Works Published in 2021
Displaying all 15 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2021 journal article
Detection and classification of neurons and glial cells in the MADM mouse brain using RetinaNet
PLOS ONE, 16(9).
MeSH headings : Animals; Brain; Cell Differentiation; Mice; Neuroglia; Neurons
TL;DR:
Object detection networks (neural networks) are utilized to detect and classify targets in complex microscopy images, while simplifying data annotation, and merging the predictions of the two computational models significantly improved the automated cell counting of glial clusters.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
8. Decent Work and Economic Growth
(OpenAlex)
Source: Web Of Science
Added: February 28, 2022
2021 journal article
Potential Human Health Hazard of Post-Hurricane Harvey Sediments in Galveston Bay and Houston Ship Channel: A Case Study of Using In Vitro Bioactivity Data to Inform Risk Management Decisions
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18(24).
author keywords: new approach methods (NAMs); environmental mixtures; disaster research
MeSH headings : Bays; Cyclonic Storms; Disasters; Environmental Monitoring; Geologic Sediments; Humans; Polycyclic Aromatic Hydrocarbons / analysis; Risk Management; Water Pollutants, Chemical / analysis; Water Pollutants, Chemical / toxicity
TL;DR:
It is found that in vitro bioactivity can be used as a comprehensive indicator of potential hazards and is an example of a new approach method (NAM) to inform risk management decisions on site cleanup.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
13. Climate Action
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 20, 2021
2021 journal article
Intra- and Inter-Species Variability in Urinary N7-(1-Hydroxy-3-buten-2-yl)guanine Adducts Following Inhalation Exposure to 1,3-Butadiene
CHEMICAL RESEARCH IN TOXICOLOGY, 34(11), 2375–2383.
MeSH headings : Animals; Butadienes / administration & dosage; Butadienes / metabolism; Butadienes / urine; Chromatography, Liquid; DNA Adducts / administration & dosage; DNA Adducts / metabolism; DNA Adducts / urine; Female; Inhalation Exposure; Male; Mice; Mice, Inbred Strains; Nanotechnology; Spectrometry, Mass, Electrospray Ionization
TL;DR:
Urinary EB-GII levels, particularly from human studies, may be useful for quantitative characterization of human variability in cancer risks to butadiene, and are largely consistent with UFH estimates for other chemicals based on human data for non-cancer endpoints.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 29, 2021
2021 journal article
Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-implanted optical fibers and GRIN lenses
CELL REPORTS, 36(13).
MeSH headings : Animals; Brain / physiology; Head / physiology; Lens, Crystalline / physiology; Lenses; Mice; Neurons / physiology; Optical Fibers; Photons; Refractometry / methods
TL;DR:
A three-dimensional post hoc histology method called “light-guided sectioning” (LiGS), which preserves the tissue with its optical implant in place and allows staining and clearing of a volume up to 500 μm in depth, is developed.
(via Semantic Scholar)
Source: Web Of Science
Added: October 26, 2021
2021 journal article
Application of Edible Montmorillonite Clays for the Adsorption and Detoxification of Microcystin
ACS APPLIED BIO MATERIALS, 4(9), 7254–7265.
author keywords: adsorption isotherm; Hydra vulgaris; Lemna minor; Caenorhabditis elegans; molecular model; dietary sorbent
MeSH headings : Adsorption; Animals; Bentonite / chemistry; Caenorhabditis elegans; Charcoal / pharmacology; Clay / chemistry; Hydra; Microcystins / chemistry
TL;DR:
Edible montmorillonite clays were characterized for their ability to bind MC containing leucine and arginine under conditions simulating the gastrointestinal tract and compared with a medical-grade activated carbon and validated in a battery of living organisms, suggesting that edible montMorillonites are safe and efficacious binders for MC-LR.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: October 12, 2021
2021 article
Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation
Carter, A., Popowski, K., Cheng, K., Greenbaum, A., Ligler, F. S., & Moatti, A. (2021, September 24). BIOELECTRICITY.
author keywords: converse piezoelectric effect; mechanical stimulation; bone regeneration
TL;DR:
The potential of the converse piezoelectric effect to enhance bone regeneration is highlighted by discussing the activation of beneficial cellular pathways, the properties of piezOElectric biomaterials, and the potential for the more effective administration of the Converse pieZoelectrics effect using wireless control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: October 4, 2021
2021 article
Phenotyping Intact Mouse Bones Using Bone CLARITY
SKELETAL DEVELOPMENT AND REPAIR, 2 EDITION, Vol. 2230, pp. 217–230.
author keywords: Tissue Clearing; Bone CLARITY; Three-dimensional imaging; Light-sheet microscopy; Fluorescence microscopy
MeSH headings : Animals; Bone and Bones / diagnostic imaging; Bone and Bones / physiology; Heme / chemistry; Humans; Hydrogels / pharmacology; Imaging, Three-Dimensional / methods; Mice; Optical Imaging / methods; Phenotype; Skull / diagnostic imaging; Skull / physiology; Staining and Labeling / methods
TL;DR:
A bone-clearing methodology, termed Bone CLARITY, which combines published techniques for clearing soft tissues, including delipidation for the removal of light-scattering membranes, hydrogel-embedding for the stabilization of fragile epitopes, and heme elution for the reduction of blood-based autofluorescence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 9, 2021
2021 journal article
ImputEHR: A Visualization Tool of Imputation for the Prediction of Biomedical Data
FRONTIERS IN GENETICS, 12.
