Han Phan

College of Agriculture and Life Sciences

Works (6)

Updated: January 13th, 2025 15:15

2024 article

Assembly of a Heterobimetallic Fe/Mn Cofactor in the <i>para</i>-Aminobenzoate Synthase Chlamydia Protein Associating with Death Domains (CADD) Initiates Long-Range Radical Hole-Hopping

Phan, H. N., Swartz, P. D., Gangopadhyay, M., Guo, Y., Smirnov, A. I., & Makris, T. M. (2024, October 29). BIOCHEMISTRY, Vol. 10.

By: H. Phan n , P. Swartz n, M. Gangopadhyay*, Y. Guo *, A. Smirnov  n & T. Makris n 

Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 29, 2024

2023 journal article

Excision of a Protein-Derived Amine for <i>p</i>-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD

BIOCHEMISTRY, 62(22), 3276–3282.

By: H. Phan n , O. Manley n, S. Skirboll n, L. Cha n , D. Hilovsky n, W. Chang n , P. Thompson n , X. Liu n, T. Makris n 

TL;DR: Turnover studies using limiting O2 have identified a para-aminobenzaldehyde metabolic intermediate that is formed on the path to pABA formation and use of pABCHO and other probe substrates shows that the heterobimetallic Fe/Mn form of the enzyme is capable of oxygen insertion to generate the pA BA-carboxylate. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 12, 2023

2023 journal article

Polysaccharide and ethanol extracts of Anoectochilus formosanus Hayata: Antioxidant, wound-healing, antibacterial, and cytotoxic activities

Heliyon.

By: T. Nguyen, H. Phan* , T. Do, G. Do, L. Ngo, H. Do, K. Nguyen

Source: ORCID
Added: November 14, 2024

2022 journal article

Distal Hydrophobic Loop Modulates the Copper Active Site and Reaction of AA13 Polysaccharide Monooxygenases

The Journal of Physical Chemistry B.

By: S. Ngo*, H. Phan* , C. Luu*, C. Le*, G. Ho*, N. Ngo*, L. Le *, B. Mai ...

Source: ORCID
Added: November 14, 2024

2022 journal article

Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(39).

By: O. Manley n, H. Phan n , A. Stewart n, D. Mosley n, S. Xue *, L. Cha n , H. Bai n, V. Lightfoot* ...

Contributors: T. Williams n 

author keywords: folate biosynthesis; radical transfer; spectroscopy; heterobinuclear cluster
MeSH headings : Bacterial Proteins / metabolism; Chlamydia trachomatis / enzymology; Folic Acid; Iron / metabolism; Manganese / metabolism; Oxygen / metabolism; Oxygenases / metabolism; Tyrosine / metabolism; para-Aminobenzoates / metabolism
TL;DR: High in vitro activity relies on the stoichiometric addition of both Fe and Mn, and CADD is shown to activate O2 to self-sacrificially produce pABA from Tyr27. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 21, 2022

2020 journal article

Fine Tuning of the Copper Active Site in Polysaccharide Monooxygenases

The Journal of Physical Chemistry B, 124(10), 1859–1865.

By: S. Ngo*, H. Phan* , C. Le*, N. Ngo*, K. Vu *, N. Tung *, C. Luu*, V. Vu *

Source: ORCID
Added: November 14, 2024

Education

Updated: June 24th, 2022 12:50

2021 - present

North Carolina State University Raleigh, North Carolina, US
Ph.D. Molecular and Structural Biochemistry

2014 - 2018

VNU University of Science Hanoi, VN
B.A. Chemistry

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