Jacklyn H. Salmon

Works (32)

Updated: August 9th, 2023 21:15

2021 journal article

Glaucoma-associated pain results in mechanical sensitivity changes in dogs: A pilot study

VETERINARY OPHTHALMOLOGY, 24, 116–124.

By: A. Zibura n, J. Salmon n, B. Lopez n, B. Lascelles  n & H. Westermeyer n 

author keywords: canine; central sensitization; chronic glaucoma; corneal esthesiometry; ocular pain; quantitative sensory testing
MeSH headings : Animals; Chronic Disease / veterinary; Dog Diseases / physiopathology; Dog Diseases / surgery; Dogs; Eye Enucleation / veterinary; Female; Glaucoma / complications; Glaucoma / surgery; Glaucoma / veterinary; Male; Pain / etiology; Pain / veterinary; Pain Measurement / veterinary; Pain Threshold; Physical Stimulation; Pilot Projects; Prospective Studies; Sensory Thresholds
TL;DR: Sensitivity to mechanical stimuli decreased both locally and at remote sites in dogs following enucleation for painful chronic glaucoma and Cranial conformation is associated with differences in sensitivity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 27, 2020

2020 journal article

A Fixed-Depth Microneedle Enhances Reproducibility and Safety for Corneal Gene Therapy

CORNEA, 39(3), 362–369.

By: B. Gilger n , E. Crabtree  n, L. Song*, T. Llanga*, M. Cullen n, A. Blanchard n, J. Salmon n, S. Patel, V. Zarnitsyn, M. Hirsch*

author keywords: cornea; stromal; gene therapy; safety
MeSH headings : Animals; Corneal Stroma / metabolism; Dependovirus / genetics; Gene Expression; Gene Transfer Techniques; Genetic Therapy / methods; Genetic Vectors; Green Fluorescent Proteins / genetics; Injections, Intraocular; Male; Microscopy, Confocal; Needles; Rabbits; Reproducibility of Results; Swine; Ultrasonography
TL;DR: This research presents a novel probabilistic approach that allows us to assess the importance of knowing the carrier and removal status of canine coronavirus as a source of infection in animals and its role in the immune system is investigated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 18, 2020

2019 journal article

AAV-mediated expression of HLA-G1/5 reduces severity of experimental autoimmune uveitis

Scientific Reports, 9(1), 19864.

By: E. Crabtree  n, L. Song*, T. Llanga*, J. Bower *, M. Cullen n, J. Salmon n, M. Hirsch*, B. Gilger n 

MeSH headings : Animals; Antibodies, Neutralizing / metabolism; Dependovirus / genetics; Female; Genetic Therapy; HLA-G Antigens / genetics; HLA-G Antigens / metabolism; HLA-G Antigens / physiology; Intravitreal Injections; Rats; Uveitis / genetics; Uveitis / metabolism; Uveitis / pathology; Uveitis / therapy
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: February 10, 2020

2017 journal article

AAV vector-meditated expression of HLA-G reduces injury-induced corneal vascularization, immune cell infiltration, and fibrosis

Scientific Reports, 7(1).

By: M. Hirsch*, L. Conatser*, S. Smith n, J. Salmon n, J. Wu *, N. Buglak*, R. Davis*, B. Gilger n 

MeSH headings : Animals; Corneal Injuries / genetics; Corneal Injuries / metabolism; Corneal Injuries / pathology; Corneal Injuries / therapy; Corneal Neovascularization / genetics; Corneal Neovascularization / metabolism; Corneal Neovascularization / pathology; Corneal Neovascularization / therapy; Dependovirus; Gene Expression; Genetic Therapy; HEK293 Cells; HLA-G Antigens / biosynthesis; HLA-G Antigens / genetics; Humans; Rabbits
TL;DR: The collective data demonstrate the clinical potential of scAAV8G9-optHLA-G to safely and effectively treat corneal vascularization and inhibit fibrosis while alluding to broader roles in ocular surface immunity and allogenic organ transplantation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Evaluation of Intracameral Pentablock Copolymer Thermosensitive Gel for Sustained Drug Delivery to the Anterior Chamber of the Eye

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 33(5), 353–360.

