Abdulkerim Eroglu
Also known as: KERIM EROGLU
carotenoids, systems biology, proteomics, metagenomics, synthetic biology, gut microbiome
Works (21)
Updated: April 3rd, 2024 20:47
2024 conference paper
Health Beneficial Effects of Carotenoids Related to Their Interactions with Gut Microbiota
Proceedings.
doi.org (publisher)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: February 2, 2024
2023 review
Carotenoids and Their Health Benefits as Derived via Their Interactions with Gut Microbiota
[Review of ]. ADVANCES IN NUTRITION, 14(2), 238–255.
author keywords: Carotenes; xanthophylls; digestion; carotenoid metabolites; gut bacteria; microbiome; mucosal layer; inflammation; oxidative stress; bactericidal effects; Bifidobacterium spp; Akkermansia spp
MeSH headings : Humans; Carotenoids / pharmacology; Carotenoids / metabolism; Gastrointestinal Microbiome; Colon / metabolism; Prebiotics; Dietary Supplements
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: April 11, 2023
2023 review
Carotenoids in Health as Studied by Omics-Related Endpoints
[Review of ]. ADVANCES IN NUTRITION, 14(6), 1538–1578.
author keywords: health; inflammation; beta-carotene; lycopene; lutein; oxidative stress; metabolites; LC-MS-MS; exposome; transcription factors; cellular compartments; body tissues
TL;DR:
This review highlights the use of omics technologies to assess health-related effects of carotenoids in mammalian organisms and models and (multi)omics–related techniques, especially transcriptomics, proteomics, lipidomics, and metabolomics, measured in a variety of biospecimens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Web Of Science
Added: September 9, 2023
2022 journal article
Carotenoids in orange carrots mitigate non-alcoholic fatty liver disease progression
FRONTIERS IN NUTRITION, 9.
author keywords: phytochemicals; nutrition; beta-oxidation; nuclear receptors; lipid metabolism
TL;DR:
Carotenoids in the orange carrots reduced HFD-induced weight gain, better than white carrots, and may display more potent efficacy in mitigating NAFLD than those with low carotenoid levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: October 24, 2022
2021 journal article
In Situ Biomanufacturing of Small Molecules in the Mammalian Gut by Probiotic Saccharomyces boulardii
ACS SYNTHETIC BIOLOGY, 10(5), 1039–1052.
author keywords: Saccharomyces boulardii; probiotic engineering; metabolic engineering; colonization profile; in situ production; beta-carotene
MeSH headings : Animals; Antineoplastic Agents / metabolism; CRISPR-Cas Systems; Feces / chemistry; Female; Gastrointestinal Microbiome; Gastrointestinal Tract / metabolism; Gastrointestinal Tract / microbiology; Gene Editing / methods; Gene Expression; Indoles / metabolism; Male; Metabolic Engineering / methods; Mice; Mice, Inbred C57BL; Microorganisms, Genetically-Modified; Multigene Family; Plasmids / genetics; Probiotics / metabolism; Promoter Regions, Genetic; Provitamins / biosynthesis; Saccharomyces boulardii / genetics; Saccharomyces boulardii / metabolism; Saccharomyces cerevisiae / genetics; beta Carotene / biosynthesis
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: May 6, 2021
2021 review
The Promising Effects of Astaxanthin on Lung Diseases
[Review of ]. ADVANCES IN NUTRITION, 12(3), 850–864.
author keywords: astaxanthin; lung diseases; oxidative stress; molecular mechanism; lung cancer
MeSH headings : Humans; Lung Diseases / drug therapy; Oxidative Stress; Phosphatidylinositol 3-Kinases / metabolism; Signal Transduction; Xanthophylls / pharmacology
TL;DR:
The potential role of ASX in protecting against lung diseases, including lung cancer, is reviewed and the underlying molecular mechanisms by which ASX protects against pulmonary diseases are summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: January 10, 2021
2021 journal article
The Role of beta-Carotene in Colonic Inflammation and Intestinal Barrier Integrity
FRONTIERS IN NUTRITION, 8.
