Lloyd Norman Fleisher

Works (43)

Updated: April 23rd, 2025 19:14

2017 article

Vitreous Humor Changes Expression of Iron-Handling Proteins in Lens Epithelial Cells

Goralska, M., Fleisher, L. N., & McGahan, M. C. (2017, February 28). Investigative Ophthalmology & Visual Science.

By: M. Goralska n, L. Fleisher n & M. McGahan n

author keywords: iron; oxidative damage; ferritin; transferrin receptor; vitreous humor
MeSH headings : Animals; Aquaporins / metabolism; Blotting, Western; Cells, Cultured; Disease Models, Animal; Dogs; Epithelial Cells / metabolism; Eye Proteins / metabolism; Ferritins / metabolism; Immunohistochemistry; Lens, Crystalline / metabolism; Receptors, Transferrin / metabolism; Vitreous Body / physiology
topics (OpenAlex): Connexins and lens biology; Iron Metabolism and Disorders; Heme Oxygenase-1 and Carbon Monoxide
TL;DR: Virreous humor may significantly limit iron uptake by transferrin/transferrin receptor pathway, and by increasing ferritin levels could profoundly increase the iron-storage capacity of ferrit in lens cells. (via Semantic Scholar)
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2014 article

Hypoxia induced changes in expression of proteins involved in iron uptake and storage in cultured lens epithelial cells

Goralska, M., Fleisher, L. N., & McGahan, M. C. (2014, May 27). Experimental Eye Research.

By: M. Goralska n, L. Fleisher n & M. McGahan n

author keywords: lens; iron; iron proteins; hypoxia
MeSH headings : Animals; Cell Hypoxia / physiology; Cells, Cultured; Dogs; Epithelial Cells / metabolism; Ferritins / metabolism; Gene Expression Regulation; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Oxidative Stress / physiology; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction; Receptors, Transferrin / metabolism; Transferrin / metabolism
topics (OpenAlex): Heme Oxygenase-1 and Carbon Monoxide; Connexins and lens biology; Aldose Reductase and Taurine
TL;DR: Changes in expression of ferritin and Tf/TfR1 in LEC cultured under hypoxic conditions are examined to better protect LEC against oxidative stress by limiting iron-catalyzed ROS formation in the low oxygen environment in which the lens resides. (via Semantic Scholar)
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2013 article

Source-Dependent Intracellular Distribution of Iron in Lens Epithelial Cells Cultured Under Normoxic and Hypoxic Conditions

Goralska, M., Nagar, S., Fleisher, L. N., Mzyk, P., & McGahan, M. C. (2013, November 5). Investigative Ophthalmology & Visual Science.

By: M. Goralska n, S. Nagar*, L. Fleisher*, P. Mzyk* & M. McGahan

author keywords: iron trafficking; transferrin; NTBI; lens epithelial cells; hypoxia
MeSH headings : Animals; Biological Transport; Cell Nucleus / metabolism; Cell Proliferation; Cell Survival; Cells, Cultured; Chlorides / metabolism; Dogs; Epithelial Cells / metabolism; Ferric Compounds / metabolism; Hypoxia / metabolism; Intracellular Fluid / metabolism; Iron Radioisotopes / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Mitochondria / metabolism; Transferrin / metabolism
topics (OpenAlex): Connexins and lens biology; Heme Oxygenase-1 and Carbon Monoxide; Iron Metabolism and Disorders
TL;DR: Uptake and distribution of NTBI are not as strictly regulated as that of iron from transferrin, and source-dependent differences in iron uptake and trafficking are found. (via Semantic Scholar)
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2012 journal article

Ceruloplasmin alters intracellular iron regulated proteins and pathways: Ferritin, transferrin receptor, glutamate and hypoxia-inducible factor-1α

Experimental Eye Research, 97(1), 90–97.

By: J. Harned n, J. Ferrell n, S. Nagar n, M. Goralska n, L. Fleisher n & M. McGahan n

author keywords: ceruloplasmin; iron; lens epithelial cells; retinal pigmented epithelial cells glutamate; hypoxia-inducible factor; transferrin receptor; ferritin
MeSH headings : Animals; Cells, Cultured; Ceruloplasmin / metabolism; Ceruloplasmin / pharmacology; Dogs; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Fluorescent Antibody Technique, Indirect; Glutamic Acid / metabolism; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Iron Chelating Agents / pharmacology; Lens, Crystalline / cytology; Oxalates / pharmacology; Receptors, Transferrin / metabolism; Retinal Pigment Epithelium / drug effects; Retinal Pigment Epithelium / metabolism
topics (OpenAlex): Trace Elements in Health; Connexins and lens biology; Iron Metabolism and Disorders
TL;DR: The Cp increased production and secretion of the neurotransmitter, glutamate, is a substantive finding of clinical relevance because of the neural and retinal degeneration found in aceruloplasminemia patients. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

2010 article

Altered Ferritin Subunit Composition: Change in Iron Metabolism in Lens Epithelial Cells and Downstream Effects on Glutathione Levels and VEGF Secretion

Harned, J., Ferrell, J., Lall, M. M., Fleisher, L. N., Nagar, S., Goralska, M., & McGahan, M. C. (2010, August 30). Investigative Ophthalmology & Visual Science.

