Statistical Genetics & Bioinformatics

Works Published in 2009

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Displaying all 11 works

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2009 journal article

A faster ordered-subset convex algorithm for iterative reconstruction in a rotation-free micro-CT system

Physics in Medicine and Biology, 54(4), 1061–1072.

By: E. Quan n & D. Lalush n

MeSH headings : Algorithms; Artificial Intelligence; Imaging, Three-Dimensional / methods; Pattern Recognition, Automated / methods; Phantoms, Imaging; Radiographic Image Enhancement / methods; Radiographic Image Interpretation, Computer-Assisted / methods; Reproducibility of Results; Sensitivity and Specificity; Tomography, X-Ray Computed / methods
TL;DR: The modified OSC (MOSC) algorithm was applied to a rotation-free micro-CT system that was proposed previously, observed its performance, and compared with the OSC algorithm for 3D cone-beam reconstruction and concluded that the MOSC algorithm is more efficient than OSC and provides comparable images. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: August 28, 2020

2009 journal article

SIMULATION FROM ENDPOINT-CONDITIONED, CONTINUOUS-TIME MARKOV CHAINS ON A FINITE STATE SPACE, WITH APPLICATIONS TO MOLECULAR EVOLUTION

ANNALS OF APPLIED STATISTICS, 3(3), 1204–1231.

author keywords: Continuous-time Markov chains; simulation; molecular evolution
TL;DR: This work considers the generation of sample paths, including intermediate states and times of transition, from a CTMC whose beginning and ending states are known across a time interval of length T, and introduces and compares three applications of CTMCs to demonstrate the pitfalls of choosing an inefficient sampler. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

On the Fiedler vectors of graphs that arise from trees by Schur complementation of the Laplacian

LINEAR ALGEBRA AND ITS APPLICATIONS, 431(10), 1869–1880.

By: E. Stone n & A. Griffing n

author keywords: Trees; Graph Laplacians; Fiedler vectors; Perron components
TL;DR: This paper considers a point of articulation r in the graph G and derives a related graph G whose Laplacian matrix is L and shows how Fiedler vectors of G relate to the structure of G and provides bounds for the algebraic connectivity of G{r} in terms of the connected components at r in G. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Estimates of natural selection due to protein tertiary structure inform the ancestry of biallelic loci

Gene, 441(1-2), 45–52.

MeSH headings : Evolution, Molecular; Gene Frequency; Humans; Polymorphism, Single Nucleotide; Protein Structure, Tertiary; Proteins / genetics; Selection, Genetic
TL;DR: This work focuses on 140 nonsynonymous single nucleotide polymorphisms of humans that are in proteins with known tertiary structures and finds that the technique for employing protein tertiary structure information yields some biologically plausible results but that it does not substantially improve the inference of ancestral human allele types. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Comparison of diffraction-enhanced computed tomography and monochromatic synchrotron radiation computed tomography of human trabecular bone

PHYSICS IN MEDICINE AND BIOLOGY, 54(20), 6123–6133.

MeSH headings : Absorption; Bone and Bones / diagnostic imaging; Bone and Bones / pathology; Equipment Design; Humans; Normal Distribution; Radiographic Image Interpretation, Computer-Assisted / methods; Scattering, Radiation; Silicon; Synchrotrons; Tibia / diagnostic imaging; Tibia / pathology; Tomography, X-Ray Computed / methods; X-Rays
TL;DR: The apparent absorption DECT images have significantly higher spatial resolution and CNR than the corresponding SRCT images, and will prove to be a useful tool for imaging applications in which high contrast and high spatial resolution are required for both soft tissue features and bone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Modulated Modularity Clustering as an Exploratory Tool for Functional Genomic Inference

PLOS GENETICS, 5(5).

By: E. Stone n & J. Ayroles n

MeSH headings : Animals; Cluster Analysis; Computer Simulation; Data Interpretation, Statistical; Databases, Genetic; Drosophila melanogaster / genetics; Gene Expression Profiling / statistics & numerical data; Genetic Techniques; Genomics / statistics & numerical data; Humans; Lymphocytes / immunology; Lymphocytes / metabolism; Models, Genetic; Multigene Family; Systems Biology
TL;DR: A new objective-based clustering method, modulated modularity clustering (MMC), which modulates the connection strengths of edges in a weighted graph to maximize an objective function (called modularity) that quantifies community structure in graphical data. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Improved Dynamic Cardiac Phantom Based on 4D NURBS and Tagged MRI

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 56(5), 2728–2738.

