Justin Chen

Works (2)

Updated: July 5th, 2023 15:33

2018 article

Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction

Chen, J. Y., Parekh, M., Seliman, H., Bakshinskaya, D., Dai, W., Kwan, K., … Liu, A. Y. C. (2018, August 24). Journal of Biological Chemistry.

By: J. Chen*, M. Parekh*, H. Seliman*, D. Bakshinskaya *, W. Dai *, K. Kwan *, K. Chen *, A. Liu *

author keywords: Huntington's disease; aggregation; heat shock protein (HSP); chaperone; heat shock factor protein 1 (HSF1); neurodegeneration; HSP chaperones; heat shock; inclusion bodies; polyQ-mHtt protein; transcription factor sequestration; CREB
MeSH headings : Animals; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cell Nucleus / pathology; Corpus Striatum / metabolism; Corpus Striatum / pathology; Cyclic AMP Response Element-Binding Protein / genetics; Cyclic AMP Response Element-Binding Protein / metabolism; Cytosol / drug effects; Cytosol / metabolism; Cytosol / pathology; Ecdysterone / analogs & derivatives; Ecdysterone / pharmacology; Embryo, Mammalian; Gene Expression Regulation; HSC70 Heat-Shock Proteins / genetics; HSC70 Heat-Shock Proteins / metabolism; HSP70 Heat-Shock Proteins / genetics; HSP70 Heat-Shock Proteins / metabolism; Heat Shock Transcription Factors / genetics; Heat Shock Transcription Factors / metabolism; Heat-Shock Response; Huntingtin Protein / genetics; Huntingtin Protein / metabolism; Huntington Disease / chemically induced; Huntington Disease / genetics; Huntington Disease / metabolism; Huntington Disease / pathology; Inclusion Bodies / chemistry; Inclusion Bodies / drug effects; Inclusion Bodies / metabolism; Models, Biological; Mutation; NF-kappa B / genetics; NF-kappa B / metabolism; Neurons / drug effects; Neurons / metabolism; Neurons / pathology; PC12 Cells; Primary Cell Culture; Rats; Sorbitol / pharmacology
topics (OpenAlex): Genetic Neurodegenerative Diseases; Mitochondrial Function and Pathology; Muscle Physiology and Disorders
TL;DR: RNA-mediated knockdown of heat shock protein 70 (HSP70) and heat shock cognate 70 protein (HSC70) provided evidence for their involvement in promoting diffuse mHtt to form IBs, and chemical chaperone sorbitol similarly promoted the structuring of diffusemHtt into IBs and supported cell survival under stress. (via Semantic Scholar)
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Source: Web Of Science
Added: October 22, 2018

2018 article

Platelet‐Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

Su, T., Huang, K., Ma, H., Liang, H., Dinh, P. U., Chen, J., … Cheng, K. (2018, November 13). Advanced Functional Materials, Vol. 29.

By: T. Su n, K. Huang n , H. Ma *, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen  n ...

author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine; Cardiac and Coronary Surgery Techniques
TL;DR: A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019

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