Works Published in 2015
Displaying works 21 - 40 of 97 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Strain-specific induction of endometrial periglandular fibrosis in mice exposed during adulthood to the endocrine disrupting chemical bisphenol A
Reproductive Toxicology, 58, 119–130.
Contributors: J. Kendziorski* & S. Belcher*
author keywords: BPA; Endocrine disruptor; Uterus; Mouse; Collagen; Dose response; Endometrial periglandular fibrosis; Equine endometrosis; Matrix metalloproteinase; Non-monotonic
MeSH headings : Age Factors; Animals; Benzhydryl Compounds / toxicity; Collagen Type I / metabolism; Collagen Type III / metabolism; Endocrine Disruptors / toxicity; Endometriosis / chemically induced; Endometriosis / genetics; Endometriosis / metabolism; Endometriosis / pathology; Endometrium / drug effects; Endometrium / metabolism; Endometrium / pathology; Female; Fibrosis; Matrix Metalloproteinase 14 / genetics; Matrix Metalloproteinase 14 / metabolism; Matrix Metalloproteinase 2 / genetics; Matrix Metalloproteinase 2 / metabolism; Mice, Inbred C57BL; Phenols / toxicity; Phenotype; Species Specificity
TL;DR:
The association between the pro-collagen shift in increased collagen expression and decreased MMP2 expression and activity implies that strain differences and BPA exposure alter regulation of endometrial remodeling and contribute to increased fibrosis, a component of several human uterine diseases.
(via Semantic Scholar)
europepmc.org (repository)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 24, 2020
2015 journal article
Phosphoproteome Analysis Links Protein Phosphorylation to Cellular Remodeling and Metabolic Adaptation during Magnaporthe oryzae Appressorium Development
Journal of Proteome Research, 14(6), 2408–2424.
author keywords: Magnaporthe oryzae; quantitative phosphoproteomics; appressorium formation; network analysis; transcription factors
MeSH headings : Adaptation, Physiological; Basic Helix-Loop-Helix Transcription Factors / metabolism; Chromatography, Liquid; Fungal Proteins / metabolism; Magnaporthe / metabolism; Magnaporthe / physiology; Oryza / microbiology; Phosphoproteins / metabolism; Phosphorylation; Proteomics; Signal Transduction; Tandem Mass Spectrometry
TL;DR:
Network analysis incorporating regulation from transcriptomic, proteomic, and phosphoproteomic data revealed new insights into the regulation of the metabolism of conidial storage reserves and phospholipids, autophagy, actin dynamics, and cell wall metabolism during appressorium formation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2015 journal article
Leachate Quality Monitoring from Conventional, Retrofit, and Bio-Reactor Landfill Cells
Journal of Hazardous, Toxic, and Radioactive Waste, 19(4), 04015009.
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 19, 2020
2015 journal article
A framework for incorporating ecological releases in single reservoir operation
Advances in Water Resources, 78, 9–21.
author keywords: Ecological flow requirements; Natural flow regime; Sustainable reservoir operation; Mixed integer linear programming
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2015 journal article
Role of multimodel combination and data assimilation in improving streamflow prediction over multiple time scales
Stochastic Environmental Research and Risk Assessment, 30(8), 2255–2269.
TL;DR:
An experimental design is proposed to test the performance of both approaches, multimodel combination and data assimilation, in improving the hydrologic prediction at daily and monthly time scales, and to compare how uncertainty due to initial conditions and Hydrologic model can be dominant at the respective time scales.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
13. Climate Action
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2015 journal article
Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma
Nature Communications, 6(1).
MeSH headings : Asthma / genetics; Carrier Proteins / genetics; Female; Genetic Predisposition to Disease / genetics; Genome-Wide Association Study / methods; Humans; Linkage Disequilibrium / genetics; Male; Membrane Proteins / genetics; Neoplasm Proteins / genetics
TL;DR:
The results suggest that associations with rare and low-frequency variants are ethnic specific and not likely to explain a significant proportion of the ‘missing heritability’ of asthma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 5, 2020
2015 journal article
Associations of Ozone and PM2.5 Concentrations With Parkinsonʼs Disease Among Participants in the Agricultural Health Study
Journal of Occupational and Environmental Medicine, 57(5), 509–517.
