Works Published in 2005
Displaying works 101 - 120 of 501 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2005 journal article
Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism
Proceedings of the National Academy of Sciences, 102(42), 15018–15023.
author keywords: disulfide; flavoprotein; selenocysteine; selenoprotein
MeSH headings : Animals; Binding Sites; Crystallography, X-Ray; Homeostasis; Isoenzymes / chemistry; Isoenzymes / metabolism; Mice; Mitochondria / enzymology; Models, Molecular; NADP / metabolism; Oxidation-Reduction; Protein Structure, Quaternary; Protein Subunits / chemistry; Protein Subunits / metabolism; Thioredoxin Reductase 2; Thioredoxin-Disulfide Reductase / chemistry; Thioredoxin-Disulfide Reductase / metabolism
TL;DR:
Detailed analysis of the structural data in conjunction with a model of the unusual C-terminal selenenylsulfide suggests molecular details of the reaction mechanism and highlights evolutionary adaptations among reductases.
(via Semantic Scholar)
www.pnas.org (publisher PDF)
Source: Crossref
Added: August 28, 2020
2005 journal article
Esophageal Reconstruction with ECM and Muscle Tissue in a Dog Model
Journal of Surgical Research, 128(1), 87–97.
author keywords: extracellular matrix; urinary bladder matrix; esophagus; surgery; tissue engineering; scaffold; esophageal cancer; regenerative medicine; bioscaffold
MeSH headings : Animals; Biomechanical Phenomena; Dogs; Esophageal Stenosis / etiology; Esophageal Stenosis / prevention & control; Esophagectomy / adverse effects; Esophagus / physiopathology; Esophagus / surgery; Extracellular Matrix / physiology; Female; Models, Animal; Muscle, Smooth / physiology; Muscle, Smooth / surgery; Plastic Surgery Procedures / methods; Recovery of Function; Tissue Engineering / methods
TL;DR:
It is concluded that ECM bioscaffolds plus autologous muscle tissue, but not ECM scaffolds or muscle tissue alone, can facilitate the in situ reconstitution of structurally and functionally acceptable esophageal tissue.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test
Biomaterials, 26(27), 5518–5531.
author keywords: bladder; ECM; multilaminate devices; mechanical properties; mechanical test; ball-burst test; scaffold
MeSH headings : Animals; Biocompatible Materials / analysis; Biocompatible Materials / chemistry; Biomechanical Phenomena / methods; Compressive Strength; Computer Simulation; Elasticity; Extracellular Matrix / chemistry; Extracellular Matrix / physiology; Manufactured Materials / analysis; Materials Testing / methods; Models, Biological; Models, Chemical; Physical Stimulation / methods; Swine; Tensile Strength
TL;DR:
The ball-burst test was used to simulate biaxial forces and to determine the strength of the ECM scaffold under a relevant physiological loading condition and proposed approximations were used to compute biaXial failure properties for a variety of multilaminate ECM devices with varying number of layers.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
Tertiary amide chemistry at the Ge(100)-2×1 surface
Surface Science, 599(1-3), 41–54.
author keywords: density functional calculations; vibrational spectroscopies; germanium; organic molecules; organo-functionalization of surfaces; desorption; amide; Ge(100)
Source: Crossref
Added: August 28, 2020
2005 journal article
Comparison of three ultrasonic axial transmission methods for bone assessment
Ultrasound in Medicine & Biology, 31(5), 633–642.
author keywords: cortical bone; ultrasound axial transmission; in vitro; bone properties
MeSH headings : Aged; Aged, 80 and over; Bone Density; Bone and Bones / anatomy & histology; Bone and Bones / diagnostic imaging; Cadaver; Female; Humans; Male; Middle Aged; Radius / anatomy & histology; Radius / diagnostic imaging; Ultrasonics; Ultrasonography / instrumentation
TL;DR:
The results suggest that different axial transmission approaches reflect different bone properties, and a multifrequency technique might be useful in probing differentBone properties, because higher frequency waves interrogate thinner cortical layers.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
A microfluidic mixer with grooves placed on the top and bottom of the channel
Lab on a Chip, 5(5), 524.
MeSH headings : Computer Simulation; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Microfluidics / instrumentation; Microfluidics / methods; Polymethyl Methacrylate / chemistry; Sensitivity and Specificity; Surface Properties
TL;DR:
A new microfluidic mixer is presented consisting of a rectangular channel with grooves placed in the top and bottom, which not only increases the driving force behind the lateral flow, but allows for the formation of advection patterns that cannot be created with structures on the bottom alone.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
Antimicrobial Peptides for Detection of Bacteria in Biosensor Assays
Analytical Chemistry, 77(19), 6504–6508.
