Justin Chen

author keywords: Huntington's disease; aggregation; heat shock protein (HSP); chaperone; heat shock factor protein 1 (HSF1); neurodegeneration; HSP chaperones; heat shock; inclusion bodies; polyQ-mHtt protein; transcription factor sequestration; CREB

MeSH headings : Animals; Cell Nucleus / drug effects; Cell Nucleus / metabolism; Cell Nucleus / pathology; Corpus Striatum / metabolism; Corpus Striatum / pathology; Cyclic AMP Response Element-Binding Protein / genetics; Cyclic AMP Response Element-Binding Protein / metabolism; Cytosol / drug effects; Cytosol / metabolism; Cytosol / pathology; Ecdysterone / analogs & derivatives; Ecdysterone / pharmacology; Embryo, Mammalian; Gene Expression Regulation; HSC70 Heat-Shock Proteins / genetics; HSC70 Heat-Shock Proteins / metabolism; HSP70 Heat-Shock Proteins / genetics; HSP70 Heat-Shock Proteins / metabolism; Heat Shock Transcription Factors / genetics; Heat Shock Transcription Factors / metabolism; Heat-Shock Response; Huntingtin Protein / genetics; Huntingtin Protein / metabolism; Huntington Disease / chemically induced; Huntington Disease / genetics; Huntington Disease / metabolism; Huntington Disease / pathology; Inclusion Bodies / chemistry; Inclusion Bodies / drug effects; Inclusion Bodies / metabolism; Models, Biological; Mutation; NF-kappa B / genetics; NF-kappa B / metabolism; Neurons / drug effects; Neurons / metabolism; Neurons / pathology; PC12 Cells; Primary Cell Culture; Rats; Sorbitol / pharmacology

TL;DR: RNA-mediated knockdown of heat shock protein 70 (HSP70) and heat shock cognate 70 protein (HSC70) provided evidence for their involvement in promoting diffuse mHtt to form IBs, and chemical chaperone sorbitol similarly promoted the structuring of diffusemHtt into IBs and supported cell survival under stress. (via Semantic Scholar)

author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome

TL;DR: A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury. (via Semantic Scholar)