By: J. Harned n, J. Ferrell n, M. Lall n, L. Fleisher n, S. Nagar n, M. Goralska n, M. McGahan n

MeSH headings : Animals; Apoferritins / genetics; Apoferritins / metabolism; Cell Nucleus / metabolism; Cells, Cultured; Culture Media, Conditioned / pharmacology; Cystine / pharmacokinetics; Dogs; Epithelial Cells / cytology; Epithelial Cells / metabolism; Glutathione / metabolism; Homeostasis / physiology; Hypoxia-Inducible Factor 1, alpha Subunit / metabolism; Iron / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Oxidative Stress / physiology; Protein Subunits / genetics; Protein Subunits / metabolism; RNA, Small Interfering; Transfection; Vascular Endothelial Growth Factor A / metabolism
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Connexins and lens biology
TL;DR: Iron storage in ferritin was greatly reduced by FHsiRNA, resulting in increased iron availability, as noted by a decrease in transferrin receptor levels and iron uptake from transferrin, and profound effects clearly demonstrate that maintenance of a specific H:L ratio is part of a basic cellular homeostatic mechanism. (via Semantic Scholar)
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2009 article

Changes in Ferritin H- and L-Chains in Canine Lenses with Age-Related Nuclear Cataract

Goralska, M., Nagar, S., Colitz, C. M. H., Fleisher, L. N., & McGahan, M. C. (2009, January 1). Investigative Ophthalmology & Visual Science.

By: M. Goralska n, S. Nagar n, C. Colitz n, L. Fleisher n & M. McGahan n

MeSH headings : Aging; Animals; Apoferritins / metabolism; Cataract / metabolism; Cataract / veterinary; Dog Diseases / metabolism; Dogs; Electrophoresis, Polyacrylamide Gel / veterinary; Enzyme-Linked Immunosorbent Assay / veterinary; Fluorescent Antibody Technique, Indirect / veterinary; Lens, Crystalline / metabolism; Microscopy, Fluorescence / veterinary
topics (OpenAlex): Connexins and lens biology; Iron Metabolism and Disorders; Trace Elements in Health
TL;DR: There are significant differences in the characteristics of ferritin H-chain and its distribution in canine cataractous lenses compared with noncataractsous lenses, which allows this molecule to sequester more iron. (via Semantic Scholar)
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2009 journal article

Distribution of ferritin chains in canine lenses with and without age-related nuclear cataracts

Molecular Vision, 15(256-59), 2404–2410.

By: M. Goralska, S. Nagar, L. Fleisher & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

2008 article

Iron Regulates L-Cystine Uptake and Glutathione Levels in Lens Epithelial and Retinal Pigment Epithelial Cells by Its Effect on Cytosolic Aconitase

Lall, M. M., Ferrell, J., Nagar, S., Fleisher, L. N., & McGahan, M. C. (2008, January 1). Investigative Ophthalmology & Visual Science.

By: M. Lall n, J. Ferrell*, S. Nagar*, L. Fleisher* & M. McGahan*

MeSH headings : 2,2'-Dipyridyl / pharmacology; Aconitate Hydratase / antagonists & inhibitors; Aconitate Hydratase / metabolism; Amino Acid Transport System y+ / genetics; Amino Acid Transport System y+ / metabolism; Animals; Cells, Cultured; Chelating Agents / pharmacology; Cystine / metabolism; Cytosol; Dogs; Enzyme Inhibitors / pharmacology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Fluorescent Antibody Technique, Indirect; Gene Expression; Glutathione / metabolism; Immunoblotting; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Oxalates / pharmacology; Pigment Epithelium of Eye / metabolism; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Transferrin / pharmacology
topics (OpenAlex): Biomedical Research and Pathophysiology; Amino Acid Enzymes and Metabolism; Connexins and lens biology
TL;DR: The authors found that the iron-induced increase in L-glutamate availability increased L-cystine uptake, with subsequent increases in GSH levels, demonstrating for the first time that iron regulates L-cycline uptake and the downstream production of GSH in two mammalian cell types. (via Semantic Scholar)
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2008 journal article

Iron metabolism in the eye: A review

Experimental Eye Research, 88(2), 204–215.

By: M. Goralska n, J. Ferrell n, J. Harned n, M. Lall n, S. Nagar n, L. Fleisher n, M. McGahan n

author keywords: iron; ferritin; transferrin; lens; retinal pigmented epithelium; retina
MeSH headings : Animals; Eye / metabolism; Eye Diseases / metabolism; Homeostasis; Humans; Iron / metabolism; Oxidative Stress; Signal Transduction / physiology
topics (OpenAlex): Heme Oxygenase-1 and Carbon Monoxide; Iron Metabolism and Disorders; Neonatal Health and Biochemistry
TL;DR: This review article covers all aspects of iron metabolism, which include studies of iron levels within the eye and the processes used to maintain normal levels of iron in ocular tissues. (via Semantic Scholar)
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2007 article

Ferritin H- and L-Chains in Fiber Cell Canine and Human Lenses of Different Ages

Goralska, M., Fleisher, L. N., & McGahan, M. C. (2007, August 27). Investigative Ophthalmology & Visual Science.

By: M. Goralska n, L. Fleisher n & M. McGahan n

MeSH headings : Adolescent; Adult; Aged; Aging / physiology; Animals; Apoferritins / metabolism; Blotting, Western; Dogs; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Ferritins / metabolism; Humans; Iron Radioisotopes / metabolism; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Middle Aged
topics (OpenAlex): Connexins and lens biology; RNA regulation and disease; Heat shock proteins research
TL;DR: Lens fiber cells, particularly from older lenses, may have limited ability to protect themselves against iron-catalyzed oxidative damage and are not likely to form functional ferritin capable of storing iron. (via Semantic Scholar)
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2006 article

Lens epithelial cells synthesize and secrete ceruloplasmin: Effects of ceruloplasmin and transferrin on iron efflux and intracellular iron dynamics

Harned, J., Fleisher, L. N., & McGahan, M. C. (2006, June 24). Experimental Eye Research.

