Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction
JOURNAL OF BIOLOGICAL CHEMISTRY, 293(40), 15581–15593.
United States of America 🇺🇸
author keywords: Huntington's disease; aggregation; heat shock protein (HSP); chaperone; heat shock factor protein 1 (HSF1); neurodegeneration; HSP chaperones; heat shock; inclusion bodies; polyQ-mHtt protein; transcription factor sequestration; CREB
MeSH headings :
Animals; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cell Nucleus / pathology; Corpus Striatum / metabolism; Corpus Striatum / pathology; Cyclic AMP Response Element-Binding Protein / genetics; Cyclic AMP Response Element-Binding Protein / metabolism; Cytosol / drug effects; Cytosol / metabolism; Cytosol / pathology; Ecdysterone / analogs & derivatives; Ecdysterone / pharmacology; Embryo, Mammalian; Gene Expression Regulation; HSC70 Heat-Shock Proteins / genetics; HSC70 Heat-Shock Proteins / metabolism; HSP70 Heat-Shock Proteins / genetics; HSP70 Heat-Shock Proteins / metabolism; Heat Shock Transcription Factors / genetics; Heat Shock Transcription Factors / metabolism; Heat-Shock Response; Huntingtin Protein / genetics; Huntingtin Protein / metabolism; Huntington Disease / chemically induced; Huntington Disease / genetics; Huntington Disease / metabolism; Huntington Disease / pathology; Inclusion Bodies / chemistry; Inclusion Bodies / drug effects; Inclusion Bodies / metabolism; Models, Biological; Mutation; NF-kappa B / genetics; NF-kappa B / metabolism; Neurons / drug effects; Neurons / metabolism; Neurons / pathology; PC12 Cells; Primary Cell Culture; Rats; Sorbitol / pharmacology
Source: Web Of Science
Added: October 22, 2018