Works Published in 2011
Displaying works 101 - 120 of 218 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
QTL Mapping for Days to Flowering under Drought Condition in Rice (Oryza sativa L.) Genome
Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 39(1), 58.
TL;DR:
The five common QTL detected by at least two models could be considered as stable QTL for days to flowering under drought and might be of practical use in marker assisted selection.
(via Semantic Scholar)
www.notulaebotanicae.ro (publisher PDF)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: July 20, 2019
2011 journal article
Using Nuclear Receptor Activity to Stratify Hepatocarcinogens
PLoS ONE, 6(2).
Contributors: I. Shah *, K. Houck *, R. Judson *, R. Kavlock*, M. Martin*, D. Reif* , J. Wambaugh *, D. Dix*
Ed(s): S. Wölfl
MeSH headings : Animals; Carcinogens / classification; Carcinogens / toxicity; Carcinoma, Hepatocellular / chemically induced; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / metabolism; Cells, Cultured; Constitutive Androstane Receptor; Disease Progression; Drug Evaluation, Preclinical / methods; Gene Expression / drug effects; Gene Expression Profiling; Gene Regulatory Networks / drug effects; High-Throughput Screening Assays / methods; Humans; Liver / drug effects; Liver / metabolism; Liver / pathology; Liver Neoplasms / chemically induced; Liver Neoplasms / genetics; Liver Neoplasms / metabolism; Mice; Microarray Analysis; Rats; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Cytoplasmic and Nuclear / physiology
TL;DR:
These results do not prove the role of NR activation in human liver cancer, but they do have implications for nuclear receptor chemical biology and provide insights into putative toxicity pathways and suggest the utility of in vitro assays for stratifying environmental contaminants based on a combination of human bioactivity and rodent toxicity.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data.
Toxicological Sciences, 124(1), 109–127.
Contributors: N. Sipes *, M. Martin*, D. Reif* , N. Kleinstreuer *, R. Judson *, A. Singh*, K. Chandler*, D. Dix*, R. Kavlock*, T. Knudsen *
author keywords: developmental toxicity; ToxCast; ToxRefDB; high-throughput screening; predictive models; computational models predictive toxicology
MeSH headings : Animals; Congenital Abnormalities / etiology; Databases, Factual; Embryonic Development / drug effects; Endpoint Determination; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Fetal Development / drug effects; High-Throughput Screening Assays; Models, Biological; Rabbits; Rats; Species Specificity; Teratogens / classification; Teratogens / toxicity; United States; United States Environmental Protection Agency
TL;DR:
This work indicates the utility of HTS assays for developing pathway-level models predictive of developmental toxicity, and builds statistical associations based on HTS and in vivo developmental toxicity data from ToxRefDB.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Predictive model of rat reproductive toxicity from ToxCast high throughput screening.
Biology of Reproduction, 85(2), 327–339.
Contributors: M. Martin*, T. Knudsen *, D. Reif* , K. Houck *, R. Judson *, R. Kavlock*, D. Dix*
author keywords: female reproductive tract; fertility; male reproductive tract; predictive toxicology; reproductive toxicity; toxicology
MeSH headings : Animals; Environmental Pollutants / toxicity; Gene Expression Regulation / drug effects; Male; Predictive Value of Tests; Rats; Reproduction / drug effects; Risk Assessment; Small Molecule Libraries; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
A robust and stable predictive model was produced capable of identifying rodent reproductive toxicants with 77% ± 2% and 74% ± 5% training and test cross-validation balanced accuracies, further indicating the model's potential for prioritizing the many thousands of environmental chemicals with little to no hazard information.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 conference paper
Optimization of grammatical evolution decision trees
Proceedings of the 13th annual conference companion on Genetic and evolutionary computation - GECCO '11, 35–36.
Contributors: K. Hoover n, R. Marceau n, T. Harris n, N. Hardison n, D. Reif n & A. Motsinger-Reif n
TL;DR:
The results of a parameter sweep evaluating the power of GEDT are presented and it is shown that improved parameter choices improves the performance of the method.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2011 journal article
Mechanistic indicators of childhood asthma (MICA) study: piloting an integrative design for evaluating environmental health.
BMC Public Health, 11, 344.
