Works Published in 2010
Displaying works 81 - 100 of 209 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 journal article
Pesticide Use Modifies the Association Between Genetic Variants on Chromosome 8q24 and Prostate Cancer
Cancer Research, 70(22), 9224–9233.
Contributors: S. Koutros *, L. Beane Freeman*, S. Berndt *, G. Andreotti *, J. Lubin*, D. Sandler *, J. Hoppin* , K. Yu *
MeSH headings : Adult; Aged; Chromosomes, Human, Pair 8 / genetics; Coumaphos / poisoning; Fonofos / poisoning; Genome-Wide Association Study; Humans; Incidence; Iowa / epidemiology; Logistic Models; Male; Middle Aged; North Carolina / epidemiology; Occupational Diseases / chemically induced; Occupational Diseases / epidemiology; Occupational Diseases / genetics; Odds Ratio; Organothiophosphorus Compounds / poisoning; Permethrin / poisoning; Pesticides / poisoning; Phorate / poisoning; Polymorphism, Single Nucleotide; Prospective Studies; Prostatic Neoplasms / chemically induced; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / genetics; Risk Assessment; Risk Factors
TL;DR:
A significant interaction among variants on chromosome 8q24, pesticide use, and risk of prostate cancer was observed, and Insecticides, particularly organophosphates, were the strongest modifiers of risk, although the biological mechanism is unclear.
(via Semantic Scholar)
cancerres.aacrjournals.org (publisher PDF)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
Coumaphos Exposure and Incident Cancer among Male Participants in the Agricultural Health Study (AHS)
Environmental Health Perspectives, 118(1), 92–96.
Contributors: C. Christensen*, E. Platz *, G. Andreotti *, A. Blair*, J. Hoppin* , S. Koutros *, C. Lynch *, D. Sandler *, M. Alavanja*
author keywords: agriculture; cancer; coumaphos; insecticide; livestock; neoplasms; occupational exposure; organophosphate; pesticide; prostate
MeSH headings : Adult; Aged; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / etiology; Animal Husbandry; Cohort Studies; Coumaphos / administration & dosage; Coumaphos / toxicity; Genetic Predisposition to Disease; Humans; Insecticides / administration & dosage; Insecticides / toxicity; Iowa / epidemiology; Male; Middle Aged; Neoplasms / epidemiology; Neoplasms / etiology; North Carolina / epidemiology; Occupational Exposure; Occupational Health; Prospective Studies; Prostatic Neoplasms / epidemiology; Prostatic Neoplasms / etiology; Prostatic Neoplasms / genetics; Risk Assessment; Surveys and Questionnaires; Young Adult
TL;DR:
Cumulative exposure to coumaphos was not associated with cancer risk overall or with any major cancer site including prostate, and there was evidence of an association between cou maphos and prostate cancer, possibly due to genetic susceptibility; however, other explanations are plausible.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
Maternal Pesticide Use and Birth Weight in the Agricultural Health Study
Journal of Agromedicine, 15(2), 127–136.
Contributors: S. Sathyanarayana*, O. Basso *, C. Karr *, P. Lozano *, M. Alavanja*, D. Sandler *, J. Hoppin*
author keywords: Agricultural exposures; birth weight; carbaryl; pesticides; reproductive epidemiology
MeSH headings : Adolescent; Adult; Agriculture; Carbaryl / adverse effects; Female; Health Surveys; Humans; Infant, Low Birth Weight; Infant, Newborn; Insecticides / adverse effects; Iowa; Male; Maternal Exposure / adverse effects; Middle Aged; Mothers; North Carolina; Occupational Exposure / adverse effects; Occupational Health; Pregnancy; Pregnancy Trimester, First / metabolism; Young Adult
TL;DR:
Overall, the authors observed no associations between birth weight and pesticide-related activities during early pregnancy and have no data on temporal specificity of individual pesticide exposures prior to or during pregnancy and therefore cannot draw conclusions related to these exposure windows.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
Effects of self-reported health conditions and pesticide exposures on probability Of Follow-Up in a prospective cohort study
American Journal of Industrial Medicine, 53(5), 486–496.