By: E. Schaefer n, S. Smith n, J. Salmon n, S. Abbaraju*, R. Amin*, S. Weiss, U. Grau, P. Velagaleti, B. Gilger n 

author keywords: ocular; sustained drug delivery; intracameral; pentablock; copolymer
MeSH headings : Animals; Anterior Chamber / drug effects; Anterior Chamber / metabolism; Drug Delivery Systems; Drug Tolerance; Gels / administration & dosage; Gels / pharmacokinetics; Injections, Intraocular; Polymers / administration & dosage; Polymers / pharmacokinetics; Rabbits; Temperature
TL;DR: The results demonstrate the potential of intracameral PTSgel formulations for sustained delivery of biologic therapies to the ocular anterior segment and drug release profile, tolerability, and polymer degradation for one of the thermosensitive, biodegradable, and biocompatible compositions were investigated through intracAMeral injection in rabbits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Evaluation of pentablock co-polymer (PTS sol ) for sustained topical ocular drug delivery

Journal of Drug Delivery Science and Technology, 39, 475–483.

By: S. Smith n, S. Abbaraju*, J. Salmon n, R. Amin*, S. Weiss, U. Grau, P. Velagaleti, B. Gilger n 

author keywords: Ocular; Sustained drug delivery; Pentablock co-polymers; Hydrophobic drugs; Brinzolamide; Hydrophilic drugs
TL;DR: Ocular retention, tolerability, and sustained pharmacodynamics of a clear topical formulation of brinzolamide (BRZ) in PTS sol pentablock co-polymer suggest that drugs in PTSsol may allow for once a day or less frequent dosing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Cytokine and chemokine profiles of aqueous humor and serum in horses with uveitis measured using multiplex bead immunoassay analysis

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 182, 43–51.

By: E. Curto n, K. Messenger n, J. Salmon n & B. Gilger n 

author keywords: Uveitis; Multiplex; Horse; Cytokine; Chemokine; Leptospirosis
MeSH headings : Animals; Aqueous Humor / immunology; Biomarkers / blood; Biomarkers / metabolism; Chemokines / blood; Chemokines / metabolism; Cytokines / blood; Cytokines / metabolism; Horse Diseases / blood; Horse Diseases / diagnosis; Horse Diseases / immunology; Horses; Immunoassay; Inflammation Mediators / blood; Inflammation Mediators / metabolism; Leptospirosis / blood; Leptospirosis / immunology; Leptospirosis / veterinary; Uveitis / blood; Uveitis / immunology; Uveitis / veterinary
TL;DR: The anti-inflammatory cytokine IL-10 and the pro- inflammatory cytokine IP-10 appear to play an important role in ERU. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Sustained Release of Protein Therapeutics from Subcutaneous Thermosensitive Biocompatible and Biodegradable Pentablock Copolymers (PTSgels)

JOURNAL OF DRUG DELIVERY, 2016.

By: E. Schaefer n, S. Abbaraju*, M. Walsh n, D. Newman n, J. Salmon n, R. Amin*, S. Weiss, U. Grau ...

TL;DR: Subcutaneous PTSgels were highly biocompatible and in vitro IgG release occurred in parallel with the disappearance of subcutaneous gel in vivo, and modulation of release of biologics to fit the therapeutic need can be achieved by varying the biocombatible and biodegradable PTSgel composition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Effect of Choroidal Perfusion on Ocular Tissue Distribution After Intravitreal or Suprachoroidal Injection in an Arterially Perfused Ex Vivo Pig Eye Model

Journal of Ocular Pharmacology and Therapeutics, 29(8), 715–722.

By: E. Abarca n, J. Salmon n & B. Gilger n 

MeSH headings : Animals; Carbocyanines / pharmacokinetics; Choroid / blood supply; Choroid / drug effects; Choroid / metabolism; Ciliary Arteries; Drug Delivery Systems; Female; Fluorescein / pharmacokinetics; In Vitro Techniques; Intravitreal Injections; Male; Metabolic Clearance Rate; Microcirculation; Microscopy, Fluorescence; Perfusion; Regional Blood Flow; Swine; Tissue Distribution; Vitreous Body / blood supply; Vitreous Body / drug effects; Vitreous Body / metabolism
TL;DR: Choroidal circulation reduces the tissue drug concentration of the hydrophilic drug suggesting an early clearance mechanism after SCS delivery, which is higher in nonperfused eyes compared to perfused eyes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Treatment of Acute Posterior Uveitis in a Porcine Model by Injection of Triamcinolone Acetonide Into the Suprachoroidal Space Using Microneedles

Investigative Opthalmology & Visual Science, 54(4), 2483.

