Works Published in 2013
Displaying works 81 - 100 of 230 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2013 journal article
Phthalate Exposure and Allergy in the U.S. Population: Results from NHANES 2005–2006
Environmental Health Perspectives, 121(10), 1129–1134.
Contributors: J. Hoppin* , R. Jaramillo *, S. London *, R. Bertelsen *, P. Salo*, D. Sandler *, D. Zeldin *
MeSH headings : Adolescent; Adult; Child; Cross-Sectional Studies; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Female; Humans; Hypersensitivity / etiology; Immune System / drug effects; Logistic Models; Male; Phthalic Acids / toxicity; Phthalic Acids / urine; United States; Young Adult
TL;DR:
HMW phthalate metabolites, particularly MBzP, were positively associated with allergic symptoms and sensitization in adults, but there was no strong evidence for associations between phthalates and allergy in children 6–17 years of age.
(via Semantic Scholar)
europepmc.org (repository)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2013 journal article
Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women
Environment International, 54, 74–84.
Contributors: A. Brantsæter *, K. Whitworth *, T. Ydersbond*, L. Haug *, M. Haugen*, H. Knutsen*, C. Thomsen *, H. Meltzer *
author keywords: Perfluoroalkyl substances; Reproductive history; Pregnancy; Dietary exposure
MeSH headings : Adult; Alkanesulfonic Acids / blood; Cohort Studies; Diet / statistics & numerical data; Environmental Pollutants / blood; Female; Fluorocarbons / blood; Humans; Maternal Exposure / statistics & numerical data; Norway; Pregnancy
TL;DR:
Previous pregnancies and breastfeeding duration were the most important determinants of PFASs in this sample of pregnant women, and diet was a significant factor explaining up to 4% of the variance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2013 journal article
Genetic Susceptibility Loci, Pesticide Exposure and Prostate Cancer Risk
PLoS ONE, 8(4), e58195.
Contributors: S. Koutros *, S. Berndt *, K. Hughes Barry *, G. Andreotti *, J. Hoppin* , D. Sandler *, M. Yeager *, L. Burdett*
Ed(s): M. Scheurer
MeSH headings : Adult; Aged; Aged, 80 and over; Case-Control Studies; Environmental Exposure; Gene-Environment Interaction; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Odds Ratio; Pesticides / adverse effects; Polymorphism, Single Nucleotide; Prospective Studies; Prostatic Neoplasms / etiology; Prostatic Neoplasms / pathology; Risk; Young Adult
TL;DR:
This study suggests known genetic susceptibility loci may modify the risk between pesticide use and prostate cancer.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2013 journal article
Arsenic Exposure and Incidence of Type 2 Diabetes in Southwestern American Indians
American Journal of Epidemiology, 177(9), 962–969.
Contributors: N. Kim, C. Mason, R. Nelson, S. Afton, A. Essader, J. Medlin, K. Levine, J. Hoppin*
author keywords: arsenic; diabetes mellitus; type 2; incidence; Indians; North American; nested case-control studies
MeSH headings : Adult; Albuminuria / urine; Arizona / epidemiology; Arsenic / adverse effects; Arsenic / urine; Biomarkers / urine; Case-Control Studies; Creatinine / urine; Diabetes Mellitus, Type 2 / ethnology; Diabetes Mellitus, Type 2 / etiology; Diabetes Mellitus, Type 2 / urine; Drinking Water / chemistry; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Female; Glucose Tolerance Test; Humans; Incidence; Indians, North American / statistics & numerical data; Logistic Models; Longitudinal Studies; Male; Odds Ratio; Prevalence; Water Pollutants, Chemical / adverse effects; Water Pollutants, Chemical / analysis
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2013 journal article
Agricultural Exposures and Stroke Mortality in the Agricultural Health Study
Journal of Toxicology and Environmental Health, Part A, 76(13), 798–814.
MeSH headings : Aged; Agricultural Workers' Diseases / etiology; Agricultural Workers' Diseases / mortality; Agriculture / statistics & numerical data; Female; Humans; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Pesticides / adverse effects; Proportional Hazards Models; Prospective Studies; Risk Factors; Spouses; Stroke / etiology; Stroke / mortality; Surveys and Questionnaires; Survival Rate
TL;DR:
The authors evaluated associations between self-reported agricultural activities including pesticide use and handling of crops and stroke mortality among 51,603 male pesticide applicators enrolled in the Agricultural Health Study (AHS).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2013 journal article
Association between Perfluoroalkyl substances and thyroid stimulating hormone among pregnant women: a cross-sectional study
Environmental Health, 12(1).
