Donald Osvaldo Freytes

Aerosolizable Formulations of Porcine Extracellular Matrix with Antibacterial and Immunomodulatory Effects

ACS Biomaterials Science & Engineering, 11(12), 7254–7268.

Functionalized screen-printed electrodes for non-invasive detection of vascular-endothelial cadherin in extracellular vesicles

RSC Advances, 15(16), 12609–12621.

Injection of vocal fold lamina propria-derived hydrogels modulates fibrosis in injured vocal folds

Biomaterials Advances, 178, 214424.

Nanodiamond‐Infused Microgels for pH‐Tunable Rheology, Lubrication, and UV Protection

Jani, P. K., Nadkarni, S. A., Ernst, K. J., Farias, B. V., Hincher, C. G., Ojuade, O. A., … Khan, S. A. (2025, September 2). Advanced Functional Materials.

Nanodiamond‐Infused Microgels for pH‐Tunable Rheology, Lubrication, and UV Protection (Adv. Funct. Mater. 46/2025)

Jani, P. K., Nadkarni, S. A., Ernst, K. J., Farias, B. V., Hincher, C. G., Ojuade, O. A., … Khan, S. A. (2025, November 1). Advanced Functional Materials.

Radiation-Induced Fibrosis in Head and Neck Cancer: Challenges and Future Therapeutic Strategies for Vocal Fold Treatments

Cancers, 17(7), 1108.

From isolation to detection, advancing insights into endothelial matrix-bound vesicles

Extracellular Vesicle, 4, 100060.

Human Cell‐Derived Matrix Composite Hydrogels with Diverse Composition for Use in Vasculature‐on‐chip Models

Advanced Healthcare Materials, 13(19).

Characterization and biological evaluation of a novel flavonoid‐collagen antioxidant hydrogel with cytoprotective properties

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 112(1).

Low-dose intrapulmonary drug delivery device for studies on next-generation therapeutics in mice

Journal of Controlled Release, 359, 287–301.

Scalable and High-Throughput In Vitro Vibratory Platform for Vocal Fold Tissue Engineering Applications

Biehl, A., Colmon, R., Timofeeva, A., Martins, A. M. G., Dion, G. R., Peters, K., & Freytes, D. O. (2023, May 17). Bioengineering, Vol. 10.

Tendon Extracellular Matrix Promotes Myotendinous Junction Protein Expression in Engineered Muscle Tissue under Both Static and Mechanically Stimulated Culture Conditions

Journal of Tissue Engineering and Regenerative Medicine, 2023, 1–13.

Donor Age and Time in Culture Affect Dermal Fibroblast Contraction in an In Vitro Hydrogel Model

Tissue Engineering Part A, 28(19-20), 833–844.

High-Axial-Aspect Tannic Acid Microparticles Facilitate Gelation and Injectability of Collagen-Based Hydrogels

Biomacromolecules, 23(11), 4696–4708.

Towards a standardized multi-tissue decellularization protocol for the derivation of extracellular matrix materials

Biomaterials Science, 11(2), 641–654.

Bioreactors for Vocal Fold Tissue Engineering

Tissue Engineering Part B: Reviews, 28(1), 182–205.

Extracellular Matrix Hydrogels Promote Expression of Muscle-Tendon Junction Proteins

Tissue Engineering Part A, 28(5-6), 270–282.

Extracellular Matrix Hydrogels Promote Expression of Muscle-Tendon Junction Proteins

Gaffney, L. S., Davis, Z. G., Mora-Navarro, C., Fisher, M. B., & Freytes, D. O. (2021, March 25). (Vol. 3). Vol. 3.

Microphysiological System for High-Throughput Computer Vision Measurement of Microtissue Contraction

ACS Sensors, 6(3), 985–994.

Monitoring decellularization via absorbance spectroscopy during the derivation of extracellular matrix scaffolds

Biomedical Materials, 17(1), 015008.

Transcriptome-targeted analysis of human peripheral blood-derived macrophages when cultured on biomaterial meshes

Biomedical Materials, 16(2), 025006.

An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs

Science Translational Medicine, 12(538).

Dermal Extracellular Matrix-Derived Hydrogels as an In Vitro Substrate to Study Mast Cell Maturation

Tissue Engineering Part A, 27(15-16), 1008–1022.

Fast Automated Approach for the Derivation of Acellular Extracellular Matrix Scaffolds from Porcine Soft Tissues

ACS Biomaterials Science & Engineering, 6(7), 4200–4213.

Mast Cell–Biomaterial Interactions and Tissue Repair

Tissue Engineering Part B: Reviews, 27(6), 590–603.

Photoinduced reconfiguration to control the protein-binding affinity of azobenzene-cyclized peptides

Journal of Materials Chemistry B, 8(33), 7413–7427.

Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects

Journal of Colloid and Interface Science, 577, 406–418.

Porcine Vocal Fold Lamina Propria-Derived Biomaterials Modulate TGF-β1-Mediated Fibroblast Activation in Vitro

ACS Biomaterials Science & Engineering, 6(3), 1690–1703.

Effects of polarized macrophages on the in vitro gene expression after Co-Culture of human pluripotent stem cell-derived cardiomyocytes

Journal of Immunology and Regenerative Medicine, 4, 100018.

Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure

ACS Nano, 12(7), 6536–6544.

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

Biomaterials Science, 7(2), 669–682.

Contributions of bone morphogenetic proteins in cardiac repair cells in three‐dimensional in vitro models and angiogenesis

Journal of Tissue Engineering and Regenerative Medicine, 12(2), 349–359.

Directed Differentiation of Human Pluripotent Stem Cells to Microglia

Stem Cell Reports, 8(6), 1516–1524.

Macrophages' role in tissue disease and regeneration

Macrophages: Origin, Functions and Biointervention, 62, 245–271.

Potential Synergistic Effects of Stem Cells and Extracellular Matrix Scaffolds

Gaffney, L., Wrona, E. A., & Freytes, D. O. (2017, July 18). ACS Biomaterials Science & Engineering, Vol. 4, pp. 1208–1222.

Extracellular Matrix for Vocal Fold Lamina Propria Replacement: A Review

Tissue Engineering Part B: Reviews, 22(6), 421–429.

Response of human macrophages to wound matrices in vitro

Wound Repair and Regeneration, 24(3), 514–524.

Tissue Engineering Strategies for Myocardial Regeneration: Acellular Versus Cellular Scaffolds?

Tissue Engineering Part B: Reviews, 22(6), 438–458.

BMP protein-mediated crosstalk between inflammatory cells and human pluripotent stem cell-derived cardiomyocytes

Journal of Tissue Engineering and Regenerative Medicine, 11(5), 1466–1478.

Controlled release of cytokines using silk-biomaterials for macrophage polarization

Biomaterials, 73, 272–283.

Derivation and characterization of porcine vocal fold extracellular matrix scaffold

The Laryngoscope, 126(4), 928–935.

Differential gene expression in human, murine, and cell line-derived macrophages upon polarization

Experimental Cell Research, 347(1), 1–13.

Reprint of: Extracellular matrix as a biological scaffold material: Structure and function

Acta Biomaterialia, 23, S17–S26.

Toward beta cell replacement for diabetes

The EMBO Journal, 34(7), 841–855.

Macrophages Modulate Engineered Human Tissues for Enhanced Vascularization and Healing

Annals of Biomedical Engineering, 43(3), 616–627.

Natural Cardiac Extracellular Matrix Hydrogels for Cultivation of Human Stem Cell-Derived Cardiomyocytes

Decellularization of Human and Porcine Lung Tissues for Pulmonary Tissue Engineering

The Annals of Thoracic Surgery, 96(3), 1046–1056.

The regulation of growth and metabolism of kidney stem cells with regional specificity using extracellular matrix derived from kidney

Biomaterials, 34(38), 9830–9841.

Macrophages modulate the viability and growth of human mesenchymal stem cells

Journal of Cellular Biochemistry, 114(1), 220–229.

549 Perfusion/Decellularization of Large Animal Lungs

The Journal of Heart and Lung Transplantation, 30(4), S184–S185.

Hybrid Gel Composed of Native Heart Matrix and Collagen Induces Cardiac Differentiation of Human Embryonic Stem Cells without Supplemental Growth Factors

Journal of Cardiovascular Translational Research, 4(5), 605–615.

Optimizing Dynamic Interactions between a Cardiac Patch and Inflammatory Host Cells

Cells Tissues Organs, 195(1-2), 171–182.

Geometry and force control of cell function

Journal of Cellular Biochemistry, 108(5), 1047–1058.

Preparation of Cardiac Extracellular Matrix from an Intact Porcine Heart

Tissue Engineering Part C: Methods, 16(3), 525–532.

Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrix

Biomaterials, 29(36), 4775–4782.

Degradation Products of Extracellular Matrix Affect Cell Migration and Proliferation

Tissue Engineering Part A, 15(3), 605–614.

Extracellular matrix as a biological scaffold material: Structure and function

Acta Biomaterialia, 5(1), 1–13.

Hybrid nanofibrous scaffolds from electrospinning of a synthetic biodegradable elastomer and urinary bladder matrix

Journal of Biomaterials Science, Polymer Edition, 19(5), 635–652.

Hydrated versus lyophilized forms of porcine extracellular matrix derived from the urinary bladder

Journal of Biomedical Materials Research Part A, 87A(4), 862–872.

Oxygen diffusivity of biologic and synthetic scaffold materials for tissue engineering

Journal of Biomedical Materials Research Part A, 91A(4), 1010–1017.

Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix

Biomaterials, 29(11), 1630–1637.

Uniaxial and biaxial properties of terminally sterilized porcine urinary bladder matrix scaffolds

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 84B(2), 408–414.

Fiber architecture and biaxial mechanical behavior of porcine urinary bladder extracellular matrix

Journal of Biomechanics, 39, S391.

Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test

Biomaterials, 26(27), 5518–5531.

Effect of storage upon material properties of lyophilized porcine extracellular matrix derived from the urinary bladder

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 78B(2), 327–333.

Esophageal Reconstruction with ECM and Muscle Tissue in a Dog Model

Journal of Surgical Research, 128(1), 87–97.

Biaxial strength of multilaminated extracellular matrix scaffolds

Biomaterials, 25(12), 2353–2361.