Shijing Fang

Works (19)

Updated: July 9th, 2023 21:19

2018 article

MARCKS and Lung Disease

Sheats, M. K., Yin, Q., Fang, S., Park, J., Crews, A. L., Parikh, I., … Adler, K. B. (2018, October 19). American Journal of Respiratory Cell and Molecular Biology, Vol. 60, pp. 16–27.

By: M. Sheats* , Q. Yin n, S. Fang n, J. Park n, A. Crews n, I. Parikh*, B. Dickson*, K. Adler n

author keywords: MARCKS; lung disease; inflammation; cancer
MeSH headings : Animals; Humans; Lung Diseases / metabolism; Lung Diseases / physiopathology; Myristoylated Alanine-Rich C Kinase Substrate / metabolism
topics (OpenAlex): Cellular Mechanics and Interactions; Skin and Cellular Biology Research
TL;DR: This article summarizes the structure and cellular function of MARCKS (also including MARC KS family proteins and MARCKSL1 [MARCKS‐like protein 1]). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019

2016 article

An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice

Yin, Q., Fang, S., Park, J., Crews, A. L., Parikh, I., & Adler, K. B. (2016, August 24). American Journal of Respiratory Cell and Molecular Biology.

By: Q. Yin n, S. Fang n, J. Park n, A. Crews n, I. Parikh* & K. Adler n

author keywords: myristoylated alanine-rich C kinase substrate; acute lung injury; LPS; neutrophils
MeSH headings : Acute Lung Injury / chemically induced; Acute Lung Injury / drug therapy; Aerosols / administration & dosage; Aerosols / pharmacology; Animals; Behavior, Animal; Bronchoalveolar Lavage Fluid; Cytokines / metabolism; Female; Inflammation Mediators / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / metabolism; Leukocytes / metabolism; Lipopolysaccharides; Lung / drug effects; Lung / metabolism; Lung / pathology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / metabolism; Mice, Inbred BALB C; Myristoylated Alanine-Rich C Kinase Substrate; NF-kappa B / metabolism; Peptides / administration & dosage; Peptides / pharmacology; Peptides / therapeutic use
topics (OpenAlex): Enzyme function and inhibition; Phosphodiesterase function and regulation; Nitric Oxide and Endothelin Effects
TL;DR: Results implicate MARCKS protein in the pathogenesis of ALI/ARDS and suggest that MARC KS-inhibitory peptide(s), delivered by inhalation, could represent a new and potent therapeutic treatment for ALi/ARDS, even if administered well after the disease process has begun. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 article

MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro

Fang, S., Crews, A. L., Chen, W., Park, J., Yin, Q., Ren, X.-R., & Adler, K. B. (2013, February 2). American Journal of Physiology-Lung Cellular and Molecular Physiology.

By: S. Fang n, A. Crews n, W. Chen *, J. Park n, Q. Yin n, X. Ren*, K. Adler n

author keywords: airway; mucin; secretion; myristoylated alanine-rich C kinase substrate; heat shock protein 70
MeSH headings : Base Sequence; Bronchi / cytology; Bronchi / drug effects; Bronchi / metabolism; Bronchi / physiology; Cell Differentiation; Cells, Cultured; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / physiology; HSP40 Heat-Shock Proteins / physiology; HSP70 Heat-Shock Proteins / antagonists & inhibitors; HSP70 Heat-Shock Proteins / genetics; HSP70 Heat-Shock Proteins / physiology; Humans; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / genetics; Membrane Proteins / physiology; Microscopy, Confocal; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport; Pyrimidinones / pharmacology; RNA, Small Interfering / genetics; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Tetradecanoylphorbol Acetate / pharmacology
topics (OpenAlex): Heat shock proteins research; Toxin Mechanisms and Immunotoxins; Endoplasmic Reticulum Stress and Disease
TL;DR: Evidence is provided of a role for HSP70 in mediating mucin secretion via interactions with MARCKS and that these interactions are critical for the cytoplasmic translocation of MARC KS upon its phosphorylation. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 journal article

A Myristoylated Alanine-Rich C Kinase Substrate–Related Peptide Suppresses Cytokine mRNA and Protein Expression in LPS-Activated Canine Neutrophils

American Journal of Respiratory Cell and Molecular Biology, 48(3), 314–321.

By: J. Li, M. D’Annibale-Tolhurst, K. Adler*, S. Fang*, Q. Yin, A. Birkenheuer* , M. Levy n, S. Jones*  ...

author keywords: MARCKS; cytokine; inflammation; neutrophil
MeSH headings : Animals; Dogs; Humans; Interleukin-8 / biosynthesis; Interleukin-8 / genetics; Interleukin-8 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Lipopolysaccharides / pharmacology; Membrane Proteins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Neutrophils / drug effects; Neutrophils / metabolism; Peptides / metabolism; Peptides / pharmacology; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Cell Adhesion Molecules Research; Immune cells in cancer
TL;DR: Observations identify MARCKS protein as a promising therapeutic target in the treatment of inflammatory diseases or syndromes attributed to neutrophil influx and inflammatory cytokine production, such as sepsis, acute lung injury, and acute respiratory distress syndrome. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2012 article

Calpain and MARCKS protein regulation of airway mucin secretion

Lampe, W. R., Park, J., Fang, S., Crews, A. L., & Adler, K. B. (2012, June 18). Pulmonary Pharmacology & Therapeutics.