author keywords: beta-carotene; colonic inflammation; colonic epithelial cells; tight junctions; vitamin A
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: November 23, 2021
2020 journal article
Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair
Antioxidants.
author keywords: lycopene; beta-carotene; lung cancer; base excision repair; gap junction communication; all-trans retinoic acid; oxidative stress
TL;DR:
Lycopene treatment at a lower dosage could inhibit smoke-induced oxidative stress and promote genome stability and shed light on the molecular mechanism of lycopene action against lung cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: July 26, 2020
2020 article
Nutrient modulation of DNA repair in lung cancer
Eroglu, A., & Balbuena, E. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
While β‐ carotene increased OGG1 expression at lower doses, it led to a dramatic decrease at higher concentrations suggesting that at higher doses β‐carotene exerted a pro‐oxidant effect, the objective is to illustrate the molecular mechanisms behind the chemoprotective effects of major dietary carotenoids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: October 12, 2020
2020 article
The Colors of Health: Chemistry, Bioactivity, and Market Demand for Colorful Foods and Natural Food Sources of Colorants
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11, Vol. 11, pp. 145–182.
author keywords: anthocyanins; betalains; bioactivity; carotenoids; natural colors; phycocyanins
MeSH headings : Color; Food; Pigments, Biological / chemistry
TL;DR:
The color industry needs new sources of stable, functional, and safe natural food colorants, and new opportunities include sourcing new colors from microbial sources and via the use of genetic biotechnology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: April 27, 2020
2019 journal article
Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model.
PloS One.
Ed(s): T. Oberyszyn
MeSH headings : Administration, Topical; Animals; Benzamides / administration & dosage; Benzamides / pharmacology; Carcinoma, Squamous Cell / drug therapy; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / metabolism; Carcinoma, Squamous Cell / prevention & control; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; Gene Expression Regulation, Neoplastic / drug effects; Histone Deacetylase Inhibitors / administration & dosage; Histone Deacetylase Inhibitors / pharmacology; Humans; Mice; Mice, Hairless; Neoplasms, Radiation-Induced / drug therapy; Neoplasms, Radiation-Induced / metabolism; Neoplasms, Radiation-Induced / prevention & control; Pyridines / administration & dosage; Pyridines / pharmacology; Skin Neoplasms / drug therapy; Skin Neoplasms / etiology; Skin Neoplasms / metabolism; Skin Neoplasms / prevention & control; Tumor Burden / drug effects; Xenograft Model Antitumor Assays
TL;DR:
The findings support the use of alternative routes of administration for histone deacetylase inhibitors in the treatment of high-risk squamous cell carcinoma which may ultimately lead to more precise delivery and reduced systemic toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 4, 2019
2018 journal article
A plasma proteome is associated with carotenoid status and dietary intake of food sources of carotenoids in Nepalese school aged children
Archives of Biochemistry and Biophysics, 646, 153–160.
Source: NC State University Libraries
Added: February 8, 2019
2018 journal article
Plasma proteins associated with circulating carotenoids in Nepalese school-aged children.
Archives of Biochemistry and Biophysics.
author keywords: Proteomics; Plasma proteins; beta-cryptoxanthin; Antioxidants; Carotenoids; Nepal
MeSH headings : Biomarkers / blood; Biomarkers / metabolism; Blood Proteins / analysis; Blood Proteins / metabolism; Carotenoids / blood; Carotenoids / metabolism; Child; Humans; Linear Models; Mass Spectrometry / methods; Nepal; Proteomics / methods
TL;DR:
Carotenoids are naturally occurring pigments that function as vitamin A precursors, antioxidants, anti-inflammatory agents or biomarkers of recent vegetable and fruit intake, and are thus important for population health and nutritional assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: May 4, 2019
2018 journal article
Plasma proteome correlates of lipid and lipoprotein: biomarkers of metabolic diversity and inflammation in children of rural Nepal
Journal of Lipid Research, 60(1), 149–160.
author keywords: plasma proteomics; high density lipoprotein-cholesterol; low density lipoprotein-cholesterol; triglycerides
MeSH headings : Biomarkers / blood; Biomarkers / metabolism; Child; Female; Humans; Inflammation / blood; Inflammation / metabolism; Lipoproteins / blood; Lipoproteins / metabolism; Male; Nepal; Proteomics; Rural Population
TL;DR:
Relative abundance of two-thirds of the HDL proteome varied with inflammation, with acute phase reactants higher by 4∼40%, and proteins involved in HDL biosynthesis, cholesterol efflux, vitamin transport, angiogenesis, and tissue repair lower by 3∼20%.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, ORCID
Added: February 8, 2019
2018 journal article
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
Nature Communications, 9(1), 53.
