Jyotsna Khosla

Works (13)

Updated: April 4th, 2024 20:41

2010 journal article

Temporal Changes in Expression of FoxA1 and Wnt7A in Isolated Adult Human Alveolar Epithelial Cells Enhanced by Heparin

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 293(6), 938–946.

By: K. Apparao n, D. Newman n, H. Zhang n, J. Khosla n, S. Randell * & P. Sannes n

author keywords: beta-catenin; differentiation; heparin; sulfated extracellular matrices
MeSH headings : Adult; Anticoagulants / physiology; Biomarkers / metabolism; Cell Differentiation / drug effects; Cell Differentiation / physiology; Cell Line; Cell Separation; Cells, Cultured; Heparin / physiology; Hepatocyte Nuclear Factor 3-alpha / biosynthesis; Hepatocyte Nuclear Factor 3-alpha / genetics; Humans; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism; Time Factors; Wnt Proteins / biosynthesis; Wnt Proteins / genetics; beta Catenin / biosynthesis; beta Catenin / genetics
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Source: Web Of Science
Added: August 6, 2018

2007 journal article

Alterations in cytoskeletal and immune function-related proteome profiles in whole rat lung following intratracheal instillation of heparin

RESPIRATORY RESEARCH, 8.

By: A. Gabr n, M. Reed*, D. Newman n, J. Pohl*, J. Khosla n & P. Sannes n

MeSH headings : Administration, Inhalation; Animals; Anticoagulants / administration & dosage; Cytoskeleton / drug effects; Cytoskeleton / ultrastructure; Gene Expression Regulation / drug effects; Heparin / administration & dosage; Lung / drug effects; Lung / immunology; Lung / ultrastructure; Proteome / drug effects; Proteomics / methods; Rats; Rats, Inbred F344; Reference Values
TL;DR: It is demonstrated that whole lung heparin treatment results in significant up-regulation of selected groups of proteins, primarily those related to cytoskeletal reorganization and immune function, which may prove to be relevant biomarkers useful in analysis of lung exposures/treatments as well as in system biology studies. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 journal article

Heparin and fibroblast growth factors affect surfactant protein gene expression in type II cells

American Journal of Respiratory Cell and Molecular Biology, 35(5), 611–618.

By: K. Leiner, D. Newman, C. Li, E. Walsh, J. Khosla & P. Sannes

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Heparin affects signaling pathways stimulated by fibroblast growth factor-1 and-2 in type II cells

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 287(1), L191–L200.

By: D. Newman n, C. Li n, R. Simmons n, J. Khosla n & P. Sannes n

author keywords: extracellular matrix; basement membrane; receptor tyrosine kinase phosphorylation; ERK pathway; fibroblast growth factor signaling
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / pharmacology; Heparin / administration & dosage; Heparin / pharmacology; Mitogen-Activated Protein Kinases / metabolism; Phosphorylation / drug effects; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins c-akt; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Pulmonary Alveoli / physiology; Rats; Rats, Inbred Strains; Signal Transduction / drug effects; Sulfates / metabolism; Thymidine / metabolism; Time Factors
TL;DR: The data suggest that heparin's known capacity to alter DNA synthesis and, possibly, other biological end points is realized via cross talk between multiple signaling pathways. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 article

Modulation of fibroblast growth factor expression and signal transduction in type II cells

Li, C. M., Newman, D., Cesta, M., Tompkins, L., Khosla, J., & Sannes, P. L. (2003, March). CHEST, Vol. 123, pp. 429S–429S.

By: C. Li n, D. Newman n, M. Cesta n, L. Tompkins n, J. Khosla n & P. Sannes n

MeSH headings : Antigenic Modulation / genetics; Antigenic Modulation / immunology; Asthma / genetics; Asthma / immunology; Epithelial Cells / immunology; Fibroblast Growth Factors / genetics; Fibroblast Growth Factors / immunology; Gene Expression / genetics; Gene Expression / immunology; Humans; In Vitro Techniques; Signal Transduction / genetics; Signal Transduction / immunology
TL;DR: The data suggests that airway fibroblasts from severe asthmatics may be of a synthetic phenotype, with altered capabilities in collagen production, as compared to those from patients with mild-to-moderate asthma and normal control subjects, and this may be driven by an increased expression of PDGFR. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Effect of growth factor-fibronectin matrix interaction on rat type II cell adhesion and DNA synthesis

EXPERIMENTAL LUNG RESEARCH, 28(2), 69–84.

By: I. Pagan n, J. Khosla n, C. Li n & P. Sannes n

author keywords: alveolar repair; beta 1integrin; cell-substratum interaction; cytoskeleton; fibroblast growth factors; fibronectin; type II cells
MeSH headings : Actins / metabolism; Animals; Blood Proteins / pharmacology; Cell Adhesion / drug effects; Cell Division / drug effects; Cell Size / drug effects; Cells, Cultured; Cytoskeletal Proteins / metabolism; DNA / biosynthesis; Extracellular Matrix / metabolism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / pharmacology; Fibronectins / pharmacology; Integrin beta1 / metabolism; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Rats; Rats, Inbred F344; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism
TL;DR: Together FGF-1 and fibronectin appear to promote adhesion, cytoskeletal organization, and in creased DNA synthesis, andin this way influence cell-substratum interactions and signaling during alveolar repair. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2002 journal article

Heparin inhibits DNA synthesis and gene expression in alveolar type II cells

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 27(3), 345–352.