By: W. Lampe n, J. Park n, S. Fang n, A. Crews n & K. Adler n

author keywords: Airway; Mucin; MARCKS; Calpain; Secretion
MeSH headings : Bronchi / cytology; Bronchi / metabolism; Calpain / antagonists & inhibitors; Calpain / metabolism; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells / metabolism; Fluorescence; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oligopeptides / administration & dosage; Oligopeptides / pharmacology; Protein Kinase C / metabolism; Tetradecanoylphorbol Acetate / pharmacology
topics (OpenAlex): RNA regulation and disease; Galectins and Cancer Biology; Lysosomal Storage Disorders Research
TL;DR: Cleavage of MARCKS by Calpain may have an important role in regulation of the PKC/MARCKS pathway regulating airway mucin secretion, as opposed to the original hypothesis, inactivating Calpain caused a decrease rather than an increase in secretion. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 journal article

Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein

Journal of Leukocyte Biology, 92(3), 633–639.

By: T. Green n, J. Park n, Q. Yin n, S. Fang n, A. Crews n, S. Jones n , K. Adler n

author keywords: cytoplasmic translocation; J774A.1 cells; monocyte chemotactic protein 1; chemotaxis
MeSH headings : Actin Cytoskeleton / immunology; Actin Cytoskeleton / metabolism; Animals; Blotting, Western; Chemotaxis, Leukocyte / physiology; Intracellular Signaling Peptides and Proteins / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Macrophages / immunology; Macrophages / metabolism; Membrane Proteins / immunology; Membrane Proteins / metabolism; Mice; Microscopy, Confocal; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport / physiology
topics (OpenAlex): Cellular Mechanics and Interactions; Cell Adhesion Molecules Research; S100 Proteins and Annexins
TL;DR: Results suggest that MARCKS is involved in directed migration of macrophages via a process involving its phosphorylation, cytoplasmic translocation, and interaction with actin. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2011 article

Mucin granule-associated proteins in human bronchial epithelial cells: the airway goblet cell "granulome"

Raiford, K. L., Park, J., Lin, K.-W., Fang, S., Crews, A. L., & Adler, K. B. (2011, September 6). Respiratory Research.

By: K. Raiford*, J. Park n, K. Lin *, S. Fang n, A. Crews n & K. Adler n

MeSH headings : Bronchi / chemistry; Bronchi / metabolism; Cells, Cultured; Cytoplasmic Granules / chemistry; Cytoplasmic Granules / metabolism; Cytoplasmic Granules / ultrastructure; Goblet Cells / chemistry; Goblet Cells / metabolism; Humans; Membrane Glycoproteins / chemistry; Membrane Glycoproteins / metabolism; Membrane Glycoproteins / ultrastructure; Mucins / chemistry; Mucins / metabolism; Respiratory Mucosa / chemistry; Respiratory Mucosa / metabolism
topics (OpenAlex): Cystic Fibrosis Research Advances; Asthma and respiratory diseases; Inhalation and Respiratory Drug Delivery
TL;DR: This work isolated mucin granules and granule membranes from primary cultures of well differentiated human bronchial epithelial cells utilizing a novel technique of immuno-isolation, based on the presence of the calcium activated chloride channel hCLCA1 on thegranule membranes, and verified via Western blotting and co-immunoprecipitation that MARCKS, HSP70, CSP and hCL CA1 were present on the granule membrane and associated with each other. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

Regulation of mucin secretion and inflammation in asthma: A role for MARCKS protein?

Green, T. D., Crews, A. L., Park, J., Fang, S., & Adler, K. B. (2011, February 1). Biochimica Et Biophysica Acta (BBA) - General Subjects.

By: T. Green, A. Crews n, J. Park n, S. Fang n & K. Adler n

author keywords: MARCKS; Mucin; Secretion; Asthma
MeSH headings : Animals; Asthma / etiology; Humans; Inflammation / etiology; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / physiology; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate
topics (OpenAlex): Protein Kinase Regulation and GTPase Signaling; Signaling Pathways in Disease
TL;DR: The properties of MARCKS and how the protein may regulate mucin secretion at a cellular level will be discussed and the roles ofMARCKS in airway inflammation related to both influx of inflammatory cells into the lung and release of granules containing inflammatory mediators by these cells will be explored. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

MARCKS and Related Chaperones Bind to Unconventional Myosin V Isoforms in Airway Epithelial Cells

Lin, K.-W., Fang, S., Park, J., Crews, A. L., & Adler, K. B. (2010, March 4). American Journal of Respiratory Cell and Molecular Biology.

