Works Published in 2012
Displaying works 21 - 40 of 221 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 conference paper
Strategies and Challenges in Dynamic Systems Biology Analysis Using Structural Mass Spectrometry”
Strategies and Challenges in Dynamic Systems Biology Analysis Using Structural Mass Spectrometry.” Ion Mobility MS: Applying Ion Mobility-Mass Spectrometry to Challenges in Proteomics and Systems Biology. Workshop presented at the American Society for Mass Spectrometry (ASMS) Annual Conference, Vancouver, BC Canada.
Event: American Society for Mass Spectrometry (ASMS) Annual Conference at Vancouver, BC Canada
Source: NC State University Libraries
Added: March 12, 2022
2012 journal article
DNA damage-specific control of cell death by cryptochrome in p53-mutant ras-transformed cells.
Cancer Research.
MeSH headings : Animals; Cell Death / genetics; Cell Line; Cell Transformation, Neoplastic / genetics; Circadian Rhythm / genetics; Cryptochromes / genetics; Cryptochromes / physiology; DNA Damage; DNA-Binding Proteins / genetics; Doxorubicin / toxicity; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagens / toxicity; Mutation; Nuclear Proteins / genetics; Organoplatinum Compounds / toxicity; Oxaliplatin; Tumor Protein p73; Tumor Suppressor Proteins / genetics; Ultraviolet Rays / adverse effects
TL;DR:
These findings establish distinct roles for cryptochromes in intrinsic apoptosis induced by UV mimetic and radiomimetic agents and Ras-transformed p53- and Cry-null mouse skin fibroblasts are more sensitive than p53 mutants to apoptotic cell death initiated by agents that activate either the intrinsic or the extrinsic apoptosis pathways.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2012 journal article
Effect of circadian clock mutations on DNA damage response in mammalian cells.
Cell Cycle (Georgetown, Tex.).
Contributors: S. Gaddameedhi* , J. Reardon*, R. Ye, N. Ozturk * & A. Sancar *
author keywords: Cryptochrome; Period; Clock; BMal1; DNA repair; checkpoint; apoptosis
MeSH headings : Animals; Apoptosis / drug effects; Apoptosis / genetics; Apoptosis / radiation effects; Ataxia Telangiectasia Mutated Proteins; CLOCK Proteins / genetics; CLOCK Proteins / metabolism; Cell Cycle Checkpoints / drug effects; Cell Cycle Checkpoints / genetics; Cell Cycle Proteins / metabolism; Cell Line; Cell Survival / drug effects; Cell Survival / genetics; Cell Survival / radiation effects; Checkpoint Kinase 2; Circadian Clocks / drug effects; Circadian Clocks / genetics; Circadian Clocks / radiation effects; DNA Damage / genetics; DNA Repair / drug effects; DNA Repair / genetics; DNA Repair / radiation effects; DNA-Binding Proteins / metabolism; Down-Regulation / drug effects; Down-Regulation / genetics; Down-Regulation / radiation effects; Enzyme Activation / drug effects; Enzyme Activation / radiation effects; Feedback, Physiological / drug effects; Feedback, Physiological / radiation effects; Humans; Mammals / genetics; Mammals / physiology; Mice; Mitomycin / pharmacology; Mutation / genetics; Protein Serine-Threonine Kinases / metabolism; Radiation, Ionizing; Tumor Suppressor Proteins / metabolism; Ultraviolet Rays
TL;DR:
It is concluded that the majority of DNA damage response reactions are not controlled by the circadian clock or that, even if such a control exists at the organism level, it is supplanted by homeostatic control mechanisms at the cellular level in tissue culture.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2012 journal article
A New Role for UvrB in NER? Single Molecule Imaging of the NER Complex UvrBC-DNA
Biophysical Journal, 102(3), 485a.
TL;DR:
A new chaperoning role for UvrB is proposed in NER, where it protects the genome from unwanted UvrC nuclease activity but facilitates UVRC's location of pre-incision UVRB complexes.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 12, 2021
2012 journal article
Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair
Proceedings of the National Academy of Sciences, 109(41), E2737–E2746.
author keywords: UV damage; ubiquitin-proteosome system; X-ray crystallography
MeSH headings : Chromatin / chemistry; Chromatin / genetics; Chromatin / metabolism; Crystallography, X-Ray; Cullin Proteins / chemistry; Cullin Proteins / metabolism; DNA / chemistry; DNA / genetics; DNA / metabolism; DNA Damage; DNA Repair; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Humans; Microscopy, Atomic Force; Microscopy, Electron; Models, Molecular; Multiprotein Complexes / chemistry; Multiprotein Complexes / metabolism; Multiprotein Complexes / ultrastructure; Nucleic Acid Conformation; Protein Binding; Protein Folding; Protein Multimerization; Protein Structure, Secondary; Protein Structure, Tertiary
TL;DR:
It is proposed that the binding of UV-damaged DNA results in conformational changes in the N-terminal domain of DDB2, inducing helical folding in the context of the bound DNA and inducing dimerization as a function of nucleotide binding.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: September 23, 2021
2012 journal article
Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences
Cell Cycle, 11(16), 3036–3044.