By: J. Harned*, L. Fleisher n & M. McGahan n

author keywords: lens; ceruloplasmin; iron; ferritin; transferrin; labile iron pool
MeSH headings : Animals; Ceruloplasmin / biosynthesis; Ceruloplasmin / pharmacology; Ceruloplasmin / physiology; Culture Media, Conditioned; Cytosol / metabolism; Dogs; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Iron / metabolism; Lens Capsule, Crystalline / cytology; Lens Capsule, Crystalline / drug effects; Lens Capsule, Crystalline / metabolism; Tissue Culture Techniques; Transferrin / biosynthesis; Transferrin / pharmacology; Transferrin / physiology
topics (OpenAlex): Connexins and lens biology; Trace Elements in Health; Yersinia bacterium, plague, ectoparasites research
TL;DR: An important role for ceruloplasmin and transferrin in iron metabolism in the lens is indicated, with results consistent with increased efflux of iron. (via Semantic Scholar)
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2005 article

Differential Degradation of Ferritin H- and L-Chains: Accumulation of L-Chain-Rich Ferritin in Lens Epithelial Cells

Goralska, M., Nagar, S., Fleisher, L. N., & McGahan, M. C. (2005, September 26). Investigative Ophthalmology & Visual Science.

By: M. Goralska n, S. Nagar*, L. Fleisher* & M. McGahan*

MeSH headings : Aging / physiology; Animals; Apoferritins; Cells, Cultured; Cysteine Proteinase Inhibitors / pharmacology; Dogs; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Iron / metabolism; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Lysosomes / metabolism; Methionine / metabolism; Plasmids; Transfection
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Connexins and lens biology
TL;DR: The formation of inclusion bodies in older lens epithelial cells, as demonstrated in the current investigation, is intriguing and could point to possible involvement of cytoplasmic L-chain-enriched ferritin aggregates in the formation of age-related cataract. (via Semantic Scholar)
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2004 article

Iron alters glutamate secretion by regulating cytosolic aconitase activity

McGahan, M. C., Harned, J., Mukunnemkeril, M., Goralska, M., Fleisher, L., & Ferrell, J. B. (2004, December 22). American Journal of Physiology-Cell Physiology.

By: M. McGahan n, J. Harned n, M. Mukunnemkeril n, M. Goralska n, L. Fleisher n & J. Ferrell n

author keywords: retinal pigment epithelial cells; lens epithelial cells
MeSH headings : Aconitate Hydratase / antagonists & inhibitors; Aconitate Hydratase / metabolism; Animals; Cells, Cultured; Citric Acid / metabolism; Cytosol / metabolism; Dogs; Enzyme Activation / drug effects; Glutamates / metabolism; Iron / metabolism; Isocitrates / metabolism; Membrane Transport Proteins / metabolism; Oxalates / pharmacology; Pigment Epithelium of Eye / drug effects; Pigment Epithelium of Eye / enzymology; Riluzole / pharmacology; Vesicular Glutamate Transport Protein 1
topics (OpenAlex): Neuroscience and Neuropharmacology Research; Retinal Development and Disorders; Connexins and lens biology
TL;DR: The results are the first to provide a functional link between these two physiologically important substances by demonstrating a significant role for iron in the regulation of glutamate production and secretion in mammalian cells resulting from iron regulation of aconitase activity. (via Semantic Scholar)
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2000 article

Rabbit Pigmented Ciliary Epithelium Produces Interleukin-6 in Response to Inflammatory Cytokines

FLEISHER, L. L. O. Y. D. N., McGAHAN, M. C. H. R. I. S. T. I. N. E., & FERRELL, J. E. N. N. Y. B. (2000, March 1). Experimental Eye Research.

By: L. Fleisher n, M. McGAHAN* & J. Ferrell*

author keywords: interleukin-6; pigmented ciliary epithelium; interleukin-1; tumor necrosis factor-alpha; adenosine 3 ',5 '-cyclic monophosphate
MeSH headings : Animals; Cell Culture Techniques; Ciliary Body / immunology; Ciliary Body / metabolism; Cyclic AMP / metabolism; Cytokines / immunology; Endotoxins / immunology; Interleukin-1 / immunology; Interleukin-6 / biosynthesis; Pigment Epithelium of Eye / immunology; Pigment Epithelium of Eye / metabolism; Rabbits; Tumor Necrosis Factor-alpha / immunology
topics (OpenAlex): Systemic Lupus Erythematosus Research; Cell Adhesion Molecules Research
TL;DR: The results indicate that the pigmented ciliary epithelium is one potential source of interleukin-6 and may contribute to the elevation in intraocular fluid interleucin- 6 levels observed during various intraocular inflammatory episodes. (via Semantic Scholar)
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1998 article

The Effect of Ascorbic Acid and Ferric Ammonium Citrate on Iron Uptake and Storage in Lens Epithelial Cells

GORALSKA, M., HARNED, J., FLEISHER, L. N., & McGAHAN, M. C. (1998, June 1). Experimental Eye Research.

