Works Published in 2005
Displaying works 61 - 80 of 148 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2005 journal article
Susceptibility of Signal Transducer and Activator of Transcription-1-Deficient Mice to Pulmonary Fibrogenesis
The American Journal of Pathology, 167(5), 1221–1229.
MeSH headings : Animals; Bleomycin / toxicity; Blotting, Western; Cell Proliferation; Cells, Cultured; Collagen / analysis; Disease Models, Animal; Epidermal Growth Factor / pharmacology; Fibroblasts / pathology; Growth Inhibitors / pharmacology; Hydroxyproline / analysis; Interferon-gamma / pharmacology; Lung / drug effects; Lung / pathology; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 3 / metabolism; Phosphorylation; Platelet-Derived Growth Factor / pharmacology; Pulmonary Fibrosis / genetics; Pulmonary Fibrosis / pathology; Pulmonary Fibrosis / physiopathology; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / physiology; STAT3 Transcription Factor / metabolism; Thymidine / metabolism
TL;DR:
The findings indicate that Stat1-/- mice are more susceptible to bleomycin-induced lung fibrosis than wild-type mice due to 1) enhanced fibroblast proliferation in response to growth factors (EGF and PDGF), 2) stimulation of fibro Blast growth by a Stat 1-independent IFN-gamma signaling pathway, and 3) increased activation of Stat3.
(via Semantic Scholar)
europepmc.org (repository)
Source: Crossref
Added: August 28, 2020
2005 journal article
Maternal–fetal Distribution of Manganese in the Rat Following Inhalation Exposure to Manganese Sulfate
NeuroToxicology, 26(4), 625–632.
author keywords: manganese; inhalation; rat; pregnancy
MeSH headings : Animals; Body Burden; Female; Fetus / metabolism; Inhalation Exposure; Male; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Maternal-Fetal Exchange / physiology; Organ Size / drug effects; Pregnancy; Rats; Sulfates / administration & dosage; Sulfates / pharmacokinetics; Tissue Distribution
TL;DR:
The results of this study demonstrate that the placenta partially sequesters inhaled manganese, thereby limiting exposure to the fetus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2005 journal article
Quantitative mass spectral evidence for the absence of circulating brain natriuretic peptide (BNP-32) in severe human heart failure
Proceedings of the National Academy of Sciences, 102(48), 17442–17447.
author keywords: biomarkers; electrospray ionization; Fourier transform-ion cyclotron resonance MS; immunoaffinity purification; targeted proteomics
MeSH headings : Chromatography, Liquid; Female; Heart Failure / metabolism; Humans; Isotope Labeling; Male; Mass Spectrometry; Natriuretic Peptide, Brain / blood; Natriuretic Peptide, Brain / isolation & purification
TL;DR:
An immunoaffinity purification assay is developed and used to isolate endogenous BNP-32 from New York Heart Association class IV patient plasma for subsequent analysis by nano-liquid chromatography (LC) electrospray ionization Fourier transform ion cyclotron resonance (FT-ICR) MS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2005 journal article
Evaluation of Protein Depletion Methods for the Analysis of Total-, Phospho- and Glycoproteins in Lumbar Cerebrospinal Fluid
Journal of Proteome Research, 4(3), 837–845.
author keywords: cerebrospinal fluid; human; two-dimensional gel electrophoresis; mass spectrometry; glycoprotein; phosphoprotein; protein depletion; low-abundance protein
MeSH headings : Adult; Aged; Cerebrospinal Fluid Proteins / analysis; Cerebrospinal Fluid Proteins / classification; Cerebrospinal Fluid Proteins / isolation & purification; Chromatography, Affinity; Electrophoresis, Gel, Two-Dimensional; Female; Fluorescent Dyes; Glycoproteins / cerebrospinal fluid; Glycoproteins / isolation & purification; Humans; Immunoglobulins; Male; Mass Spectrometry; Methods; Microspheres; Middle Aged; Phosphoproteins / cerebrospinal fluid; Phosphoproteins / isolation & purification
TL;DR:
Phospho- and glycoprotein specific fluorescent stains and mass spectrometry were used to map proteins from CSF on two-dimensional gel electropherograms after immunoaffinity based protein removal, and fifty proteins were identified from 66 spots, and 12 proteins have not been annotated in previously published 2D gels.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2005 journal article
Coordination-Driven Self-Assemblies with a Carborane Backbone
Journal of the American Chemical Society, 127(34), 12131–12139.
MeSH headings : Boranes / chemistry; Crystallography, X-Ray; Isotope Labeling; Magnetic Resonance Spectroscopy; Molecular Structure; Pyridines / chemistry; Spectrometry, Mass, Electrospray Ionization
TL;DR:
Isotopically resolved mass spectrometry data confirm the existence of the rectangle, triangle, and hexagon, and NMR data are consistent with the formation of all five assemblies.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2005 journal article
Gentle Protein Ionization Assisted by High-Velocity Gas Flow
Analytical Chemistry, 77(19), 6174–6183.
MeSH headings : Cytochromes c / chemistry; Hydrogen-Ion Concentration; Ions / chemistry; Myoglobin / chemistry; Proteins / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Ubiquitin / chemistry
TL;DR:
Evidence is provided for the importance of the conditions used in the desolvation process for the preservation of the protein conformation and suggest that the conditions achieved when using high-velocity gas flows to assist droplet evaporation and ion Desolvation are much gentler than those in conventional ESI experiments.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2005 journal article
Statistical Evaluation of Internal and External Mass Calibration Laws Utilized in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
Analytical Chemistry, 77(8), 2406–2414.
