Works Published in 2009
Displaying works 41 - 60 of 241 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2009 journal article
Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: The case of bisphenol A
Environmental Health Perspectives, 117(3), 309–315.
Contributors: J. Myers, F. Saal *, B. Akingbemi *, K. Arizono *, S. Belcher* , T. Colborn*, I. Chahoud*, D. Crain*
author keywords: bisphenol A; endocrine disruptors; FDA; Food and Drug Administration; GLP; good laboratory practices; low-dose; nonmonotonic; positive control
MeSH headings : Benzhydryl Compounds; Clinical Laboratory Techniques / standards; Ecotoxicology / methods; Ecotoxicology / standards; Endocrine Disruptors / toxicity; Phenols / toxicity; Public Health Practice / standards; Risk Assessment / methods; Risk Assessment / standards
TL;DR:
Differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and non-GLP studies conducted in academic and government laboratories are reviewed to identify hazards and molecular mechanisms mediating adverse effects.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: ORCID
Added: March 5, 2021
2009 journal article
Good laboratory practices: Myers et al. respond
Environmental Health Perspectives, 117(11).
Contributors: J. Myers, F. Vom Saal *, J. Taylor *, B. Akingbemi *, K. Arizono *, S. Belcher* , T. Colborn*, I. Chahoud*
TL;DR:
The aim in writing the commentary was to show—through an analysis of the application of GLP data on bisphenol A (BPA) in regulatory proceedings—that GLP by itself is insufficient to guarantee valid and reliable science.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2009 journal article
Blockade of estrogen receptor signaling to improve outlook for medulloblastoma sufferers
Future Oncology, 5(6), 751–754.
Contributors: S. Belcher*
MeSH headings : Adolescent; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms / drug therapy; Child; Child, Preschool; Drug Synergism; Estrogen Antagonists / therapeutic use; Humans; Infant; Medulloblastoma / drug therapy; Receptors, Estrogen / antagonists & inhibitors; Signal Transduction / drug effects; Young Adult
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2009 journal article
Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma
Endocrinology, 150(3), 1112–1121.
Contributors: S. Belcher* , X. Ma* & H. Le*
MeSH headings : Adolescent; Animals; Cell Movement / drug effects; Cell Proliferation / drug effects; Cells, Cultured; Cerebellar Neoplasms / genetics; Cerebellar Neoplasms / metabolism; Cerebellar Neoplasms / pathology; Child; Child, Preschool; Down-Regulation / drug effects; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Antagonists / pharmacology; Female; Fulvestrant; Humans; Infant; Male; Medulloblastoma / genetics; Medulloblastoma / metabolism; Medulloblastoma / pathology; Mice; Mice, Nude; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / antagonists & inhibitors; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Xenograft Model Antitumor Assays
TL;DR:
It is demonstrated that the physiological actions of estrogens in MD are mediated by ERbeta, which has defined antiestrogen therapy as a potentially efficacious clinical approach to improve the long-term outcomes for MD patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2009 journal article
IGF2Rpolymorphisms and risk of esophageal and gastric adenocarcinomas
International Journal of Cancer, 125(11), 2673–2678.
author keywords: genetic association; neoplasm; esophagus; gastric-cardia; gastric; insulin-like growth factors
MeSH headings : Adenocarcinoma / epidemiology; Adenocarcinoma / genetics; Adenocarcinoma / secondary; Aged; Case-Control Studies; Esophageal Neoplasms / epidemiology; Esophageal Neoplasms / genetics; Esophageal Neoplasms / pathology; Female; Genotype; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic / genetics; Prognosis; Receptor, IGF Type 2 / genetics; Risk Factors; Stomach Neoplasms / epidemiology; Stomach Neoplasms / genetics; Stomach Neoplasms / pathology; Survival Rate
TL;DR:
It is suggested that nonsynonymous polymorphisms in M6P/IGF2R may contribute to the risks of EGA and noncardia adenocarcinomas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 24, 2021
2009 chapter
The ABC’s of indoor health: Allergens, baits, and cockroach mitigation strategies
In J. M. Clark, J. R. Bloomquist, & H. Kawada (Eds.), Advances in Human Vector Control (pp. 89–106).
