Abdulkerim Eroglu

Also known as: KERIM EROGLU

https://orcid.org/0000-0001-5350-450X

carotenoids, systems biology, proteomics, metagenomics, synthetic biology, gut microbiome

Works (20)

Updated: November 28th, 2023 04:31
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2023 review

Carotenoids and Their Health Benefits as Derived via Their Interactions with Gut Microbiota

[Review of ]. ADVANCES IN NUTRITION, 14(2), 238–255.

By: A. Eroglu n , I. Al'Abri n, R. Kopec *, N. Crook n  & T. Bohn *

co-author countries: Luxembourg 🇱🇺 United States of America 🇺🇸
author keywords: Carotenes; xanthophylls; digestion; carotenoid metabolites; gut bacteria; microbiome; mucosal layer; inflammation; oxidative stress; bactericidal effects; Bifidobacterium spp; Akkermansia spp
MeSH headings : Humans; Carotenoids / pharmacology; Carotenoids / metabolism; Gastrointestinal Microbiome; Colon / metabolism; Prebiotics; Dietary Supplements
Sources: Web Of Science, ORCID
Added: April 11, 2023

2023 journal article

Carotenoids in Health as Studied by Omics-Related Endpoints

Advances in Nutrition.

By: T. Bohn *, E. Balbuena n, H. Ulus n, M. Iddir*, G. Wang  n, N. Crook  n, A. Eroglu n 

co-author countries: Luxembourg 🇱🇺 United States of America 🇺🇸
Source: ORCID
Added: September 9, 2023

2022 journal article

Carotenoids in orange carrots mitigate non-alcoholic fatty liver disease progression

FRONTIERS IN NUTRITION, 9.

By: E. Balbuena n, J. Cheng n & A. Eroglu n 

co-author countries: United States of America 🇺🇸
author keywords: phytochemicals; nutrition; beta-oxidation; nuclear receptors; lipid metabolism
Sources: Web Of Science, ORCID
Added: October 24, 2022

2021 journal article

In Situ Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic Saccharomyces boulardii

ACS SYNTHETIC BIOLOGY, 10(5), 1039–1052.

By: D. Durmusoglu n, I. Al'Abri n, S. Collins n, J. Cheng n, A. Eroglu n , C. Beisel n, N. Crook n 

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
author keywords: Saccharomyces boulardii; probiotic engineering; metabolic engineering; colonization profile; in situ production; beta-carotene
MeSH headings : Animals; Antineoplastic Agents / metabolism; CRISPR-Cas Systems; Feces / chemistry; Female; Gastrointestinal Microbiome; Gastrointestinal Tract / metabolism; Gastrointestinal Tract / microbiology; Gene Editing / methods; Gene Expression; Indoles / metabolism; Male; Metabolic Engineering / methods; Mice; Mice, Inbred C57BL; Microorganisms, Genetically-Modified; Multigene Family; Plasmids / genetics; Probiotics / metabolism; Promoter Regions, Genetic; Provitamins / biosynthesis; Saccharomyces boulardii / genetics; Saccharomyces boulardii / metabolism; Saccharomyces cerevisiae / genetics; beta Carotene / biosynthesis
Sources: Web Of Science, ORCID
Added: May 6, 2021

2021 review

The Promising Effects of Astaxanthin on Lung Diseases

[Review of ]. ADVANCES IN NUTRITION, 12(3), 850–864.

By: J. Cheng n & A. Eroglu n 

co-author countries: United States of America 🇺🇸
author keywords: astaxanthin; lung diseases; oxidative stress; molecular mechanism; lung cancer
MeSH headings : Humans; Lung Diseases / drug therapy; Oxidative Stress; Phosphatidylinositol 3-Kinases / metabolism; Signal Transduction; Xanthophylls / pharmacology
Sources: Web Of Science, ORCID
Added: January 10, 2021

2021 journal article

The Role of beta-Carotene in Colonic Inflammation and Intestinal Barrier Integrity

FRONTIERS IN NUTRITION, 8.

