Works Published in 2014
Displaying works 21 - 40 of 270 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 conference paper
PCR detection of Delftia acidovorans in Samples from Sinks
Poster presented at the North Carolina State University Summer Undergraduate Research Symposium, Raleigh, NC.
Event: North Carolina State University Summer Undergraduate Research Symposium at Raleigh, NC on July 30, 2014
Source: NC State University Libraries
Added: June 3, 2022
2014 conference paper
Analyzing big data with simple flowcharts and questioning techniques
Poster presented at the 111th Annual meeting North Carolina Academy of Science, North Carolina Museum of Natural Sciences, Raleigh, NC.
Event: 111th Annual meeting North Carolina Academy of Science at North Carolina Museum of Natural Sciences, Raleigh, NC on March 29, 2014
Source: NC State University Libraries
Added: June 3, 2022
2014 speech
Golden nuggets: Research and discoveries from the teaching lab
Goller, C. C. (2014, October). Presented at the Shaw University, Raleigh, NC.
Event: Shaw University at Raleigh, NC on October 22, 2014
Source: NC State University Libraries
Added: June 3, 2022
2014 speech
The wildlife around us and the fascinating questions we can ask using biotechnology techniques
Goller, C. C. (2014, October). Presented at the Biomanufacturing Training and Education Center (BTEC), North Carolina State University, Raleigh, NC.
Event: Biomanufacturing Training and Education Center (BTEC) at North Carolina State University, Raleigh, NC on October 3, 2014
Source: NC State University Libraries
Added: June 3, 2022
2014 journal article
The circadian clock controls sunburn apoptosis and erythema in mouse skin.
The Journal of Investigative Dermatology.
MeSH headings : Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins / metabolism; Circadian Clocks; Cytokines / metabolism; DNA Damage; DNA Repair; Erythema / etiology; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / metabolism; Sunburn; Time Factors; Ultraviolet Rays
TL;DR:
Interestingly, it is observed that sunburn apoptosis, inflammatory cytokine induction, and erythema were maximal following an acute early morning exposure to UV and minimal following an afternoon exposure, the first evidence that the circadian clock plays an important role in the ery themal response in UV-irradiated skin.
(via Semantic Scholar)
www.jidonline.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2014 journal article
Circadian clock, cancer, and chemotherapy.
Biochemistry.
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Circadian Clocks; DNA Damage / drug effects; DNA Repair / drug effects; DNA Repair Enzymes / metabolism; Drug Chronotherapy; Humans; Neoplasms / drug therapy; Neoplasms / epidemiology; Neoplasms / genetics; Neoplasms / metabolism; Risk Factors
TL;DR:
The circadian clock may affect the efficacy of cancer treatment by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2014 journal article
Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock.
Genes & Development.
Contributors: R. Ye, C. Selby *, Y. Chiou *, I. Ozkan-Dagliyan *, S. Gaddameedhi* & A. Sancar *
author keywords: circadian; Cryptochrome; Period; transcription; DNA binding
MeSH headings : ARNTL Transcription Factors / genetics; ARNTL Transcription Factors / metabolism; Active Transport, Cell Nucleus; Animals; CLOCK Proteins / genetics; CLOCK Proteins / metabolism; Cell Line; Circadian Clocks / genetics; Circadian Clocks / physiology; Cryptochromes / genetics; Cryptochromes / metabolism; Mice; Multiprotein Complexes; Mutation; Period Circadian Proteins / genetics; Period Circadian Proteins / metabolism; Protein Structure, Tertiary
TL;DR:
It is shown that CRY binds to CLOCK–BMAL1 at the promoter and inhibits CLock–BMal1-dependent transcription without dissociating the complex.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2014 journal article
DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair.
The Journal of Biological Chemistry.