Contributors: Y. Wang *, A. Starling *, L. Haug *, M. Eggesbo *, G. Becher*, C. Thomsen *, G. Travlos*, D. King*
author keywords: Perfluorinated alkyl substances; Thyroid stimulating hormone; Pregnant women; The Norwegian Mother and child cohort study; MoBa
MeSH headings : Adolescent; Adult; Alkanes / blood; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Environmental Exposure; Environmental Monitoring; Environmental Pollutants / blood; Female; Fluorocarbons / blood; Humans; Immunoassay; Linear Models; Norway; Odds Ratio; Pregnancy; Tandem Mass Spectrometry; Thyrotropin / blood; Young Adult
TL;DR:
An association between PFOS and TSH in pregnant women is suggested that is small and may be of no clinical significance, and other PFASs were unrelated to TSH.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2013 journal article
A-clustering: a novel method for the detection of co-regulated methylation regions, and regions associated with exposure
Bioinformatics, 29(22), 2884–2891.
Contributors: T. Sofer *, E. Schifano*, J. Hoppin* , L. Hou * & A. Baccarelli *
MeSH headings : Algorithms; Cluster Analysis; CpG Islands; DNA Methylation; Environmental Exposure; Humans
TL;DR:
An analysis pipeline for high-dimensional methylation data in which CpG sites within regions identified by A-clustering are modeled as multivariate responses to environmental exposure using a generalized estimating equation approach that assumes exposure equally affects all sites in the cluster.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
2013 journal article
A Conserved Mammalian Protein Interaction Network
PLoS ONE, 8(1).
Contributors: Å. Pérez-Bercoff*, C. Hudson * & G. Conant*
MeSH headings : Animals; Conserved Sequence / genetics; Evolution, Molecular; Humans; Mammals / classification; Mammals / genetics; Models, Genetic; Phylogeny; Primates / genetics; Protein Interaction Maps / genetics; Time Factors
TL;DR:
Paired alignments of orthologous and putatively interacting protein-coding genes from eight mammals are analyzed to suggest that, on the whole, protein interactions in mammals are under selective constraint, presumably due to their functional roles.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2013 journal article
Watching the grin fade: Tracing the effects of polyploidy on different evolutionary time scales
Seminars in Cell and Developmental Biology, 24(4), 320–331.
Contributors: D. Mayfield-Jones*, J. Washburn *, T. Arias *, P. Edger *, J. Pires * & G. Conant*
author keywords: Polyploidy; WGD; Network evolution; Meiosis; Mitosis; Cancer; Warburg effect; Crabtree effect
MeSH headings : Animals; Biological Evolution; Evolution, Molecular; Genome; Humans; Plants / genetics; Polyploidy
TL;DR:
It is argued that the study of polyploidy across organisms, cell types, and time scales serves not only as a window into basic cell biology, but also as a basis for a predictive biology with applications ranging from crop improvement to treating cancer.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2013 conference paper
A distributed CPU-GPU framework for pairwise alignments on large-scale sequence datasets
Proceedings of the International Conference on Application-Specific Systems, Architectures and Processors, 329–338.
Contributors: D. Li *, K. Sajjapongse*, H. Truong*, G. Conant* & M. Becchi *
TL;DR:
This paper presents a parallel version of the Needleman-Wunsch alignment algorithm for graphics processing units (GPUs), which can be used for all-against-all pairwise comparisons on large datasets.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2013 journal article
Extreme evolutionary conservation of functionally important regions in H1N1 influenza proteome
PLoS ONE, 8(11).
Contributors: S. Warren*, X. Wan *, G. Conant* & D. Korkin *
MeSH headings : Biological Evolution; Influenza A Virus, H1N1 Subtype / classification; Influenza A Virus, H1N1 Subtype / genetics; Influenza A Virus, H1N1 Subtype / metabolism; Phylogeny; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR:
A single coherent pattern of faster evolution on the protein surfaces that characterizes all influenza proteins is found, consistent with the events of inter-species reassortment, the worldwide introduction of the flu vaccine in the early 80’s, as well as the differences caused by the geographic origins of the virus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 12, 2019
2013 journal article
New Mechanistic and Functional Insights into DNA Topoisomerases
Annual Review of Biochemistry.
