Works Published in 2004
Displaying works 41 - 60 of 139 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2004 journal article
Of mice and missing data: what we know (and need to learn) about male sexual behavior
Physiology & Behavior, 83(2), 217–232.
author keywords: androgen receptor; estrogen receptor; inbred strain; knockout; mice; medial preoptic area; masculinization
MeSH headings : Animals; Gonadal Steroid Hormones / physiology; Male; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Models, Animal; Rats; Receptors, Steroid / physiology; Sex Characteristics; Sexual Behavior, Animal / physiology; Species Specificity
TL;DR:
The current knowledge about the sexual behavior of male mice, with an emphasis on hormonal bases of these behaviors, is summarized and suggestions are made for the standardization of experimental protocols used in investigations of the sexual physiology and behavior ofmale mice.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2004 journal article
Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9
Molecular Brain Research, 129(1-2), 124–134.
Contributors: Y. Ge *, S. Belcher* , D. Pierce* & K. Light*
author keywords: apoptosis; Bcl2; Bad; Bax; RT-PCR; Purkinje; cerebellum; ethanol; mRNA
MeSH headings : Actins / metabolism; Animals; Animals, Newborn; Apoptosis / drug effects; Apoptosis / physiology; Calbindins; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cerebellum / cytology; Cerebellum / drug effects; Cerebellum / physiology; Dose-Response Relationship, Drug; Ethanol / administration & dosage; Ethanol / blood; Ethanol / pharmacology; Female; Humans; Male; Pregnancy; Proto-Oncogene Proteins c-bcl-2 / genetics; Proto-Oncogene Proteins c-bcl-2 / metabolism; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G / metabolism; bcl-2-Associated X Protein; bcl-Associated Death Protein
TL;DR:
The results of this study are in agreement with and provide further support for the hypothesis that ethanol interrupts the active suppression of apoptosis that is a crucial feature of Purkinje cell vulnerability during this time period.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2004 journal article
Alterations of cerebellar mRNA specific for BDNF, p75NTR, and TrkB receptor isoforms occur within hours of ethanol administration to 4-day-old rat pups
Developmental Brain Research, 151(1-2), 99–109.
Contributors: Y. Ge *, S. Belcher* & K. Light*
author keywords: Purkinje cell; TrkB isoform; ethanol exposure; RT-PCR; mRNA; neurotrophin; cerebellum; toxicity; apoptosis; BDNF signaling
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; Central Nervous System Depressants / pharmacology; Cerebellum / drug effects; Cerebellum / metabolism; Dose-Response Relationship, Drug; Ethanol / pharmacology; Female; Male; Pregnancy; RNA, Messenger / drug effects; RNA, Messenger / metabolism; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptor, trkB / genetics; Receptor, trkB / metabolism; Receptors, Nerve Growth Factor / genetics; Receptors, Nerve Growth Factor / metabolism; Reverse Transcriptase Polymerase Chain Reaction / methods; Time Factors
TL;DR:
The hypothesis that ethanol induces a disruption of BDNF-TrkB signaling that results in loss of apoptotic suppression in vulnerable Purkinje cells by growth factor withdrawal is supported.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2004 journal article
Spatial, temporal, and cellular distribution of the activated extracellular signal regulated kinases 1 and 2 in the developing and mature rat cerebellum
Developmental Brain Research, 150(2), 199–209.
Contributors: A. Zsarnovszky* & S. Belcher*
author keywords: neurotransmitters, modulators, transporters and receptors; second messengers and phosphorylation; Bergmann glia; cerebellum; development; active EPK1/2; glia; granule cell; neuron; immunohistochemistry; kinase; MAPK; Purkinje cell; signal transduction
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Cell Count / methods; Cerebellum / enzymology; Cerebellum / growth & development; Cerebellum / metabolism; Glial Fibrillary Acidic Protein / metabolism; Immunohistochemistry / methods; Indoles / metabolism; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / metabolism; Purkinje Cells / metabolism; Rats; Rats, Sprague-Dawley
TL;DR:
A high degree of developmental plasticity was observed in the spatiotemporal distribution of cerebellar pERK-IR suggesting that the ERK-pathway plays a dynamic role in regulating neuronal and glial migration, proliferation and differentiation in the developing cerebellum.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2004 journal article
Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity
Marine Environmental Research, 58(2-5), 469–473.
