Works (6)
Updated: November 19th, 2024 03:40
2024 journal article
Assembly of a Heterobimetallic Fe/Mn Cofactor in the para-Aminobenzoate Synthase Chlamydia Protein Associating with Death Domains (CADD) Initiates Long-Range Radical Hole-Hopping
Biochemistry.
Source: ORCID
Added: October 29, 2024
2023 journal article
Excision of a Protein-Derived Amine for <i>p</i>-Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD
BIOCHEMISTRY, 62(22), 3276–3282.
TL;DR:
Turnover studies using limiting O2 have identified a para-aminobenzaldehyde metabolic intermediate that is formed on the path to pABA formation and use of pABCHO and other probe substrates shows that the heterobimetallic Fe/Mn form of the enzyme is capable of oxygen insertion to generate the pA BA-carboxylate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 12, 2023
2023 journal article
Polysaccharide and ethanol extracts of Anoectochilus formosanus Hayata: Antioxidant, wound-healing, antibacterial, and cytotoxic activities
Heliyon.
open access via doi.org (publisher)
Source: ORCID
Added: November 14, 2024
2022 journal article
Distal Hydrophobic Loop Modulates the Copper Active Site and Reaction of AA13 Polysaccharide Monooxygenases
The Journal of Physical Chemistry B.
Source: ORCID
Added: November 14, 2024
2022 journal article
Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(39).
Contributors: T. Williams n
author keywords: folate biosynthesis; radical transfer; spectroscopy; heterobinuclear cluster
MeSH headings : Bacterial Proteins / metabolism; Chlamydia trachomatis / enzymology; Folic Acid; Iron / metabolism; Manganese / metabolism; Oxygen / metabolism; Oxygenases / metabolism; Tyrosine / metabolism; para-Aminobenzoates / metabolism
TL;DR:
High in vitro activity relies on the stoichiometric addition of both Fe and Mn, and CADD is shown to activate O2 to self-sacrificially produce pABA from Tyr27.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 21, 2022
2020 journal article
Fine Tuning of the Copper Active Site in Polysaccharide Monooxygenases
The Journal of Physical Chemistry B, 124(10), 1859–1865.
Source: ORCID
Added: November 14, 2024
Education
Updated: June 24th, 2022 12:50
2021 - present
North Carolina State University Raleigh, North Carolina, US
Ph.D.
Molecular and Structural Biochemistry
2014 - 2018
VNU University of Science Hanoi, VN
B.A.
Chemistry
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