By: B. Gilger n , E. Abarca n, J. Salmon n & S. Patel *

author keywords: drug delivery; suprachoroidal space; microneedle; posterior segment; uveitis
MeSH headings : Acute Disease; Animals; Aqueous Humor / cytology; Aqueous Humor / metabolism; Cell Count; Choroid; Disease Models, Animal; Electroretinography / drug effects; Extracellular Space; Eye Proteins / metabolism; Female; Glucocorticoids / therapeutic use; Intraocular Pressure / drug effects; Intravitreal Injections; Leukocytes / pathology; Male; Needles; Sus scrofa; Tomography, Optical Coherence; Triamcinolone Acetonide / therapeutic use; Uveitis, Posterior / drug therapy; Uveitis, Posterior / pathology; Vitreous Body / metabolism; Vitreous Body / pathology
TL;DR: Delivery of TA to the SCS using microneedles was simple, effective, and not associated with adverse effects or toxicity, and there were no adverse effects, increased IOP, or evidence of procedural or drug toxicity following injection of TA into theSCS in porcine eyes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Treatment of immune-mediated keratitis in horses with episcleral silicone matrix cyclosporine delivery devices

Veterinary Ophthalmology, 17, 23–30.

By: B. Gilger n , R. Stoppini, D. Wilkie*, A. Clode n, N. Pinto n, J. Hempstead n, J. Gerding n, J. Salmon n

author keywords: cyclosporine; horse; immune-mediated; keratitis; sustained release
MeSH headings : Animals; Cyclosporine / administration & dosage; Cyclosporine / therapeutic use; Drug Implants / administration & dosage; Female; Horse Diseases / drug therapy; Horses; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / therapeutic use; Keratitis / drug therapy; Keratitis / veterinary; Male; Sclera; Silicones; Treatment Outcome
TL;DR: Results from this preliminary retrospective study suggest that the ESMC implants were well tolerated and associated with treatment success with superficial and endothelial IMMK, especially if placed early in the disease process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

A topical aqueous calcineurin inhibitor for the treatment of naturally occurring keratoconjunctivitis sicca in dogs

Veterinary Ophthalmology, 16(3), 192–197.

By: B. Gilger n , D. Wilkie*, J. Salmon n & M. Peel*

author keywords: calcineurin inhibitor; canine; clinical trial; keratoconjunctivitis sicca
MeSH headings : Administration, Topical; Animals; Calcineurin Inhibitors; Cyclosporins / pharmacology; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Keratoconjunctivitis Sicca / drug therapy; Keratoconjunctivitis Sicca / veterinary; Pilot Projects
TL;DR: Results indicate that topical SCY-641, in a stable clear aqueous solution, is efficacious in a spontaneous model of KCS and warrants further evaluation as a treatment of immune-mediated KCS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Immunohistochemical and immunopathologic characterization of superficial stromal immune-mediated keratitis in horses

American Journal of Veterinary Research, 73(7), 1067–1073.

By: D. Pate n, A. Clode n, T. Olivry n , J. Cullen  n, J. Salmon n & B. Gilger n 

Contributors: D. Pate n, A. Clode n, T. Olivry n , J. Cullen  n, J. Salmon n & B. Gilger n 

TL;DR: Pathogenesis of superficial stromal immune-mediated keratitis included cell-mediated inflammation governed by both cytotoxic and helper T cells and local immunoglobulins were present in affected corneas; however, corneal-binding immunoglolins were not detected in the serum or AH from horses with IMMK. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Sustained-Release Celecoxib from Incubated Acrylic Intraocular Lenses Suppresses Lens Epithelial Cell Growth in an Ex Vivo Model of Posterior Capsule Opacity

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 28(4), 359–368.

