Works Published in 2014
Displaying works 21 - 40 of 259 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 conference paper
Oral Fluid Pain Management Panel by "Dilute and Shoot" LC-MS/MS
Presented at the Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) Annual Conference, San Diego, CA.
Event: Association for Mass Spectrometry Applications to the Clinical Lab (MSACL) Annual Conference at San Diego, CA
Source: NC State University Libraries
Added: March 12, 2022
2014 journal article
Enhancement of single particle rare earth doped NaYF4: Yb, Er emission with a gold shell
Nanotechnology, 26(2), 025101.
author keywords: bioimaging; upconversion; near infrared
doi.org (publisher)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 7, 2022
2014 report
Evaluation of Available Scale-up Approaches for the Design of GAC Contactors
(Final Report No. 4235). Denver, Colorado: Water Research Foundation.
Source: NC State University Libraries
Added: December 24, 2021
2014 journal article
The circadian clock controls sunburn apoptosis and erythema in mouse skin.
The Journal of Investigative Dermatology.
MeSH headings : Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins / metabolism; Circadian Clocks; Cytokines / metabolism; DNA Damage; DNA Repair; Erythema / etiology; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / metabolism; Sunburn; Time Factors; Ultraviolet Rays
TL;DR:
Interestingly, it is observed that sunburn apoptosis, inflammatory cytokine induction, and erythema were maximal following an acute early morning exposure to UV and minimal following an afternoon exposure, the first evidence that the circadian clock plays an important role in the ery themal response in UV-irradiated skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2014 journal article
Circadian clock, cancer, and chemotherapy.
Biochemistry.
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Circadian Clocks; DNA Damage / drug effects; DNA Repair / drug effects; DNA Repair Enzymes / metabolism; Drug Chronotherapy; Humans; Neoplasms / drug therapy; Neoplasms / epidemiology; Neoplasms / genetics; Neoplasms / metabolism; Risk Factors
TL;DR:
The circadian clock may affect the efficacy of cancer treatment by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2014 journal article
Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock.
Genes & Development.
Contributors: R. Ye, C. Selby *, Y. Chiou *, I. Ozkan-Dagliyan *, S. Gaddameedhi* & A. Sancar *
author keywords: circadian; Cryptochrome; Period; transcription; DNA binding
MeSH headings : ARNTL Transcription Factors / genetics; ARNTL Transcription Factors / metabolism; Active Transport, Cell Nucleus; Animals; CLOCK Proteins / genetics; CLOCK Proteins / metabolism; Cell Line; Circadian Clocks / genetics; Circadian Clocks / physiology; Cryptochromes / genetics; Cryptochromes / metabolism; Mice; Multiprotein Complexes; Mutation; Period Circadian Proteins / genetics; Period Circadian Proteins / metabolism; Protein Structure, Tertiary
TL;DR:
It is shown that CRY binds to CLOCK–BMAL1 at the promoter and inhibits CLock–BMal1-dependent transcription without dissociating the complex.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2014 journal article
DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair.
The Journal of Biological Chemistry.
Contributors: M. Kemp *, S. Gaddameedhi* , J. Choi *, J. Hu * & A. Sancar *
MeSH headings : Cell Cycle Checkpoints; Cell Line, Tumor; Cell Nucleus / metabolism; DNA / biosynthesis; DNA Cleavage; DNA Repair; Humans; Polydeoxyribonucleotides / metabolism; Replication Protein A / metabolism; Transcription Factor TFIIH / metabolism
TL;DR:
It is demonstrated that sedDNAs are localized to the nucleus in two biochemically distinct forms, which include chromatin-associated, transcription factor II H-bound complexes and more readily solubilized, RPA-bound Complex.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2014 article
Rising suitability and declining severity of malaria transmission in Africa under climate change
Source: ORCID
Added: November 8, 2021
2014 journal article
TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres
Nucleic Acids Research, 42(4), 2493–2504.
Source: ORCID
Added: September 23, 2021
2014 report
Establishment of Captive Populations of Magnificent Ramshorn (Planorbella magnifica) and Greenfield Ramshorn (Helisoma eucosmium)
[Final report]. US Fish and Wildlife Service.
Source: NC State University Libraries
Added: September 11, 2021
2014 journal article
Choice of commuting mode among employees: Do home neighborhood environment, worksite neighborhood environment, and worksite policy and supports matter?
Journal of Transport and Health, 2(2), 212–218.
Contributors: L. Yang *, J. Hipp *, D. Adlakha *, C. Marx *, R. Tabak * & R. Brownson *
author keywords: Active commuting; Public transit; Neighborhood environment; Worksite support; Worksite policy; Employees
TL;DR:
Both environment features and worksite supports and policies are associated with the choice of commuting mode, and future studies should use longitudinal designs to investigate the potential of promoting alternative commuting modes through worksite efforts that support sustainable commuting behaviors as well as the Potential of built environment improvements.
(via Semantic Scholar)
Source: ORCID
Added: August 31, 2021
2014 journal article
Optimization of a Yeast RNA Interference System for Controlling Gene Expression and Enabling Rapid Metabolic Engineering
ACS Synth. Biol., 3(5), 307–313.
author keywords: yeast; RNA interference; metabolic engineering; itaconic acid; gene knockdown
MeSH headings : Escherichia coli; Gene Expression / genetics; Gene Knockdown Techniques; Metabolic Engineering / methods; Nucleic Acid Conformation; RNA Interference; RNA, Small Interfering / chemistry; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Succinates / analysis; Succinates / metabolism; Synthetic Biology
TL;DR:
The approach developed here enables rapid prototyping of knockdown strategies and thus accelerates and reduces the cost of the design-build-test cycle in yeast.
