraction; Fibrin; Wound Healing
TL;DR: Application of ultrasound in combination with a subtherapeutic dosage of PLPs resulted in increased clot density and stiffness, improved fibroblast migration in vitro and increased epidermal thickness and angiogenesis in vivo, indicating that this combination therapy has potential to facilitate multiphase pro-healing outcomes. (via Semantic Scholar)
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Added: June 8, 2020

2019 journal article

Development of Biomimetic Antimicrobial Platelet-Like Particles Comprised of Microgel Nanogold Composites

Regenerative Engineering and Translational Medicine, 6(3), 299–309.

By: E. Sproul n, S. Nandi n, E. Chee n, S. Sivadanam n, B. Igo  n, L. Schreck*, A. Brown n 

author keywords: Synthetic platelet; Fibrin; Hemostatic material; Trauma; Antimicrobial material; Microgels
TL;DR: These results demonstrate NGCs fabricated through noncovalent and covalent methods retain deformability necessary for clot collapse and exhibit some antimicrobial potential, and are promising materials for preventing blood loss and infection following traumatic injury. (via Semantic Scholar)
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Added: October 12, 2020

2019 journal article

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

Biomaterials Science, 7(2), 669–682.

By: S. Nandi n, E. Sproul n, K. Nellenbach n, M. Erb n, L. Gaffney n, D. Freytes n, A. Brown n 

MeSH headings : Animals; Biomimetic Materials / chemistry; Blood Platelets / metabolism; Blood Platelets / physiology; Fibrin / chemistry; Fibrin / pharmacology; Humans; Mechanical Phenomena; Mice; Platelet Activation / drug effects; Skin / drug effects; Skin / injuries; Wound Healing / drug effects
TL;DR: The utility of PLPs for enhancing wound repair is demonstrated and the role of native platelet-mediated clot retraction in wound healing is provided, to provide insight into the role in vitro and in vivo models of wound healing. (via Semantic Scholar)
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Added: February 18, 2019

2018 journal article

Biomimetic Microgels with Controllable Deformability Improve Healing Outcomes

Advanced Biosystems, 2(10).

By: E. Sproul n, S. Nandi n, C. Roosa n, L. Schreck* & A. Brown n 

author keywords: biomimetic; fibrin; microgel; synthetic platelet; wound healing
TL;DR: Hollow PLPs with low degrees of shell crosslinking improve some wound healing outcomes in vivo, recapitulating the clot retraction function of platelets, while other particle types do not. (via Semantic Scholar)
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Added: October 29, 2018

2018 article

Fibrin biomaterials for tissue regeneration and repair

PEPTIDES AND PROTEINS AS BIOMATERIALS FOR TISSUE REGENERATION AND REPAIR, pp. 151–173.

By: E. Sproul n, S. Nandi n & A. Brown n 

TL;DR: This chapter first provides an overview of the structure and function of fibrin(ogen) and details the role offibrin-cell interactions in wound repair and the design and use of fibin-based materials for promoting tissue repair. (via Semantic Scholar)
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Added: August 6, 2018

2018 journal article

Study of Poly(<i>N</i>-isopropylacrylamide-<i>co</i>-acrylic acid) (pNIPAM) Microgel Particle Induced Deformations of Tissue-Mimicking Phantom by Ultrasound Stimulation

Langmuir, 34(4), 1457–1465.

By: A. Joshi*, S. Nandi n, D. Chester n, A. Brown n  & M. Muller n 

MeSH headings : Acrylates / chemistry; Acrylic Resins / chemistry; Drug Delivery Systems; Gels / chemistry; Polymers / chemistry
TL;DR: It is demonstrated in tissue-mimicking phantoms that using ultrasound insonification causes deformations of ULC microgel particles, and increasing the degree of microgel cross-linking reduces the magnitude of the deformation and increases the optimal concentration required to achieve the largest amount of deformation. (via Semantic Scholar)
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Added: August 6, 2018

2017 journal article

Characterizing Cell Migration Within Three-dimensional <em>In Vitro</em> Wound Environments

Journal of Visualized Experiments, 8(126).

By: S. Nandi n & A. Brown n 

author keywords: Bioengineering; Issue 126; cell migration; three dimensional; fibrin; wound healing; extracellular matrix; integrins; in vitro wound healing assay
MeSH headings : Bioengineering / methods; Cell Movement / physiology; Humans; Wound Healing / physiology
TL;DR: The method described herein allows for the study of cell migration in a three-dimensional model that better reflects physiological conditions than previously established two-dimensional scratch assays, thus increasing the relevance of in vitro cell studies prior to the use of in vivo animal models. (via Semantic Scholar)
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Added: August 6, 2018

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