By: J. Davis n, N. Yi n, J. Salmon n, A. Charlton n, C. Colitz n & B. Gilger n 

MeSH headings : Animals; Cataract Extraction; Celecoxib; Corneal Opacity / pathology; Corneal Opacity / prevention & control; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / pharmacokinetics; Cyclooxygenase 2 Inhibitors / therapeutic use; Delayed-Action Preparations; Dogs; Epithelial Cells / drug effects; Epithelium / drug effects; Epithelium / growth & development; In Vitro Techniques; Lens, Crystalline / cytology; Lens, Crystalline / drug effects; Lens, Crystalline / growth & development; Lenses, Intraocular; Polymethyl Methacrylate; Posterior Capsule of the Lens / cytology; Posterior Capsule of the Lens / drug effects; Posterior Capsule of the Lens / pathology; Postoperative Complications / pathology; Postoperative Complications / prevention & control; Pyrazoles / administration & dosage; Pyrazoles / pharmacokinetics; Pyrazoles / therapeutic use; Sulfonamides / administration & dosage; Sulfonamides / pharmacokinetics; Sulfonamides / therapeutic use
TL;DR: A 4-day treatment of LCs with a concentration of 20 μM CXB may effectively prevent PCO and further studies are needed to determine whether C XB-incubated IOLs can effectively prevent the development of PCO in vivo. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Aqueous humor and plasma concentrations of a compounded 0.2% solution of terbinafine following topical ocular administration to normal equine eyes

Veterinary Ophthalmology, 14(1), 41–47.

By: A. Clode n, J. Davis n, G. Davidson n, J. Salmon n, H. Lafevers n & B. Gilger n 

author keywords: aqueous humor; equine; keratomycosis; terbinafine
MeSH headings : Absorption; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / analysis; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Chromatography, High Pressure Liquid / veterinary; Cornea / metabolism; Female; Horses / metabolism; Male; Naphthalenes / administration & dosage; Naphthalenes / analysis; Naphthalenes / blood; Naphthalenes / pharmacokinetics; Ophthalmic Solutions; Terbinafine
TL;DR: Topical ocular administration of compounded 0.2% terbinafine solution does not result in detectable AH or plasma levels following administration to normal equine eyes, suggesting its use for deep corneal or intraocular fungal infections in equine ophthalmology may be limited. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

Effect and Distribution of Contrast Medium after Injection into the Anterior Suprachoroidal Space in Ex Vivo Eyes

Investigative Opthalmology & Visual Science, 52(8), 5730.

By: G. Seiler*, J. Salmon n, R. Mantuo n, S. Feingold n, P. Dayton n & B. Gilger n 

MeSH headings : Age Factors; Animals; Anterior Chamber / diagnostic imaging; Anterior Chamber / metabolism; Choroid / diagnostic imaging; Choroid / metabolism; Contrast Media / pharmacokinetics; Dogs; Drug Delivery Systems; Imaging, Three-Dimensional; In Vitro Techniques; Injections, Intraocular / methods; Latex / pharmacokinetics; Microbubbles; Posterior Eye Segment / diagnostic imaging; Posterior Eye Segment / metabolism; Retina / diagnostic imaging; Retina / metabolism; Swine; Ultrasonography
TL;DR: The authors' hypothesis that a single anterior SCS injection can reach the ocular posterior segment was supported and it is suggested that the SCS can expand, in a dose-dependent manner, to accommodate various volumes of fluid and that it is possible to image theSCS with ultrasound contrast. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Aqueous humor and plasma concentrations of ciprofloxacin and moxifloxacin following topical ocular administration in ophthalmologically normal horses

American Journal of Veterinary Research, 71(5), 564–569.

By: A. Clode n, J. Davis*, J. Salmon*, H. LaFevers & B. Gilger* 

MeSH headings : Administration, Oral; Administration, Topical; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / blood; Anti-Infective Agents / metabolism; Aqueous Humor / metabolism; Aza Compounds / administration & dosage; Aza Compounds / blood; Aza Compounds / metabolism; Ciprofloxacin / administration & dosage; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Female; Fluoroquinolones; Horses / blood; Horses / metabolism; Male; Moxifloxacin; Orchiectomy / veterinary; Quinolines / administration & dosage; Quinolines / blood; Quinolines / metabolism
TL;DR: Moxifloxacin was better able to penetrate healthy equine corneas and reach measurable AH concentrations than was ciprofloxacIn, suggesting moxif loxac in might be of greater value in the treatment of deep corneal or intraocular bacterial infections caused by susceptible organisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Evaluation of 30- and 25-diopter intraocular lens implants in equine eyes after surgical extraction of the lens

American Journal of Veterinary Research, 71(7), 809–816.