By: J. Cheng n, E. Balbuena n, B. Miller n & A. Eroglu n 

co-author countries: United States of America 🇺🇸
author keywords: beta-carotene; colonic inflammation; colonic epithelial cells; tight junctions; vitamin A
Sources: Web Of Science, ORCID
Added: November 23, 2021

2020 journal article

Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair

Antioxidants.

By: J. Cheng  n, B. Miller n, E. Balbuena n & A. Eroğlu n 

co-author countries: United States of America 🇺🇸
author keywords: lycopene; beta-carotene; lung cancer; base excision repair; gap junction communication; all-trans retinoic acid; oxidative stress
Source: ORCID
Added: July 26, 2020

2020 article

Nutrient modulation of DNA repair in lung cancer

Eroglu, A., & Balbuena, E. (2020, April). FASEB JOURNAL, Vol. 34.

By: A. Eroglu n  & E. Balbuena n

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: October 12, 2020

2020 article

The Colors of Health: Chemistry, Bioactivity, and Market Demand for Colorful Foods and Natural Food Sources of Colorants

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11, Vol. 11, pp. 145–182.

By: E. Mejia*, Q. Zhang *, K. Penta n, A. Eroglu n  & M. Lila n 

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: anthocyanins; betalains; bioactivity; carotenoids; natural colors; phycocyanins
MeSH headings : Color; Food; Pigments, Biological / chemistry
Sources: Web Of Science, ORCID
Added: April 27, 2020

2019 journal article

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model.

PloS One.

By: J. Kalin *, A. Eroglu* , H. Liu *, W. Holtzclaw*, I. Leigh *, C. Proby *, J. Fahey *, P. Cole *, A. Dinkova-Kostova *

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸

Ed(s): T. Oberyszyn

MeSH headings : Administration, Topical; Animals; Benzamides / administration & dosage; Benzamides / pharmacology; Carcinoma, Squamous Cell / drug therapy; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / prevention & control; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Gene Expression Regulation, Neoplastic / drug effects; Histone Deacetylase Inhibitors / administration & dosage; Histone Deacetylase Inhibitors / pharmacology; Humans; Mice; Mice, Hairless; Neoplasms, Radiation-Induced / drug therapy; Neoplasms, Radiation-Induced / metabolism; Neoplasms, Radiation-Induced / prevention & control; Pyridines / administration & dosage; Pyridines / pharmacology; Skin Neoplasms / drug therapy; Skin Neoplasms / etiology; Skin Neoplasms / metabolism; Skin Neoplasms / prevention & control; Tumor Burden / drug effects; Xenograft Model Antitumor Assays
Source: ORCID
Added: May 4, 2019

2018 journal article

A plasma proteome is associated with carotenoid status and dietary intake of food sources of carotenoids in Nepalese school aged children

Archives of Biochemistry and Biophysics, 646, 153–160.

By: A. Eroglu , K. Schulze, J. Yager, R. Cole, P. Christian, B. Nonyane, S. Lee, L. Wu ...

Source: NC State University Libraries
Added: February 8, 2019

2018 journal article

Plasma proteins associated with circulating carotenoids in Nepalese school-aged children.

Archives of Biochemistry and Biophysics.

By: A. Eroglu* , K. Schulze *, J. Yager*, R. Cole, P. Christian *, B. Nonyane *, S. Lee *, L. Wu* ...

co-author countries: United States of America 🇺🇸
author keywords: Proteomics; Plasma proteins; beta-cryptoxanthin; Antioxidants; Carotenoids; Nepal
MeSH headings : Biomarkers / blood; Biomarkers / metabolism; Blood Proteins / analysis; Blood Proteins / metabolism; Carotenoids / blood; Carotenoids / metabolism; Child; Humans; Linear Models; Mass Spectrometry / methods; Nepal; Proteomics / methods
Source: ORCID
Added: May 4, 2019

2018 journal article

Plasma proteome correlates of lipid and lipoprotein: biomarkers of metabolic diversity and inflammation in children of rural Nepal

Journal of Lipid Research, 60(1), 149–160.