MeSH headings : Anti-Infective Agents / analysis; Anti-Infective Agents / metabolism; Antimicrobial Cationic Peptides / analysis; Antimicrobial Cationic Peptides / metabolism; Biosensing Techniques / methods; Escherichia coli / isolation & purification; Escherichia coli / metabolism; Salmonella typhimurium / isolation & purification; Salmonella typhimurium / metabolism
TL;DR:
The results showed that both specific and nonspecific binding strongly depend on the method used for peptide immobilization, and direct attachment of magainin to the substrate surface not only decreased nonspecial cell binding but also resulted in improved detection limits for both Salmonella and E. coli.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
Array Biosensor for Detection of Ochratoxin A in Cereals and Beverages
Analytical Chemistry, 77(1), 148–154.
MeSH headings : Beverages / analysis; Beverages / microbiology; Biosensing Techniques / methods; Edible Grain / chemistry; Edible Grain / microbiology; Immunoassay; Ochratoxins / analysis; Sensitivity and Specificity
TL;DR:
The development of a rapid and highly sensitive array biosensor for the detection and quantitation of ochratoxin A (OTA) using a competitive immunoassay format and measuring the formation of the fluorescent immunocomplex on the waveguide surface.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
A “do-it-yourself” array biosensor
Methods, 37(1), 65–72.
author keywords: biosensor; evanescent wave; array; planar waveguide; fluorescence
MeSH headings : Biosensing Techniques / methods; Fluorescence; Immunoassay
TL;DR:
This array biosensor, based on a planar waveguide, a modified microscope slide, with a pattern of small sensing regions, can detect many different targets, including proteins, toxins, cells, virus, and explosives with detection limits rivaling those of the ELISA detection system.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
A portable automated multianalyte biosensor
Talanta, 65(5), 1078–1085.
author keywords: array biosensor; multianalyte; fluorescence; portable biosensor
TL;DR:
The miniaturization and automation of the array biosensor for portability and on-site use is described, and simultaneous assays were automatically conducted on samples containing both ovalbumin and staphylococcal enterotoxin B.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
Evanescent wave fluorescence biosensors
Biosensors and Bioelectronics, 20(12), 2470–2487.
author keywords: fluorescence; biosensors; evanescent; planar waveguide; fiber optic
MeSH headings : Biosensing Techniques / instrumentation; Biosensing Techniques / methods; Equipment Design; Equipment Failure Analysis; Fiber Optic Technology / instrumentation; Microfluidics / instrumentation; Microfluidics / methods; Spectrometry, Fluorescence / instrumentation; Spectrometry, Fluorescence / methods
TL;DR:
The important patents that have impacted the evolution from laboratory curiosities to fully automated commercial products are summarized and the critical issues that evanescent wave fluorescence biosensors will face in the coming years are addressed.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
Synthesis of Homoallylic Amines by Hydrozirconation−Imine Addition of Allenes
Organic Letters, 7(16), 3537–3540.
TL;DR:
Hydrozirconation of allenes followed by in situ transmetalation to dialkylzinc leads to the formation of an allylic zinc species that, upon addition of aldimines to the reaction mixture, provides homoallylic amines in 64-85% yield.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2005 journal article
Silver(I)-Catalyzed Addition of Zirconocenes to Glycal Epoxides. A New Synthesis of α-C-Glycosides
Organic Letters, 7(3), 483–485.
MeSH headings : Catalysis; Epoxy Compounds / chemical synthesis; Glycosides / chemical synthesis; Indicators and Reagents; Molecular Conformation; Organometallic Compounds / chemistry; Silver / chemistry; Stereoisomerism; Zirconium / chemistry
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2005 journal article
High-Affinity CD25-Binding IL-2 Mutants Potently Stimulate Persistent T Cell Growth†
Biochemistry, 44(31), 10696–10701.
MeSH headings : Amino Acid Substitution / genetics; Cell Line; Cell Membrane / genetics; Cell Membrane / immunology; Cell Membrane / metabolism; Cell Proliferation; Directed Molecular Evolution; Humans; Interleukin-15 / metabolism; Interleukin-15 / physiology; Interleukin-2 / genetics; Interleukin-2 / metabolism; Interleukin-2 / physiology; Interleukin-2 Receptor alpha Subunit; Lymphocyte Activation / genetics; Mitogens / genetics; Mitogens / metabolism; Mitogens / physiology; Protein Binding / genetics; Receptors, Interleukin / metabolism; Receptors, Interleukin-15; Receptors, Interleukin-2 / metabolism; T-Lymphocytes / cytology; T-Lymphocytes / immunology
TL;DR:
These IL-2 mutants exhibit T cell growth response-receptor occupancy curves indistinguishable from that for IL-15, suggesting that much of the difference between wild-type IL-1 and IL-3 effects arises simply from their 1000-fold differing affinities for their private alpha receptor subunits.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2005 journal article
Mapping Sites of Protein Phosphorylation by Mass Spectrometry Utilizing a Chemical-Enzymatic Approach: Characterization of Products from α-S1Casein Phosphopeptides
Journal of Proteome Research, 4(2), 424–434.