Contributors: M. Kemp *, S. Gaddameedhi* , J. Choi *, J. Hu * & A. Sancar *
MeSH headings : Cell Cycle Checkpoints; Cell Line, Tumor; Cell Nucleus / metabolism; DNA / biosynthesis; DNA Cleavage; DNA Repair; Humans; Polydeoxyribonucleotides / metabolism; Replication Protein A / metabolism; Transcription Factor TFIIH / metabolism
TL;DR:
It is demonstrated that sedDNAs are localized to the nucleus in two biochemically distinct forms, which include chromatin-associated, transcription factor II H-bound complexes and more readily solubilized, RPA-bound Complex.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2014 journal article
Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
Cell Death & Differentiation, 21(3), 451–461.
author keywords: c-FLIP; inflammasome; IL-1 beta; caspase-1; caspase-8; macrophages
MeSH headings : Animals; CASP8 and FADD-Like Apoptosis Regulating Protein / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Down-Regulation; HEK293 Cells; Humans; Inflammasomes / metabolism; Interleukin-1beta / metabolism; Macrophages / metabolism; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Peptides; Signal Transduction
TL;DR:
It is demonstrated that c-FLIPL is an unexpected contributor to canonical inflammasome activation for the generation of caspase-1 and active IL-1β and suggest that c -FLIP could be a valid target for treatment of inflammatory diseases caused by over-activation of inflamMASomes.
(via Semantic Scholar)
Source: ORCID
Added: August 24, 2021
2014 journal article
c-FLIP Protects Eosinophils from TNF-α-Mediated Cell Death In Vivo
PLoS ONE, 9(10), e107724.
Ed(s): H. Nakano
MeSH headings : Animals; Apoptosis / drug effects; Bone Marrow Cells / cytology; Bone Marrow Transplantation; CASP8 and FADD-Like Apoptosis Regulating Protein / genetics; CASP8 and FADD-Like Apoptosis Regulating Protein / metabolism; Cells, Cultured; Chromosomes, Artificial, Bacterial / genetics; Eosinophils / cytology; Eosinophils / drug effects; Eosinophils / metabolism; Genotype; Mice; Mice, Transgenic; NF-kappa B / metabolism; Tumor Necrosis Factor-alpha / pharmacology; Up-Regulation / drug effects
TL;DR:
It is shown for the first time that eosinophils express the caspase 8-inhibitory protein c- FLIP, and c-FLIP expression is upregulated upon TNF-α stimulation, and this suggests c-FlIP as a potential therapeutic target for the treatment of eOSinophil-mediated disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 24, 2021
2014 journal article
Assessing the Effectiveness of the Pesticides and Farmworker Health Toolkit: A Curriculum for Enhancing Farmworkers’ Understanding of Pesticide Safety Concepts
Journal of Agromedicine, 19(2), 222–223.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 16, 2021
2014 conference paper
An adaptive control strategy for the West Africa Ebola outbreak
http://daphnia.ecology.uga.edu/drakelab/wp-content/uploads/2016/01/meyer-et-al-geogia-tech-ebola-jan-22-2015.pdf
Source: NC State University Libraries
Added: April 5, 2021
2014 magazine article
Dinosaurs are important
Schweitzer, M. H. (2014, June). Scientific American, 310(6), 12.
MeSH headings : Animals; Climate Change; Dinosaurs / physiology; Fossils; Humans
Sources: Web Of Science, NC State University Libraries
Added: March 12, 2021
2014 journal article
Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease
Endocrine-Related Cancer, 21(2).