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / metabolism; Catalysis; Coumarins / metabolism; Cytochrome P-450 CYP3A; Fluorescence; Kinetics; Models, Chemical; Oryzias / metabolism; Oxidoreductases, N-Demethylating / metabolism; Phenols / metabolism; Protein Binding; Substrate Specificity
TL;DR:
This study demonstrates that medaka CYP3A catalysis exhibits unusual kinetic behaviors consistent with allosteric interaction which cannot be described by hyperbolic kinetic models, and describes both homotropic and heterotropic cooperative interactions.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2004 journal article
Absolute Quantification of the Model Biomarker Prostate-Specific Antigen in Serum by LC−MS/MS Using Protein Cleavage and Isotope Dilution Mass Spectrometry
Journal of Proteome Research, 3(3), 644–652.
author keywords: LC-MS/MS; absolute quantification; serum; biomarker; prostate-specific antigen; protein
MeSH headings : Humans; Isotope Labeling; Male; Mass Spectrometry; Peptide Fragments / chemistry; Prostate-Specific Antigen / chemistry; Protein Processing, Post-Translational; Serum / chemistry; Trypsin / chemistry; Urea / chemistry
TL;DR:
absolute quantification can be performed on the model biomarker PSA introduced into denatured serum when analyzed by LC-MS/MS, and concerns still exist regarding sensitivity compared to existing immunoassays as well as the reproducibility of PC-IDMS performed in different matrixes.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2004 journal article
Evaluation of a Cleavable Stable Isotope Labeled Synthetic Peptide for Absolute Protein Quantification Using LC−MS/MS
Journal of Proteome Research, 3(3), 658–661.
author keywords: LC-MS/MS; absolute quantification; biomarker; cleavable internal standard
MeSH headings : Chromatography, Liquid; Isotope Labeling; Mass Spectrometry; Peptides / chemistry
TL;DR:
The work presented here evaluates the use of tryptic cleavage sites incorporated into the internal standard synthetic peptide in an attempt to create an internal standard that has cleavage characteristics more similar to the protein being quantified.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2004 journal article
Analysis of the Low Molecular Weight Fraction of Serum by LC-Dual ESI-FT-ICR Mass Spectrometry: Precision of Retention Time, Mass, and Ion Abundance
Analytical Chemistry, 76(17), 5097–5103.
MeSH headings : Algorithms; Biomarkers, Tumor / blood; Chromatography, Liquid / standards; Female; Humans; Ions / blood; Molecular Weight; Ovarian Neoplasms / blood; Reproducibility of Results; Serum / chemistry; Software; Spectrometry, Mass, Electrospray Ionization / standards
TL;DR:
These measures of analytical reproducibility establish a statistical rationale for differentiating healthy and disease patient populations for the elucidation of biomarkers in the low molecular fraction of serum.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2004 journal article
Dose-dependent transitions in mechanisms of toxicity: case studies
Toxicology and Applied Pharmacology, 201(3), 226–294.
author keywords: dose-dependent transitions; mechanisms of toxicity; dose response; acetaminophen; butadiene; ethylene glycol; formaldehyde; manganese; methylene chloride; peroxisome proliferator-activated receptor; progesterone/hydroxyflutamide; propylene oxide; vinyl acetate; vinyl chloride; vinylidene chloride; zinc
MeSH headings : Acetaminophen / administration & dosage; Acetaminophen / pharmacokinetics; Acetaminophen / toxicity; Analgesics, Non-Narcotic / administration & dosage; Analgesics, Non-Narcotic / pharmacokinetics; Analgesics, Non-Narcotic / toxicity; Androgen Antagonists / administration & dosage; Androgen Antagonists / pharmacokinetics; Androgen Antagonists / toxicity; Animals; Butadienes / administration & dosage; Butadienes / pharmacokinetics; Butadienes / toxicity; Dichloroethylenes / administration & dosage; Dichloroethylenes / pharmacokinetics; Dichloroethylenes / toxicity; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions / chemically induced; Drug-Related Side Effects and Adverse Reactions / metabolism; Epoxy Compounds / administration & dosage; Epoxy Compounds / pharmacokinetics; Epoxy Compounds / toxicity; Ethylene Glycol / administration & dosage; Ethylene Glycol / pharmacokinetics; Ethylene Glycol / toxicity; Flutamide / administration & dosage; Flutamide / analogs & derivatives; Flutamide / pharmacokinetics; Flutamide / toxicity; Formaldehyde / administration & dosage; Formaldehyde / pharmacokinetics; Formaldehyde / toxicity; Humans; Manganese / administration & dosage; Manganese / pharmacokinetics; Manganese Poisoning / metabolism; Methylene Chloride / administration & dosage; Methylene Chloride / pharmacokinetics; Methylene Chloride / toxicity; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptors / physiology; Progesterone / administration & dosage; Progesterone / pharmacokinetics; Progesterone / toxicity; Vinyl Compounds / administration & dosage; Vinyl Compounds / pharmacokinetics; Vinyl Compounds / toxicity; Zinc / administration & dosage; Zinc / pharmacokinetics; Zinc / toxicity
TL;DR:
A group of academic, government, and industry scientists, formed under the leadership of the ILSI Health and Environmental Sciences Institute (HESI), developed a series of case studies to illustrate the existence of dose-dependent transitions in mechanisms of toxicity.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2004 journal article
Dose-dependent transitions in mechanisms of toxicity
Toxicology and Applied Pharmacology, 201(3), 203–225.