By: S. Lee *, K. Schulze *, C. Stewart *, R. Cole *, L. Wu*, A. Eroğlu* , J. Yager*, J. Groopman* ...

co-author countries: United States of America 🇺🇸
author keywords: plasma proteomics; high density lipoprotein-cholesterol; low density lipoprotein-cholesterol; triglycerides
MeSH headings : Biomarkers / blood; Biomarkers / metabolism; Child; Female; Humans; Inflammation / blood; Inflammation / metabolism; Lipoproteins / blood; Lipoproteins / metabolism; Male; Nepal; Proteomics; Rural Population
Sources: Web Of Science, ORCID
Added: February 8, 2019

2018 journal article

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

Nature Communications, 9(1), 53.

By: J. Kalin *, M. Wu *, A. Gomez*, Y. Song *, J. Das *, D. Hayward*, N. Adejola*, M. Wu * ...

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 Italy 🇮🇹 United States of America 🇺🇸
MeSH headings : Aged; Animals; Antineoplastic Agents; Benzamides / pharmacology; Cell Line, Tumor; Cell Proliferation; Co-Repressor Proteins / antagonists & inhibitors; Co-Repressor Proteins / metabolism; Drug Design; Drug Screening Assays, Antitumor; Female; Histone Deacetylase Inhibitors / pharmacology; Histone Deacetylases / chemistry; Humans; Male; Melanoma / drug therapy; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Nerve Tissue Proteins / antagonists & inhibitors; Nerve Tissue Proteins / metabolism; Oligonucleotide Array Sequence Analysis; Pyridines / pharmacology; Repressor Proteins / antagonists & inhibitors; Repressor Proteins / metabolism; Skin Neoplasms / drug therapy; Tranylcypromine / pharmacology; Xenograft Model Antitumor Assays
Sources: Web Of Science, ORCID
Added: February 8, 2019

2017 journal article

Synthesis of apo-13- and apo-15-lycopenoids, cleavage products of lycopene that are retinoic acid antagonists

Journal of Lipid Research, 58(5), 1021–1029.

By: S. Narayanasamy *, J. Sun *, R. Pavlovicz*, A. Eroglu* , C. Rush*, B. Sunkel *, C. Li *, E. Harrison *, R. Curley*

co-author countries: United States of America 🇺🇸
MeSH headings : Carotenoids / chemical synthesis; Carotenoids / chemistry; Carotenoids / metabolism; Carotenoids / pharmacology; Chemistry Techniques, Synthetic; Gene Expression Regulation / drug effects; Hep G2 Cells; Humans; Lycopene; Molecular Docking Simulation; Protein Conformation; Receptors, Retinoic Acid / antagonists & inhibitors; Receptors, Retinoic Acid / chemistry; Receptors, Retinoic Acid / metabolism
Sources: NC State University Libraries, ORCID
Added: February 8, 2019

2016 journal article

Inhibition of RPE65 retinol isomerase activity by inhibitors of lipid metabolism

Journal of Biological Chemistry, 291, 4966–4973.

By: A. Eroglu* , S. Gentleman*, E. Poliakov * & T. Redmond *

co-author countries: United States of America 🇺🇸
author keywords: enzyme inhibitor; liposome; retinal metabolism; retinoid; vision; RPE65; triacsin C; visual cycle; fatty acyl:CoA ligase
MeSH headings : Amino Acid Sequence; Animals; Binding Sites; Chickens; Coenzyme A Ligases / antagonists & inhibitors; Enzyme Inhibitors / pharmacology; HEK293 Cells; Humans; Molecular Sequence Data; Protein Binding; Triazenes / pharmacology; cis-trans-Isomerases / antagonists & inhibitors; cis-trans-Isomerases / chemistry; cis-trans-Isomerases / genetics; cis-trans-Isomerases / metabolism
Sources: Web Of Science, ORCID
Added: February 8, 2019

2013 journal article

Carotenoid metabolism in mammals, including man; formation, occurrence, and function of apocarotenoids

Journal of Lipid Research, 54, 1719–1730.