MeSH headings : Aged; Animals; Antineoplastic Agents; Benzamides / pharmacology; Cell Line, Tumor; Cell Proliferation; Co-Repressor Proteins / antagonists & inhibitors; Co-Repressor Proteins / metabolism; Drug Design; Drug Screening Assays, Antitumor; Female; Histone Deacetylase Inhibitors / pharmacology; Histone Deacetylases / chemistry; Humans; Male; Melanoma / drug therapy; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Nerve Tissue Proteins / antagonists & inhibitors; Nerve Tissue Proteins / metabolism; Oligonucleotide Array Sequence Analysis; Pyridines / pharmacology; Repressor Proteins / antagonists & inhibitors; Repressor Proteins / metabolism; Skin Neoplasms / drug therapy; Tranylcypromine / pharmacology; Xenograft Model Antitumor Assays
TL;DR:
A bifunctional small molecule inhibitor that simultaneously targets the deacetylase (HDAC1) and demethylase (LSD1) activities of the CoREST complex is reported, highlighting the promise of a new class of two-pronged hybrid agents that may show preferential targeting of particular epigenetic regulatory complexes and offer unique therapeutic opportunities.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 8, 2019
2017 journal article
Synthesis of apo-13- and apo-15-lycopenoids, cleavage products of lycopene that are retinoic acid antagonists
Journal of Lipid Research, 58(5), 1021–1029.
MeSH headings : Carotenoids / chemical synthesis; Carotenoids / chemistry; Carotenoids / metabolism; Carotenoids / pharmacology; Chemistry Techniques, Synthetic; Gene Expression Regulation / drug effects; Hep G2 Cells; Humans; Lycopene; Molecular Docking Simulation; Protein Conformation; Receptors, Retinoic Acid / antagonists & inhibitors; Receptors, Retinoic Acid / chemistry; Receptors, Retinoic Acid / metabolism
TL;DR:
The “first half” putative oxidative cleavage products of the symmetrical lycopene have been synthesized and isothermal titration calorimetry studies reveal that apo-13-lycopenone acts as an antagonist of RAR by inhibiting coactivator recruitment to the receptor.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID
Added: February 8, 2019
2016 journal article
Inhibition of RPE65 retinol isomerase activity by inhibitors of lipid metabolism
Journal of Biological Chemistry, 291, 4966–4973.
author keywords: enzyme inhibitor; liposome; retinal metabolism; retinoid; vision; RPE65; triacsin C; visual cycle; fatty acyl:CoA ligase
MeSH headings : Amino Acid Sequence; Animals; Binding Sites; Chickens; Coenzyme A Ligases / antagonists & inhibitors; Enzyme Inhibitors / pharmacology; HEK293 Cells; Humans; Molecular Sequence Data; Protein Binding; Triazenes / pharmacology; cis-trans-Isomerases / antagonists & inhibitors; cis-trans-Isomerases / chemistry; cis-trans-Isomerases / genetics; cis-trans-Isomerases / metabolism
TL;DR:
An inhibitor of ACSLs is identified as a potent inhibitor of RPE65 that competes with the atRE substrate of R PE65 for binding, and triacsin C, with an alkenyl chain resembling but not identical to either acyl or retinyl chains, may compete with binding of the acyl moiety of atRE via the alkeny moiety.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 8, 2019
2013 journal article
Carotenoid metabolism in mammals, including man; formation, occurrence, and function of apocarotenoids
Journal of Lipid Research, 54, 1719–1730.
author keywords: retinoids; vitamin A; beta-carotene; lycopene
MeSH headings : Animals; Carotenoids / metabolism; Humans; Male
TL;DR:
Understanding the interactions of apocarotenoids with other lipid-binding proteins, chaperones, and metabolizing enzymes will undoubtedly increase the understanding of the biological roles of these carotenoid metabolites.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 8, 2019
2012 journal article
Naturally-occurring eccentric cleavage products of provitamin A carotene b-carotene function as antagonists of retinoic acid receptors
Journal of Biological Chemistry, 287, 15886–158995.