By: M. Goralska n, J. Harned*, L. Fleisher* & M. McGAHAN*

author keywords: ascorbic acid; ferritin; lens; iron; ferric ammonium citrate; transferrin
MeSH headings : Animals; Apoferritins / biosynthesis; Ascorbic Acid / pharmacology; Cells, Cultured; Chlorides; Dogs; Epithelial Cells / metabolism; Ferric Compounds / metabolism; Ferric Compounds / pharmacology; Homeostasis; Humans; Infant, Newborn; Iron Radioisotopes / metabolism; Lens, Crystalline / metabolism; Quaternary Ammonium Compounds / pharmacology; Transferrin / metabolism
topics (OpenAlex): Connexins and lens biology; Iron Metabolism and Disorders; Trace Elements in Health
TL;DR: Iron homeostasis in lens epithelial cells is affected mainly by changes in apoferritin synthesis, which is greatly stimulated by ascorbic acid, rather than by altering the rate of protein degradation, which has been very slow in these cells under all circumstances. (via Semantic Scholar)
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1998 article

The lens influences aqueous humor levels of transforming growth factor-β2

Allen, J. B., Davidson, M. G., Nasisse, M. P., Fleisher, L. N., & McGahan, M. C. (1998, March 18). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: J. Allen*, M. Davidson n, M. Nasisse*, L. Fleisher* & M. McGahan*

MeSH headings : Animals; Aphakia / etiology; Aphakia / metabolism; Aphakia / pathology; Aqueous Humor / metabolism; Biological Assay; Cataract / etiology; Cataract / metabolism; Cataract / pathology; Cells, Cultured; Ciliary Body / cytology; Ciliary Body / metabolism; Disease Models, Animal; Dogs; Enzyme-Linked Immunosorbent Assay; Female; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Male; Pigment Epithelium of Eye / cytology; Pigment Epithelium of Eye / metabolism; Rabbits; Transforming Growth Factor beta / metabolism
topics (OpenAlex): Intraocular Surgery and Lenses; Glaucoma and retinal disorders; Retinal and Macular Surgery
TL;DR: Surprisingly, aqueous humor from aphakic rabbit eyes contained significantly higher levels of TGF-β2 than their contralateral phakic controls, and that the presence and status of the lens may influence IOF TGF -β2 levels. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 article

Mechanisms by which Ascorbic Acid Increases Ferritin levels in Cultured Lens Epithelial Cells

GORALSKA, M., HARNED, J., GRIMES, A. M., FLEISHER, L. N., & McGAHAN, M. C. (1997, March 1). Experimental Eye Research.

By: M. Goralska n, J. Harned n, A. Grimes n, L. Fleisher n & M. McGAHAN n

author keywords: ascorbic acid; ferritin; lens; cataract
MeSH headings : Animals; Ascorbic Acid / metabolism; Ascorbic Acid / pharmacology; Base Sequence; Blotting, Northern; Cells, Cultured; DNA / metabolism; Deferoxamine / pharmacology; Dithiothreitol / pharmacology; Dogs; Epithelium / drug effects; Epithelium / metabolism; Ferric Compounds / metabolism; Ferritins / biosynthesis; Ferritins / drug effects; Ferritins / genetics; Hydrogen Peroxide / pharmacology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism; Molecular Sequence Data; Oxidation-Reduction; Protein Biosynthesis; Protein Synthesis Inhibitors / pharmacology; RNA, Messenger / drug effects; RNA, Messenger / metabolism
topics (OpenAlex): Connexins and lens biology
TL;DR: The ability of ascorbic acid to increase ferritin concentration in lens epithelial cells could provide an additional protective mechanism for this antioxidant vitamin. (via Semantic Scholar)
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Source: Web Of Science
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1997 article

Nitric Oxide in Ocular Inflammation

Allen, J. B., McGahan, M. C., Fleisher, L. N., Jaffe, G. J., Keng, T., & Privalle, C. T. (1997, January 1).

By: J. Allen n, M. McGahan n, L. Fleisher n, G. Jaffe *, T. Keng & C. Privalle

Ed(s):

topics (OpenAlex): Nitric Oxide and Endothelin Effects; Eicosanoids and Hypertension Pharmacology; Neuropeptides and Animal Physiology
TL;DR: Differential competitive inhibition of isoforms of NOS by NG-substituted L-arginine analogues allows selective intervention to inhibit production of NO as well as to further determine its functions. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1996 article

Hemoglobin exacerbates the ocular inflammatory response to endotoxin

McGahan, M. C., Grimes, A. M., & Fleisher, L. N. (1996, October 1). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: M. McGahan n, A. Grimes n & L. Fleisher n

MeSH headings : Animals; Apoproteins / toxicity; Aqueous Humor / metabolism; Deferoxamine / toxicity; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination; Escherichia coli; Eye Proteins / metabolism; Hemoglobins / toxicity; Leukocytes / pathology; Lipopolysaccharides / toxicity; Rabbits; Random Allocation; Siderophores / toxicity; Transferrin / toxicity; Uveitis, Anterior / chemically induced; Uveitis, Anterior / pathology; Uveitis, Anterior / physiopathology; Vitreous Body / metabolism
topics (OpenAlex): Biochemical effects in animals; High Altitude and Hypoxia; Advanced Glycation End Products research
TL;DR: It is likely that hemoglobinic Fe is responsible for the increased infiltration of white cells caused by the co-injection of autologous hemaglobin and endotoxin, which was increased 15-fold. (via Semantic Scholar)
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1996 article

Interleukin-1β Increases Prostaglandin E2-Stimulated Adenosine 3′,5′-cyclic Monophosphate Production in Rabbit Pigmented Ciliary Epithelium

FLEISHER, L. L. O. Y. D. N., McGAHAN, C. H. R. I. S. T. I. N. E. M., FERRELL, J. E. N. N. Y. B., & PAGAN, I. N. E. S. (1996, July 1). Experimental Eye Research.