Contributors: M. Montgomery *, F. Kamel*, J. Hoppin* , L. Freeman*, M. Alavanja* & D. Sandler *
author keywords: selection bias; follow-up studies; prospective studies; cohort studies; pesticides; agriculture
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agriculture; Confidence Intervals; Female; Humans; Iowa / epidemiology; Logistic Models; Male; Middle Aged; Multivariate Analysis; North Carolina / epidemiology; Occupational Diseases / epidemiology; Occupational Diseases / etiology; Occupational Exposure / adverse effects; Odds Ratio; Patient Acceptance of Health Care; Pesticides / toxicity; Probability; Prospective Studies; Risk Assessment; Risk Factors; Selection Bias; Surveys and Questionnaires; Time Factors; United States / epidemiology; Young Adult
TL;DR:
Differences between non-participants and participants in the follow-up interview were generally small, and significant evidence of selection bias was found, however, the extent of bias may depend on the specific exposure and outcome under study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Source: ORCID
Added: September 13, 2019
2010 journal article
Identification of Iowa Live Births in the Agricultural Health Study
Archives of Environmental & Occupational Health, 65(3), 154–162.
Contributors: P. Romitti *, S. Watanabe-Galloway *, W. Budelier*, C. Lynch *, S. Puzhankara*, D. Wong-Gibbons*, J. Hoppin* , M. Alavanja*
author keywords: children; occupational exposures; pesticides; pregnancy; prospective cohort
MeSH headings : Agricultural Workers' Diseases / epidemiology; Agriculture / statistics & numerical data; Birth Certificates; Family Characteristics; Female; Health Surveys; Humans; Iowa / epidemiology; Live Birth / epidemiology; Male; Occupational Exposure / adverse effects; Occupational Exposure / statistics & numerical data; Parity; Pregnancy
TL;DR:
A probabilistic and deterministic approach was used to link available demographic data from 31,707 households and information on live births from 13,599 households with 1,014,916 Iowa birth certificates, producing an expanded cohort of live-born children among Iowa participants.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
Body mass index, effect modifiers, and risk of pancreatic cancer: a pooled study of seven prospective cohorts
Cancer Causes & Control, 21(8), 1305–1314.
Contributors: L. Jiao *, A. Berrington De Gonzalez *, P. Hartge*, R. Pfeiffer *, Y. Park *, D. Freedman*, M. Gail *, M. Alavanja*
author keywords: Pancreatic cancer; Body mass index; Pooled analysis; Prospective cohort; Effect modification
MeSH headings : Age Factors; Body Mass Index; Cohort Studies; Effect Modifier, Epidemiologic; Female; Humans; Male; Middle Aged; Pancreatic Neoplasms / epidemiology; Pancreatic Neoplasms / etiology; Proportional Hazards Models; Prospective Studies; Risk Factors; Sex Factors
TL;DR:
The present evidence suggests that a high BMI is an independent risk factor of pancreatic cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
Assessment of a pesticide exposure intensity algorithm in the agricultural health study
Journal of Exposure Science and Environmental Epidemiology, 20(6), 559–569.
Contributors: K. Thomas *, M. Dosemeci*, J. Coble*, J. Hoppin* , L. Sheldon*, G. Chapa*, C. Croghan*, P. Jones *
author keywords: 2,4-D; chlorpyrifos; exposure measurement; occupational exposure; Agricultural Health Study
MeSH headings : 2,4-Dichlorophenoxyacetic Acid / analysis; 2,4-Dichlorophenoxyacetic Acid / urine; Agriculture; Air Pollutants, Occupational / analysis; Air Pollutants, Occupational / urine; Algorithms; Biomarkers / urine; Chlorpyrifos / analysis; Chlorpyrifos / urine; Cohort Studies; Environmental Exposure / analysis; Environmental Monitoring / methods; Gas Chromatography-Mass Spectrometry; Humans; Iowa; Linear Models; North Carolina; Occupational Exposure / analysis; Pesticides / analysis; Pesticides / urine; Risk Assessment / methods; Skin Absorption; Surveys and Questionnaires
TL;DR:
The results of the measurements support the use of the algorithm for estimating questionnaire-based exposure intensities in the AHS for liquid pesticide products and refine the algorithm may be possible using the results from this and other measurement studies.
(via Semantic Scholar)
Source: ORCID
Added: September 13, 2019
2010 journal article
Body mass index, agricultural pesticide use, and cancer incidence in the Agricultural Health Study cohort
Cancer Causes & Control, 21(11), 1759–1775.