(via Semantic Scholar)
Source: ORCID
Added: May 6, 2021
2014 journal article
Design of synthetic yeast promoters via tuning of nucleosome architecture
Nat Comms, 5.
MeSH headings : Gene Expression Regulation, Fungal; Models, Genetic; Mutation / genetics; Nucleosomes / metabolism; Promoter Regions, Genetic; Saccharomyces cerevisiae / genetics
TL;DR:
It is demonstrated that nucleosome architecture can have a role in defining yeast promoter activity and a computationally-guided approach is utilized that can enable both the redesign of endogenous promoter sequences and the de novo design of synthetic promoters.
(via Semantic Scholar)
Source: ORCID
Added: May 6, 2021
2014 journal article
Seasonal Changes in Microbial Community Structure in Freshwater Stream Sediment in a North Carolina River Basin
Diversity, 6(1), 18–32.
Sources: Crossref, NC State University Libraries
Added: April 26, 2021
2014 chapter
Atmospheric Pressure Mass Spectrometry Imaging
In R. A. Meyers (Ed.), Encyclopedia of Analytical Chemistry: Applications, Theory and Instrumentation (pp. 1–44).
Ed(s): R. Meyers
Sources: NC State University Libraries, NC State University Libraries
Added: March 8, 2021
2014 journal article
Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease
Endocrine-Related Cancer, 21(2).
Contributors: E. Kopras *, V. Potluri*, M. Bermudez*, K. Williams *, S. Belcher* & S. Kasper*
author keywords: endocrine disruptors; stem cell/progenitor cell; cancer stem cell; organ development; steroid hormone receptors
MeSH headings : Adipogenesis / drug effects; Animals; Bone Development / drug effects; Disease; Endocrine Disruptors / toxicity; Environmental Pollutants / toxicity; Germ Cells / drug effects; Heart / drug effects; Humans; Immune System / drug effects; Male; Mammary Glands, Human / drug effects; Neurogenesis / drug effects; Prostate / drug effects; Stem Cells / drug effects
TL;DR:
The current status of the understanding of the molecular mechanisms by which endocrine disruptors alter embryonic stem cell and adult stem/progenitor cell fate, organ development, cancer stem cell activity, and tumorigenesis is reviewed.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2014 journal article
Systems Biology of Lignin Biosynthesis in Populus trichocarpa: Heteromeric 4-Coumaric Acid:Coenzyme A Ligase Protein Complex Formation, Regulation, and Numerical Modeling
The Plant Cell, 26(3), 876–893.
MeSH headings : Coenzyme A Ligases / genetics; Coenzyme A Ligases / metabolism; Coumaric Acids / metabolism; Immunoprecipitation; Lignin / biosynthesis; Mass Spectrometry; Models, Biological; Populus / metabolism; Propionates; RNA, Messenger / genetics; Substrate Specificity; Systems Biology
TL;DR:
This work shows that 4CL, an enzyme in monolignol biosynthesis, is found as a heterotetrameric complex of two isoforms in Populus trichocarpa, where the two 4-coumaric acid:CoA ligase (4CL) isoforms, 4CL3 and 4CL5, interact in vivo and in vitro to form a heterosymmetric protein complex.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 12, 2021
2014 journal article
Carbohydrate intake, glycemic index and prostate cancer risk
The Prostate, 75(4), 430–439.
author keywords: carbohydrates; glycemic index; prostate cancer
MeSH headings : Aged; Black People; Case-Control Studies; Diet; Dietary Carbohydrates / administration & dosage; Dietary Carbohydrates / adverse effects; Glycemic Index; Humans; Male; Middle Aged; Prostatic Neoplasms / etiology; Risk; Surveys and Questionnaires; White People
TL;DR:
Reported associations between dietary carbohydrate and prostate cancer risk are poorly characterized by race and may be driven by different underlying mechanisms, including diet and age.
(via Semantic Scholar)
Source: Crossref
Added: January 21, 2021
2014 journal article
Editorial overview: Endocrine and metabolic diseases: Conversations on endocrine disruptors — rising above the din
Current Opinion in Pharmacology, 19, vi-vii.
Contributors: S. Belcher*
MeSH headings : Endocrine Disruptors / toxicity; Endocrine System Diseases; Environmental Exposure / adverse effects; Environmental Pollutants / toxicity; Humans; Metabolic Diseases; Risk Assessment
TL;DR:
Professorott Belcher is professor of Pharmacology d Cell Biophysics in the College of edicine at the University of Cincinnati and his search interests center on mechanisms involving estrogen ceptor beta action that influence cardiac thology and estrogen-responsive growth childhood brain tumors.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: December 21, 2020
2014 journal article
Screening Analysis of Heroin Samples for Possible Cutting Agents and Adulterants
ToxTalk, 38(3), 12–16. https://www.soft-tox.org/files/toxtalk/SOFT_ToxTalk_v38-3.pdf
Source: NC State University Libraries
Added: November 16, 2020
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