Justin Chen

Works (2)

Updated: July 5th, 2023 15:33

2018 journal article

Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction

JOURNAL OF BIOLOGICAL CHEMISTRY, 293(40), 15581–15593.

By: J. Chen*, M. Parekh*, H. Seliman*, D. Bakshinskaya *, W. Dai *, K. Kwan *, K. Chen *, A. Liu *

author keywords: Huntington's disease; aggregation; heat shock protein (HSP); chaperone; heat shock factor protein 1 (HSF1); neurodegeneration; HSP chaperones; heat shock; inclusion bodies; polyQ-mHtt protein; transcription factor sequestration; CREB
MeSH headings : Animals; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cell Nucleus / pathology; Corpus Striatum / metabolism; Corpus Striatum / pathology; Cyclic AMP Response Element-Binding Protein / genetics; Cyclic AMP Response Element-Binding Protein / metabolism; Cytosol / drug effects; Cytosol / metabolism; Cytosol / pathology; Ecdysterone / analogs & derivatives; Ecdysterone / pharmacology; Embryo, Mammalian; Gene Expression Regulation; HSC70 Heat-Shock Proteins / genetics; HSC70 Heat-Shock Proteins / metabolism; HSP70 Heat-Shock Proteins / genetics; HSP70 Heat-Shock Proteins / metabolism; Heat Shock Transcription Factors / genetics; Heat Shock Transcription Factors / metabolism; Heat-Shock Response; Huntingtin Protein / genetics; Huntingtin Protein / metabolism; Huntington Disease / chemically induced; Huntington Disease / genetics; Huntington Disease / metabolism; Huntington Disease / pathology; Inclusion Bodies / chemistry; Inclusion Bodies / drug effects; Inclusion Bodies / metabolism; Models, Biological; Mutation; NF-kappa B / genetics; NF-kappa B / metabolism; Neurons / drug effects; Neurons / metabolism; Neurons / pathology; PC12 Cells; Primary Cell Culture; Rats; Sorbitol / pharmacology
TL;DR: RNA-mediated knockdown of heat shock protein 70 (HSP70) and heat shock cognate 70 protein (HSC70) provided evidence for their involvement in promoting diffuse mHtt to form IBs, and chemical chaperone sorbitol similarly promoted the structuring of diffusemHtt into IBs and supported cell survival under stress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 22, 2018

2018 journal article

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

ADVANCED FUNCTIONAL MATERIALS, 29(4).

By: T. Su n, K. Huang n , H. Ma *, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen  n ...

author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
TL;DR: A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019

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