Contributors: J. Gallagher*, E. Hudgens*, A. Williams *, J. Inmon*, S. Rhoney*, G. Andrews*, D. Reif* , B. Heidenfelder*
MeSH headings : Adolescent; Asthma / diagnosis; Asthma / etiology; Biomarkers / blood; Child; Disease Susceptibility; Environmental Health; Environmental Monitoring / methods; Female; Genetic Predisposition to Disease / genetics; Humans; Male; Michigan; Risk Factors
TL;DR:
The MICA study provides an opportunity to evaluate complex relationships between environmental factors, physiological biomarkers, genetic susceptibility and health outcomes and incorporates exposure metrics, internal dose measures, and clinical indicators to decipher the biological complexity inherent in diseases such as asthma and cardiovascular disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2011 journal article
Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
BMC Medical Genetics, 12, 25.
Contributors: B. Joubert *, D. Reif* , S. Edwards*, K. Leiner*, E. Hudgens*, P. Egeghy *, J. Gallagher*, E. Hubal
MeSH headings : Adolescent; Black or African American / genetics; Asthma / genetics; Child; Chromosomes, Human, Pair 11 / genetics; Cross-Sectional Studies; Female; Food Hypersensitivity / genetics; Genetic Predisposition to Disease; Glutathione S-Transferase pi / genetics; Glutathione Transferase / genetics; Haplotypes; Humans; Hypersensitivity / genetics; Hypersensitivity, Immediate / genetics; Linkage Disequilibrium; Male; Michigan; Odds Ratio; Polymorphism, Single Nucleotide; Receptors, IgE / genetics; Risk Factors; Sequence Deletion; Urban Population
TL;DR:
Variation in genes associated with asthma in predominantly non-African ethnic groups contributed to increased odds of asthma in this African American study population.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2011 journal article
Evaluation of 309 Environmental Chemicals Using a Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity Assay
PLoS ONE, 6(6), e18540.
Contributors: K. Chandler*, M. Barrier*, S. Jeffay*, H. Nichols*, N. Kleinstreuer *, A. Singh*, D. Reif* , N. Sipes *
Ed(s): A. Cooney
MeSH headings : Animals; Biological Assay; Cell Adhesion / drug effects; Cell Death / drug effects; Cell Differentiation / drug effects; Cell Line; Embryonic Stem Cells / cytology; Embryonic Stem Cells / drug effects; Endpoint Determination; Environmental Pollutants / toxicity; Male; Mice; Models, Biological; Multivariate Analysis; Toxicity Tests / methods
TL;DR:
An initial characterization of metabolic and regulatory pathways by which some environmental chemicals may act to disrupt ES cell growth and differentiation is provided.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Environmental Impact on Vascular Development Predicted by High-Throughput Screening
Environ Health Perspect, 119(11), 1596â1603.
Contributors: N. Kleinstreuer *, R. Judson *, D. Reif* , N. Sipes *, A. Singh*, K. Chandler*, R. DeWoskin*, D. Dix*, R. Kavlock*, T. Knudsen *
author keywords: angiogenesis; developmental toxicity; high-throughput screening (HTS); thalidomide; vascular development
MeSH headings : Animals; Cardiovascular System / drug effects; Cardiovascular System / embryology; Computational Biology; Databases, Factual; Environmental Pollutants / analysis; Environmental Pollutants / classification; Environmental Pollutants / immunology; Environmental Pollutants / toxicity; Female; High-Throughput Screening Assays; Humans; Male; Maternal Exposure; Mice; Models, Animal; Multivariate Analysis; Pregnancy; Rabbits; Rats; Risk Assessment; Small Molecule Libraries / analysis; Small Molecule Libraries / classification; Small Molecule Libraries / toxicity; Species Specificity; Toxicology / methods; United States; United States Environmental Protection Agency
TL;DR:
It is predicted that blood vessel development is a target for environmental chemicals acting as putative vascular disruptor compounds (pVDCs) and identified potential species differences in sensitive vascular developmental pathways.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets
Toxicology, 282(1-2), 1â15.
Contributors: T. Knudsen *, K. Houck *, N. Sipes *, A. Singh*, R. Judson *, M. Martin*, A. Weissman, N. Kleinstreuer *
author keywords: High-throughput screening; Computational toxicology; ToxCast; Environmental chemicals
MeSH headings : Animal Use Alternatives; Animals; Automation, Laboratory; Cell-Free System; Data Interpretation, Statistical; Databases, Factual; Environmental Pollutants / classification; Environmental Pollutants / toxicity; Enzyme Inhibitors / toxicity; High-Throughput Screening Assays; Humans; Ligands; Models, Biological; Osmolar Concentration; Pesticide Residues / toxicity; Rats; Reproducibility of Results; Toxicity Tests; United States; United States Environmental Protection Agency
TL;DR:
Mapping relationships across 93,440 chemical-assay pairs based on half-maximal activity concentration (AC50) revealed both known and novel targets in signaling and metabolic pathways.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2011 journal article
Effect of forest fragmentation on tick infestations of birds and tick infection rates by Rickettsia in the Atlantic forest of Brazil
Ecohealth, 8(3), 320–331.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
A new ant species from Borneo closely resembling Tetramorium flagellatum Bolton, 1977 (Hymenoptera: Formicidae)
Asian Myrmecology, 4, 1–7.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
The Arabidopsis YUCCA1 Flavin Monooxygenase Functions in the Indole-3-Pyruvic Acid Branch of Auxin Biosynthesis
PLANT CELL, 23(11), 3961–3973.
