Han Phan

College of Agriculture and Life Sciences

Works (7)

Updated: March 3rd, 2026 13:55

2025 article

The Heme Oxygenase-Like Diiron Enzyme HrmI Reveals Altered Regulatory Mechanisms for Dioxygen Activation and Substrate N-Oxygenation

Skirboll, S. S., Gangopadhyay, M., Phan, H. N., Hartsell, J., Mudireddy, A., Hilovsky, D., … Makris, T. M. (2025, August 7). Journal of the American Chemical Society, Vol. 8.

By: S. Skirboll n, M. Gangopadhyay*, H. Phan n , J. Hartsell n, A. Mudireddy n, D. Hilovsky n, P. Swartz n, X. Liu n, Y. Guo *, T. Makris n 

topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Porphyrin and Phthalocyanine Chemistry; Radioactive element chemistry and processing
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 8, 2025

2024 article

Assembly of a Heterobimetallic Fe/Mn Cofactor in the para-Aminobenzoate Synthase Chlamydia Protein Associating with Death Domains (CADD) Initiates Long-Range Radical Hole-Hopping

Phan, H. N., Swartz, P. D., Gangopadhyay, M., Guo, Y., Smirnov, A. I., & Makris, T. M. (2024, October 29). Biochemistry, Vol. 10.

By: H. Phan n , P. Swartz n, M. Gangopadhyay*, Y. Guo *, A. Smirnov n  & T. Makris n 

MeSH headings : Manganese / metabolism; Manganese / chemistry; Iron / metabolism; Iron / chemistry; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Bacterial Proteins / genetics; Chlamydia trachomatis / enzymology; Chlamydia trachomatis / metabolism; Crystallography, X-Ray; Catalytic Domain; Models, Molecular; 4-Aminobenzoic Acid / chemistry; 4-Aminobenzoic Acid / metabolism; Electron Spin Resonance Spectroscopy
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Porphyrin Metabolism and Disorders; Enzyme Structure and Function
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 29, 2024

2023 article

Excision of a Protein-Derived Amine for p-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD

Phan, H. N., Manley, O. M., Skirboll, S. S., Cha, L., Hilovsky, D., Chang, W.-chen, … Makris, T. M. (2023, November 7). Biochemistry, Vol. 62, pp. 3276–3282.

By: H. Phan n , O. Manley n, S. Skirboll n, L. Cha n , D. Hilovsky n, W. Chang n , P. Thompson n , X. Liu n, T. Makris n 

MeSH headings : para-Aminobenzoates / metabolism; 4-Aminobenzoic Acid / metabolism; Folic Acid / metabolism
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Heme Oxygenase-1 and Carbon Monoxide; Porphyrin Metabolism and Disorders
TL;DR: Turnover studies using limiting O2 have identified a para-aminobenzaldehyde metabolic intermediate that is formed on the path to pABA formation and use of pABCHO and other probe substrates shows that the heterobimetallic Fe/Mn form of the enzyme is capable of oxygen insertion to generate the pA BA-carboxylate. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 12, 2023

2023 article

Polysaccharide and ethanol extracts of Anoectochilus formosanus Hayata: Antioxidant, wound-healing, antibacterial, and cytotoxic activities

Nguyen, T.-P., Phan, H. N., Do, T. D., Do, G. D., Ngo, L. H., Do, H. D. K., & Nguyen, K. T. (2023, February 14). Heliyon.

By: T. Nguyen, H. Phan* , T. Do *, G. Do*, L. Ngo, H. Do, K. Nguyen

topics (OpenAlex): Biological and pharmacological studies of plants; Medicinal Plants and Neuroprotection; Phytochemistry and Biological Activities
Source: ORCID
Added: November 14, 2024

2022 article

Distal Hydrophobic Loop Modulates the Copper Active Site and Reaction of AA13 Polysaccharide Monooxygenases

Ngo, S. T., Phan, H. N., Luu, C. X., Le, C. N., Ho, G. T., Ngo, N. T. C., … Vu, V. V. (2022, September 22). The Journal of Physical Chemistry B.

By: S. Ngo*, H. Phan* , C. Luu*, C. Le*, G. Ho*, N. Ngo*, L. Le *, B. Mai * ...

MeSH headings : Catalytic Domain; Copper / chemistry; Ligands; Mixed Function Oxygenases / chemistry; Oxygen / chemistry; Polysaccharides / chemistry; Starch / chemistry; Starch / metabolism; Superoxides
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Metal complexes synthesis and properties; Enzyme Catalysis and Immobilization
Source: ORCID
Added: November 14, 2024

2022 article

Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para -aminobenzoate in Chlamydia trachomatis

Manley, O. M., Phan, H. N., Stewart, A. K., Mosley, D. A., Xue, S., Cha, L., … Makris, T. M. (2022, September 19). Proceedings of the National Academy of Sciences, Vol. 119.

By: O. Manley n, H. Phan n , A. Stewart n, D. Mosley n, S. Xue *, L. Cha n , H. Bai n, V. Lightfoot* ...

Contributors: T. Williams n 

author keywords: folate biosynthesis; radical transfer; spectroscopy; heterobinuclear cluster
MeSH headings : Bacterial Proteins / metabolism; Chlamydia trachomatis / enzymology; Folic Acid; Iron / metabolism; Manganese / metabolism; Oxygen / metabolism; Oxygenases / metabolism; Tyrosine / metabolism; para-Aminobenzoates / metabolism
topics (OpenAlex): Porphyrin Metabolism and Disorders; Reproductive tract infections research; Urinary Tract Infections Management
TL;DR: High in vitro activity relies on the stoichiometric addition of both Fe and Mn, and CADD is shown to activate O2 to self-sacrificially produce pABA from Tyr27. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 21, 2022

2020 article

Fine Tuning of the Copper Active Site in Polysaccharide Monooxygenases

Ngo, S. T., Phan, H. N., Le, C. N., Ngo, N. C. T., Vu, K. B., Tung, N. T., … Vu, V. V. (2020, January 28). The Journal of Physical Chemistry B, Vol. 124, pp. 1859–1865.

By: S. Ngo*, H. Phan* , C. Le*, N. Ngo*, K. Vu *, N. Tung *, C. Luu*, V. Vu *

MeSH headings : Catalytic Domain; Copper; Electron Spin Resonance Spectroscopy; Humans; Mixed Function Oxygenases / genetics; Mixed Function Oxygenases / metabolism; Polysaccharides
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Metal complexes synthesis and properties; Enzyme Structure and Function
Source: ORCID
Added: November 14, 2024

Education

Updated: June 24th, 2022 12:50

2021 - present

North Carolina State University Raleigh, North Carolina, US
Ph.D. Molecular and Structural Biochemistry

2014 - 2018

VNU University of Science Hanoi, VN
B.A. Chemistry

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