By: L. Fleisher n, C. McGAHAN n, J. Ferrell n & I. Pagan n

author keywords: ciliary epithelium; cyclic AMP, interleukin-1; prostaglandins; transforming growth factor-beta; pigmented ciliary epithelium
MeSH headings : Animals; Cells, Cultured; Colforsin / pharmacology; Cyclic AMP / biosynthesis; Cycloheximide / pharmacology; Cyclooxygenase Inhibitors / pharmacology; Dinoprostone / pharmacology; Dose-Response Relationship, Drug; Indomethacin / pharmacology; Interleukin-1 / pharmacology; Isoproterenol / pharmacology; Kinetics; Lipopolysaccharides / pharmacology; Pigment Epithelium of Eye / drug effects; Pigment Epithelium of Eye / metabolism; Protein Synthesis Inhibitors / pharmacology; Rabbits; Stimulation, Chemical; Transforming Growth Factor beta / pharmacology; Tumor Necrosis Factor-alpha / pharmacology; Up-Regulation; Vasoactive Intestinal Peptide / pharmacology
topics (OpenAlex): Inflammatory mediators and NSAID effects; Adenosine and Purinergic Signaling; Corneal Surgery and Treatments
TL;DR: This is the first report of prostaglandin E2-induced stimulation of adenosine 3',5'-cyclic monophosphate production by pigmented ciliary epithelial cells and of the unique ability of interleukin-1 to increase this effect. (via Semantic Scholar)
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1996 article

Intravitreal transforming growth factor-β2 decreases cellular infiltration in endotoxin-induced ocular inflammation in rabbits

Allen, J. B., McGahan, M. C., Ogawa, Y., Sellon, D. C., Clark, B. D., & Fleisher, L. N. (1996, January 1). Current Eye Research.

By: J. Allen*, M. McGahan n, Y. Ogawa, D. Sellon  n, B. Clark* & L. Fleisher n

author keywords: inflammation; in situ hybridization; rabbits; transforming growth factor-beta (TGF-beta); uveitis; endotoxin
MeSH headings : Animals; Anterior Eye Segment / pathology; Body Fluids / metabolism; Cell Movement / drug effects; Injections; Interleukin-1 / metabolism; Lipopolysaccharides; Male; Rabbits; Transforming Growth Factor beta / pharmacology; Uveitis / chemically induced; Uveitis / metabolism; Uveitis / pathology; Vitreous Body
topics (OpenAlex): Corneal Surgery and Treatments; Retinal Diseases and Treatments; Angiogenesis and VEGF in Cancer
TL;DR: In a rabbit model of LPS-induced uveitis, TGF-beta may interrupt the cascade of events leading to ocular inflammation, thereby suggesting therapeutic potential. (via Semantic Scholar)
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1996 article

Nitric Oxide Synthase Inhibitors Exert Differential Time-Dependent Effects on LPS-Induced Uveitis

ALLEN, J. B., McGAHAN, M. C., FERRELL, J. B., ADLER, K. B., & FLEISHER, L. N. (1996, January 1). Experimental Eye Research.

By: J. Allen n, M. McGAHAN n, J. Ferrell n, K. Adler n & L. Fleisher n

author keywords: nitric oxide; uveitis; nitric oxide synthase; nitric oxide synthase inhibitors; inflammation
MeSH headings : Animals; Aqueous Humor / metabolism; Arginine / analogs & derivatives; Arginine / therapeutic use; Cell Count / drug effects; Dose-Response Relationship, Drug; Eye Proteins / drug effects; Guanidines / therapeutic use; Kinetics; Lipopolysaccharides; NG-Nitroarginine Methyl Ester; Nitric Oxide / antagonists & inhibitors; Nitric Oxide / physiology; Nitric Oxide Synthase / antagonists & inhibitors; Rabbits; Uveitis, Anterior / etiology; Uveitis, Anterior / metabolism; Uveitis, Anterior / prevention & control
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Retinal and Optic Conditions
TL;DR: Investigation of the effects of NOS inhibitors with different NOS isoform specificities in the rabbit model of endotoxin-induced ocular inflammation suggests that cNOS may play a greater role in the earlier stages of this developing inflammatory response, and extends others' observations that NO is a key mediator in uveitis. (via Semantic Scholar)
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1995 article

Inflammation induced changes in adenosine 3′,5′-cyclic monophosphate production by ciliary epithelial cell bilayers

Fleisher, L. N., Ferrell, J. B., & McGahan, M. C. (1995, February 1). Experimental Eye Research.

By: L. Fleisher n, J. Ferrell n & M. McGahan n

author keywords: ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE; INTERLEUKIN-1; TUMOR NECROSIS FACTOR; ANTERIOR UVEA; CILIARY EPITHELIUM; ENDOTOXIN; UVEITIS
MeSH headings : Animals; Ciliary Body / drug effects; Ciliary Body / metabolism; Colforsin / pharmacology; Culture Techniques; Cyclic AMP / biosynthesis; Epithelium / drug effects; Epithelium / metabolism; Interleukin-1 / pharmacology; Isoproterenol / pharmacology; Lipopolysaccharides / pharmacology; Male; Rabbits; Recombinant Proteins / pharmacology; Tumor Necrosis Factor-alpha / pharmacology; Uveitis, Anterior / etiology; Uveitis, Anterior / metabolism
topics (OpenAlex): Ocular Surface and Contact Lens; Neuroinflammation and Neurodegeneration Mechanisms; Glaucoma and retinal disorders
TL;DR: The inability of IL-1 beta, TNF alpha, or the low concentration of endotoxin to increase cAMP production by bilayers, in vitro, suggests that the enhanced cAMPProduction observed with inflamed bilayer, ex vivo, was not due to a direct action of these inflammatory agonists on the ciliary epithelial bilayer. (via Semantic Scholar)
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1995 article

Iron uptake by cultured lens epithelial cells

McGahan, M. C., Grimes, A. M., Nasisse, M. P., & Fleisher, L. N. (1995, June 1). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: M. McGahan*, A. Grimes n, M. Nasisse n & L. Fleisher n

