Works Published in 2015
Displaying works 1 - 20 of 29 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2015 journal article
Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases
Scientific Reports, 5(1), 15145.
MeSH headings : Adult; Aged; Aging / genetics; Animals; Cluster Analysis; Computational Biology / methods; Female; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Genetic Association Studies; Humans; Male; Mice; Middle Aged; Molecular Sequence Annotation; Mutation; Organ Specificity / genetics; Young Adult
TL;DR:
This work catalogueed age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project, finding the aging gene expression signatures are very tissue specific and enrichment for some well-known aging components such as mitochondria biology is observed in many tissues.
(via Semantic Scholar)
www.nature.com (publisher PDF)
Source: Crossref
Added: January 4, 2021
2015 journal article
Erratum: Gene expression in major depressive disorder
Molecular Psychiatry, 21(3), 444–444.
TL;DR:
The authors noticed that the Supplementary Figure legends were not published with the paper, and the legends accompany this erratum.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2015 journal article
Gene expression in major depressive disorder
Molecular Psychiatry, 21(3), 339–347.
MeSH headings : Adult; Anxiety Disorders / genetics; Cross-Sectional Studies; Depressive Disorder, Major / diagnosis; Depressive Disorder, Major / genetics; Female; Gene Expression / genetics; Gene Expression Regulation / genetics; Genetic Predisposition to Disease / genetics; Genome-Wide Association Study; Humans; Interleukin-6 / genetics; Interleukin-6 / metabolism; Killer Cells, Natural / metabolism; Longitudinal Studies; Male; Middle Aged; Polymorphism, Single Nucleotide / genetics; Signal Transduction / genetics
TL;DR:
Multiple gene expression associations with MDD were identified and a measurable impact of current MDD state on gene expression is suggested, in line with the immune suppression and immune activation hypothesis of MDD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020
2015 journal article
Prediction of human population responses to toxic compounds by a collaborative competition
Nature Biotechnology, 33(9), 933–940.
MeSH headings : Computer Simulation; Dose-Response Relationship, Drug; Genetic Predisposition to Disease / genetics; Genetics, Population; Hazardous Substances / toxicity; High-Throughput Screening Assays / methods; Humans; Incidence; Lymphocytes / cytology; Lymphocytes / drug effects; Lymphocytes / physiology; Models, Genetic; Risk Assessment / methods; Toxicity Tests / methods
TL;DR:
The results from a community-based DREAM challenge to predict toxicities of environmental compounds with potential adverse health effects for human populations highlight the possibility of predicting health risks associated with unknown compounds, although risk estimation accuracy remains suboptimal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Crossref
Added: February 24, 2020
2015 journal article
Erratum: Prediction of human population responses to toxic compounds by a collaborative competition
Nature Biotechnology, 33(10), 1109–1109.
TL;DR:
The authors have added 12 additional authors to the list of “Other participants in the NIEHS-NCATS-UNC DREAM Toxicogenetics Collaboration,” including Alok Jaiswal, Antti Poso, Himanshu Chheda, Ismeet Kaur, Jing Tang, John-Patrick Mpindi, Krister Wennerberg, Natalio Krasnogor, Samuel Kaski and Tero Aittokallio.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
Nature Communications, 6(1).
MeSH headings : Adolescent; Adult; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral / genetics; Child; Cystic Fibrosis / genetics; Cystic Fibrosis / metabolism; Cystic Fibrosis / pathology; Female; Genome-Wide Association Study; Humans; Lung / metabolism; Lung / pathology; Male; Middle Aged; Mucin-4 / genetics; Mucins / genetics; Severity of Illness Index; Transcription Factors / genetics; Young Adult
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: February 5, 2020
2015 journal article
Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer
Chemical Research in Toxicology, 28(6), 1144–1155.
MeSH headings : Adult; Aged; Arsenic / metabolism; Arsenic / toxicity; Cell Transformation, Neoplastic / chemically induced; DNA Methylation / drug effects; DNA Methylation / genetics; Female; Humans; Middle Aged; Urinary Bladder Neoplasms / chemically induced; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / pathology; Urothelium / cytology; Urothelium / drug effects; Young Adult
TL;DR:
Both the arsenic- and cancer-associated genes are enriched for the binding sites of common transcription factors known to play roles in carcinogenesis, demonstrating a novel potential mechanistic link between iAs exposure and bladder cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Source: Crossref
Added: February 5, 2020
2015 journal article
High dimension low sample size asymptotics of robust PCA
Electronic Journal of Statistics, 9(1), 204–218.
Source: ORCID
Added: October 7, 2019
2015 journal article
Metabolomic evaluation of neutrophilic airway inflammation in cystic fibrosis
Chest, 148(2), 507–515.
Source: ORCID
Added: October 7, 2019
2015 journal article
The projack: a resampling approach to correct for ranking bias in high-throughput studies
Biostatistics, 17(1), 54–64.
Source: ORCID
Added: October 7, 2019
2015 journal article
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
Nature Communications, 6, 8382.
Source: ORCID
Added: October 7, 2019
2015 journal article
Population-based in vitro hazard and concentration--response assessment of chemicals: the 1000 genomes high-throughput screening study
Environmental Health Perspectives, 123(5), 458.
Source: ORCID
Added: October 7, 2019
2015 journal article
PathwaySeq: Pathway analysis for RNA-Seq data using a score-based approach
Dim (Data. Test), 1(1000), 448.
Source: ORCID
Added: October 7, 2019
2015 journal article
Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer
Chemical Research in Toxicology, 28(6), 1144–1155.
Source: ORCID
Added: October 7, 2019
2015 journal article
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
Human Molecular Genetics, 24(15), 4464–4479.
Source: ORCID
Added: October 7, 2019
2015 journal article
Effect of predicted protein-truncating genetic variants on the human transcriptome
Science, 348(6235), 666–669.
Source: ORCID
Added: October 7, 2019
2015 journal article
Gene expression in transformed lymphocytes reveals variation in endomembrane and HLA pathways modifying cystic fibrosis pulmonary phenotypes
The American Journal of Human Genetics, 96(2), 318–328.
Source: ORCID
Added: October 7, 2019
2015 journal article
Consistent testing for recurrent genomic aberrations
BIOMETRIKA, 102(4), 783–796.
author keywords: Consistency; DNA copy number; DNA methylation; Genome-wide association study; Hypothesis testing
TL;DR:
The analysis establishes the consistency of cyclic shift values for datasets with a fixed set of samples as the number of observed variables tends to infinity, under the assumption that each sample is an independent realization of a stationary Markov chain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
High dimension low sample size asymptotics of robust PCA
ELECTRONIC JOURNAL OF STATISTICS, 9(1), 204–218.
author keywords: Outlier; robustness; spherical PCA; spike model
TL;DR:
The study of the effects of outliers for high dimension and low sample size data, using asymptotics to show that the robust method of spherical principal components is consistent with the population eigenvector for the spike model, even in the presence of contamination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
Nature Communications, 6.
Source: NC State University Libraries
Added: August 6, 2018
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