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agriculture; Air Pollutants, Occupational / adverse effects; Air Pollutants, Occupational / analysis; Air Pollution / adverse effects; Air Pollution / analysis; Child; Farmers; Female; Follow-Up Studies; Humans; Iowa; Logistic Models; Male; Middle Aged; North Carolina; Occupational Diseases / etiology; Occupational Exposure / adverse effects; Occupational Exposure / analysis; Ozone / adverse effects; Ozone / analysis; Parkinson Disease / etiology; Particulate Matter / adverse effects; Particulate Matter / analysis; Young Adult
TL;DR:
The plausibility of an effect of ambient concentrations of these pollutants on Parkinson's disease risk is supported by experimental data demonstrating damage to dopaminergic neurons at relevant concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2015 journal article
IARC Monographs: 40 Years of Evaluating Carcinogenic Hazards to Humans
Environmental Health Perspectives, 123(6), 507–514.
MeSH headings : Biomedical Research; Carcinogens, Environmental; Humans; International Agencies / organization & administration; Neoplasms; Public Health; Publications
TL;DR:
Criticism of the IARC classification process are unconvincing, the procedures employed by IARC to assemble Working Groups of scientists from the various disciplines and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 5, 2020
2015 journal article
Enhancing bottom-up and top-down proteomic measurements with ion mobility separations
Proteomics, 15(16), 2766–2776.
Contributors: E. Baker* , K. Burnum-Johnson *, Y. Ibrahim *, D. Orton *, M. Monroe *, R. Kelly *, R. Moore *, X. Zhang *
author keywords: Ion mobility separations; Ion mobility spectrometry; Mass spectrometry; Proteomics
MeSH headings : Chromatography, Liquid / methods; Complex Mixtures; Mass Spectrometry / methods; Peptides / analysis; Peptides / chemistry; Proteins / analysis; Proteins / chemistry; Proteomics / methods
TL;DR:
Applications illustrating increased sensitivity, throughput, and structural information by utilizing IMS–MS and LC–IMS–MS measurements for both bottom‐up and top‐down proteomics measurements are reported on.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2015 journal article
Enhancing biological analyses with three dimensional field asymmetric ion mobility, low field drift tube ion mobility and mass spectrometry (μFAIMS/IMS-MS) separations
Analyst, 140(20), 6955–6963.
Contributors: X. Zhang *, Y. Ibrahim *, T. Chen *, J. Kyle *, R. Norheim*, M. Monroe *, R. Smith *, E. Baker*
MeSH headings : Animals; Cattle; Mass Spectrometry / methods; Motion; Peptide Fragments / chemistry; Peptide Fragments / isolation & purification; Proteolysis; Serum Albumin, Bovine / chemistry; Serum Albumin, Bovine / metabolism; Trypsin / metabolism
TL;DR:
The μFAIMS/IMS-MS platform was used to analyze biological samples and simultaneously acquire multidimensional FAIMS compensation fields, IMS drift times, and accurate ion masses for the detected features, which increased the overall measurement separation power, resulting in greater information content and more complete characterization of the complex samples.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2015 journal article
Development of a new ion mobility (quadrupole) time-of-flight mass spectrometer
International Journal of Mass Spectrometry, 377(1), 655–662.
Contributors: Y. Ibrahim *, E. Baker* , W. Danielson*, R. Norheim*, D. Prior*, G. Anderson*, M. Belov*, R. Smith *
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: December 5, 2019
2015 journal article
Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus
Journal of Biological Chemistry, 290(24), 15337–15349.
Contributors: J. Cha*, K. Burnum-Johnson *, A. Bartos*, Y. Li*, E. Baker* , S. Tilton *, B. Webb-Robertson *, P. Piehowski *
MeSH headings : Animals; Embryonic Development / genetics; Female; Genes, Homeobox; Homeodomain Proteins / genetics; Homeodomain Proteins / physiology; Inflammation / genetics; MSX1 Transcription Factor / genetics; MSX1 Transcription Factor / physiology; Mice; Mice, Knockout; Muscle, Smooth / pathology; Pregnancy; Uterus / metabolism; Uterus / pathology
TL;DR:
It is found that uterine Msx expression persists during diapause across species; their inactivation in the mouse uterus results in termination of diAPause with the development of implantation-like responses (“pseudoimplantation”) that ultimately succumbed to resorption.
(via Semantic Scholar)
Source: ORCID
Added: December 5, 2019
2015 book
Mass spectrometry for biomarker development
In General Methods in Biomarker Research and their Applications (Vol. 1-2, pp. 17–48).
Contributors: C. Wu *, T. Liu *, E. Baker* , K. Rodland * & R. Smith *
Source: ORCID
Added: December 5, 2019
2015 journal article
Ion manipulations in structures for lossless ion manipulations (SLIM): computational evaluation of a 90° turn and a switch.