MeSH headings : Arabidopsis Proteins / genetics; Arabidopsis Proteins / metabolism; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Gene Knockdown Techniques; Indoleacetic Acids / metabolism; Indoles / metabolism; Oxygenases / genetics; Oxygenases / metabolism; Tryptophan Transaminase / genetics; Tryptophan Transaminase / metabolism
TL;DR:
Results strongly suggest that the enzymatic reactions involved in indole-3-acetic acid (IAA) production via IPyA are different than those previously postulated, and a new and testable model for how IAA is produced in plants is needed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Shared and Unique Patterns of Embryo Development in Extremophile Poeciliids
PLOS ONE, 6(11).
MeSH headings : Adaptation, Physiological; Animals; Ecosystem; Embryonic Development; Hydrogen Sulfide; Phenotype; Poecilia / anatomy & histology; Poecilia / embryology
TL;DR:
The results clearly demonstrate that even among sister taxa convergence in phenotypic traits is not always achieved by the same processes during embryo development, and discusses how the apparent ability of cave mollies to overcome this carotenoid-dependency may represent another potential mechanism explaining the lack of gene flow between surface and cave molls.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Competitive interactions between walleye (Sander vitreus) and smallmouth bass (Micropterus dolomieu) under various controlled conditions
Journal of Freshwater Ecology, 26(3), 299–314.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Food rationing affects dietary selenium bioaccumulation and life cycle performance in the mayfly Centroptilum triangulifer
ECOTOXICOLOGY, 20(8), 1840–1851.
author keywords: Selenium; Mayfly; Periphyton; Toxicity; Maternal transfer; Fecundity; Trophic transfer; Chronic; Bioconcentration
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Body Weight; Female; Fertility; Food Chain; Insecta / growth & development; Insecta / metabolism; Insecta / physiology; Life Cycle Stages; Ovum; Selenium / pharmacokinetics
TL;DR:
The results suggest that the influence of Se on mayfly performance in nature may be tied to food resource availability and quality and nutritional status is an important consideration when applying laboratory derived estimates of toxicity to risk assessments for wild populations.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Evaluating a novel technique for individual identification of anuran tadpoles using coded wire tags
Herpetological Conservation and Biology, 6(1), 155–160.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Enteric Microbiome Metabolites Correlate with Response to Simvastatin Treatment
PLOS ONE, 6(10).
MeSH headings : Bile Acids and Salts / metabolism; Cholesterol, LDL / blood; Demography; Female; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / metabolism; Gastrointestinal Tract / microbiology; Humans; Liver-Specific Organic Anion Transporter 1; Male; Metabolomics; Metagenome / drug effects; Middle Aged; Models, Biological; Organic Anion Transporters / genetics; Pharmacogenetics; Polymorphism, Single Nucleotide / genetics; Simvastatin / pharmacology; Treatment Outcome
TL;DR:
Interactions between genome, gut microbiome and environmental influences should be considered in the study and management of cardiovascular disease and metabolic profiles could provide valuable information about treatment outcomes and could contribute to a more personalized approach to therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Climate Projections Using Bayesian Model Averaging and Space-Time Dependence
JOURNAL OF AGRICULTURAL BIOLOGICAL AND ENVIRONMENTAL STATISTICS, 16(4), 606–628.
author keywords: Bayesian hierarchical modeling; Bayesian model averaging; Climate change; Climate model; Gaussian process; Space-time data
TL;DR:
This work analyzes the problem of combining multiple climate models using Bayesian Model Averaging (BMA) to derive future projections and quantify uncertainty estimates of spatiotemporally resolved temperature hindcasts and projections and achieves computational efficiency using a kernel mixing approach for representing a space–time process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
13. Climate Action
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Wing patterning gene redefines the mimetic history of Heliconius butterflies
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(49), 19666–19671.
author keywords: Mullerian mimicry; population genetics; phylogeography
TL;DR:
A long-standing debate about the origins of the races within each species is resolved, supporting the hypothesis that the red-rayed Amazonian pattern evolved recently and expanded, causing disjunctions of more ancestral patterns.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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