Deliang Shen

Works (8)

Updated: July 5th, 2023 15:35

2021 journal article

Exosome-eluting stents for vascular healing after ischaemic injury

NATURE BIOMEDICAL ENGINEERING, 5(10), 1174–1188.

By: S. Hu n , Z. Li n, D. Shen n, D. Zhu n , K. Huang n , T. Su n, P. Dinh n, J. Cores n, K. Cheng n

Contributors: S. Hu n , Z. Li n, D. Shen n, D. Zhu n , K. Huang n , T. Su n, P. Dinh n, J. Cores n, K. Cheng n

MeSH headings : Animals; Drug-Eluting Stents; Endothelial Cells; Endothelium, Vascular; Exosomes; Ischemia; Rats; Stents
TL;DR: It is shown that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischaemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 6, 2021

2020 journal article

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis

NANO RESEARCH, 13(8), 2197–2202.

By: H. Liang*, Z. Li n, Z. Ren *, Q. Jia*, L. Guo *, S. Li *, H. Zhang *, S. Hu n  ...

Contributors: H. Liang*, Z. Li n, Z. Ren *, Q. Jia*, L. Guo *, S. Li *, H. Zhang *, S. Hu n  ...

author keywords: liver fibrosis; nitric oxide (NO); hepatic stellate cells (HSC); nanoparticles; near infrared light (NIR)-controlled release
TL;DR: A targeted and controlled release method that triggers HSC apoptosis and reverses the liver fibrosis is provided the theoretical and experimental basis for novel therapeutic approaches to treat hepatic fibrosis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 29, 2020

2020 journal article

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

THERANOSTICS, 10(8), 3474–3487.

By: L. Qiao  n, S. Hu n , K. Huang n , T. Su n, Z. Li*, A. Vandergriff n, J. Cores n, P. Dinh n ...

author keywords: exosome; homing; integrin; doxorubicin; cancer therapy
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antineoplastic Agents / administration & dosage; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / analogs & derivatives; Drug Delivery Systems; Exosomes / metabolism; HeLa Cells; Humans; Mice; Mice, Nude; Polyethylene Glycols / administration & dosage
TL;DR: It is demonstrated that the exosomes' ability to target the parent cancer is a phenomenon that opens up new ways to devise targeted therapies to deliver anti-tumor drugs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020

2019 journal article

Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells

NANO LETTERS, 19(3), 1883–1891.

By: D. Shen n, Z. Li n, S. Hu n , K. Huang n , T. Su n, H. Liang n, F. Liu  n, K. Cheng n

author keywords: Myocardium infarction; platelets; endogenous stem cells; antibodies
MeSH headings : Animals; Antigens, CD34 / immunology; Blood Platelets / chemistry; Blood Platelets / immunology; Cell- and Tissue-Based Therapy; Disease Models, Animal; Heart Injuries / genetics; Heart Injuries / pathology; Heart Injuries / therapy; Humans; Mice; Myocardial Infarction / pathology; Myocardial Infarction / therapy; Myocardium / immunology; Myocardium / pathology; Stem Cells / immunology; Stem Cells / metabolism
TL;DR: Taking advantage of the natural infarct-homing ability of platelets, CD34 antibody-linked platelets (P-CD34) are engineered to capture circulating CD34-positive endogenous stem cells and direct them to the injured heart for effective heart repair. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 journal article

Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells

ADVANCED THERAPEUTICS, 2(10).

By: K. Huang* , Z. Li n, T. Su n, D. Shen*, S. Hu n  & K. Cheng n

author keywords: bispecific antibodies; immunotherapy; myocardial infarction; stem cells
TL;DR: In vivo studies in a mouse model with heart ischemia/reperfusion injury demonstrate the safety and therapeutic potency of SCRD BsAb, which supports cardiac recovery by reducing scarring, promoting angiomyogenesis, and boosting cardiac function. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020

2018 journal article

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

ADVANCED FUNCTIONAL MATERIALS, 29(4).

By: T. Su n, K. Huang n , H. Ma *, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen  n ...

author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
TL;DR: A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019

2018 journal article

Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair

ACS NANO, 12(12), 12193–12200.

By: Z. Li n, D. Shen*, S. Hu n , T. Su n, K. Huang n , F. Liu  n, L. Hou *, K. Cheng n

author keywords: pretargeting; bioorthogonal click chemistry; heart repair; endogenous stem cells; engineered antibodies
MeSH headings : Animals; Antibodies / administration & dosage; Antibodies / metabolism; Blood Vessels / metabolism; Blood Vessels / pathology; Cells, Cultured; Click Chemistry; Collagen / chemistry; Collagen / metabolism; Disease Models, Animal; Endothelial Progenitor Cells / cytology; Endothelial Progenitor Cells / metabolism; Heart Diseases / metabolism; Heart Diseases / therapy; Humans; Mice; Mice, Inbred C57BL; Molecular Structure; Stem Cell Transplantation; Stem Cells / cytology; Stem Cells / metabolism
TL;DR: In a mouse model of acute myocardial infarction, the in vivo results of cardiac function, heart morphometry, and immunohistochemistry assessment all confirmed effective heart repair by the PTBC system. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019

2018 journal article

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

Nature Biomedical Engineering, 2(1), 17–26.

By: J. Tang  n, T. Su n, K. Huang n , P. Dinh n, Z. Wang*, A. Vandergriff n, M. Hensley n, J. Cores n ...

Contributors: J. Tang  n, T. Su n, K. Huang n , P. Dinh n, Z. Wang*, A. Vandergriff n, M. Hensley n, J. Cores n ...

TL;DR: The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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