Works (7)
Updated: July 5th, 2023 15:45
2019 journal article
microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential
JOURNAL OF CLINICAL INVESTIGATION, 129(6), 2237–2250.
MeSH headings : Animals; Exosomes / genetics; Exosomes / metabolism; Exosomes / pathology; Female; Heart / physiology; Heart Failure / genetics; Heart Failure / metabolism; Heart Failure / pathology; Human Umbilical Vein Endothelial Cells / metabolism; Human Umbilical Vein Endothelial Cells / pathology; Humans; Male; Mice; MicroRNAs / genetics; MicroRNAs / metabolism; Myocardium / metabolism; Myocardium / pathology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / pathology; Neovascularization, Physiologic; Proto-Oncogene Proteins c-akt / genetics; Proto-Oncogene Proteins c-akt / metabolism; Regeneration; Signal Transduction; Stromal Cells / metabolism; Stromal Cells / pathology
TL;DR:
The heart failure pathological condition altered the miR cargos of cardiac-derived exosomes and impaired their regenerative activities, and mechanistic studies revealed that miR-21-5p augmented Akt kinase activity through the inhibition of phosphatase and tensin homolog.
(via Semantic Scholar)
open access via www.jci.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019
2018 review
MARCKS and Lung Disease
[Review of ]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 60(1), 16–27.
author keywords: MARCKS; lung disease; inflammation; cancer
MeSH headings : Animals; Humans; Lung Diseases / metabolism; Lung Diseases / physiopathology; Myristoylated Alanine-Rich C Kinase Substrate / metabolism
TL;DR:
This article summarizes the structure and cellular function of MARCKS (also including MARC KS family proteins and MARCKSL1 [MARCKS‐like protein 1]).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019
2018 journal article
Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury
ADVANCED FUNCTIONAL MATERIALS, 29(4).
author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
TL;DR:
A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019
2016 journal article
An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 55(5), 617–622.
author keywords: myristoylated alanine-rich C kinase substrate; acute lung injury; LPS; neutrophils
MeSH headings : Acute Lung Injury / chemically induced; Acute Lung Injury / drug therapy; Aerosols / administration & dosage; Aerosols / pharmacology; Animals; Behavior, Animal; Bronchoalveolar Lavage Fluid; Cytokines / metabolism; Female; Inflammation Mediators / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / metabolism; Leukocytes / metabolism; Lipopolysaccharides; Lung / drug effects; Lung / metabolism; Lung / pathology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / metabolism; Mice, Inbred BALB C; Myristoylated Alanine-Rich C Kinase Substrate; NF-kappa B / metabolism; Peptides / administration & dosage; Peptides / pharmacology; Peptides / therapeutic use
TL;DR:
Results implicate MARCKS protein in the pathogenesis of ALI/ARDS and suggest that MARC KS-inhibitory peptide(s), delivered by inhalation, could represent a new and potent therapeutic treatment for ALi/ARDS, even if administered well after the disease process has begun.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 304(8), L511–L518.
author keywords: airway; mucin; secretion; myristoylated alanine-rich C kinase substrate; heat shock protein 70
MeSH headings : Base Sequence; Bronchi / cytology; Bronchi / drug effects; Bronchi / metabolism; Bronchi / physiology; Cell Differentiation; Cells, Cultured; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / physiology; HSP40 Heat-Shock Proteins / physiology; HSP70 Heat-Shock Proteins / antagonists & inhibitors; HSP70 Heat-Shock Proteins / genetics; HSP70 Heat-Shock Proteins / physiology; Humans; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / genetics; Membrane Proteins / physiology; Microscopy, Confocal; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport; Pyrimidinones / pharmacology; RNA, Small Interfering / genetics; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Tetradecanoylphorbol Acetate / pharmacology
TL;DR:
Evidence is provided of a role for HSP70 in mediating mucin secretion via interactions with MARCKS and that these interactions are critical for the cytoplasmic translocation of MARC KS upon its phosphorylation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
A Myristoylated Alanine-Rich C Kinase Substrate–Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils
American Journal of Respiratory Cell and Molecular Biology, 48(3), 314–321.
author keywords: MARCKS; cytokine; inflammation; neutrophil
MeSH headings : Animals; Dogs; Humans; Interleukin-8 / biosynthesis; Interleukin-8 / genetics; Interleukin-8 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Lipopolysaccharides / pharmacology; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / metabolism; Peptides / pharmacology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Observations identify MARCKS protein as a promising therapeutic target in the treatment of inflammatory diseases or syndromes attributed to neutrophil influx and inflammatory cytokine production, such as sepsis, acute lung injury, and acute respiratory distress syndrome.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein
Journal of Leukocyte Biology, 92(3), 633–639.
author keywords: cytoplasmic translocation; J774A.1 cells; monocyte chemotactic protein 1; chemotaxis
MeSH headings : Actin Cytoskeleton / immunology; Actin Cytoskeleton / metabolism; Animals; Blotting, Western; Chemotaxis, Leukocyte / physiology; Intracellular Signaling Peptides and Proteins / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Macrophages / immunology; Macrophages / metabolism; Membrane Proteins / immunology; Membrane Proteins / metabolism; Mice; Microscopy, Confocal; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport / physiology
TL;DR:
Results suggest that MARCKS is involved in directed migration of macrophages via a process involving its phosphorylation, cytoplasmic translocation, and interaction with actin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018