MeSH headings : 2,2'-Dipyridyl / pharmacology; Animals; Ascorbic Acid / pharmacology; Biological Transport / drug effects; Cataract / metabolism; Cataract / pathology; Cells, Cultured; Dogs; Epithelium / metabolism; Iron / metabolism; Iron Radioisotopes; Lens, Crystalline / cytology; Lens, Crystalline / metabolism; Receptors, Transferrin / metabolism; Transferrin / metabolism
topics (OpenAlex): Connexins and lens biology; Aldose Reductase and Taurine
TL;DR: The reduction of Fe uptake by the subcultured and cataract cell lines probably reflects a decrease in transferrin receptor expression and in the activity of an alternative pathway for Fe transferrin uptake occurring over time. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1995 article

Mediators of the ocular inflammatory response to interleukin-1β plus tumor necrosis factor-α

Fleisher, L., Ferrell, J., & McGahan, C. (1995, February 1). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: L. Fleisher n, J. Ferrell n & C. McGahan n

MeSH headings : Animals; Indomethacin / therapeutic use; Interleukin-1 / toxicity; Male; Platelet Activating Factor / antagonists & inhibitors; Platelet Activating Factor / metabolism; Rabbits; Tumor Necrosis Factor-alpha / toxicity; Uveitis, Anterior / immunology; Uveitis, Anterior / prevention & control; Uveitis, Posterior / immunology; Uveitis, Posterior / prevention & control
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Immune Response and Inflammation
TL;DR: The findings do not support an important role for PAF in TNFa/IL-1β-induced uveitis, and it cannot be ruled out that more intensive treatment with a specific and long-acting PAF-receptor antagonist might yield more positive results. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1995 article

Transferrin secretion by lens epithelial cells in culture

McGahan, M. C., Harned, J., Goralska, M., Sherry, B., & Fleisher, L. N. (1995, June 1). Experimental Eye Research.

By: M. McGahan n, J. Harned n, M. Goralska n, B. Sherry n & L. Fleisher n

author keywords: TRANSFERRIN; LENS; ANTIOXIDANTS; GROWTH FACTORS; AQUEOUS HUMOR
MeSH headings : Animals; Aqueous Humor / chemistry; Blotting, Northern; Cells, Cultured; Ciliary Body / metabolism; Dogs; Epithelium / metabolism; Lens, Crystalline / metabolism; Rabbits; Secretory Rate; Time Factors; Transferrin / metabolism; Vitreous Body / chemistry
topics (OpenAlex): Connexins and lens biology; Intraocular Surgery and Lenses; Urinary Bladder and Prostate Research
TL;DR: This is the first experimental demonstration that an intraocular tissue can make and secrete Tf, and transferrin secretion by the lens may contribute significantly to the IOF content of this important intraocular protein. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1994 article

Influence of Exposure Time on Inflammatory Response to Neodymium:YAG Cyclophotocoagulation in Rabbits

Echelman, D. A. (1994, July 1). Archives of Ophthalmology.

By: D. Echelman*

MeSH headings : Animals; Aqueous Humor / metabolism; Ciliary Body / metabolism; Ciliary Body / pathology; Ciliary Body / surgery; Erythrocyte Count; Inflammation; Laser Coagulation / adverse effects; Leukocyte Count; Rabbits; Time Factors; Uveitis / etiology; Uveitis / metabolism; Uveitis / pathology
topics (OpenAlex): Glaucoma and retinal disorders; Intraocular Surgery and Lenses; Anorectal Disease Treatments and Outcomes
TL;DR: When energy is constant, a shorter duration of exposure with transscleral Nd:YAG cyclophotocoagulation in rabbits is associated with greater tissue disruption and inflammation. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1994 article

Regulation of Ferritin Levels in Cultured Lens Epithelial Cells

McGahan, M. C., Harned, J., Grimes, A. M., & Fleisher, L. N. (1994, November 1). Experimental Eye Research.

By: M. McGahan n, J. Harned n, A. Grimes n & L. Fleisher n

author keywords: IRON; FERRITIN; LENS EPITHELIAL CELLS; PEROXIDE; FREE RADICALS; ASCORBIC ACID
MeSH headings : Animals; Cells, Cultured; Chelating Agents / pharmacology; Deferoxamine / pharmacology; Dogs; Enzyme-Linked Immunosorbent Assay; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Ferritins / metabolism; Hemin / pharmacology; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / metabolism
topics (OpenAlex): Connexins and lens biology; Aldose Reductase and Taurine; Iron Metabolism and Disorders
TL;DR: Regulation of ferritin levels may represent a mechanism by which the lens epithelium is protected from oxidative damage, and in pathological circumstances, the iron content and redox state of the aqueous humor is dramatically altered and may affect the steady state levels of Ferritin within the lens. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1994 article

Transferrin Inhibits the Ocular Inflammatory Response

McGahan, M. C., Grimes, A. M., & Fleisher, L. N. (1994, April 1). Experimental Eye Research.

