Works (43)

2022 journal article

Bioreactors for Vocal Fold Tissue Engineering

TISSUE ENGINEERING PART B-REVIEWS, 28(1), 182–205.

By: A. Gracioso Martins, A. Biehl n, D. Sze & D. Freytes

author keywords: vocal fold; bioreactor; lamina propria; gene expression; fibrosis; inflammation
Source: Web Of Science
Added: March 29, 2021

2022 article

Donor Age and Time in Culture Affect Dermal Fibroblast Contraction in an In Vitro Hydrogel Model

Detwiler, A., Polkoff, K., Gaffney, L., Freytes, D. O., & Piedrahita, J. A. (2022, August 4). TISSUE ENGINEERING PART A.

By: A. Detwiler n, K. Polkoff, L. Gaffney, D. Freytes & J. Piedrahita

author keywords: cell proliferation; collagen; dermis; extracellular matrix; fibroblasts; hydrogels; skin; wound healing
Source: Web Of Science
Added: August 29, 2022

2022 article

High-Axial-Aspect Tannic Acid Microparticles Facilitate Gelation and Injectability of Collagen-Based Hydrogels

Sarker, P., Nalband, D. M., Freytes, D. O., Rojas, O. J., & Khan, S. A. (2022, October 5). BIOMACROMOLECULES, Vol. 10.

By: P. Sarker, D. Nalband, D. Freytes, O. Rojas & S. Khan

Sources: Web Of Science, ORCID
Added: October 6, 2022

2022 journal article

Monitoring decellularization via absorbance spectroscopy during the derivation of extracellular matrix scaffolds

BIOMEDICAL MATERIALS, 17(1).

By: C. Mora-Navarro n, M. Garcia*, P. Sarker, E. Ozpinar, J. Enders, S. Khan, R. Branski*, D. Freytes

author keywords: extracellular matrix; manufacturing; decellularization; monitoring; vocal fold
Sources: Web Of Science, ORCID
Added: November 4, 2021

2022 article

Towards a standardized multi-tissue decellularization protocol for the derivation of extracellular matrix materials

Biehl, A., Martins, A. M. G. M., Davis, Z. G. G., Sze, D., Collins, L., Mora-Navarro, C., … Freytes, D. O. O. (2022, December 12). BIOMATERIALS SCIENCE, Vol. 12.

Sources: Web Of Science, ORCID
Added: January 3, 2023

2021 journal article

Dermal Extracellular Matrix-Derived Hydrogels as an In Vitro Substrate to Study Mast Cell Maturation

TISSUE ENGINEERING PART A, 27(15-16), 1008–1022.

By: E. Ozpinar, A. Frey*, G. Arthur, C. Mora-Navarro n, A. Biehl n, D. Snider n, G. Cruse, D. Freytes

author keywords: extracellular matrix; mast cell; allergy; metabolism
Sources: Web Of Science, ORCID
Added: December 11, 2020

2021 article

Extracellular Matrix Hydrogels Promote Expression of Muscle-Tendon Junction Proteins

Gaffney, L. S., Davis, Z. G., Mora-Navarro, C., Fisher, M. B., & Freytes, D. O. (2021, November 2). TISSUE ENGINEERING PART A, Vol. 11.

author keywords: extracellular matrix; engineered tissues; myotendinous junction; paxillin
Sources: Web Of Science, ORCID
Added: November 15, 2021

2021 journal article

Mast Cell-Biomaterial Interactions and Tissue Repair

TISSUE ENGINEERING PART B-REVIEWS, 27(6), 590–603.

By: E. Ozpinar, A. Frey n, G. Cruse & D. Freytes

author keywords: mast cells; biomaterials; inflammation; tissue repair; foreign body response; wound healing
Sources: Web Of Science, ORCID
Added: March 8, 2021

2021 journal article

Microphysiological System for High-Throughput Computer Vision Measurement of Microtissue Contraction

ACS SENSORS, 6(3), 985–994.

author keywords: high throughput; 3D culture; tissue function; tissue contraction; computer vision
Source: Web Of Science
Added: May 10, 2021

2021 journal article

Transcriptome-targeted analysis of human peripheral blood-derived macrophages when cultured on biomaterial meshes

BIOMEDICAL MATERIALS, 16(2).

author keywords: surgical meshes; macrophage polarization; biomaterials; targeted transcriptome; poly-4-hydroxybutyrate (P4HB); polypropylene
Sources: Web Of Science, ORCID
Added: January 16, 2021

2020 journal article

Photoinduced reconfiguration to control the protein-binding affinity of azobenzene-cyclized peptides

JOURNAL OF MATERIALS CHEMISTRY B, 8(33), 7413–7427.

