Qi Yin

Works (7)

Updated: July 5th, 2023 15:45

2019 article

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential

Qiao, L., Hu, S., Liu, S., Zhang, H., Ma, H., Huang, K., … Cheng, K. (2019, April 28). Journal of Clinical Investigation, Vol. 129, pp. 2237–2250.

By: L. Qiao  n, S. Hu n , S. Liu *, H. Zhang *, H. Ma*, K. Huang n , Z. Li n, T. Su n ...

MeSH headings : Animals; Exosomes / genetics; Exosomes / metabolism; Exosomes / pathology; Female; Heart / physiology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Human Umbilical Vein Endothelial Cells / metabolism; Human Umbilical Vein Endothelial Cells / pathology; Humans; Male; Mice; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Regeneration; Signal Transduction; Stromal Cells / metabolism; Stromal Cells / pathology
topics (OpenAlex): Extracellular vesicles in disease; MicroRNA in disease regulation; Circular RNAs in diseases
TL;DR: The heart failure pathological condition altered the miR cargos of cardiac-derived exosomes and impaired their regenerative activities, and mechanistic studies revealed that miR-21-5p augmented Akt kinase activity through the inhibition of phosphatase and tensin homolog. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019

2018 article

MARCKS and Lung Disease

Sheats, M. K., Yin, Q., Fang, S., Park, J., Crews, A. L., Parikh, I., … Adler, K. B. (2018, October 19). American Journal of Respiratory Cell and Molecular Biology, Vol. 60, pp. 16–27.

By: M. Sheats* , Q. Yin n, S. Fang n, J. Park n, A. Crews n, I. Parikh*, B. Dickson*, K. Adler n

author keywords: MARCKS; lung disease; inflammation; cancer
MeSH headings : Animals; Humans; Lung Diseases / metabolism; Lung Diseases / physiopathology; Myristoylated Alanine-Rich C Kinase Substrate / metabolism
topics (OpenAlex): Cellular Mechanics and Interactions; Skin and Cellular Biology Research
TL;DR: This article summarizes the structure and cellular function of MARCKS (also including MARC KS family proteins and MARCKSL1 [MARCKS‐like protein 1]). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019

2018 article

Platelet‐Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

Su, T., Huang, K., Ma, H., Liang, H., Dinh, P. U., Chen, J., … Cheng, K. (2018, November 13). Advanced Functional Materials, Vol. 29.

By: T. Su n, K. Huang n , H. Ma *, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen  n ...

author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine; Cardiac and Coronary Surgery Techniques
TL;DR: A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019

2016 article

An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice

Yin, Q., Fang, S., Park, J., Crews, A. L., Parikh, I., & Adler, K. B. (2016, August 24). American Journal of Respiratory Cell and Molecular Biology.

By: Q. Yin n, S. Fang n, J. Park n, A. Crews n, I. Parikh* & K. Adler n

author keywords: myristoylated alanine-rich C kinase substrate; acute lung injury; LPS; neutrophils
MeSH headings : Acute Lung Injury / chemically induced; Acute Lung Injury / drug therapy; Aerosols / administration & dosage; Aerosols / pharmacology; Animals; Behavior, Animal; Bronchoalveolar Lavage Fluid; Cytokines / metabolism; Female; Inflammation Mediators / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / metabolism; Leukocytes / metabolism; Lipopolysaccharides; Lung / drug effects; Lung / metabolism; Lung / pathology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / metabolism; Mice, Inbred BALB C; Myristoylated Alanine-Rich C Kinase Substrate; NF-kappa B / metabolism; Peptides / administration & dosage; Peptides / pharmacology; Peptides / therapeutic use
topics (OpenAlex): Enzyme function and inhibition; Phosphodiesterase function and regulation; Nitric Oxide and Endothelin Effects
TL;DR: Results implicate MARCKS protein in the pathogenesis of ALI/ARDS and suggest that MARC KS-inhibitory peptide(s), delivered by inhalation, could represent a new and potent therapeutic treatment for ALi/ARDS, even if administered well after the disease process has begun. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 article

MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro

Fang, S., Crews, A. L., Chen, W., Park, J., Yin, Q., Ren, X.-R., & Adler, K. B. (2013, February 2). American Journal of Physiology-Lung Cellular and Molecular Physiology.

By: S. Fang n, A. Crews n, W. Chen *, J. Park n, Q. Yin n, X. Ren*, K. Adler n

author keywords: airway; mucin; secretion; myristoylated alanine-rich C kinase substrate; heat shock protein 70
MeSH headings : Base Sequence; Bronchi / cytology; Bronchi / drug effects; Bronchi / metabolism; Bronchi / physiology; Cell Differentiation; Cells, Cultured; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / physiology; HSP40 Heat-Shock Proteins / physiology; HSP70 Heat-Shock Proteins / antagonists & inhibitors; HSP70 Heat-Shock Proteins / genetics; HSP70 Heat-Shock Proteins / physiology; Humans; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / genetics; Membrane Proteins / physiology; Microscopy, Confocal; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport; Pyrimidinones / pharmacology; RNA, Small Interfering / genetics; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Tetradecanoylphorbol Acetate / pharmacology
topics (OpenAlex): Heat shock proteins research; Toxin Mechanisms and Immunotoxins; Endoplasmic Reticulum Stress and Disease
TL;DR: Evidence is provided of a role for HSP70 in mediating mucin secretion via interactions with MARCKS and that these interactions are critical for the cytoplasmic translocation of MARC KS upon its phosphorylation. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 journal article

A Myristoylated Alanine-Rich C Kinase Substrate–Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils

American Journal of Respiratory Cell and Molecular Biology, 48(3), 314–321.

By: J. Li, M. D’Annibale-Tolhurst, K. Adler*, S. Fang*, Q. Yin, A. Birkenheuer* , M. Levy n, S. Jones*  ...

author keywords: MARCKS; cytokine; inflammation; neutrophil
MeSH headings : Animals; Dogs; Humans; Interleukin-8 / biosynthesis; Interleukin-8 / genetics; Interleukin-8 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Lipopolysaccharides / pharmacology; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / metabolism; Peptides / pharmacology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Cell Adhesion Molecules Research; Immune cells in cancer
TL;DR: Observations identify MARCKS protein as a promising therapeutic target in the treatment of inflammatory diseases or syndromes attributed to neutrophil influx and inflammatory cytokine production, such as sepsis, acute lung injury, and acute respiratory distress syndrome. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein

Journal of Leukocyte Biology, 92(3), 633–639.

By: T. Green n, J. Park n, Q. Yin n, S. Fang n, A. Crews n, S. Jones n , K. Adler n

author keywords: cytoplasmic translocation; J774A.1 cells; monocyte chemotactic protein 1; chemotaxis
MeSH headings : Actin Cytoskeleton / immunology; Actin Cytoskeleton / metabolism; Animals; Blotting, Western; Chemotaxis, Leukocyte / physiology; Intracellular Signaling Peptides and Proteins / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Macrophages / immunology; Macrophages / metabolism; Membrane Proteins / immunology; Membrane Proteins / metabolism; Mice; Microscopy, Confocal; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport / physiology
topics (OpenAlex): Cellular Mechanics and Interactions; Cell Adhesion Molecules Research; S100 Proteins and Annexins
TL;DR: Results suggest that MARCKS is involved in directed migration of macrophages via a process involving its phosphorylation, cytoplasmic translocation, and interaction with actin. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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