High-dimensional Integration of Biological Systems

Works Published in 2005

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2005 journal article

Genetic Modifiers of Lung Disease in Cystic Fibrosis

New England Journal of Medicine, 353(14), 1443–1453.

By: M. Drumm *, M. Konstan *, M. Schluchter*, A. Handler, R. Pace, F. Zou, M. Zariwala, D. Fargo* ...

MeSH headings : Adolescent; Adult; Child; Cystic Fibrosis / classification; Cystic Fibrosis / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; DNA Replication; Female; Forced Expiratory Volume; Genotype; Humans; Linkage Disequilibrium; Logistic Models; Lung Diseases / classification; Lung Diseases / genetics; Lung Diseases / physiopathology; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Severity of Illness Index; Transforming Growth Factor beta / genetics
TL;DR: Genetic variation in the 5' end of TGFbeta1 or a nearby upstream region modifies disease severity in cystic fibrosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 28, 2020

2005 journal article

Group A Streptococcus Transcriptome Dynamics during Growth in Human Blood Reveals Bacterial Adaptive and Survival Strategies

The American Journal of Pathology, 166(2), 455–465.

By: M. Graham*, K. Virtaneva *, S. Porcella*, W. Barry*, B. Gowen *, C. Johnson*, F. Wright*, J. Musser *

MeSH headings : DNA, Complementary / metabolism; Female; Flow Cytometry; Gene Expression Regulation, Bacterial; Humans; Male; Models, Biological; Mutation; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; RNA / metabolism; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Streptococcal Infections / blood; Streptococcal Infections / metabolism; Streptococcus / metabolism; Time Factors
TL;DR: Investigation of the transcriptome of a wild-type serotype M1 GAS strain in human blood reinforced the hypothesis that CovR-CovS has an important role linking key biosynthetic, catabolic, and virulence functions during transcriptome restructuring. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

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