By: W. Segars*, D. Lalush n, E. Frey*, D. Manocha*, M. King* & B. Tsui*

author keywords: Cardiac; medical imaging; phantom; simulation
TL;DR: The new cardiac model was incorporated into the 4D NURBS-based Cardiac-Torso (NCAT) phantom widely used in imaging research and will provide a useful tool in the study of cardiac imaging and the effects of cardiac motion in medical images. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Multiple interval mapping for gene expression QTL analysis

GENETICA, 137(2), 125–134.

By: W. Zou n & Z. Zeng n

author keywords: eQTL; FDR; MIM; Model selection
MeSH headings : Chromosome Mapping / methods; Computer Simulation; Gene Expression; Genomics / methods; Models, Genetic; Quantitative Trait Loci / genetics; Yeasts
TL;DR: A statistical method to claim expression quantitative trait loci (eQTL) in a genome is developed based on multiple interval mapping (MIM), a model selection procedure, and uses false discovery rate (FDR) to measure the statistical significance of the large number of eQTL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Design and characterization of a spatially distributed multibeam field emission x-ray source for stationary digital breast tomosynthesis

MEDICAL PHYSICS, 36(10), 4389–4399.

By: X. Qian*, R. Rajaram*, X. Calderon-Colon*, G. Yang*, T. Phan*, D. Lalush n, J. Lu*, O. Zhou*

author keywords: tomosynthesis; breast imaging; x-ray; carbon nanotube; field emission
MeSH headings : Computer-Aided Design; Equipment Design; Equipment Failure Analysis; Mammography / instrumentation; Radiographic Image Enhancement / instrumentation; Radiometry; Reproducibility of Results; Scattering, Radiation; Sensitivity and Specificity; Tomography, X-Ray Computed / instrumentation; Transducers; X-Rays
TL;DR: The authors demonstrate experimentally the feasibility of achieving 11 s scanning time at full detector resolution with 0.3 mm source resolution without motion blur and evaluate the emission current, current variation, lifetime, and focal spot sizes of the source array. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Characterization of Conserved and Nonconserved Imprinted Genes in Swine

BIOLOGY OF REPRODUCTION, 81(5), 906–920.

author keywords: assisted reproductive technology; comparative genomic imprinting; epigenetics; gene regulation; genomic imprinting; parthenogenesis; placenta; swine parthenote
MeSH headings : Animals; Female; Fetus / anatomy & histology; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genomic Imprinting / genetics; Oligonucleotide Array Sequence Analysis; Organ Size; Parthenogenesis / genetics; Placenta / anatomy & histology; Polymorphism, Single Nucleotide; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction; Staining and Labeling; Swine / genetics
TL;DR: To increase the understanding of imprinted genes in swine, a comprehensive analysis of this gene family was carried out using two complementary approaches: expression and phenotypic profiling of parthenogenetic fetuses, and analysis of imprinting by pyrosequencing. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

A dynamic micro-CT scanner based on a carbon nanotube field emission x-ray source

PHYSICS IN MEDICINE AND BIOLOGY, 54(8), 2323–2340.

By: G. Cao*, Y. Lee*, R. Peng*, Z. Liu*, R. Rajaram*, X. Calderon-Colon*, L. An*, P. Wang* ...

MeSH headings : Anesthesia; Animals; Feasibility Studies; Linear Models; Mice; Nanotubes, Carbon; Prospective Studies; Radiation Dosage; Respiration; Respiratory-Gated Imaging Techniques; Time Factors; X-Ray Microtomography / instrumentation
TL;DR: A prototype physiologically gated micro-computed tomography (micro-CT) scanner based on a carbon nanotube field emission micro-focus x-ray source with high spatial and temporal resolutions that is well suited for high-resolution imaging of free-breathing small animals. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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