By: R. McMullen n, M. Davidson*, N. Campbell*, J. Salmon* & B. Gilger* 

MeSH headings : Animals; Anterior Chamber / surgery; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / therapeutic use; Euthanasia, Animal; Eye Enucleation / methods; Eye Enucleation / veterinary; Horse Diseases / surgery; Horses; Lens Implantation, Intraocular / methods; Lens Implantation, Intraocular / veterinary; Lens, Crystalline / anatomy & histology; Lens, Crystalline / surgery; Lenses, Intraocular / veterinary; Refraction, Ocular / physiology; Refractive Errors / therapy; Refractive Errors / veterinary; Refractive Surgical Procedures / methods; Refractive Surgical Procedures / veterinary
TL;DR: Investigation of intraocular lens (IOL) implant strength to approximate emmetropia in horses found insertion of 30-D (enucleated globes) and 25-D IOL implants (adult horses) resulted in overcorrection of refractive error. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Long-term outcome after implantation of a suprachoroidal cyclosporine drug delivery device in horses with recurrent uveitis

Veterinary Ophthalmology, 13(5), 294–300.

By: B. Gilger n , D. Wilkie*, A. Clode n, R. McMullen n, M. Utter*, A. Komaromy *, D. Brooks*, J. Salmon n

author keywords: cyclosporine; equine; implant; recurrent uveitis
MeSH headings : Animals; Cyclosporine / administration & dosage; Cyclosporine / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / therapeutic use; Infusion Pumps, Implantable / veterinary; Male; Uveitis / drug therapy; Uveitis / veterinary
TL;DR: The increased vision loss related to uveitis episode of inflammation in eyes after the likely depletion of CsA from the CSI suggests that a repeat CSI may be required at or before 48 months after surgery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Ocular distribution and toxicity of intravitreal injection of triamcinolone acetonide in normal equine eyes

Veterinary Ophthalmology, 11, 15–19.

By: N. Yi n, J. Davis n, J. Salmon n & B. Gilger n 

author keywords: horses; intravitreal; pharmacokinetics; toxicity; triamcinolone acetonide
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacokinetics; Anti-Inflammatory Agents / toxicity; Aqueous Humor / chemistry; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Dose-Response Relationship, Drug; Electroretinography / veterinary; Horses / blood; Horses / metabolism; Injections / adverse effects; Injections / veterinary; Retina / drug effects; Tissue Distribution; Triamcinolone Acetonide / pharmacokinetics; Triamcinolone Acetonide / toxicity; Vitreous Body / chemistry
TL;DR: There was no evidence of overt toxicity from intravitreal TA in normal horses and a single intravItreal injection resulted in TA ocular levels for 21 days, however, the risk for bacterial infections with intrav itreal injection or anterior chamber aspirations in horses is high. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Ocular toxicity and distribution of subconjunctival and intravitreal rapamycin in horses

Journal of Veterinary Pharmacology and Therapeutics, 31(6), 511–516.

By: L. Douglas n, N. Yi n, J. Davis n, J. Salmon n & B. Gilger n 

MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Chromatography, High Pressure Liquid; Dermatitis, Phototoxic; Horses; Sirolimus / adverse effects; Sirolimus / pharmacokinetics; Sirolimus / therapeutic use; Tissue Distribution; Uveitis / drug therapy; Uveitis / veterinary
TL;DR: Drug could be detected in both the aqueous and vitreous humor after intravitreal injection and no evidence of ocular toxicity was noted on ophthalmic examination or histopathology, suggesting a lack of RAPA phototoxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2008 journal article

Role of bacteria in the pathogenesis of recurrent uveitis in horses from the southeastern United States

American Journal of Veterinary Research, 69(10), 1329–1335.

By: B. Gilger n , J. Salmon*, N. Yi*, C. Barden, H. Chandler, J. Wendt, C. Colitz*

MeSH headings : Animals; Aqueous Humor / microbiology; Horse Diseases / microbiology; Horses; Leptospira / genetics; Leptospira / isolation & purification; Leptospirosis / microbiology; Leptospirosis / veterinary; Polymerase Chain Reaction; RNA, Ribosomal / genetics; Recurrence; Reference Values; Southeastern United States; Uveitis / microbiology; Uveitis / veterinary; Vitreous Body / microbiology
TL;DR: In horses from the southeastern United States, Leptospira organisms may have helped initiate ERU in some, but the continued presence of the organisms did not play a direct role in the pathogenesis of this recurrent disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 journal article

A Novel Bioerodible Deep Scleral Lamellar Cyclosporine Implant for Uveitis

Investigative Opthalmology & Visual Science, 47(6), 2596.