Ed(s): J. Clark, J. Bloomquist & H. Kawada
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
11. Sustainable Cities and Communities
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 23, 2021
2009 journal article
Effects of self-reported health conditions and pesticide exposures on probability of follow-up in a prospective cohort study
American Journal of Industrial Medicine, 53(5), n/a-n/a.
author keywords: selection bias; follow-up studies; prospective studies; cohort studies; pesticides; agriculture
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agriculture; Confidence Intervals; Female; Humans; Iowa / epidemiology; Logistic Models; Male; Middle Aged; Multivariate Analysis; North Carolina / epidemiology; Occupational Diseases / epidemiology; Occupational Diseases / etiology; Occupational Exposure / adverse effects; Odds Ratio; Patient Acceptance of Health Care; Pesticides / toxicity; Probability; Prospective Studies; Risk Assessment; Risk Factors; Selection Bias; Surveys and Questionnaires; Time Factors; United States / epidemiology; Young Adult
TL;DR:
Differences between non-participants and participants in the follow-up interview were generally small, and significant evidence of selection bias was found, however, the extent of bias may depend on the specific exposure and outcome under study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 21, 2021
2009 journal article
Genetic Modifiers of Liver Disease in Cystic Fibrosis
JAMA, 302(10), 1076–1083.
MeSH headings : Adolescent; Adult; Age Factors; Child; Child, Preschool; Cystic Fibrosis / complications; Cystic Fibrosis / genetics; Female; Glutathione S-Transferase pi / genetics; Humans; Hypertension, Portal / etiology; Hypertension, Portal / genetics; Infant; Liver Cirrhosis / etiology; Liver Cirrhosis / genetics; Liver Diseases / etiology; Liver Diseases / genetics; Logistic Models; Male; Mannose-Binding Lectin / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic; Risk; Transforming Growth Factor beta1 / genetics; Young Adult; alpha 1-Antitrypsin / genetics
TL;DR:
The SERPINA1 Z allele is a risk factor for liver disease in CF and patients who carry the Z allele are at greater risk of developing severe liver disease with portal hypertension.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 17, 2021
2009 chapter
Sexual communication in Lepidoptera: a need for wedding genetics, biochemistry, and molecular biology
In M. R. Goldsmith & F. Marec (Eds.), Molecular Biology and Genetics of the Lepidoptera (pp. 169–193). Boca Raton, Florida: CRC Press.
Ed(s): M. Goldsmith & F. Marec
Source: NC State University Libraries
Added: November 20, 2020
2009 conference paper
Ecological context of restorative environments
Proceedings of the annual conference of the Environmental Design Research Association, 40. Edmond, Oklahoma: Environmental Design Research Association.
Event: EDRA at Kansas City, MO
Source: NC State University Libraries
Added: November 3, 2020
2009 chapter
Tritrichomonas
In J. D. Bonagura, D. C. Twedt, & R. W. Kirk (Eds.), Kirk's current veterinary therapy. XIV (14th ed., pp. 509–512). St. Louis, MO: Elsevier Saunders.
Ed(s): J. Bonagura, D. Twedt & R. Kirk
Source: NC State University Libraries
Added: October 21, 2020
2009 chapter
Antiprotozoal Drugs
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 1145–1179). Ames, Iowa: Blackwell Publishing.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: October 21, 2020
2009 journal article
Occupational Risk Factors for Rhinitis Among Farmers in the Agricultural Health Study
Journal of Allergy and Clinical Immunology, 123(2), S266–S266.
TL;DR:
Handling hays and grains as well as farm maintenance activities may increase the risk of rhinitis in farmers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 10, 2020
2009 journal article
Cancer Incidence Among Pesticide Applicators Exposed to Methyl Bromide in the AHS
Annals of Epidemiology, 19(9), 662–663.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 10, 2020
2009 journal article
Multivariate Spatial-Temporal Modeling and Prediction of Speciated Fine Particles
Journal of Statistical Theory and Practice, 3(2), 407–418.
author keywords: Air pollution; Bayesian inference; Linear coregionalization model; Multivariate spatiotemporal processes; Speciated particulate matter
TL;DR:
A multivariate spatial-temporal model for speciated PM2.5 is introduced and a spatiotemporal extension of the linear model of coregionalization is developed to account for spatial and temporal dependency structures for each component as well as the associations among the components.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 8, 2020
2009 journal article
Urinary biomarker, dermal, and air measurement results for 2,4-D and chlorpyrifos farm applicators in the Agricultural Health Study
Journal of Exposure Science & Environmental Epidemiology, 20(2), 119–134.