By: K. Day, J. Schneible, A. Young, V. Pozdin, G. Driessche n, L. Gaffney, R. Prodromou, D. Freytes ...

Sources: Web Of Science, ORCID
Added: September 14, 2020

2020 journal article

Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 577, 406–418.

author keywords: Fibrin; Biomimetic; Platelet; Hemophilia; Biomaterials
Source: Web Of Science
Added: August 24, 2020

2019 journal article

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

BIOMATERIALS SCIENCE, 7(2), 669–682.

By: S. Nandi, E. Sproul, K. Nellenbach, M. Erb*, L. Gaffney, D. Freytes, A. Brown

Source: Web Of Science
Added: February 18, 2019

2018 journal article

Enhanced tissue remodelling efficacy of adipose-derived mesenchymal stem cells using injectable matrices in radiation-damaged salivary gland model

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 12(2), E695–E706.

By: J. Choi, H. An, H. Shin, Y. Kim & J. Lim

author keywords: salivary gland; adipose tissue-derived mesenchymal stem cells; small intestinal submucosa gel; radiation; regeneration; local transplantation
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure

ACS Nano, 12(7), 6536–6544.

By: H. Liang n, K. Huang n, T. Su n, Z. Li n, S. Hu n, P. Dinh n, E. Wrona*, C. Shao* ...

author keywords: mesenchymal stem cells; red blood cells; biomimetic; nanoparticles; membrane cloaking; liver failure
Sources: Crossref, ORCID
Added: September 10, 2019

2018 review

Potential Synergistic Effects of Stem Cells and Extracellular Matrix Scaffolds

[Review of ]. ACS BIOMATERIALS SCIENCE & ENGINEERING, 4(4), 1208–1222.

By: L. Gaffney, E. Wrona n & D. Freytes

author keywords: extracellular matrix (ECM); stem cells; pluripotent stem cells (PSCs); wound healing; macrophage polarization
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

BMP protein-mediated crosstalk between inflammatory cells and human pluripotent stem cell-derived cardiomyocytes

Journal of Tissue Engineering and Regenerative Medicine, 11(5), 1466–1478.

By: I. Pallotta*, B. Sun*, E. Wrona* & D. Freytes

author keywords: cardiomyocytes; macrophages; inflammation; BMP; migration; tissue engineering; regenerative medicine
Sources: Crossref, ORCID
Added: September 10, 2019

2017 journal article

Directed Differentiation of Human Pluripotent Stem Cells to Microglia

STEM CELL REPORTS, 8(6), 1516–1524.

By: P. Douvaras*, B. Sun*, M. Wang*, I. Kruglikov*, G. Lallos*, M. Zimmer*, C. Terrenoire*, B. Zhang* ...

Source: Web Of Science
Added: August 6, 2018

2017 journal article

Macrophages' role in tissue disease and regeneration

Macrophages: Origin, Functions and Biointervention, 62, 245–271.

By: L. Gaffney, P. Warren, E. Wrona, M. Fisher & D. Freytes

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Differential gene expression in human, murine, and cell line-derived macrophages upon polarization

Experimental Cell Research, 347(1), 1–13.

By: K. Spiller*, E. Wrona*, S. Romero-Torres*, I. Pallotta*, P. Graney*, C. Witherel*, L. Panicker*, R. Feldman* ...

author keywords: Classically activated; Alternatively activated macrophages; Wound healing; In vitro characterization; Angiogenesis; Tissue engineering; Induced pluripotent stem cells; Biomaterials
Sources: Crossref, ORCID
Added: September 10, 2019

2016 review

Extracellular Matrix for Vocal Fold Lamina Propria Replacement: A Review

[Review of ]. TISSUE ENGINEERING PART B-REVIEWS, 22(6), 421–429.