MeSH headings : Animals; Binding, Competitive; COS Cells; Carotenoids / chemistry; Carotenoids / metabolism; Carotenoids / pharmacology; Chlorocebus aethiops; Cytochrome P-450 Enzyme System; Gene Expression / drug effects; Hep G2 Cells; Humans; Models, Molecular; Molecular Structure; Radioligand Assay; Receptors, Retinoic Acid / antagonists & inhibitors; Receptors, Retinoic Acid / genetics; Receptors, Retinoic Acid / metabolism; Retinoic Acid 4-Hydroxylase; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation / drug effects; Tretinoin / metabolism; Tretinoin / pharmacology; Tritium; beta Carotene / chemistry; beta Carotene / metabolism
TL;DR:
Findings suggest that β-apocarotenoids function as naturally occurring retinoid receptor antagonists, which may have implications for the activities of dietary β-carotene as a provitamin A and as a modulator of risk for cardiovascular disease and cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID
Added: February 8, 2019
2012 journal article
The formation, occurrence and function of b-apocarotenoids: b-Carotene metabolites that may modulate nuclear receptor signaling
American Journal of Clinical Nutrition, 96, 1189–1192.
MeSH headings : Animals; Carotenoids / metabolism; Food; Mice; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Retinoic Acid / antagonists & inhibitors; Receptors, Retinoic Acid / metabolism; Signal Transduction; Transcriptional Activation; Tretinoin / metabolism; beta Carotene / metabolism
TL;DR:
The findings suggest that a possible biological function of β-apocarotenoids is their ability to interfere with nuclear receptor signaling.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 8, 2019
2010 journal article
The eccentric cleavage product of b- carotene, b-apo-13-carotenone, functions as an antagonist of RXRa
Archives of Biochemistry and Biophysics, 504, 11–16.
author keywords: beta-Apocarotenoids; Retinoids; Retinoid receptors; Carotenoids
MeSH headings : Animals; COS Cells; Carotenoids / metabolism; Carotenoids / pharmacology; Chlorocebus aethiops; Humans; Ligands; Mice; Models, Molecular; Protein Multimerization; Protein Structure, Quaternary; Rats; Retinoid X Receptor alpha / agonists; Retinoid X Receptor alpha / antagonists & inhibitors; Retinoid X Receptor alpha / chemistry; Retinoid X Receptor alpha / metabolism; Transcriptional Activation / drug effects; Tretinoin / metabolism; Tretinoin / pharmacology; beta Carotene / metabolism
TL;DR:
Molecular modeling studies revealed that β-apo-13-carotenone makes molecular interactions like an antagonist of RXRα, suggesting a possible function of BACs on RXR α signaling.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 8, 2019
Employment
Updated: December 9th, 2018 08:55
2018 - present
North Carolina State University Raleigh, NC, US
Assistant Professor
Molecular and Structural Biochemistry
2016 - 2018
Johns Hopkins Bloomberg School of Public Health Baltimore, MD, US
Micronutrient Lab Manager
International Health
2015 - 2016
Johns Hopkins School of Medicine Baltimore, MD, US
Research Scholar
Pharmacology and Molecular Sciences
2012 - 2015
National Institutes of Health Bethesda, MD, US
Post-doc
National Eye Institute
2005 - 2006
Nationwide Children's Hospital Columbus, OH, US
Research Assistant
Center for Vaccines and Immunity
Education
Updated: December 10th, 2019 15:49
2006 - 2012
The Ohio State University Columbus, Ohio, US
Ph.D.
Biochemistry
2001 - 2005
Haliç Üniversitesi Istanbul, TR
B.Sc.
Molecular Biology and Genetics
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