By: K. Lin n, S. Fang n, J. Park n, A. Crews n & K. Adler n

author keywords: airway; mucin; MARCKS; chaperones; myosin
MeSH headings : Bronchi / pathology; Epithelial Cells / cytology; Gene Expression Regulation; HSP70 Heat-Shock Proteins / chemistry; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Biological; Molecular Chaperones; Mucins / metabolism; Myosin Heavy Chains / chemistry; Myosin Type V / chemistry; Myristoylated Alanine-Rich C Kinase Substrate; Protein Binding; Protein Isoforms; Tetradecanoylphorbol Acetate / chemistry; Transfection
topics (OpenAlex): Signaling Pathways in Disease; Viral Infections and Immunology Research; RNA regulation and disease
TL;DR: It is reported that myristoylated alanine-rich C kinase substrate (MARCKS) also interacts with unconventional myosin isoforms within these cells, and further molecular interactions between MARCKS and these chaperones/cytoskeletal proteins are elucidated. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

MARCKS protein regulation of mucin secretion in airway epithelial cells: binding of MARCKS to chaperones and to MyosinV.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A993.

By: K. Lin, F. J. J., . S. & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

MARCKS regulation of mucin secretion by airway epithelial cells in vitro: interactions with chaperone proteins.

American Journal of Respiratory Cell and Molecular Biology, 102, 949–955.

By: J. Park, S. Fang, A. Crews, K. Lin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 article

MARCKS regulation of mucin secretion by airway epithelium in vitro - Interaction with chaperones

Joungjoa Park; Shijing Fang; Anne Crews; Ko-Wei Lin; Kenneth Adler

topics (OpenAlex):
Source: NC State University Libraries
Added: August 6, 2018

2007 article

Protein Kinase Cδ Regulates Airway Mucin Secretion via Phosphorylation of MARCKS Protein

Park, J.-A., Crews, A. L., Lampe, W. R., Fang, S., Park, J., & Adler, K. B. (2007, November 30). American Journal Of Pathology.

By: J. Park n, A. Crews n, W. Lampe n, S. Fang n, J. Park n & K. Adler n

MeSH headings : Acetophenones / pharmacology; Benzopyrans / pharmacology; Bronchi / drug effects; Bronchi / enzymology; Bronchi / metabolism; Bryostatins / pharmacology; Cell Line; Enzyme Activation; Epithelial Cells / drug effects; Epithelial Cells / enzymology; Epithelial Cells / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C-delta / antagonists & inhibitors; Protein Kinase C-delta / genetics; Protein Kinase C-delta / physiology; Protein Kinase Inhibitors / pharmacology; Tetradecanoylphorbol Acetate / pharmacology
topics (OpenAlex): Cystic Fibrosis Research Advances; Glycosylation and Glycoproteins Research; Proteoglycans and glycosaminoglycans research
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Source: Web Of Science
Added: August 6, 2018

2007 article

Proteomic analysis of mucin granule membrane-associated proteins in human airway epithelial cells: a mechanistic link between MARCKS and hClCA1?

404nOtfound, Vol. 175, p. A511.

By: K. Raiford, K. Lin, J. Park, S. Fang, A. Crews & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2006 article

Regulation of Airway Mucin Secretion by MARCKS Protein Involves the Chaperones Heat Shock Protein 70 and Cysteine String Protein

Park, J., Fang, S., & Adler, K. B. (2006, August 1). Proceedings of the American Thoracic Society.

By: J. Park n, S. Fang n & K. Adler n

MeSH headings : Blotting, Western; Bronchi / cytology; Bronchi / metabolism; HSP40 Heat-Shock Proteins / metabolism; HSP70 Heat-Shock Proteins / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Nerve Tissue Proteins / metabolism; Protein Kinase C / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism
topics (OpenAlex): Heat shock proteins research; Galectins and Cancer Biology; Endoplasmic Reticulum Stress and Disease
Source: NC State University Libraries
Added: August 6, 2018

2005 article

A peptide directed against the N-terminus of MARCKS protein attenuates release of myeloperoxidase (MPO) from human and canine neutrophils in vitro.

404nOtfound, Vol. 2, p. A633.

By: S. Takashi, C. Pettersen, J. Park, S. Fang, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2005 article

Cysteine String Protein is involved in mucin secretion from normal human bronchial epithelial (NHBE) cells in vitro.

404nOtfound, Vol. 2, p. A215.

By: J. Park, S. Fang & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2005 article

Mechanisms of mucus secretion in the airways

Adler, K. B., Fang, S., Lin, K.-W., & Park, J. (2005, December 6). Journal of Organ Dysfunction.

By: K. Adler n, S. Fang n, K. Lin n & J. Park n

topics (OpenAlex): Neuroscience of respiration and sleep; Pediatric health and respiratory diseases; Neonatal Respiratory Health Research
Source: NC State University Libraries
Added: August 6, 2018

2004 article

Small interfering RNA?s directed against MARCKS protein and Heat Shock Protein 70 (Hsp70) attenuate mucin secretion in human airway epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 169, p. A712.

By: S. Fang, J. Park & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

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