Contributors: G. Andreotti *, L. Hou *, L. Beane Freeman*, R. Mahajan*, S. Koutros *, J. Coble*, J. Lubin*, A. Blair*, J. Hoppin* , M. Alavanja*
author keywords: Obesity; Body mass index; Pesticides; Cancer; Agriculture
MeSH headings : Agriculture; Body Mass Index; Breast Neoplasms / complications; Breast Neoplasms / epidemiology; Cohort Studies; Colonic Neoplasms / complications; Colonic Neoplasms / epidemiology; Female; Humans; Incidence; Male; Neoplasms / epidemiology; Neoplasms / etiology; Obesity / complications; Obesity / epidemiology; Overweight / epidemiology; Pesticides / adverse effects; Prospective Studies; Surveys and Questionnaires
TL;DR:
It is suggested that certain pesticides may modify the effects of BMI on the risks of colon and lung cancers and not in non-users of these pesticides.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
An Update of Cancer Incidence in the Agricultural Health Study
Journal of Occupational and Environmental Medicine, 52(11), 1098–1105.
Contributors: S. Koutros, M. Alavanja, J. Lubin, D. Sandler, J. Hoppin* , C. Lynch, C. Knott, A. Blair, L. Freeman
MeSH headings : Adult; Aged; Agricultural Workers' Diseases / chemically induced; Agricultural Workers' Diseases / epidemiology; Air Pollutants, Occupational / adverse effects; Female; Humans; Incidence; Male; Middle Aged; Neoplasms / chemically induced; Neoplasms / epidemiology; North Carolina / epidemiology; Occupational Exposure / adverse effects; Pesticides / adverse effects; Prospective Studies; Registries; Spouses / statistics & numerical data
TL;DR:
Although lower rates of smoking and increased physical activity probably contribute to the lower overall cancer incidence, agricultural exposures including pesticides, viruses, bacteria, sunlight, and other chemicals may increase risks for specific cancer sites.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
Body-Mass Index and Mortality among 1.46 Million White Adults
New England Journal of Medicine, 363(23), 2211–2219.
Contributors: A. De Gonzalez *, P. Hartge*, J. Cerhan *, A. Flint*, L. Hannan*, R. MacInnis *, S. Moore*, G. Tobias *
MeSH headings : Adult; Body Mass Index; Cause of Death; Confounding Factors, Epidemiologic; Exercise; Female; Follow-Up Studies; Humans; Male; Mortality / ethnology; Overweight / mortality; Proportional Hazards Models; Smoking / adverse effects; Socioeconomic Factors; Thinness / mortality; White People / statistics & numerical data
TL;DR:
In white adults, overweight and obesity (and possibly underweight) are associated with increased all-cause mortality and the hazard ratios for the men were similar.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2010 journal article
Selective translocation of Ca2+/calmodulin protein kinase II (CaMKII ) to inhibitory synapses
Proceedings of the National Academy of Sciences, 107(47), 20559–20564.
MeSH headings : Animals; Calcineurin / metabolism; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism; Hippocampus / cytology; Image Processing, Computer-Assisted; Immunohistochemistry; Long-Term Potentiation / physiology; Microscopy, Fluorescence; Neurons / metabolism; Rats; Receptors, GABA-A / metabolism; Receptors, N-Methyl-D-Aspartate / metabolism; Synapses / metabolism
TL;DR:
It is shown that CaMKIIα translocates to inhibitory but not excitatory synapses in response to more moderate NMDAR-activating stimuli that trigger GABAA-receptor (GABAAR) insertion and enhance inhibitory transmission.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2010 chapter
Understanding environment-disease connections: An introduction to the comparative toxicogenomics database (ctd)
In Nature Pathway Interaction Database.
Source: NC State University Libraries
Added: August 10, 2019
2010 journal article
2,3,7,8-Tetrachlorodibenzo-p-dioxin Upregulates FoxQ1b in Zebrafish Jaw Primordium
Chemical Research in Toxicology, 23(3), 480–487.
Contributors: A. Planchart* & C. Mattingly*
MeSH headings : Animals; Embryo, Nonmammalian / metabolism; Enhancer Elements, Genetic; Environmental Pollutants / pharmacology; Forkhead Transcription Factors / genetics; Gene Expression Regulation, Developmental / drug effects; Jaw / metabolism; Jaw / pathology; Jaw Abnormalities / chemically induced; Polychlorinated Dibenzodioxins / pharmacology; Receptors, Aryl Hydrocarbon / metabolism; Up-Regulation / drug effects; Zebrafish / genetics; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
FoxQ1b is specifically expressed in the jaw primordium where it discretely outlines a developing jaw structure known as Meckel's cartilage--a conserved structure in all jawed vertebrates that develops abnormally in the presence of TCDD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: August 10, 2019
2010 journal article
The Comparative Toxicogenomics Database: update 2011
Nucleic Acids Research, 39(Database), D1067–D1072.