Contributors: E. Kopras *, V. Potluri*, M. Bermudez*, K. Williams *, S. Belcher* & S. Kasper*
author keywords: endocrine disruptors; stem cell/progenitor cell; cancer stem cell; organ development; steroid hormone receptors
MeSH headings : Adipogenesis / drug effects; Animals; Bone Development / drug effects; Disease; Endocrine Disruptors / toxicity; Environmental Pollutants / toxicity; Germ Cells / drug effects; Heart / drug effects; Humans; Immune System / drug effects; Male; Mammary Glands, Human / drug effects; Neurogenesis / drug effects; Prostate / drug effects; Stem Cells / drug effects
TL;DR:
The current status of the understanding of the molecular mechanisms by which endocrine disruptors alter embryonic stem cell and adult stem/progenitor cell fate, organ development, cancer stem cell activity, and tumorigenesis is reviewed.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2014 journal article
Carbohydrate intake, glycemic index and prostate cancer risk
The Prostate, 75(4), 430–439.
author keywords: carbohydrates; glycemic index; prostate cancer
MeSH headings : Aged; Black People; Case-Control Studies; Diet; Dietary Carbohydrates / administration & dosage; Dietary Carbohydrates / adverse effects; Glycemic Index; Humans; Male; Middle Aged; Prostatic Neoplasms / etiology; Risk; Surveys and Questionnaires; White People
TL;DR:
Reported associations between dietary carbohydrate and prostate cancer risk are poorly characterized by race and may be driven by different underlying mechanisms, including diet and age.
(via Semantic Scholar)
Source: Crossref
Added: January 21, 2021
2014 journal article
Lifting the Mask: Identification of New Small Molecule Inhibitors of Uropathogenic Escherichia coli Group 2 Capsule Biogenesis
PLoS ONE, 9(7), e96054.
Ed(s): M. Skurnik
MeSH headings : Animals; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacterial Capsules / metabolism; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Escherichia coli Infections / drug therapy; Escherichia coli Infections / pathology; Female; Humans; Mice; Urinary Tract Infections / drug therapy; Urinary Tract Infections / pathology; Uropathogenic Escherichia coli / metabolism
TL;DR:
This work has provided a conceptually new class of molecules to combat UPEC infection, and future studies will establish the molecular basis for their action along with efficacy in UTI and other UPEC infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 30, 2020
2014 journal article
A Modern Twist on the Beaumont and St. Martin Case: Encouraging Analysis and Discussion in the Bioethics Classroom with Reflective Writing and Concept Mapping †
Journal of Microbiology & Biology Education, 15(2), 229–231.
TL;DR:
An activity was developed to encourage reflection on a classical ethical dilemma between a patient, St. Martin, and his employer/caretaker, Beaumont and mirrored the course’s structured approach of using concept mapping and reflection to dissect ethical dilemmas.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 30, 2020
2014 journal article
Editorial overview: Endocrine and metabolic diseases: Conversations on endocrine disruptors — rising above the din
Current Opinion in Pharmacology, 19, vi-vii.
Contributors: S. Belcher*
MeSH headings : Endocrine Disruptors / toxicity; Endocrine System Diseases; Environmental Exposure / adverse effects; Environmental Pollutants / toxicity; Humans; Metabolic Diseases; Risk Assessment
TL;DR:
Professorott Belcher is professor of Pharmacology d Cell Biophysics in the College of edicine at the University of Cincinnati and his search interests center on mechanisms involving estrogen ceptor beta action that influence cardiac thology and estrogen-responsive growth childhood brain tumors.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: December 21, 2020
2014 book
Baby Gorilla: Photographic and Descriptive Atlas of Skeleton, Muscles and Internal Organs Including CT Scans and Comparison with Adult Gorillas, Humans and Other Primates
Sources: NC State University Libraries, NC State University Libraries
Added: November 3, 2020
2014 journal article
Strong reinforcing selection in a Texas wildflower.
Current Biology : CB, 9.
MeSH headings : Flowers / genetics; Flowers / physiology; Magnoliopsida / genetics; Magnoliopsida / physiology; Models, Genetic; Pigmentation; Reproductive Isolation; Selection, Genetic
TL;DR:
This work quantifies the strength of reinforcing selection in the Texas wildflower Phlox drummondii using a strategy that weds a population genetic model with field data and finds that selection on flower color genes generated by reinforcement is exceptionally strong.
(via Semantic Scholar)
Source: ORCID
Added: September 15, 2020
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