author keywords: 2,4-D; chlorpyrifos; exposure measurement; farm applicator; occupational exposure; Agricultural Health Study
MeSH headings : 2,4-Dichlorophenoxyacetic Acid / analysis; 2,4-Dichlorophenoxyacetic Acid / urine; Biomarkers / urine; Chlorpyrifos / analysis; Chlorpyrifos / urine; Humans; Skin / chemistry
Sources: Crossref, NC State University Libraries
Added: September 2, 2020
2009 journal article
Within-person variability in urinary phthalate metabolite concentrations: measurements from specimens after long-term frozen storage
Journal of Exposure Science & Environmental Epidemiology, 20(2), 169–175.
author keywords: biomarker; phthalate; reproducibility; menstrual cycle; temporal variability
MeSH headings : Cryopreservation; Female; Freezing; Humans; Menstrual Cycle; Phthalic Acids / urine; Reference Standards; Reproducibility of Results
TL;DR:
Results suggest that the measurement of phthalate metabolites after long-term sample storage yield generally similar distributions and temporal reliability as those reported for recently collected specimens, and support the use of stored urine specimens collected during the relevant stage of human pregnancy to investigate the influence ofphthalate exposures on later outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 2, 2020
2009 journal article
Assessment of a pesticide exposure intensity algorithm in the agricultural health study
Journal of Exposure Science & Environmental Epidemiology, 20(6), 559–569.
author keywords: 2,4-D; chlorpyrifos; exposure measurement; occupational exposure; Agricultural Health Study
MeSH headings : 2,4-Dichlorophenoxyacetic Acid / analysis; 2,4-Dichlorophenoxyacetic Acid / urine; Agriculture; Air Pollutants, Occupational / analysis; Air Pollutants, Occupational / urine; Algorithms; Biomarkers / urine; Chlorpyrifos / analysis; Chlorpyrifos / urine; Cohort Studies; Environmental Exposure / analysis; Environmental Monitoring / methods; Gas Chromatography-Mass Spectrometry; Humans; Iowa; Linear Models; North Carolina; Occupational Exposure / analysis; Pesticides / analysis; Pesticides / urine; Risk Assessment / methods; Skin Absorption; Surveys and Questionnaires
TL;DR:
The results of the measurements support the use of the algorithm for estimating questionnaire-based exposure intensities in the AHS for liquid pesticide products and refine the algorithm may be possible using the results from this and other measurement studies.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 2, 2020
2009 journal article
Hyaluronidase Activity of Human Hyal1 Requires Active Site Acidic and Tyrosine Residues
Journal of Biological Chemistry, 284(14), 9433–9442.
MeSH headings : Acids / chemistry; Biocatalysis; Catalytic Domain; Cell Line; Crystallography, X-Ray; Disulfides / chemistry; Glycosylation; Humans; Hyaluronoglucosaminidase / chemistry; Hyaluronoglucosaminidase / genetics; Hyaluronoglucosaminidase / metabolism; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutation / genetics; Oligosaccharides / chemistry; Oligosaccharides / metabolism; Protein Structure, Tertiary; Tyrosine / genetics; Tyrosine / metabolism
TL;DR:
Structural information, site-directed mutagenesis, and steady state enzyme kinetics are used to probe molecular determinants of human Hyal1 function and define key components of Hyal 1 active site catalysis, and structural factors critical for stability.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2009 journal article
Mechanistic Details of Glutathione Biosynthesis Revealed by Crystal Structures of Saccharomyces cerevisiae Glutamate Cysteine Ligase
Journal of Biological Chemistry, 284(47), 32700–32708.
MeSH headings : Binding Sites; Catalytic Domain; Crystallography, X-Ray / methods; Escherichia coli / metabolism; Glutamate-Cysteine Ligase / chemistry; Glutathione / chemistry; Humans; Magnesium / chemistry; Magnesium Chloride / chemistry; Models, Molecular; Mutation; Protein Conformation; Protein Processing, Post-Translational; Saccharomyces cerevisiae / metabolism; Software; Sulfhydryl Compounds / chemistry
TL;DR:
Structural data are determined and Examination of the hGCLC model suggests that post-translational modifications of cysteine residues may be involved in the regulation of enzymatic activity, and elucidates the molecular basis of glutathione deficiency associated with patient hG CLC mutations.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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