By: E. Wrona n, R. Peng*, M. Amin*, R. Branski* & D. Freytes

author keywords: voice; vocal fold; extracellular matrix; scaffold
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Response of human macrophages to wound matrices in vitro

WOUND REPAIR AND REGENERATION, 24(3), 514–524.

By: C. Witherel*, P. Graney*, D. Freytes, M. Weingarten* & K. Spiller*

Source: Web Of Science
Added: August 6, 2018

2015 journal article

Controlled release of cytokines using silk-biomaterials for macrophage polarization

Biomaterials, 73, 272–283.

By: A. Reeves*, K. Spiller*, D. Freytes, G. Vunjak-Novakovic* & D. Kaplan*

author keywords: Macrophage; Polarization; Silk; Cytokine
Source: Crossref
Added: February 24, 2020

2015 journal article

Derivation and characterization of porcine vocal fold extracellular matrix scaffold

The Laryngoscope, 126(4), 928–935.

By: E. Wrona*, R. Peng*, H. Born*, M. Amin*, R. Branski* & D. Freytes

author keywords: Vocal fold; extracellular matrix; mesenchymal stem cells; scaffold
Sources: Crossref, ORCID
Added: September 10, 2019

2015 journal article

Reprint of: Extracellular matrix as a biological scaffold material: Structure and function

Acta Biomaterialia, 23, S17–S26.

By: S. Badylak*, D. Freytes & T. Gilbert*

Source: Crossref
Added: February 24, 2020

2014 journal article

Macrophages Modulate Engineered Human Tissues for Enhanced Vascularization and Healing

Annals of Biomedical Engineering, 43(3), 616–627.

author keywords: Scaffold; Vascularization; Inflammatory response; Tissue engineering; Healing
Source: Crossref
Added: January 21, 2021

2013 journal article

Decellularization of Human and Porcine Lung Tissues for Pulmonary Tissue Engineering

The Annals of Thoracic Surgery, 96(3), 1046–1056.

By: J. O'Neill*, R. Anfang*, A. Anandappa*, J. Costa*, J. Javidfar*, H. Wobma*, G. Singh*, D. Freytes ...

Source: Crossref
Added: August 28, 2020

2013 journal article

The regulation of growth and metabolism of kidney stem cells with regional specificity using extracellular matrix derived from kidney

Biomaterials, 34(38), 9830–9841.

By: J. O'Neill*, D. Freytes, A. Anandappa*, J. Oliver* & G. Vunjak-Novakovic*

author keywords: Extracellular matrix; Hydrogels; Kidney; Stem cells; Niche; Regional specificity
Source: Crossref
Added: August 28, 2020

2012 journal article

Macrophages modulate the viability and growth of human mesenchymal stem cells

Journal of Cellular Biochemistry, 114(1), 220–229.

By: D. Freytes, J. Kang*, I. Marcos-Campos* & G. Vunjak-Novakovic*

author keywords: MESENCHYMAL STEM CELLS; MACROPHAGES; INFLAMMATION
Source: Crossref
Added: January 21, 2021

2011 journal article

549 Perfusion/Decellularization of Large Animal Lungs

The Journal of Heart and Lung Transplantation, 30(4), S184–S185.

By: G. Singh*, J. Javidfar*, J. Costa*, J. Guarrera*, J. Miller*, S. Henry*, Q. Jallerat*, D. Freytes ...

Source: Crossref
Added: August 28, 2020

2011 journal article

Hybrid Gel Composed of Native Heart Matrix and Collagen Induces Cardiac Differentiation of Human Embryonic Stem Cells without Supplemental Growth Factors

Journal of Cardiovascular Translational Research, 4(5), 605–615.

author keywords: Tissue engineering; Cardiac differentiation; Human embryonic stem cells; Biomaterial; Native cardiac matrix
Source: Crossref
Added: August 28, 2020

2009 journal article

Extracellular matrix as a biological scaffold material: Structure and function

Acta Biomaterialia, 5(1), 1–13.

