Douglas Heath Lafevers

Works (9)

Updated: August 3rd, 2023 21:17

2013 article

Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses

Davis, J. L., Kruger, K., LaFevers, D. H., Barlow, B. M., Schirmer, J. M., & Breuhaus, B. A. (2013, November 1). Equine Veterinary Journal, Vol. 46, pp. 729–733.

By: J. Davis n, K. Kruger n, D. LaFevers n, B. Barlow n, J. Schirmer n & B. Breuhaus n 

author keywords: horse; angiotensin converting enzyme; renin; mitral insufficiency
MeSH headings : Administration, Intravenous; Administration, Oral; Angiotensin-Converting Enzyme Inhibitors / blood; Angiotensin-Converting Enzyme Inhibitors / metabolism; Angiotensin-Converting Enzyme Inhibitors / pharmacokinetics; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Area Under Curve; Gene Expression Regulation, Enzymologic; Half-Life; Horses / blood; Horses / metabolism; Peptidyl-Dipeptidase A / blood; Peptidyl-Dipeptidase A / genetics; Peptidyl-Dipeptidase A / metabolism; Quinapril; Renin / blood; Tetrahydroisoquinolines / blood; Tetrahydroisoquinolines / metabolism; Tetrahydroisoquinolines / pharmacokinetics; Tetrahydroisoquinolines / pharmacology
topics (OpenAlex): Renin-Angiotensin System Studies; Pharmacological Effects and Assays; Heart Failure Treatment and Management
TL;DR: Results suggest that, despite low plasma concentrations, quinapril has sufficient oral absorption to produce inhibition of ACE in healthy horses and provides a potential treatment alternative for horses with cardiovascular and renal disease. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Aqueous humor and plasma concentrations of a compounded 0.2% solution of terbinafine following topical ocular administration to normal equine eyes

Veterinary Ophthalmology, 14(1), 41–47.

By: A. Clode n, J. Davis n, G. Davidson n, J. Salmon n, H. Lafevers n & B. Gilger n 

author keywords: aqueous humor; equine; keratomycosis; terbinafine
MeSH headings : Absorption; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / analysis; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Chromatography, High Pressure Liquid / veterinary; Cornea / metabolism; Female; Horses / metabolism; Male; Naphthalenes / administration & dosage; Naphthalenes / analysis; Naphthalenes / blood; Naphthalenes / pharmacokinetics; Ophthalmic Solutions; Terbinafine
topics (OpenAlex): Ocular Infections and Treatments; Ocular Surface and Contact Lens; Antimicrobial Peptides and Activities
TL;DR: Topical ocular administration of compounded 0.2% terbinafine solution does not result in detectable AH or plasma levels following administration to normal equine eyes, suggesting its use for deep corneal or intraocular fungal infections in equine ophthalmology may be limited. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 article

Intravenous and sublingual buprenorphine in horses: pharmacokinetics and influence of sampling site

Messenger, K. M., Davis, J. L., LaFevers, D. H., Barlow, B. M., & Posner, L. P. (2011, April 19). Veterinary Anaesthesia and Analgesia.

By: K. Messenger  n, J. Davis n, D. LaFevers n, B. Barlow n & L. Posner n

author keywords: analgesia; buprenorphine; equine; opioids; pharmacokinetics; sampling site
MeSH headings : Administration, Sublingual; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Biological Availability; Blood Chemical Analysis / methods; Blood Chemical Analysis / veterinary; Buprenorphine / administration & dosage; Buprenorphine / analogs & derivatives; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Cross-Over Studies; Horses / metabolism; Injections, Intravenous / veterinary; Jugular Veins; Male; Prospective Studies
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Pharmacological Effects and Assays; Veterinary Equine Medical Research
TL;DR: Buprenorphine has a long plasma half-life and results in plasma concentrations that are consistent with analgesia in other species for up to 4 hours following IV administration of this dose in horses. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse

Journal of Veterinary Pharmacology and Therapeutics, 35(1), 52–58.

By: J. Davis n, K. Messenger*, D. Lafevers*, B. Barlow n & L. Posner*

MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Cross-Over Studies; Female; Half-Life; Horses / blood; Horses / metabolism; Injections, Intramuscular; Injections, Intravenous; Male
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Pharmacological Effects and Assays; Veterinary Equine Medical Research
TL;DR: Buprenorphine has a moderate T(1/2) in the horse and was detected at concentrations expected to be therapeutic in other species after i.v. and i.m. administration of 0.005 mg/kg. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 journal article

Aqueous humor and plasma concentrations of ciprofloxacin and moxifloxacin following topical ocular administration in ophthalmologically normal horses

American Journal of Veterinary Research, 71(5), 564–569.

