Works Published in 2013
Displaying all 11 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2013 journal article
Single Nucleotide Polymorphism (SNP) Detection and Genotype Calling from Massively Parallel Sequencing (MPS) Data
Statistics in Biosciences, 5(1), 3–25.
author keywords: Massively parallel sequencing; Next-generationsequencing; SNP detection; Genotype calling; Linkage disequilibrium (LD)
TL;DR:
A review of statistical methods proposed in the past five years to detect SNPs and call genotypes at the detected polymorphic sites from the sequencing data, and discusses emerging issues and future directions related to SNP detection and genotype calling from MPS data.
(via Semantic Scholar)
europepmc.org (repository)
Source: Crossref
Added: December 21, 2020
2013 journal article
Unified Analysis of Secondary Traits in Case–Control Association Studies
Journal of the American Statistical Association, 108(502), 566–576.
author keywords: GWAS; Profile likelihood; Pseudo-likelihood; Retrospective study; Secondary phenotype; Semiparametric method
TL;DR:
A general retrospective likelihood framework is presented to perform association testing for both binary and continuous secondary traits, which respects marginal models and incorporates the interaction term and an alternative pseudo-likelihood method for handling covariates is presented.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
The Genotype-Tissue Expression (GTEx) project
Nature Genetics, 45(6), 580–585.
MeSH headings : Consensus Development Conferences, NIH as Topic; Gene Expression; Gene Expression Profiling; Genome-Wide Association Study; Government Programs / ethics; Government Programs / legislation & jurisprudence; Humans; Molecular Sequence Annotation; Organ Specificity; Quantitative Trait Loci; Tissue Banks; United States
TL;DR:
The Genotype-Tissue Expression (GTEx) project is described, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity
Toxicology and Applied Pharmacology, 273(3), 500–507.
author keywords: iPSC; Calcium flux; Cardiotoxicity; hERG; Phenotypic screening; Predictive toxicology
MeSH headings : Area Under Curve; Cardiotoxins / pharmacology; Cell Survival / drug effects; Cells, Cultured; Drug Evaluation, Preclinical / methods; Drug-Related Side Effects and Adverse Reactions / diagnosis; Heart Diseases / chemically induced; Heart Diseases / diagnosis; Heart Diseases / pathology; High-Throughput Screening Assays; Humans; Induced Pluripotent Stem Cells / drug effects; Induced Pluripotent Stem Cells / metabolism; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / physiology; Phenotype; Risk Assessment
TL;DR:
Multi-parameter screening of beating profiles allows for cardiotoxicity risk assessment and identification of specific patterns defining mechanism-specific effects, and may be used widely for compound screening and early safety evaluation in drug development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2013 journal article
The Value of Statistical or Bioinformatics Annotation for Rare Variant Association With Quantitative Trait
Genetic Epidemiology, 37(7), 666–674.
author keywords: rare variants; association; weighting; variable selection; variant annotation
MeSH headings : Computational Biology; Genetic Variation / genetics; Genome-Wide Association Study; Genomics; Genotype; Humans; Models, Genetic; Molecular Sequence Annotation; Phenotype; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci
TL;DR:
A systematic evaluation of multiple weighting schemes through a series of simulations intended to mimic large sequencing studies of a quantitative trait finds that the difference in power between phenotype‐dependent schemes is negligible when high‐quality functional annotations are available.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2013 journal article
Stochastic comparisons in a price-quantity setting firm with uncertain demand and emergency procurement
Journal of Systems Science and Systems Engineering, 22(4), 401–420.
author keywords: Price-dependent newsvendor; stochastic comparison; demand uncertainty; pricing; emergency supply option
Source: Crossref
Added: February 5, 2020
2013 journal article
Stochastic comparisons in a price-quantity setting firm with uncertain demand and emergency procurement
Journal of Systems Science and Systems Engineering, 22(4), 401–420.
Source: ORCID
Added: October 7, 2019
2013 chapter
Metabolomic Evaluation Of Cystic Fibrosis Airways Disease
In A26. PEDIATRIC CYSTIC FIBROSIS (pp. A1165–A1165). American Thoracic Society.
Source: ORCID
Added: October 7, 2019
2013 journal article
Space-time clustering and the permutation moments of quadratic forms
Stat, 2(1), 292–302.
author keywords: exact testing; resampling; statistical computing
TL;DR:
The extension of this work to quadratic forms greatly expands the utility of density approximations for these problems, including for high-dimensional applications, where the statistics must be extreme in order to exceed stringent testing thresholds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID
Added: October 7, 2019
2013 journal article
Skill-assessments of statistical and Ensemble Kalman Filter data assimilative analyses using surface and deep observations in the Gulf of Mexico
Frontiers of Earth Science, 7(3), 271–281.
author keywords: data assimilation; deep observation; Gulf of Mexico
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, ORCID
Added: October 7, 2019
2013 journal article
Empirical pathway analysis, without permutation
Biostatistics, (doi:10.1093/biostatistics/kxt004), 1–13.
Source: ORCID
Added: October 7, 2019
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