author keywords: dose-dependent transitions; mechanisms of toxicity; dose-response
MeSH headings : Animals; DNA Adducts / drug effects; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Humans; Inactivation, Metabolic; Research Design; Risk Assessment
TL;DR:
This paper addresses the issues discussed at both workshops, and presents the consensus conclusions drawn by expert participants on the impact of dose-dependent transitions on the risk assessment process.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2004 journal article
Respiratory tract toxicity of inhaled hydrogen sulfide in Fischer-344 rats, Sprague–Dawley rats, and B6C3F1 mice following subchronic (90-day) exposure
Toxicology and Applied Pharmacology, 198(1), 29–39.
author keywords: rat; mouse; inhalation; hydrogen sulfide; nose; lung; toxicity; pathology
MeSH headings : Administration, Inhalation; Air Pollutants / toxicity; Animals; Body Weight / drug effects; Bronchi / drug effects; Bronchi / pathology; Dose-Response Relationship, Drug; Eating / drug effects; Epithelial Cells / drug effects; Epithelial Cells / pathology; Female; Hydrogen Sulfide / administration & dosage; Hydrogen Sulfide / toxicity; Male; Mice; Mice, Inbred Strains; No-Observed-Adverse-Effect Level; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Respiratory System / drug effects; Respiratory System / pathology; Rhinitis / chemically induced; Rhinitis / pathology; Species Specificity; Toxicity Tests, Chronic; Turbinates / drug effects; Turbinates / pathology
TL;DR:
The results confirm that the rodent nose, and less so the lung, are highly sensitive to H2S-induced toxicity, with 10 ppm representing the NOAEL for ONL following subchronic inhalation.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2004 journal article
Androgens Negatively Regulate Forkhead Transcription Factor FKHR (FOXO1) through a Proteolytic Mechanism in Prostate Cancer Cells
Journal of Biological Chemistry, 279(14), 13866–13877.
MeSH headings : Amino Acid Sequence; Androgens / pharmacology; Apoptosis / drug effects; Apoptosis / physiology; Cell Line, Tumor / cytology; Cell Line, Tumor / drug effects; Cell Line, Tumor / physiology; Cell Nucleus / metabolism; Cysteine Endopeptidases / metabolism; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic / drug effects; Humans; Male; Metribolone / pharmacology; Molecular Sequence Data; Mutagenesis; Prostatic Neoplasms; Protease Inhibitors / pharmacology; RNA, Messenger / analysis; Transcription Factors / genetics; Transcription Factors / metabolism; Transcriptional Activation / drug effects; Transfection
TL;DR:
This work demonstrates that forkhead transcription factor FKHR (FOXO1)-induced death of LNCaP cells was blocked by a synthetic androgen R1881, and suggests that androgens induce increased activity of an acidic cysteine protease, which in turn cleaves FK HR.
(via Semantic Scholar)
www.jbc.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2004 journal article
A method for calculating 16o/18o peptide ion ratios for the relative quantification of proteomes
Journal of the American Society for Mass Spectrometry, 15(4), 437–445.
MeSH headings : Amino Acid Sequence; Animals; Apoproteins / analysis; Apoproteins / chemistry; Cattle; Mass Spectrometry; Molecular Sequence Data; Oxygen Isotopes; Peptides / analysis; Peptides / chemistry; Proteome / analysis; Proteome / chemistry; Serum Albumin / analysis; Serum Albumin / chemistry; Spectroscopy, Fourier Transform Infrared; Transferrin / analysis; Transferrin / chemistry
TL;DR:
The data demonstrate that for biomarker discovery, it is advantageous to label the proteome representing the disease state with 18O; and the method is not sensitive to variations in 18O1/18O2 ratio.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2004 journal article
Determination of the relative energies of activation for the dissociation of aromatic versus aliphatic phosphopeptides by ESI-FTICR-MS and IRMPD
Journal of the American Society for Mass Spectrometry, 15(1), 121–127.