Source: ORCID
Added: September 23, 2021
2012 report
Propagation and Culture of Federally Listed Freshwater Mussel Species
(FInal Report No. HWY-2009-16).
Source: NC State University Libraries
Added: September 18, 2021
2012 conference paper
Mariculture of oysters as a conservation tools: a proposed pilot study in Southwest PR
Presented at the Fourth Congress on the State of the Environment: From the mountain to the beach upland management and the state of coastal resources in Puerto Rico, San German, Puerto Rico.
Event: Fourth Congress on the State of the Environment: From the mountain to the beach upland management and the state of coastal resources in Puerto Rico at San German, Puerto Rico
Source: NC State University Libraries
Added: September 18, 2021
2012 journal article
Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas
Cancer, 118(23), 5878–5887.
author keywords: angiosarcoma; p53; phosphoinositide-3-kinase; catalytic; alpha polypeptide; phosphatase and tensin homolog; complex karyotype
MeSH headings : Adult; Aged; Aged, 80 and over; Class I Phosphatidylinositol 3-Kinases; Female; Genes, p53; Genomics; Hemangiosarcoma / etiology; Hemangiosarcoma / genetics; Humans; Male; Middle Aged; Mutation; PTEN Phosphohydrolase / genetics; Phosphatidylinositol 3-Kinases / physiology; Proto-Oncogene Proteins B-raf / genetics; Proto-Oncogene Proteins c-akt / physiology; Proto-Oncogene Proteins c-mdm2 / analysis; Signal Transduction / physiology; TOR Serine-Threonine Kinases / physiology
TL;DR:
The p53 and phosphoinositide‐3‐kinase, catalytic, alpha polypeptide/v‐akt murine thymoma viral oncogene homolog/mechanistic target of rapamycin (PIK3CA/AKT/mTOR) pathways frequently are altered in sarcoma with complex genomics, such as leiomyosarcoma (LMS) or undifferentiated pleomorphic sarcomA (UPS).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: August 14, 2021
2012 journal article
A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations
Cancer Genetics, 205(11), 572–587.
author keywords: Osteosarcoma; oligo-aCGH; canine; comparative oncology
MeSH headings : Adolescent; Adult; Algorithms; Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Child; Chromosome Aberrations; Comparative Genomic Hybridization / methods; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Genome, Human; Genomics / methods; Humans; Male; Osteosarcoma / genetics; Osteosarcoma / veterinary; Species Specificity
TL;DR:
These findings support and build upon the high level of cytogenetic complexity, through the identification of shared regions of microaberration and functional analysis of possible orthologous OS-associated genes to pinpoint the cellular processes most commonly affected by aberration in human and canine OS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 14, 2021
2012 journal article
QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION FOR COCHLODINIUM FULVESCENS (DINOPHYCEAE), A HARMFUL DINOFLAGELLATE FROM CALIFORNIA COASTAL WATERS1
Journal of Phycology, 48(2), 384–393.
author keywords: 18S rDNA; Cochlodinium; harmful algal blooms; protist; qPCR
TL;DR:
The onset of Cochlodinium blooms in central California was consistent with previously reported findings of correlations to decreased surface temperature and increased inputs of nitrogenous nutrients, and initial application of the qPCR method to archived field samples revealed no statistically significant correlations between gene copy number and environmental parameters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: August 4, 2021
2012 journal article
An oceanographic, meteorological, and biological ‘perfect storm’ yields a massive fish kill
Marine Ecology Progress Series, 468, 231–243.
author keywords: Fish kill; Hypoxia; Nearshore embayment; Upwelling; Mixing
TL;DR:
The findings underscore the essential role of ocean observing and rapid response in the study of these events and the role that oceanographic processes play in hypoxia-driven fish mortalities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: August 4, 2021
2012 journal article
Marine Protistan Diversity
Annual Review of Marine Science, 4(1), 467–493.
author keywords: protist; protozoa; phytoplankton; biodiversity; molecular ecology; rarefaction; rank abundance curves
MeSH headings : Animals; Ciliophora / classification; Ciliophora / genetics; Ciliophora / physiology; Ecosystem; Oceans and Seas; Phylogeny; Phytoplankton
TL;DR:
Studies of protistan diversity provide insight regarding how species richness and community composition contribute to ecosystem function and support the development of predictive models that describe how microbial communities will respond to natural or anthropogenically mediated changes in environmental conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: August 4, 2021
2012 journal article
MALDI mass spectrometric imaging of cardiac tissue following myocardial infarction in a rat coronary artery ligation model
Analytical Chemistry, 84(2), 1117–1125.