author keywords: antibiotics; anticancer drugs; chromosome segregation; DNA cleavage; DNA religation; DNA strand passage; resolution of recombination intermediates
MeSH headings : Antineoplastic Agents / pharmacology; Catalytic Domain; DNA / genetics; DNA / metabolism; DNA Replication; DNA Topoisomerases, Type I / chemistry; DNA Topoisomerases, Type I / genetics; DNA Topoisomerases, Type I / metabolism; DNA Topoisomerases, Type II / chemistry; DNA Topoisomerases, Type II / genetics; DNA Topoisomerases, Type II / metabolism; Humans; Protein Structure, Tertiary
TL;DR:
Recent advances in mechanistic insights into topoisomerases are covered, including a DNA helicase capable of modulating the directionality of strand passage, enabling important functions like reannealing denatured DNA and resolving recombination intermediates.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2013 journal article
Scaling of forearm muscle architecture in primates
American Journal of Physical Anthropology, 150, 144. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000318043201343&KeyUID=WOS:000318043201343
Contributors: A. Hartstone-Rose , K. Allen, K. Macneill, K. Reilly & D. Marchi
Source: ORCID
Added: September 12, 2019
2013 journal article
Hypercarnivory, durophagy or generalised carnivory in the Mio-Pliocene hyaenids of South Africa?
South African Journal of Science, 109(5-6).
Contributors: A. Hartstone-Rose* & D. Stynder*
author keywords: hyena; Carnivora; Langebaanweg; Miocene; osteophagy
TL;DR:
Results from an analysis of dental radii-of-curvature and premolar intercuspid notches suggest that the Mio-Pliocene hyaenids were neither bone crackers nor flesh specialists, but were dietary generalists.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2013 journal article
Aye-aye jaw adductors: Anatomy, architecture, and allometry
American Journal of Physical Anthropology, 150, 220. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000318043202166&KeyUID=WOS:000318043202166
Contributors: J. Perry, A. Hartstone-Rose , K. Macneill & A. Heckler
Source: ORCID
Added: September 12, 2019
2013 journal article
A new species of fox from the Australopithecus sediba type locality, Malapa, South Africa
Transactions of the Royal Society of South Africa, 68(1), 1–9.
Contributors: A. Hartstone-Rose* , B. Kuhn*, S. Nalla *, L. Werdelin * & L. Berger *
TL;DR:
It is concluded that these Carnivora specimens recovered from the site of ‘Malapa’ are distinct enough to be referred to a new species, here described and named Vulpes skinneri.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2013 journal article
Improved Sparse Multi-Class SVM and Its Application for Gene Selection in Cancer Classification
Cancer Informatics, 12, CIN.S10212.
author keywords: support vector machine (SVM); multi-class SVM; variable selection; shrinkage methods; classification; microarray; cancer classification
TL;DR:
The method is improved by introducing soft-thresholding type penalties to incorporate variable selection into multi-class classification for high dimensional data and demonstrates that the new methods can select a small number of genes for building accurate multi- class classification rules.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 20, 2019
2013 journal article
Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals.
Environmental Health Perspectives, 121(1), 7–14.
Contributors: D. Rotroff *, D. Dix, K. Houck, T. Knudsen, M. Martin, K. McLaurin, D. Reif* , K. Crofton*
author keywords: androgen; endocrine; estrogen; high throughput; in vitro; ToxCast
MeSH headings : Androgens / analysis; Endocrine Disruptors / analysis; Estrogens / analysis; High-Throughput Screening Assays / methods; United States; United States Environmental Protection Agency
TL;DR:
Overall, results suggest that current ToxCast assays can accurately identify chemicals with potential to interact with the estrogenic and androgenic pathways, and could help prioritize chemicals for EDSP T1S assays.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2013 journal article
ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence.
Bioinformatics, 29(3), 402–403.
Contributors: D. Reif* , M. Sypa*, E. Lock *, F. Wright*, A. Wilson *, T. Cathey*, R. Judson *, I. Rusyn *
MeSH headings : Computer Graphics; Software; Toxicity Tests / methods; User-Computer Interface
TL;DR:
The Toxicological Prioritization Index (ToxPi) was developed to enable integration of multiple sources of evidence on exposure and/or safety, transformed into transparent visual rankings to facilitate decision making.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2013 journal article
Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells.
Chemical Research in Toxicology, 26(7), 1097–1107.
Contributors: D. Rotroff *, D. Dix*, K. Houck *, R. Kavlock*, T. Knudsen *, M. Martin*, D. Reif* , A. Richard *
MeSH headings : Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Carcinoma, Ductal, Breast / metabolism; Carcinoma, Ductal, Breast / pathology; Cell Line, Tumor; Cell Proliferation / drug effects; Environmental Pollutants / toxicity; Female; High-Throughput Screening Assays; Hormones / metabolism; Humans; Kinetics; Molecular Mimicry; Receptors, Estrogen / metabolism; Time Factors; Toxicity Tests
TL;DR:
This cell-based assay rapidly detects chemical effects on T-47D growth and shows potential, in combination with other HTS assays, to detect environmentally relevant chemicals with potential estrogenic activity.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
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