Works Published in 2018
Displaying all 16 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2018 journal article
Eigenvalue Significance Testing for Genetic Association
Biometrics.
author keywords: Eigenvalue testing; Population stratification
MeSH headings : Computer Simulation; Cystic Fibrosis / genetics; Data Interpretation, Statistical; Genetic Association Studies / methods; Genomics / methods; Genotype; Humans; Models, Genetic; Models, Statistical
TL;DR:
A novel block permutation approach is introduced, designed to produce an appropriate null eigen value distribution by eliminating long‐range genomic correlation while preserving local correlation, and a fast approach based on eigenvalue distribution modeling is proposed.
(via Semantic Scholar)
doi.org (publisher)
Source: ORCID
Added: October 7, 2019
2018 journal article
A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure
Cell Reports, 23(2), 327–336.
Source: ORCID
Added: October 7, 2019
2018 journal article
Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity
American Journal of Respiratory and Critical Care Medicine, 197(1), 79–93.
Source: ORCID
Added: October 7, 2019
2018 journal article
Periconceptional Maternal Mediterranean Diet Is Associated With Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted Genes
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 6.
TL;DR:
In this ethnically diverse cohort, maternal adherence to a Mediterranean diet in early pregnancy was associated with favorable neurobehavioral outcomes in early childhood and with sex-dependent methylation differences of MEG3, IGF2, and SGCE/PEG10 DMRs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: January 21, 2019
2018 journal article
A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(4), 441–452.
MeSH headings : Cardiotoxicity / genetics; Cardiovascular Agents / pharmacology; Cardiovascular Agents / toxicity; Cell Differentiation / drug effects; Cell Differentiation / genetics; Female; Healthy Volunteers; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / drug effects; Male; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Phenotype; Reproducibility of Results
TL;DR:
iPSC-derived cardiomyocytes exhibited reproducible donor-specific differences in baseline function and drug-induced effects, demonstrating the feasibility of using a panel of population-based organotypic cells from healthy donors as an animal replacement experimental model to quantify inter-individual variability in xenobiotic responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 10, 2018
2018 journal article
Estimation of cis-eQTL effect sizes using a log of linear model
BIOMETRICS, 74(2), 616–625.
author keywords: eQTL analyses; EQTL effect size; Multiple testing; Nonlinear regression
MeSH headings : Algorithms; Alleles; Gene Expression; Humans; Linear Models; Quantitative Trait Loci; Statistics as Topic
TL;DR:
A new, log‐of‐linear model for eQTL action is proposed, termed ACME, that captures allelic contributions to cis‐acting eZTLs in an additive fashion, yielding effect size estimates that correspond to a biologically coherent model of cis‐eQTLs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 16, 2018
2018 journal article
Polyphasic characterization of four soil-derived phenanthrene-degrading Acidovorax strains and proposal of Acidovorax carolinensis sp nov.
SYSTEMATIC AND APPLIED MICROBIOLOGY, 41(5), 460–472.
author keywords: Acidovorax; Phenanthrene; Polycyclic aromatic hydrocarbons
MeSH headings : Biodegradation, Environmental; Comamonadaceae / chemistry; Comamonadaceae / classification; Comamonadaceae / genetics; Comamonadaceae / physiology; DNA, Bacterial; Genes, Bacterial; Genome, Bacterial / genetics; Metabolic Networks and Pathways / genetics; North Carolina; Phenanthrenes / metabolism; Phylogeny; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Soil Microbiology; Soil Pollutants / metabolism
TL;DR:
Four bacterial strains identified as members of the Acidovorax genus were isolated from two geographically distinct but similarly contaminated soils in North Carolina, USA, characterized, and their genomes sequenced, indicating that they likely represent a single species within the genus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: October 16, 2018
2018 journal article
An empirical Bayes approach for multiple tissue eQTL analysis
Biostatistics (Oxford, England), 19(3), 391–406.
MeSH headings : Bayes Theorem; Biostatistics / methods; Gene Expression; Genomics / methods; Genotyping Techniques / methods; Humans; Models, Statistical; Quantitative Trait Loci
TL;DR:
A hierarchical Bayesian model (MT‐eQTL) for multi‐tissue eQTL analysis that explicitly captures patterns of variation in the presence or absence of eQ TL, as well as the heterogeneity of effect sizes across tissues is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
A zero-inflated beta-binomial model for microbiome data analysis
STAT, 7(1).
author keywords: count data; penalized generalized linear model; zero-inflated beta-binomial modelling
TL;DR:
A zero‐inflated beta‐binomial is introduced to model the distribution of microbiome count data and to determine association with a continuous or categorical phenotype of interest and has higher power than competing methods to detect taxa associated with phenotype.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2018 journal article
A common allele in FGF21 associated with sugar intake is associated with body shape, lower total body-fat percentage, and higher blood pressure
Cell Reports, 23(2), 327–336.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Computation of ancestry scores with mixed families and unrelated individuals
BIOMETRICS, 74(1), 155–164.
author keywords: Genetic association; Population stratification; Principal components
MeSH headings : Cystic Fibrosis / genetics; Family; Genome; Genotype; Humans; Models, Genetic; Pedigree; Principal Component Analysis
TL;DR:
Two main novel strategies are considered: matrix substitution based on decomposition of a target family‐orthogonalized covariance matrix, and using family‐averaged data to obtain loadings using the family‐average method, which shows superior performance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2018 journal article
ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models
BMC Bioinformatics, 19.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse
MAMMALIAN GENOME, 29(1-2), 168–181.
MeSH headings : Animals; Dose-Response Relationship, Drug; Genetics, Population; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Mice; Transcription, Genetic / drug effects; Transcriptome / genetics; Trichloroacetic Acid / metabolism; Trichloroethylene / toxicity
TL;DR:
The usefulness of mouse population-based studies in assessing inter-individual variation in toxicological responses is highlighted, but it is cautioned that genetic mapping may be challenging because of the complexity in gene exposure–dose relationships.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues
BMC Bioinformatics, 19.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
A survey of high dimension low sample size asymptotics
AUSTRALIAN & NEW ZEALAND JOURNAL OF STATISTICS, 60(1), 4–19.
author keywords: canonical correlations; classification; geometric representation; hypothesis testing; principal component analysis
TL;DR:
A survey of one of those areas, initiated by a seminal paper in 2005, on high dimension low sample size asymptotics, which contains deep and insightful concepts which are frequently surprising and counter‐intuitive, yet have mathematical underpinnings which tend to be direct and not difficult to prove.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
Airway mucosal host defense is key to genomic regulation of cystic fibrosis lung disease severity
American Journal of Respiratory and Critical Care Medicine, 197(1), 79–93.
Source: NC State University Libraries
Added: August 6, 2018
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