Statistical Genetics & Bioinformatics

Works Published in 2003

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Displaying all 9 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2003 journal article

Time flies, a new molecular time-scale for brachyceran fly evolution without a clock

Systematic Biology, 52(6), 745–756.

By: B. Wiegmann, D. Yeates, J. Thorne & H. Kishino

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Bayesian models of episodic evolution support a late Precambrian explosive diversification of the Metazoa

MOLECULAR BIOLOGY AND EVOLUTION, 20(12), 1947–1954.

author keywords: divergence dates; Metazoa; molecular clock; Bayes
MeSH headings : Algorithms; Animals; Bayes Theorem; Cell Nucleus / genetics; Computer Simulation; Evolution, Molecular; Fossils; Invertebrates / genetics; Mitochondria / genetics; Models, Genetic; Phylogeny; Time Factors
TL;DR: Bayes posterior estimates of evolutionary rates indicated at least one major burst of molecular evolution at the end of the Precambrian when protostomes and deuterostomes diverged, which is broadly consistent with the fossil records. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Horizontally transferred genes in plant-parasitic nematodes: a high-throughput genomic approach

Genome Biology, 4(6), R39–1.

By: E. Scholl, J. Thorne, J. McCarter & D. Bird

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

How Bayes tests of molecular phylogenies compare with frequentist approaches

BIOINFORMATICS, 19(5), 618–624.

MeSH headings : Algorithms; Bayes Theorem; DNA Mutational Analysis / methods; DNA, Mitochondrial / genetics; Evolution, Molecular; Gene Expression Profiling / methods; HIV-1 / genetics; Humans; Models, Genetic; Models, Statistical; Phylogeny; Reproducibility of Results; Sensitivity and Specificity; Sequence Alignment / methods; Sequence Analysis, DNA / methods
TL;DR: The BHT and BST are shown to construct similar confidence sets to the bootstrap and the Shimodaira Hasegawa test, respectively, which suggests that the known difference among previous tests is mainly due to the null hypothesis considered. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2003 review

Time scale of eutherian evolution estimated without assuming a constant rate of molecular evolution

[Review of ]. GENES & GENETIC SYSTEMS, 78(4), 267–283.

By: M. Hasegawa*, J. Thorne n & H. Kishino*

author keywords: Bayesian method; divergence times; variation of evolutionary
MeSH headings : Animals; Bayes Theorem; Evolution, Molecular; Fossils; Genetic Variation; Humans; Mathematics; Models, Biological; Models, Genetic; Phylogeny; Probability; Time Factors
TL;DR: This Bayesian method not only takes account of the variation of molecular evolutionary rate among lineages and among genes, but it also incorporates fossil evidence via constraints on node times and is expected to increase the accuracy of divergence time estimates. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Least and most powerful phylogenetic tests to elucidate the origin of the seed plants in the presence of conflicting signals under misspecified models

SYSTEMATIC BIOLOGY, 52(6), 781–793.

author keywords: approximately unbiased test; bootstrap proportion; hypothesis test; P-value adjustment; Shimodaira-Hasegawa test; significance test
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Selection of genetic markers for association analyses, using linkage disequilibrium and haplotypes

AMERICAN JOURNAL OF HUMAN GENETICS, 73(1), 115–130.

By: Z. Meng n, D. Zaykin*, C. Xu*, M. Wagner* & M. Ehm*

MeSH headings : Alleles; Genetic Markers; Haplotypes; Humans; Linkage Disequilibrium; Polymorphism, Single Nucleotide
TL;DR: A method based on the spectral decomposition of the matrices of pairwise LD between markers, and the selection of an optimum subset of SNPs that could be efficiently genotyped on larger numbers of samples while retaining most of the genetic variation in samples is proposed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Protein evolution with dependence among codons due to tertiary structure

MOLECULAR BIOLOGY AND EVOLUTION, 20(10), 1692–1704.

By: D. Robinson n, D. Jones, H. Kishino, N. Goldman & J. Thorne*

author keywords: protein structure; evolution; Markov chain Monte Carlo; Bayesian
MeSH headings : Annexin A5 / chemistry; Annexin A5 / genetics; Codon; Computational Biology; Computer Simulation; Data Interpretation, Statistical; Evolution, Molecular; Markov Chains; Muramidase / chemistry; Muramidase / genetics; Protein Structure, Tertiary; Proteins / chemistry; Proteins / genetics
TL;DR: The focus here is evolutionary dependence among codons that is associated with protein structure and could be applied to diverse cases of evolutionary dependence where surrogates for sequence fitness can be measured or modeled. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Pedigree data analysis with crossover interference

Genetics, 164(4), 1561–1566.

Source: NC State University Libraries
Added: August 6, 2018

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