By: S. Badylak, D. Freytes & T. Gilbert

author keywords: Extracellular matrix; Scaffold; Remodeling; Degradation; Ultrastructure
Source: Crossref
Added: August 28, 2020

2009 journal article

Geometry and force control of cell function

Journal of Cellular Biochemistry, 108(5), 1047–1058.

author keywords: STEM CELLS; BIOPHYSICAL REGULATION; SCAFFOLDS; BIOREACTORS; TISSUE ENGINEERING
Source: Crossref
Added: August 28, 2020

2009 journal article

Oxygen diffusivity of biologic and synthetic scaffold materials for tissue engineering

Journal of Biomedical Materials Research Part A, 91A(4), 1010–1017.

By: J. Valentin*, D. Freytes, J. Grasman*, C. Pesyna*, J. Freund*, T. Gilbert*, S. Badylak*

author keywords: biologic scaffold material; extracellular matrix; tissue engineering; oxygen diffusivity; ultrastructure
Source: Crossref
Added: August 28, 2020

2008 journal article

Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrix

Biomaterials, 29(36), 4775–4782.

By: T. Gilbert*, S. Wognum*, E. Joyce*, D. Freytes, M. Sacks* & S. Badylak*

author keywords: Extracellular matrix; Scaffold; Collagen fiber alignment; Biaxial mechanical behavior
Source: Crossref
Added: August 28, 2020

2008 journal article

Hydrated versus lyophilized forms of porcine extracellular matrix derived from the urinary bladder

Journal of Biomedical Materials Research Part A, 87A(4), 862–872.

By: D. Freytes, R. Tullius*, J. Valentin*, A. Stewart-Akers* & S. Badylak*

author keywords: extracellular matrix; lyophilization; freeze-drying; scaffold; structural properties; urinary bladder
Source: Crossref
Added: August 28, 2020

2008 journal article

Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix

Biomaterials, 29(11), 1630–1637.

By: D. Freytes, J. Martin*, S. Velankar*, A. Lee* & S. Badylak*

author keywords: extracellular matrix; viscoelasticity; rheology; scaffold; gel
Source: Crossref
Added: August 28, 2020

2008 journal article

Uniaxial and biaxial properties of terminally sterilized porcine urinary bladder matrix scaffolds

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 84B(2), 408–414.

By: D. Freytes, R. Stoner* & S. Badylak*

author keywords: sterilization; extracellular matrix; material properties; strength; scaffolds
Source: Crossref
Added: August 28, 2020

2006 journal article

Effect of storage upon material properties of lyophilized porcine extracellular matrix derived from the urinary bladder

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 78B(2), 327–333.

By: D. Freytes, R. Tullius* & S. Badylak*

author keywords: stability; suture; scaffold; permeability; mechanical properties; urinary bladder; extracellular matrix
Source: Crossref
Added: August 28, 2020

2006 journal article

Fiber architecture and biaxial mechanical behavior of porcine urinary bladder extracellular matrix

Journal of Biomechanics, 39, S391.

By: T. Gilbert, D. Freytes, A. Willment, M. Sacks & S. Badylak

Source: Crossref
Added: August 28, 2020

2005 journal article

Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test

Biomaterials, 26(27), 5518–5531.

By: D. Freytes, A. Rundell*, J. Vandegeest*, D. Vorp*, T. Webster* & S. Badylak*

author keywords: bladder; ECM; multilaminate devices; mechanical properties; mechanical test; ball-burst test; scaffold
Source: Crossref
Added: August 28, 2020

2005 journal article

Esophageal Reconstruction with ECM and Muscle Tissue in a Dog Model

Journal of Surgical Research, 128(1), 87–97.

By: S. Badylak*, D. Vorp*, A. Spievack*, A. Simmons-Byrd*, J. Hanke*, D. Freytes, A. Thapa*, T. Gilbert*, A. Nieponice*

author keywords: extracellular matrix; urinary bladder matrix; esophagus; surgery; tissue engineering; scaffold; esophageal cancer; regenerative medicine; bioscaffold
Source: Crossref
Added: August 28, 2020

2004 journal article

Biaxial strength of multilaminated extracellular matrix scaffolds

Biomaterials, 25(12), 2353–2361.

By: D. Freytes, S. Badylak*, T. Webster*, L. Geddes* & A. Rundell*

author keywords: ECM (extracellular matrix); ball-burst strength; mechanical properties; SEM (scanning electron microscopy); SIS (small intestinal submucosa); disinfection
Source: Crossref
Added: August 28, 2020