By: A. Eroglu*  & E. Harrison *

co-author countries: United States of America 🇺🇸
author keywords: retinoids; vitamin A; beta-carotene; lycopene
MeSH headings : Animals; Carotenoids / metabolism; Humans; Male
Sources: Web Of Science, ORCID
Added: February 8, 2019

2012 journal article

Naturally-occurring eccentric cleavage products of provitamin A carotene b-carotene function as antagonists of retinoic acid receptors

Journal of Biological Chemistry, 287, 15886–158995.

By: A. Eroglu* , D. Hruszkewycz*, C. Sena*, S. Narayanasamy *, K. Riedl*, R. Kopec *, S. Schwartz*, E. Harrison *, R. Curley*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Binding, Competitive; COS Cells; Carotenoids / chemistry; Carotenoids / metabolism; Carotenoids / pharmacology; Chlorocebus aethiops; Cytochrome P-450 Enzyme System; Gene Expression / drug effects; Hep G2 Cells; Humans; Models, Molecular; Molecular Structure; Radioligand Assay; Receptors, Retinoic Acid / antagonists & inhibitors; Receptors, Retinoic Acid / genetics; Receptors, Retinoic Acid / metabolism; Retinoic Acid 4-Hydroxylase; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation / drug effects; Tretinoin / metabolism; Tretinoin / pharmacology; Tritium; beta Carotene / chemistry; beta Carotene / metabolism
Sources: Web Of Science, ORCID
Added: February 8, 2019

2012 journal article

The formation, occurrence and function of b-apocarotenoids: b-Carotene metabolites that may modulate nuclear receptor signaling

American Journal of Clinical Nutrition, 96, 1189–1192.

By: E. Harrison, C. Sena, A. Eroglu*  & M. Fleshman

MeSH headings : Animals; Carotenoids / metabolism; Food; Mice; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Retinoic Acid / antagonists & inhibitors; Receptors, Retinoic Acid / metabolism; Signal Transduction; Transcriptional Activation; Tretinoin / metabolism; beta Carotene / metabolism
Sources: Web Of Science, ORCID
Added: February 8, 2019

2010 journal article

The eccentric cleavage product of b- carotene, b-apo-13-carotenone, functions as an antagonist of RXRa

Archives of Biochemistry and Biophysics, 504, 11–16.

By: A. Eroglu* , D. Hruszkewycz*, R. Curley* & E. Harrison *

co-author countries: United States of America 🇺🇸
author keywords: beta-Apocarotenoids; Retinoids; Retinoid receptors; Carotenoids
MeSH headings : Animals; COS Cells; Carotenoids / metabolism; Carotenoids / pharmacology; Chlorocebus aethiops; Humans; Ligands; Mice; Models, Molecular; Protein Multimerization; Protein Structure, Quaternary; Rats; Retinoid X Receptor alpha / agonists; Retinoid X Receptor alpha / antagonists & inhibitors; Retinoid X Receptor alpha / chemistry; Retinoid X Receptor alpha / metabolism; Transcriptional Activation / drug effects; Tretinoin / metabolism; Tretinoin / pharmacology; beta Carotene / metabolism
Sources: Web Of Science, ORCID
Added: February 8, 2019

Employment

Updated: December 9th, 2018 08:55

2018 - present

North Carolina State University Raleigh, NC, US
Assistant Professor Molecular and Structural Biochemistry

2016 - 2018

Johns Hopkins Bloomberg School of Public Health Baltimore, MD, US
Micronutrient Lab Manager International Health

2015 - 2016

Johns Hopkins School of Medicine Baltimore, MD, US
Research Scholar Pharmacology and Molecular Sciences

2012 - 2015

National Institutes of Health Bethesda, MD, US
Post-doc National Eye Institute

2005 - 2006

Nationwide Children's Hospital Columbus, OH, US
Research Assistant Center for Vaccines and Immunity

Education

Updated: December 10th, 2019 15:49

2006 - 2012

The Ohio State University Columbus, Ohio, US
Ph.D. Biochemistry

2001 - 2005

Haliç Üniversitesi Istanbul, TR
B.Sc. Molecular Biology and Genetics