By: B. Gilger n , J. Salmon n, D. Wilkie*, L. Cruysberg*, J. Kim *, M. Hayat*, H. Kim *, S. Kim * ...

MeSH headings : Absorbable Implants / veterinary; Animals; Cyclosporine / administration & dosage; Cyclosporine / adverse effects; Cyclosporine / pharmacokinetics; Drug Delivery Systems / veterinary; Feasibility Studies; Horse Diseases / drug therapy; Horse Diseases / metabolism; Horse Diseases / pathology; Horses; Humans; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / adverse effects; Immunosuppressive Agents / pharmacokinetics; Leptospira interrogans / drug effects; Leptospira interrogans / growth & development; Microbial Sensitivity Tests; Panuveitis / drug therapy; Panuveitis / metabolism; Panuveitis / pathology; Panuveitis / veterinary; Permeability; Recurrence; Sclera / metabolism; Treatment Outcome
TL;DR: Diffusion of CsA across the sclera from the episcleral space was not a feasible method of drug delivery to the equine eye, but placing a deep scleral lamellar C sA implant adjacent to the suprachoroidal space was effective in achieving therapeutic ocular drug concentrations and controlling uveitis in horses with ERU. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 journal article

Effect of ophthalmic Nd:YAG laser energy on intraocular lenses after posterior capsulotomy in normal dog eyes

Veterinary Ophthalmology, 9(5), 335–340.

By: A. Beale n, J. Salmon n, T. Michau n & B. Gilger n 

author keywords: canine; Nd : YAG laser capsulotomy; posterior capsular opacity
MeSH headings : Acrylates; Animals; Dogs; Intraoperative Complications; Laser Therapy / adverse effects; Lens Capsule, Crystalline / surgery; Lenses, Intraocular; Models, Anatomic
TL;DR: Both posterior lens capsules and Iols were disrupted in an energy-dependent manner with minimal difference in number of capsulotomy sites or damage to the IOL between acrylic and PMMA IOLs in normal canine cadaver eyes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 journal article

Evaluation of concentration of voriconazole in aqueous humor after topical and oral administration in horses

American Journal of Veterinary Research, 67(2), 296–301.

By: A. Clode n, J. Davis*, J. Salmon*, T. Michau* & B. Gilger* 

MeSH headings : Administration, Oral; Administration, Topical; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / adverse effects; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Aqueous Humor / chemistry; Dose-Response Relationship, Drug; Female; Horses / metabolism; Male; Pyrimidines / administration & dosage; Pyrimidines / adverse effects; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Triazoles / administration & dosage; Triazoles / adverse effects; Triazoles / blood; Triazoles / pharmacokinetics; Voriconazole
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2006 journal article

Pharmacokinetics and tissue distribution of doxycycline after oral administration of single and multiple doses in horses

AMERICAN JOURNAL OF VETERINARY RESEARCH, 67(2), 310–316.

By: J. Davis*, J. Salmon* & M. Papich* 

MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Doxycycline / administration & dosage; Doxycycline / blood; Doxycycline / pharmacokinetics; Drug Administration Schedule; Female; Food Deprivation; Half-Life; Horses / metabolism; Male; Tissue Distribution
TL;DR: Results suggest that doxycycline administered at a dosage of 20 mg/kg, PO, every 24 hours will result in drug concentrations adequate for killing intracellular bacteria and bacteria with minimum inhibitory concentration < or = 0.25 microg/mL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Pharmacokinetics of voriconazole after oral and intravenous administration to horses

AMERICAN JOURNAL OF VETERINARY RESEARCH, 67(6), 1070–1075.