Contributors: R. Menger*, W. Stutts* , D. Anbukumar *, J. Bowden *, D. Ford * & R. Yost *
MeSH headings : Animals; Coronary Vessels / metabolism; Coronary Vessels / pathology; Heart / physiology; Image Processing, Computer-Assisted; Ligation; Male; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry
TL;DR:
The investigation of an in vivo rat model of MI using mass spectrometric imaging (MSI) and multivariate data analysis suggests increased activity of phospholipase A(2), an enzyme that has been implicated in coronary heart disease and inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: May 20, 2021
2012 journal article
Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin
Journal of Molecular Biology, 422(2), 245–262.
author keywords: directed evolution; cytochrome P450; MRI contrast agents; neurotransmitter; biosensors
MeSH headings : Animals; Catalytic Domain; Cells, Cultured; Cytochrome P-450 Enzyme System / chemistry; Cytochrome P-450 Enzyme System / metabolism; Dopamine / chemistry; Dopamine / metabolism; Evolution, Molecular; Heme / chemistry; Heme / metabolism; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Rats; Serotonin / chemistry; Serotonin / metabolism
TL;DR:
It is shown that structure-guided directed evolution of the active site of the cytochrome P450-BM3 heme domain produces highly selective MRI probes with submicromolar affinities for small molecules.
(via Semantic Scholar)
Source: ORCID
Added: May 6, 2021
2012 journal article
Linking Yeast Gcn5p Catalytic Function and Gene Regulation Using a Quantitative, Graded Dominant Mutant Approach
PLoS ONE, 7(4), e36193.
Ed(s): C. Chan
MeSH headings : Acetylation; Biocatalysis; Gene Expression Regulation, Fungal / genetics; Histone Acetyltransferases / metabolism; Histones / metabolism; Mutation; Phenotype; Saccharomyces cerevisiae / cytology; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / metabolism; Systems Biology; Transcriptome / genetics
TL;DR:
A novel approach to extract quantitative, causative links by modulating the expression of a dominant mutant allele to create a function-specific competitive inhibition is described and a graded dominant mutant approach is utilized in conjunction with a traditional knockout to study multifunctional proteins and generate higher-resolution data that more accurately probes protein domain function and influence.
(via Semantic Scholar)
Source: ORCID
Added: May 6, 2021
2012 journal article
Innovation at the intersection of synthetic and systems biology
Current Opinion in Biotechnology, 23(5), 712–717.
MeSH headings : Biotechnology / trends; Synthetic Biology / trends; Systems Biology / trends
TL;DR:
This review seeks to highlight the activity at the intersection of the top-down systems approach and the bottom-up synthetic approach that enables the precise control of cellular state for systems studies and the discovery of novel parts, control strategies, and interactions for the design of robust synthetic function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(OpenAlex)
Source: ORCID
Added: May 6, 2021
2012 article
Classical Strain Improvement
Crook, N., & Alper, H. S. (2012, October). Engineering Complex Phenotypes in Industrial Strains, pp. 1–33.
TL;DR:
Almost all industrial microbiology processes require the initial isolation of cultures from nature, followed by small scale cultivations and optimization, before large scale production can become a reality, and the classical approach to strain engineering is concerned.
(via Semantic Scholar)
Source: ORCID
Added: May 6, 2021
2012 journal article
Return to use and performance following exploratory celiotomy for colic in horses: 195 cases (2003-2010)
Equine Veterinary Journal, 45(2), 224–228.
author keywords: horse; colic; surgery; prognosis; performance
MeSH headings : Animals; Colic / surgery; Colic / veterinary; Female; Horse Diseases / surgery; Horses; Logistic Models; Male; Odds Ratio; Postoperative Complications
TL;DR:
Targeted owner education regarding preoperative lameness, post operative rehabilitation and treatment for complications, such as incisional hernioplasty, may help inform owners about their horse's potential for return to use and performance following colic surgery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 22, 2021
2012 journal article
Re-evaluating the role of ascorbic acid and phenolic glycosides in ozone scavenging in the leaf apoplast of Arabidopsis thaliana L.
Plant, Cell & Environment, 8.
author keywords: Air pollution; flavonoids; kaempferol; reactive oxygen; sinapoyl malate; vitamin C
MeSH headings : Arabidopsis / metabolism; Ascorbic Acid / metabolism; Biomass; Glycosides / metabolism; Ozone / metabolism; Phenols / metabolism; Plant Leaves / metabolism; Reactive Oxygen Species / metabolism
TL;DR:
Current understanding of O(3) defence schemes deserves reassessment as mechanisms other than direct scavenging of O (3) by extracellular AA and antioxidant activity of some phenolics may predominate in some plant species.
(via Semantic Scholar)
Source: ORCID
Added: April 8, 2021
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