MeSH headings : Peptide Mapping / methods; Phosphopeptides / analysis; Phosphopeptides / chemistry; Protein Structure, Secondary; Serine / analysis; Serine / chemistry; Spectrometry, Mass, Electrospray Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods; Thermodynamics; Tyrosine / analysis; Tyrosine / chemistry
TL;DR:
The data presented in this manuscript support the theory that for phosphopeptides, the phosphate moiety’s P-O stretch is in direct resonance with the infrared laser, thus increasing the relative absorptivity of the modified species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2004 journal article
Informed use of proteolytic inhibitors in biomarker discovery
Rapid Communications in Mass Spectrometry, 18(9), 1001–1002.
MeSH headings : Biomarkers / analysis; Combinatorial Chemistry Techniques; Drug Design; Prealbumin / analysis; Protease Inhibitors / chemistry; Spectrometry, Mass, Electrospray Ionization / methods
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2004 journal article
Nasal Toxicity of Manganese Sulfate and Manganese Phosphate in Young Male Rats Following Subchronic (13-Week) Inhalation Exposure
Inhalation Toxicology, 16(6-7), 481–488.
MeSH headings : Air Pollutants / toxicity; Animals; Cerebellum / metabolism; Corpus Striatum / metabolism; Dose-Response Relationship, Drug; Drug Administration Schedule; Glial Fibrillary Acidic Protein / metabolism; Inhalation Exposure; Male; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Nasal Mucosa / drug effects; Nasal Mucosa / metabolism; Nasal Mucosa / pathology; Olfactory Bulb / metabolism; Organometallic Compounds / administration & dosage; Organometallic Compounds / pharmacokinetics; Organometallic Compounds / toxicity; Rats; Rats, Inbred Strains; Sulfates / administration & dosage; Sulfates / pharmacokinetics; Sulfates / toxicity
TL;DR:
It is confirmed that high-doseManganese inhalation can result in nasal toxicity (irritation) and increased delivery of manganese to the brain; however, it is not confirmed that mangane inhalation would result in altered brain GFAP concentrations.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2004 journal article
Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats
Toxicology and Applied Pharmacology, 197(2), 113–124.
Source: Crossref
Added: February 24, 2020
2004 journal article
Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats
Toxicology and Applied Pharmacology, 197(2), 113–124.
author keywords: age; gender; manganese
MeSH headings : Administration, Inhalation; Aging / metabolism; Animals; Body Weight / drug effects; Female; Male; Manganese / metabolism; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Neostriatum / drug effects; Neostriatum / metabolism; Organ Size / drug effects; Organometallic Compounds / administration & dosage; Organometallic Compounds / pharmacokinetics; Organometallic Compounds / toxicity; Radioisotopes; Rats; Sex Characteristics; Sulfates / administration & dosage; Sulfates / pharmacokinetics; Sulfates / toxicity; Tissue Distribution
TL;DR:
Gender and age did not affect manganese delivery to the striatum, a known target site for neurotoxicity in humans, but did influenceManganese concentrations in other tissues, and end-of-exposure olfactory bulb, lung, and blood manganes concentrations were higher in young male rats than in female or aged male rats and may reflect a portal-of theentry effect.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2004 journal article
Manganese exposure and induced oxidative stress in the rat brain
Science of The Total Environment, 334-335, 409–416.
author keywords: brain; manganese; neurotoxicity; glutathione; metallothionein; glutamine synthetase; MMT
MeSH headings : Animals; Antioxidants / pharmacology; Biomarkers; Brain / drug effects; Brain / pathology; Environmental Pollutants / adverse effects; Manganese / adverse effects; Oxidation-Reduction; Oxidative Stress; Rats
TL;DR:
The link between manganese neurotoxicity in the rat brain and common pathways to oxidative stress is examined, particularly in rat brain tissue.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2004 journal article
Health and environmental testing of manganese exhaust products from use of methylcyclopentadienyl manganese tricarbonyl in gasoline
Science of The Total Environment, 334-335, 397–408.
author keywords: methylcyclopentadienyl manganese tricarbonyl; MMT; manganese; pharmacokinetics
MeSH headings : Animals; Carcinogens, Environmental; Environmental Exposure; Gasoline; Humans; Manganese; Organometallic Compounds / adverse effects; Organometallic Compounds / analysis; Organometallic Compounds / pharmacokinetics; Public Health; Risk Assessment; Rodentia; Vehicle Emissions / analysis
TL;DR:
A great amount of toxicological research has been carried out during the past few years that provides data for use in developing a PBPK model in rodents, and these data add greatly to the existing body of knowledge regarding the relationship between Mn exposure and tissue disposition.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
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