By: J. Davis n, J. Salmon* & M. Papich* 

MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / blood; Antifungal Agents / pharmacokinetics; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Drug Stability; Female; Horses / blood; Injections, Intravenous; Male; Pyrimidines / administration & dosage; Pyrimidines / blood; Pyrimidines / pharmacokinetics; Triazoles / administration & dosage; Triazoles / blood; Triazoles / pharmacokinetics; Voriconazole
TL;DR: It was concluded that administration of voriconazole at a dosage of 4 mg/kg, PO, every 24 hours will attain plasma concentrations adequate for treatment of horses with fungal infections for which the fungi have a minimum inhibitory concentration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Immune-mediated keratitis in horses: 19 cases (1998-2004)

Veterinary Ophthalmology, 8(4), 233–239.

By: B. Gilger n , T. Michau n & J. Salmon n

author keywords: cornea; equine; immune-mediated diseases; keratitis
MeSH headings : Animals; Cyclosporine / administration & dosage; Dexamethasone / administration & dosage; Female; Horse Diseases / epidemiology; Horse Diseases / etiology; Horse Diseases / pathology; Horse Diseases / therapy; Horses; Immunosuppressive Agents / administration & dosage; Keratitis / epidemiology; Keratitis / veterinary; Male; North Carolina / epidemiology; Ophthalmic Solutions / administration & dosage; Ophthalmologic Surgical Procedures / veterinary; Records / veterinary; Retrospective Studies; Severity of Illness Index
TL;DR: Clinical and histologic findings, treatment, and outcome of horses with suspected immune-mediated keratitis (IMMK) are described, with horses with superficial IMMK responding to topical medical therapy, but responded best to surgical removal of the lesion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2005 article

Pharmacokinetics and tissue distribution of itraconazole after oral and intravenous administration to horses

Davis, J. L., Salmon, J. H., & Papich, M. G. (2005, October). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 66, pp. 1694–1701.

By: J. Davis n, J. Salmon* & M. Papich* 

MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Horses / metabolism; Injections, Intravenous / veterinary; Itraconazole / administration & dosage; Itraconazole / blood; Itraconazole / pharmacokinetics; Protein Binding
TL;DR: Itraconazole administered orally as a solution had higher, more consistent absorption than orally administered capsules and attained plasma concentrations that are inhibitory against fungi that infect horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 journal article

Pharmacokinetics and tissue fluid distribution of cephalexin in the horse after oral and i.v. administration

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(5), 425–431.

By: J. Davis, J. Salmon n & M. Papich* 

MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Cephalexin / administration & dosage; Cephalexin / blood; Cephalexin / pharmacokinetics; Cross-Over Studies; Female; Horses / metabolism; Injections, Intravenous / veterinary; Male; Tissue Distribution
TL;DR: This study showed that cephalexin at a dose of 30 mg/kg administered orally at 8 h dosage intervals in horses can produce plasma and interstitial fluid drug concentrations that are in a range recommended to treat susceptible gram-positive bacteria (MIC < or = 0.5 microg/mL). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 journal article

Expression of a chemokine by ciliary body epithelium in horses with naturally occurring recurrent uveitis and in cultured ciliary body epithelial cells

AMERICAN JOURNAL OF VETERINARY RESEARCH, 63(7), 942–947.

By: B. Gilger* , P. Yang, J. Salmon*, G. Jaffe & J. Allen*

MeSH headings : Animals; Aqueous Humor / metabolism; Chemokine CCL5 / biosynthesis; Chemokine CCL5 / genetics; Chemotaxis; Ciliary Body / cytology; Ciliary Body / metabolism; Epithelial Cells / metabolism; Female; Horse Diseases / metabolism; Horses; Male; RNA / chemistry; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction / veterinary; Sequence Analysis, DNA; Uveitis / metabolism; Uveitis / veterinary
TL;DR: Ciliary epithelium may play a role in recruitment and activation of leukocytes through expression of RANTES in horses by use of intradermal hypersensitivity testing and significant chemotaxis of equine leukocyte to rh-RANTES. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

journal article

Treatment of immune-mediated keratitis in horses with episcleral cyclosporine-silicone matrix- implant

Gilger, B. C., Stoppini, R., Wilkie, D. A., Clode, A. B., Pinto, N. H., Hempstead, J., … Salmon, J. H. Pferdeheilkunde, 30(6), 711–712.

By: B. Gilger , R. Stoppini, D. Wilkie, A. Clode, N. Pinto, J. Hempstead, J. Gerding, J. Salmon

Source: NC State University Libraries
Added: August 6, 2018

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