By: A. Clode n, J. Davis*, J. Salmon*, H. LaFevers* & B. Gilger* 

MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / metabolism; Aqueous Humor / metabolism; Aza Compounds / administration & dosage; Aza Compounds / blood; Aza Compounds / metabolism; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Female; Fluoroquinolones; Horses / blood; Horses / metabolism; Male; Moxifloxacin; Orchiectomy / veterinary; Quinolines / administration & dosage; Quinolines / blood; Quinolines / metabolism
topics (OpenAlex): Ocular Infections and Treatments; Antibiotics Pharmacokinetics and Efficacy; Intraocular Surgery and Lenses
TL;DR: Moxifloxacin was better able to penetrate healthy equine corneas and reach measurable AH concentrations than was ciprofloxacIn, suggesting moxif loxac in might be of greater value in the treatment of deep corneal or intraocular bacterial infections caused by susceptible organisms. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2007 article

Cardiovascular Effects of Acute Pulmonary Obstruction in Horses with Recurrent Airway Obstruction

Johansson, A. M., Gardner, S. Y., Atkins, C. E., LaFevers, D. H., & Breuhaus, B. A. (2007, January 1). Journal of Veterinary Internal Medicine, Vol. 21, pp. 302–307.

By: A. Johansson n, S. Gardner n, C. Atkins n, D. LaFevers n & B. Breuhaus n 

author keywords: cardiac; echocardiogram; equine; heaves
topics (OpenAlex): Veterinary Equine Medical Research; Veterinary Pharmacology and Anesthesia; Pharmacological Effects and Assays; Hemodynamic Monitoring and Therapy; Sports Performance and Training
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 article

Moxifloxacin pharmacokinetics in horses and disposition into phagocytes after oral dosing

Gardner, S. Y., Davis, J. L., Jones, S. L., LaFevers, D. H., Hoskins, M. S., Mcarver, E. M., & Papich, M. G. (2004, February 1). Journal of Veterinary Pharmacology and Therapeutics, Vol. 27, pp. 57–60.

By: S. Gardner n, J. Davis*, S. Jones* , D. LaFevers*, M. Hoskins*, E. Mcarver*, M. Papich n 

MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Area Under Curve; Aza Compounds / administration & dosage; Aza Compounds / blood; Aza Compounds / pharmacokinetics; Female; Fluoroquinolones; Horses / metabolism; Moxifloxacin; Phagocytes / metabolism; Quinolines / administration & dosage; Quinolines / blood; Quinolines / pharmacokinetics
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Drug Transport and Resistance Mechanisms; Pneumonia and Respiratory Infections
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2004 article

Pharmacokinetics and Pharmacodynamics of Furosemide after Oral Administration to Horses

Johansson, A. M., Gardner, S. Y., Levine, J. F., Papich, M. G., LaFevers, D. H., Goldman, R. B., … Atkins, C. E. (2004, January 1). Journal of Veterinary Internal Medicine, Vol. 18, pp. 739–743.

By: A. Johansson n, S. Gardner*, J. Levine* , M. Papich* , D. LaFevers*, R. Goldman, M. Sheets, C. Atkins*

author keywords: equine; frusemide; loop diuretic; oral bioavailability
topics (OpenAlex): Plant Toxicity and Pharmacological Properties; Pharmacogenetics and Drug Metabolism; Antibiotics Pharmacokinetics and Efficacy
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 article

Furosemide Continuous Rate Infusion in the Horse: Evaluation of Enhanced Efficacy and Reduced Side Effects

Johansson, A. M., Gardner, S. Y., Levine, J. F., Papich, M. G., LaFevers, D. H., Fuquay, L. R., … Atkins, C. E. (2003, January 1). Journal of Veterinary Internal Medicine, Vol. 17, pp. 887–895.

By: A. Johansson n, S. Gardner n, J. Levine n , M. Papich n , D. LaFevers n, L. Fuquay n, V. Reagan n, C. Atkins n

author keywords: electrolyte; equine; fluid balance; frusemide; lasix; loop diuretic
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Coccidia and coccidiosis research; Plant Toxicity and Pharmacological Properties
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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