By: M. McGahan*, A. Grimes* & L. Fleisher*

MeSH headings : Animals; Eye Proteins / metabolism; Leukocyte Count / drug effects; Rats; Transferrin / therapeutic use; Uveitis / prevention & control; Xanthine Oxidase
topics (OpenAlex): Retinal Diseases and Treatments; Iron Metabolism and Disorders; Retinal Development and Disorders
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1992 article

Cellular response to intravitreal injection of endotoxin and xanthine oxidase in rabbits

McGahan, M. C., & Fleisher, L. N. (1992, August 1). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: M. McGahan* & L. Fleisher n

MeSH headings : Animals; Aqueous Humor / cytology; Endotoxins / administration & dosage; Endotoxins / pharmacology; Escherichia coli; Injections; Leukocyte Count / drug effects; Leukocytes; Lipopolysaccharides; Rabbits; Vitreous Body / cytology; Xanthine Oxidase / administration & dosage; Xanthine Oxidase / pharmacology
topics (OpenAlex): Connexins and lens biology; Glaucoma and retinal disorders; Heme Oxygenase-1 and Carbon Monoxide
TL;DR: Myeloperoxidase (MPO) activity of the iris-ciliary body was increased only in those eyes with a large neutrophilic response and thus is not recommended for use as a definitive index of the ocular inflammatory response, but may be a useful adjunct for such studies. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1992 journal article

Effects of copper loading and depletion on rabbit superoxide dismutase activity

Trace Elements in Medicine, 9, 55–58.

By: J. Ferrell, L. Fleisher, M. Smith & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

1992 journal article

Synergistic uveitic effects of tumor necrosis factor-alpha and interleukin-1 beta

Investigative Ophthalmology and Visual Science, 33, 2120–2127.

By: L. Fleisher, J. Ferrell & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

1991 article

Effects of copper depletion andd-penicillamine treatment on the ocular inflammatory response

McGahan, M. C., Fleisher, L. N., & Grimes, A. M. (1991, November 1). Inflammation Research.

By: M. McGahan*, L. Fleisher n & A. Grimes n

MeSH headings : Animals; Antioxidants; Aqueous Humor / metabolism; Ceruloplasmin / metabolism; Copper / deficiency; Copper / metabolism; Endophthalmitis / metabolism; Endophthalmitis / pathology; Free Radicals; Penicillamine / pharmacology; Rabbits
topics (OpenAlex): Connexins and lens biology; Trace Elements in Health; Vanadium and Halogenation Chemistry
TL;DR: Rabbits placed on a copper (Cu)-deficient diet for four weeks had lower plasma Cu concentration, ferroxidase activity, and antioxidant activity than rabbits fed an identical Cu-adequate basel diet and it is likely that ceruloplasmin plays a protective role in the intraocular inflammatory response. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1991 journal article

Lipid mediators of TNF- induced uveitis

Investigative Ophthalmology and Visual Science, 32, 2393–2399.

By: L. Fleisher, J. Ferrell & M. McGahan

Source: NC State University Libraries
Added: August 6, 2018

1990 article

Ocular inflammatory effects of intravitreally injected tumor necrosis factor-alpha and endotoxin

Fleisher, L. N., Ferrell, J. B., & McGahan, M. C. (1990, June 1). Inflammation.

By: L. Fleisher*, J. Ferrell n & M. McGahan n

MeSH headings : Animals; Aqueous Humor / analysis; Drug Synergism; Endotoxins / administration & dosage; Endotoxins / toxicity; Inflammation; Injections; Male; Rabbits; Recombinant Proteins / administration & dosage; Recombinant Proteins / toxicity; Tumor Necrosis Factor-alpha / administration & dosage; Tumor Necrosis Factor-alpha / toxicity; Uveitis / chemically induced; Uveitis / pathology; Vitreous Body
topics (OpenAlex): Neuroinflammation and Neurodegeneration Mechanisms; Glaucoma and retinal disorders; Immune Response and Inflammation
TL;DR: Intravitreal injection of human recombinant tumor necrosis factor-alpha induced inflammation in the rabbit eye characterized by dilation of blood vessels in the iris, disruption of the blood-ocular barriers, infiltration of inflammatory cells into the anterior chamber, and accumulation of prostaglandin E in intraocular fluids differed from that reported for intravitreally injected endotoxin in terms of time course and the types ofinflammatory cells in the aqueous humor. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1989 article

Clinical signs of acute ocular inflammatory response to endotoxin are not altered by increasing antioxidant potency of intraocular fluids

Mcgahan, M. C., Fleisher, L. N., & Grimes, A. M. (1989, August 1). Inflammation.

By: M. Mcgahan*, L. Fleisher n & A. Grimes n

MeSH headings : Animals; Antioxidants; Aqueous Humor / metabolism; Ceruloplasmin / metabolism; Copper / blood; Copper / pharmacology; Endotoxins / toxicity; Rabbits; Transferrin / metabolism; Uveitis / physiopathology
topics (OpenAlex): Vanadium and Halogenation Chemistry; Connexins and lens biology; S100 Proteins and Annexins
TL;DR: Increased intraocular fluid antioxidant activity did not affect the acute anterior segment response to endotoxin, and it is possible that the time course and resolution of the response is altered by changes in extracellular fluid antioxidants activity. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1989 article

Dimethylthiourea inhibits the inflammatory response to intravitreally-injected endotoxin

Fleisher, L. N., Ferrell, J. B., Olson, N. C., & McGahan, M. C. (1989, April 1). Experimental Eye Research.

By: L. Fleisher n, J. Ferrell n, N. Olson n & M. McGahan n

MeSH headings : Animals; Endotoxins; Escherichia coli; Male; Rabbits; Thiourea / administration & dosage; Thiourea / analogs & derivatives; Thiourea / pharmacology; Uveitis, Anterior / chemically induced; Uveitis, Anterior / prevention & control; Vitreous Body
topics (OpenAlex): Inflammatory mediators and NSAID effects; Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Vanadium and Halogenation Chemistry
TL;DR: The ability of dimethylthiourea to significantly inhibit the inflammatory response to intravitreally-injected endotoxin suggests that toxic oxygen metabolites may play an important role in the initiation and/or propagation of this form of acute anterior uveitis. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1989 article

Ferroxidase Activity Increases in the Aqueous Humor during the Ocular Inflammatory Response

McGahan, C., Grimes, A. M., & Fleisher, L. N. (1989, January 1). Ophthalmic Research.