MeSH headings : Databases, Factual; Disease / etiology; Disease / genetics; Environmental Exposure; Gene Regulatory Networks; Genes; Hazardous Substances / toxicity; Humans; Software; Toxicogenetics
TL;DR:
Since 2009, the content of CTD has dramatically increased the content to 1.4 million chemical–gene–disease data points and added many features, statistical analyses and analytical tools, including GeneComps and ChemComps, to help users generate testable hypotheses about the molecular mechanisms of environmental diseases.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 7, 2019
2010 journal article
An Organotypic Slice Assay for High-Resolution Time-Lapse Imaging of Neuronal Migration in the Postnatal Brain
Journal of Visualized Experiments, (46).
MeSH headings : Animals; Brain / anatomy & histology; Brain / cytology; Cell Movement / physiology; Image Processing, Computer-Assisted / methods; Lateral Ventricles / cytology; Mice; Neural Stem Cells / cytology; Neurogenesis / physiology; Neurons / cytology; Olfactory Bulb / cytology; Organ Culture Techniques / methods
TL;DR:
An organotypic slice assay optimized for postnatal brain tissue, in which the extracellular conditions closely mimic the in vivo environment for migrating neuroblasts within the RMS, is described.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
2010 journal article
Zwitterionic phosphorylcholine as a better ligand for gold nanorods cell uptake and selective photothermal ablation of cancer cells
Chemical Communications, 46(9), 1479–1481.
MeSH headings : Cell Line, Tumor; Gold / chemistry; Humans; Infrared Rays; Ligands; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; Phosphorylcholine / chemistry
TL;DR:
The conjugation of zwitterionic phosphorylcholine onto gold nanorods leads to enhanced and selective uptake within cancer cells.
(via Semantic Scholar)
Source: ORCID
Added: March 21, 2019
2010 article
Signal Generation with Gold Nanoparticles: Photophysical Properties for Sensor and Imaging Applications
Wei, Q., & Wei, A. (2010, June). The Supramolecular Chemistry of Organic-Inorganic Hybrid Materials, pp. 319–349.
Source: ORCID
Added: March 21, 2019
2010 journal article
Plasmon-Resonant Nanoparticles and Nanostars with Magnetic Cores: Synthesis and Magnetomotive Imaging
Acs Nano, 4(9), 5163–5173.
author keywords: imaging; magnetic nanoparticles; nanomedicine; nanostars; plasmonics; synthesis
MeSH headings : Animals; Cattle; Cell Line; Gold / chemistry; Macrophages / metabolism; Magnetics; Magnetite Nanoparticles / chemistry; Mice; Microscopy, Electron, Transmission; Molecular Imaging / methods; Optical Phenomena; Protein Transport; Serum Albumin, Bovine / metabolism
TL;DR:
The polarization-sensitive MM imaging modality offers the dual advantage of enhanced signal quality and reduced background signal and can be applied toward the detection of magnetomotive NSTs in heterogeneous biological samples, as illustrated by their detection inside of granular cells such as macrophages.
(via Semantic Scholar)
Source: ORCID
Added: March 21, 2019
2010 journal article
Gold nanorods: multifunctional agents for cancer imaging and therapy.
Methods in Molecular Biology (Clifton, N.J.), 624, 119–130.
author keywords: Gold; biomedical imaging; nonlinear optical microscopy; photothermal effects; surface functionalization; targeting
MeSH headings : Animals; Diagnostic Imaging / methods; Folic Acid / metabolism; Gold; Mice; Nanomedicine / methods; Nanotubes / chemistry; Nanotubes / ultrastructure; Neoplasms / diagnosis; Neoplasms / therapy; Polyethylene Glycols / metabolism; Surface Properties
TL;DR:
Gold nanorods are strongly absorbing at near-infrared (NIR) frequencies and can be employed as multifunctional agents for biological imaging and theragnostics, but future clinical applications will require the rigorous removal of CTAB and reliable methods of surface functionalization for cell-selective targeting and for minimizing nonspecific uptake into cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: March 21, 2019
2010 article
Cellular Interactions of Plasmon-Resonant Gold Nanorods
Wei, Q., & Wei, A. (2010, August). Organelle-Specific Pharmaceutical Nanotechnology, pp. 507–533.
Source: ORCID
Added: March 21, 2019
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