By: C. Li n, D. Newman n, J. Khosla n & P. Sannes n

MeSH headings : Animals; Cell Division / drug effects; Cells, Cultured; DNA / biosynthesis; DNA / drug effects; Extracellular Matrix / drug effects; Extracellular Matrix / metabolism; Fibroblast Growth Factor 1 / genetics; Fibroblast Growth Factor 1 / metabolism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Heparin / pharmacology; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / physiology; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases / drug effects; Receptor Protein-Tyrosine Kinases / genetics; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor / drug effects; Receptors, Fibroblast Growth Factor / genetics; Thymidine / metabolism
TL;DR: It is demonstrated that sulfated molecules in the ABM may play important regulatory role(s) in selected type II cell activities during normal cell homeostasis, turnover, and repair after lung injury. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2002 journal article

Pre- and postnatal lung development, maturation, and plasticity: Detection of chondroitin sulfates and decorin in developing fetal and neonatal rat lung

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 282(3), L484–L490.

By: Y. Wang n, K. Sakamoto n , J. Khosla n & P. Sannes n

Contributors: Y. Wang n, K. Sakamoto n , J. Khosla n & P. Sannes n

author keywords: extracellular matrix; basal laminae; growth factors; mesenchyme
MeSH headings : Aging / metabolism; Animals; Animals, Newborn / growth & development; Animals, Newborn / metabolism; Chondroitin Sulfates / metabolism; Decorin; Embryonic and Fetal Development; Extracellular Matrix Proteins; Fetus / physiology; Immunologic Techniques; Lung / embryology; Lung / growth & development; Lung / metabolism; Proteoglycans / metabolism; Rats; Rats, Inbred F344; Staining and Labeling
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Sources: Web Of Science, ORCID
Added: August 6, 2018

2001 article

Transforming growth factor-beta(1) modifies fibroblast growth factor-2 production in type II cells

Li, C. M., Khosla, J., Hoyle, P., & Sannes, P. L. (2001, July). CHEST, Vol. 120, pp. 60S–61S.

By: C. Li n, J. Khosla n, P. Hoyle n & P. Sannes n

author keywords: alveolar epithelium; extracellular matrix; growth factors
MeSH headings : Animals; Fibroblast Growth Factor 2 / biosynthesis; Pulmonary Alveoli / metabolism; Rats; Rats, Inbred F344; Transforming Growth Factor beta / physiology; Transforming Growth Factor beta1
TL;DR: Important regulatory links between FGF-2, sulfated ECMs, and both TGF-β 1 and FGF, which could contribute to the modulation of normal cell turnover, development, and repair processes attendant to fibrosis in the lung are demonstrated. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2000 journal article

TGF-beta 1 and fibroblast growth factor-1 modify fibroblast growth factor-2 production in type II cells

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 279(6), L1038–L1046.

By: C. Li n, J. Khosla n, I. Pagan n, P. Hoyle n & P. Sannes n

author keywords: basic fibroblast growth factor; acidic fibroblast growth factor; alveolar epithelium; alveolar injury; pulmonary fibrosis; transforming growth factor
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Pulmonary Fibrosis / metabolism; RNA, Messenger / analysis; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases / genetics; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor / genetics; Specific Pathogen-Free Organisms; Transforming Growth Factor beta / pharmacology
TL;DR: Fibroblast growth factor (FGF)-2, which stimulates DNA synthesis by type II cells in the lung, has been shown to be regulated by transforming growth factors (TGF)-β1, an important inflammatory cytokine. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1998 journal article

Sulfation of extracellular matrices modifies growth factor effects on type II cells on laminin substrata

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 275(4), L701–L708.

By: P. Sannes n, J. Khosla n, C. Li n & I. Pagan n

author keywords: sulfated proteoglycans; basement membrane; acidic fibroblast growth factor; basic fibroblast growth factor; keratinocyte growth factor
MeSH headings : Animals; Cell Adhesion / drug effects; Cell Division / drug effects; Cells, Cultured; Chondroitin / pharmacology; Chondroitin Sulfates / pharmacology; Chondroitin Sulfates / physiology; Extracellular Matrix / physiology; Fibroblast Growth Factor 1; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2 / pharmacology; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Growth Substances / pharmacology; Growth Substances / physiology; Heparin / pharmacology; Heparin / physiology; Heparitin Sulfate / pharmacology; Heparitin Sulfate / physiology; Laminin / pharmacology; Laminin / physiology; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / physiology; Rats; Rats, Inbred F344
TL;DR: It is demonstrated that decreased levels of sulfate in ECM substrata act to upregulate responses to heparin-binding growth factors by alveolar epithelial cells on laminin substrata. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1997 journal article

Biosynthesis of sulfated extracellular matrices by alveolar type II cells increases with time in culture

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 273(4), L840–L847.

By: P. Sannes n, J. Khosla n & B. Peters n

author keywords: basement membrane; heparan sulfate proteoglycan; laminin; type IV collagen; entactin; fibronectin; type I pneumocytes; alveolar epithelium; sulfation; extracellular matrix
MeSH headings : Animals; Cells, Cultured; Cellular Senescence; Cysteine / metabolism; Extracellular Matrix / metabolism; Extracellular Matrix / ultrastructure; Extracellular Matrix Proteins / biosynthesis; Kinetics; Phenotype; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Pulmonary Alveoli / ultrastructure; Rats; Rats, Inbred F344; Sulfates / metabolism; Sulfur Radioisotopes; Time Factors
TL;DR: The data suggest that regulation of sulfation constitutes a potential mechanism by which type I and type II cells alter their environment in such a manner as to stabilize phenotype and modulate responses to growth factors. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1988 article

Morphometric and biochemical characterization of a chamber system for maintaining differentiated guinea pig respiratory mucosal cells between air and liquid phases.

American Review of Respiratory Disease, Vol. 137, p. 14.

By: K. Adler, J. Khosla & K. Kim

Source: NC State University Libraries
Added: August 6, 2018

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