author keywords: chemical-enzymatic; phosphorylation; 2-aminoethanethiol; isotope dilution mass spectrometry; phosphoproteins; phosphopeptides; quantification
MeSH headings : Amino Acid Sequence; Animals; Caseins / metabolism; Cattle; Molecular Sequence Data; Peptide Fragments / metabolism; Phosphopeptides / metabolism; Phosphorylation; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
ESI-TOF mass spectrometry was used to characterize products from the chemical-enzymatic cleavage of specific phosphorylation sites in bovine alpha-S1 casein and synthetic phosphopeptides containing substitutions at a single phosphorylated site.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2005 journal article
Protein expression profiling of CLL B cells using replicate off-line strong cation exchange chromatography and LC–MS/MS
Journal of Chromatography B, 819(1), 33–39.
author keywords: CLL; 2D-LC-MS/MS; B cell; expression profiling; off-line SCX; reproducibility
MeSH headings : Antigens, CD / isolation & purification; B-Lymphocytes / metabolism; Blood Proteins / isolation & purification; Cell Fractionation; Cell Membrane / chemistry; Chromatography, Ion Exchange / methods; Chromatography, Liquid / methods; Gene Expression Profiling / methods; Humans; Leukemia, Lymphocytic, Chronic, B-Cell / metabolism; Mass Spectrometry / methods; Neoplasm Proteins / blood
TL;DR:
Examination of crude membranes from B cells derived from a patient with chronic lymphocytic leukemia to examine the protein expression profile of CLL B cells shows an overlap of 64% between proteins identified in replicate runs was achieved for this system.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2005 journal article
Déjà Vu All Over Again: Skin Cap Still Contains a High-Potency Glucocorticosteroid
Archives of Dermatology, 141(6).
MeSH headings : Administration, Topical; Adrenal Cortex Hormones / adverse effects; Adrenal Cortex Hormones / chemistry; Adrenal Cortex Hormones / therapeutic use; Chemistry, Pharmaceutical; Dermatologic Agents / adverse effects; Dermatologic Agents / pharmacology; Dermatologic Agents / therapeutic use; Female; Humans; Male; Materials Testing; Psoriasis / diagnosis; Psoriasis / drug therapy; Risk Assessment; Sensitivity and Specificity
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2005 journal article
51 PHENOTYPIC VARIATION IN CLONED SWINE IS CORRECTED IN THE F1 GENERATION
Reproduction, Fertility and Development, 17(2), 175.
TL;DR:
The hypothesis that offspring of clones are to all intent and purposes indistinguishable from offspring of naturally bred animals, and as such there should not be any increased risks associated with consumption of products from these animals, is strongly supported.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2005 journal article
A nanotube-based field emission x-ray source for microcomputed tomography
Review of Scientific Instruments, 76(9), 094301.
Source: Crossref
Added: August 28, 2020
2005 journal article
Susceptibility of Signal Transducer and Activator of Transcription-1-Deficient Mice to Pulmonary Fibrogenesis
The American Journal of Pathology, 167(5), 1221–1229.
MeSH headings : Animals; Bleomycin / toxicity; Blotting, Western; Cell Proliferation; Cells, Cultured; Collagen / analysis; Disease Models, Animal; Epidermal Growth Factor / pharmacology; Fibroblasts / pathology; Growth Inhibitors / pharmacology; Hydroxyproline / analysis; Interferon-gamma / pharmacology; Lung / drug effects; Lung / pathology; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 3 / metabolism; Phosphorylation; Platelet-Derived Growth Factor / pharmacology; Pulmonary Fibrosis / genetics; Pulmonary Fibrosis / pathology; Pulmonary Fibrosis / physiopathology; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / physiology; STAT3 Transcription Factor / metabolism; Thymidine / metabolism
TL;DR:
The findings indicate that Stat1-/- mice are more susceptible to bleomycin-induced lung fibrosis than wild-type mice due to 1) enhanced fibroblast proliferation in response to growth factors (EGF and PDGF), 2) stimulation of fibro Blast growth by a Stat 1-independent IFN-gamma signaling pathway, and 3) increased activation of Stat3.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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