author keywords: electronic health records; imputation; gradient boosting; prediction; decision trees
TL;DR:
A new graphical tool, ImputEHR, is created that allows implementation of a range of simple and sophisticated data imputation approaches and enables data exploration for informed decision-making, as well as implementing machine learning prediction tools for response data selected by the user.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 2, 2021
2021 journal article
Data Processing Workflow to Identify Structurally Related Compounds in Petroleum Substances Using Ion Mobility Spectrometry-Mass Spectrometry
ENERGY & FUELS, 35(13), 10529–10539.
TL;DR:
This work demonstrates how rapid untargeted IMS-MS analysis and the proposed data processing workflow can be used to provide confident compositional characterization of hydrocarbon-containing substances.
(via Semantic Scholar)
Source: Web Of Science
Added: July 26, 2021
2021 journal article
Eigenvector-based sparse canonical correlation analysis: Fast computation for estimation of multiple canonical vectors
JOURNAL OF MULTIVARIATE ANALYSIS, 185.
author keywords: GTEx; High-dimensional data analysis; Multivariate regression; Sparse canonical correlation analysis
TL;DR:
This work provides an explicit link between sparse multiple regression with sparse canonical correlation analysis, and an efficient algorithm that can estimate multiple canonical pairs simultaneously rather than sequentially, and naturally allows parallel computing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 19, 2021
2021 journal article
Environmental impacts of Hurricane Florence flooding in eastern North Carolina: temporal analysis of contaminant distribution and potential human health risks
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 31(5), 810–822.
author keywords: Disaster research response; Superfund; Chemical contaminants
MeSH headings : Cyclonic Storms; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Humans; Metals; North Carolina / epidemiology; Soil
TL;DR:
PAH and metals detected downstream from the coal ash storage pond that leaked were detected and were indicative of a pyrogenic source of contamination and PAH at these sites were of human health concern because cancer risk values exceeded 1 × 10−6 threshold.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 24, 2021
2021 journal article
Relationships between constituents of energy drinks and beating parameters in human induced pluripotent stem cell (iPSC)-Derived cardiomyocytes
FOOD AND CHEMICAL TOXICOLOGY, 149.
author keywords: Cardiovascular; Heart rate; QT interval; Theophylline; Adenine; Azelate
MeSH headings : Calcium / metabolism; Cell Differentiation; Cell Survival / drug effects; Drug-Related Side Effects and Adverse Reactions; Energy Drinks / analysis; Heart Diseases / chemically induced; Humans; Induced Pluripotent Stem Cells / drug effects; Myocytes, Cardiac / drug effects; Risk Assessment
TL;DR:
It was found that some of the energy drinks elicited adverse effects on the cardiomyocytes with the most common being an increase in the beat rate, while QT prolongation was also observed at the lowest concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021
2021 personal communication
The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning
Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January).
MeSH headings : COVID-19 / epidemiology; Data Visualization; Health Status Indicators; Humans; Machine Learning; Models, Statistical; Vulnerable Populations
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 22, 2021
2021 journal article
Grouping of UVCB Substances with New Approach Methodologies (NAMs) Data
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 38(1), 123–137.
MeSH headings : Animal Testing Alternatives / methods; Hazardous Substances / chemistry; Hazardous Substances / toxicity; Humans; Induced Pluripotent Stem Cells / drug effects; Petroleum / analysis; Petroleum / toxicity; Toxicity Tests / methods
TL;DR:
It is demonstrated that in vitro test-derived biological activity signatures, including bioactivity from human induced pluripotent stem cell and primary cells, can be used to inform groupings of UVCBs, to assist in identification of representative substances in each group for testing when needed, and to fill data gaps by read-across.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: March 15, 2021
2021 journal article
Risk Characterization of Environmental Samples Using In Vitro Bioactivity and Polycyclic Aromatic Hydrocarbon Concentrations Data
TOXICOLOGICAL SCIENCES, 179(1), 108–120.
author keywords: polycyclic aromatic hydrocarbons; mixtures toxicology; in vitro models; iPSC; humanized models; human risk assessment; risk assessment; new approach methods; bioactivity; spatial analysis
MeSH headings : Cyclonic Storms; Endothelial Cells; Environmental Exposure / adverse effects; Environmental Monitoring; Humans; Polycyclic Aromatic Hydrocarbons / toxicity
TL;DR:
This work sets the stage for identification of the areas of concern and direct quantitative risk characterization based on bioactivity data, thereby providing an important supplement to traditional individual chemical analyses by shedding light on constituents that may be missed from targeted chemical monitoring.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: March 15, 2021
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