The Analyst, 140(20), 6845–6852.
Contributors: S. Garimella *, Y. Ibrahim *, I. Webb *, A. Ipsen*, T. Chen*, A. Tolmachev *, E. Baker* , G. Anderson*, R. Smith *
MeSH headings : Mass Spectrometry / methods; Models, Theoretical; Motion; Pressure
TL;DR:
More robust SLIM designs that reduce the race track effect while maximizing ion transmission are reported, and the dynamic switching of ions into orthogonal channels was also evaluated both using SIMION ion trajectory simulations and experimentally.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: December 5, 2019
2015 journal article
Ion Trapping, Storage, and Ejection in Structures for Lossless Ion Manipulations
Analytical Chemistry, 87(12), 6010–6016.
Contributors: X. Zhang *, S. Garimella *, S. Prost*, I. Webb *, T. Chen*, K. Tang *, A. Tolmachev *, R. Norheim*
MeSH headings : Electrodes; Ions / analysis; Mass Spectrometry / instrumentation
TL;DR:
It is shown that ions can be trapped and accumulated with up to 100% efficiency, stored for at least 5 h with no significant losses, and then could be rapidly ejected from the SLIM trap.
(via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 5, 2019
2015 journal article
Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study
Occupational and Environmental Medicine, 73(1), 3–12.
MeSH headings : Agriculture; Herbicides / adverse effects; Humans; Incidence; Iowa; Kidney Failure, Chronic / etiology; Male; North Carolina; Occupational Diseases / etiology; Occupational Exposure / adverse effects; Occupations; Pesticides / adverse effects; Proportional Hazards Models; Prospective Studies; Risk Factors
TL;DR:
The findings support an association between ESRD and chronic exposure to specific pesticides, and suggest pesticide exposures resulting in medical visits may increase the risk of E SRD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, Crossref
Added: September 13, 2019
2015 conference paper
Integrating literature-based curated data to predict mechanisms of toxicity
Presented at the OpenTox USA 2015, Baltimore, MD.
Event: OpenTox USA 2015 at Baltimore, MD on February 10-12, 2015
Source: NC State University Libraries
Added: August 10, 2019
2015 journal article
Impact of low-dose oral exposure to bisphenol A (BPA) on Juvenile and adult rat exploratory and anxiety behavior: A CLARITY-BPA Consortium Study
Toxicological Sciences, 148(2), 341–354.
Contributors: M. Rebuli n, L. Camacho*, M. Adonay n, D. Reif n , D. Aylor n & H. Patisaul n
author keywords: bisphenol A; CLARITY; behavior; anxiety; exploratory activity; endocrine disruption; EDC; sexually dimorphic; brain; BPA; plastic
MeSH headings : Age Factors; Animals; Anxiety / chemically induced; Anxiety / psychology; Behavior, Animal / drug effects; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Exploratory Behavior / drug effects; Female; Gestational Age; Lactation; Male; Maternal Exposure / adverse effects; Motor Activity / drug effects; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / psychology; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Risk Assessment; Sex Factors
TL;DR:
No consistent effects of BPA were observed for any endpoint, in either sex, at either age compared to vehicle controls; however, significant differences between BPA-exposed and ethinyl estradiol-exp exposed groups were identified for some endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: ORCID
Added: May 14, 2019
2015 journal article
Food for Thought...: Toxicity testing in the 21st century beyond environmental chemicals
Altex, 32(3), 171–181.
Contributors: C. Rovida*, S. Asakura*, M. Daneshian*, H. Hofman-Huether*, M. Leist *, L. Meunier *, D. Reif n , A. Rossi*
author keywords: food ingredients; drugs; Tox21c; safety assessment
MeSH headings : Animal Testing Alternatives / methods; Animals; Drug Approval; Drug Evaluation / methods; Drug Industry; Humans; In Vitro Techniques; Risk Assessment; Safety / standards; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
The question is whether the latest paradigm shift proposed by the Tox21c report for chemicals may provide a useful tool to improve the risk assessment approach also for drugs and food ingredients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: May 14, 2019
2015 book
Embracing complexity: Searching for gene-gene and gene environment interactions in genetic epidemiology
In Genomics and Proteomics: Principles, Technologies, and Applications (pp. 19–58).
Contributors: A. Motsinger & D. Reif
TL;DR:
Mango (Mangifera indica L.) is an important tropical fruit crop that is thought to be an allotetraploid species with an estimated genome size of 439 mega base pairs.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
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