By: C. McGahan n, A. Grimes n & L. Fleisher n

MeSH headings : Animals; Aqueous Humor / enzymology; Ceruloplasmin / analysis; Ceruloplasmin / metabolism; Copper / analysis; Copper / blood; Endophthalmitis / enzymology; Endotoxins; Escherichia coli / metabolism; Proteins / analysis; Rabbits; Spectrophotometry, Atomic; Time Factors; Vitreous Body
topics (OpenAlex): Connexins and lens biology; Glaucoma and retinal disorders; Neutrophil, Myeloperoxidase and Oxidative Mechanisms
TL;DR: Plasma copper transport protein ceruloplasmin (plasma ferroxidase) entered the inflamed aqueous humor from plasma through disrupted blood ocular barriers and would facilitate the removal of potentially damaging, free radical generating Fe+2.2. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1988 article

Inflammation-induced changes in the iron concentration and total iron-binding capacity of the intraocular fluids of rabbits

McGahan, M. C., & Fleisher, L. N. (1988, January 1). Graefe s Archive for Clinical and Experimental Ophthalmology.

By: M. McGahan n & L. Fleisher n

MeSH headings : Animals; Aqueous Humor / metabolism; Endophthalmitis / chemically induced; Endophthalmitis / metabolism; Eye / metabolism; Iron / analysis; Iron / blood; Iron / metabolism; Rabbits; Transferrin / metabolism; Vitreous Body / metabolism
topics (OpenAlex): Heme Oxygenase-1 and Carbon Monoxide; Connexins and lens biology; Barrier Structure and Function Studies
TL;DR: The influx of the partially saturated plasma protein transferrin through disrupted blood-ocular barriers most likely accounts for the increased TIBC in the inflamed eye and could provide some protection against the potentially harmful effects of Fe arising from tissue necrosis and hemolysis subsequent to hemorrhage. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

1986 article

A micromethod for the determination of iron and total iron-binding capacity in intraocular fluids and plasma using electrothermal atomic absorption spectroscopy

McGahan, M. C., & Fleisher, L. N. (1986, August 1). Analytical Biochemistry.

By: M. McGahan n & L. Fleisher n

MeSH headings : Animals; Aqueous Humor / metabolism; Cats; Dogs; Electrochemistry; Eye / metabolism; Horses; Indicators and Reagents; Iron / analysis; Iron / blood; Iron / metabolism; Rabbits; Species Specificity; Spectrophotometry, Atomic; Swine; Temperature; Vitreous Body / metabolism
topics (OpenAlex): Intraocular Surgery and Lenses; Glaucoma and retinal disorders; Retinal Diseases and Treatments
TL;DR: Using this method considerably less species variation in IOF Fe concentration was found as compared to previous studies, and some possible methodological reasons for this difference are discussed. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1986 article

Antioxidant activity of aqueous and vitreous humor from the inflamed rabbit eye

McGahan, M. C., & Fleisher, L. N. (1986, January 1). Current Eye Research.

By: M. McGahan n & L. Fleisher n

MeSH headings : Animals; Antioxidants / metabolism; Aqueous Humor / metabolism; Brain / metabolism; Endophthalmitis / metabolism; Eye Proteins / metabolism; Male; Malondialdehyde / biosynthesis; Oxidation-Reduction; Rabbits; Time Factors; Vitreous Body / metabolism
topics (OpenAlex): Glaucoma and retinal disorders; Connexins and lens biology; Traumatic Brain Injury and Neurovascular Disturbances
TL;DR: Entry of plasma proteins through disrupted blood ocular barriers may function in protecting ocular tissues against the increased oxidation which occurs during inflammation. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1986 article

Time course for prostaglandin synthesis by rabbit lens during endotoxin-induced ocular inflammation

Fleisher, L. N., & McGahan, M. C. (1986, January 1). Current Eye Research.

By: L. Fleisher n & M. McGahan n

MeSH headings : Animals; Body Fluids / metabolism; Dinoprost; Dinoprostone; Endophthalmitis / chemically induced; Endophthalmitis / metabolism; Endophthalmitis / pathology; Endotoxins / pharmacology; Escherichia coli; Lens, Crystalline / metabolism; Male; Prostaglandins E / biosynthesis; Prostaglandins F / biosynthesis; Rabbits
topics (OpenAlex): Inflammatory mediators and NSAID effects; Glaucoma and retinal disorders; Immune Response and Inflammation
TL;DR: The results suggest that during ocular inflammation, aqueous humor PGE2 may be derived, at least in part, from the lens and leukocytes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1985 article

Endotoxin-induced ocular inflammation increases prostaglandin E2 synthesis by rabbit lens

Fleisher, L. N., & McGahan, M. C. (1985, May 1). Experimental Eye Research.

By: L. Fleisher n & M. McGahan n

MeSH headings : Animals; Aqueous Humor / metabolism; Dinoprostone; Endotoxins / pharmacology; Escherichia coli; Eye / drug effects; Eye / pathology; Inflammation / metabolism; Lens, Crystalline / metabolism; Male; Prostaglandins E / biosynthesis; Rabbits
topics (OpenAlex): Biochemical effects in animals; Inflammatory mediators and NSAID effects; Aldose Reductase and Taurine
TL;DR: Twenty-four hours after the intravitreal injection of 0.1-100 ng of Escherichia coli endotoxin into one eye of the New Zealand white rabbit, lenses from the inflamed eyes synthesized significantly more prostaglandin E2 (PGE2) than their contralateral lenses at all doses of endotoxin. (via Semantic Scholar)
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Added: August 6, 2018

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