MeSH headings : Calibration; Cyclotrons; Data Interpretation, Statistical; Fourier Analysis; Polymers / analysis; Polymers / chemistry; Propylene Glycols / analysis; Propylene Glycols / chemistry; Quaternary Ammonium Compounds / chemistry; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
The statistical evaluation of two common and three new calibration laws utilized in Fourier transform ion cyclotron resonance mass spectrometry are presented and the number of calibrant ions as well as their required m/z range is investigated in order to successfully achieve high MMA.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2005 journal article
Derivatives of pentamidine designed to target the Leishmania lipophosphoglycan
Tetrahedron Letters, 46(4), 695–698.
author keywords: boronate drug targeting; pentamidine; Leishmania
TL;DR:
Pentamidine has been modified with boronic acids so that it might bind more selectively to the phosphodisaccharide repeating unit of the LPG, which could serve to target the drug to the protozoan surface and increase its efficacy in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2005 journal article
Leveling response factors in the electrospray ionization process using a heated capillary interface
Journal of the American Society for Mass Spectrometry, 16(5), 772–778.
MeSH headings : Capillary Action; DNA / analysis; DNA / chemistry; Equipment Design; Equipment Failure Analysis; Hot Temperature; Humans; Specimen Handling / instrumentation; Specimen Handling / methods; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods
TL;DR:
The implementation of a heated electrospray source was used to denature amplicons containing 7-deaza purines, which can be used to facilitate sequencing by mass spectrometry.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2005 journal article
Normalization of relative peptide ratios derived from in-gel digests: applications to protein variant analysis at the peptide level
Rapid Communications in Mass Spectrometry, 19(19), 2871–2877.
MeSH headings : Algorithms; Chromatography, High Pressure Liquid / methods; Gas Chromatography-Mass Spectrometry / methods; Gas Chromatography-Mass Spectrometry / standards; Humans; Osmotic Fragility; Peptide Mapping / methods; Peptide Mapping / standards; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Spectrin / analysis; Spectrin / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
A strategy was developed to normalize for sample variability due to ionization efficiency, solvent effects, digestion and extraction efficiency by utilizing multiple isotopically labeled internal standards for multiple peptides derived from the same protein.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2005 journal article
Effect of post-excitation radius on ion abundance, mass measurement accuracy, and isotopic distributions in Fourier transform ion cyclotron resonance mass spectrometry
Rapid Communications in Mass Spectrometry, 19(7), 915–918.
MeSH headings : Bradykinin / analysis; Ions; Isotopes; Reproducibility of Results; Spectroscopy, Fourier Transform Infrared / instrumentation; Spectroscopy, Fourier Transform Infrared / methods; Tritium
TL;DR:
The findings presented herein underscore the importance of determining the optimal post-excitation radius in FT-ICR-MS to achieve high ion abundance (low limits of detection), high MMA, and valid isotopic distributions.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2005 journal article
Manganese Dosimetry: Species Differences and Implications for Neurotoxicity
Critical Reviews in Toxicology, 35(1), 1–32.
author keywords: biomarkers; brain; manganese; metabolism; neurotoxicity; pharmacokinetics
MeSH headings : Absorption; Adult; Blood-Brain Barrier; Central Nervous System / drug effects; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Inhalation Exposure; Male; Manganese / administration & dosage; Manganese / adverse effects; Manganese / pharmacokinetics; Maternal-Fetal Exchange; Pregnancy; Public Health; Risk Assessment
Source: Crossref
Added: February 24, 2020
2005 journal article
Applying the discrete vortex method in environmental fluid mechanics: A study of the time-averaged near wake behind a circular cylinder
Environmental Fluid Mechanics, 4(4), 455–463.
Contributors: J. Richmond-Bryant* & M. Flynn*
author keywords: bluff bodies; computational fluid dynamics; environmental fluid mechanics; near wake; vortex methods
Source: ORCID
Added: January 13, 2020
2005 journal article
Electrophysiological Properties of Neurons in the Basal Ganglia of the Domestic Chick: Conservation and Divergence in the Evolution of the Avian Basal Ganglia
Journal of Neurophysiology, 94(1), 454–467.
MeSH headings : Age Factors; Animals; Animals, Newborn; Basal Ganglia / cytology; Basal Ganglia / growth & development; Chickens; Choline O-Acetyltransferase / metabolism; Dose-Response Relationship, Radiation; Electric Stimulation / methods; Electrophysiology; Immunohistochemistry / methods; In Vitro Techniques; Lysine / analogs & derivatives; Lysine / metabolism; Membrane Potentials / drug effects; Membrane Potentials / physiology; Membrane Potentials / radiation effects; Neurons / classification; Neurons / physiology; Patch-Clamp Techniques / methods
TL;DR:
It is discovered that spiny neurons, the most common cell type in the striatum of all amniotes, possess a diverse set of physiological properties in chicks that distinguish them from both mammals and songbirds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2005 journal article
Seasonal-like plasticity of spontaneous firing rate in a songbird pre-motor nucleus
Journal of Neurobiology, 64(2), 181–191.
author keywords: androgen; estrogen; testosterone; electrophysiology; birdsong
MeSH headings : Action Potentials / drug effects; Action Potentials / physiology; Analysis of Variance; Animals; Brain / cytology; Brain / drug effects; Brain / physiology; Dihydrotestosterone / blood; Dihydrotestosterone / pharmacology; Drug Interactions; Estradiol / blood; Estradiol / pharmacology; In Vitro Techniques; Male; Neural Pathways / drug effects; Neural Pathways / physiology; Neuronal Plasticity / drug effects; Neuronal Plasticity / physiology; Neurons / drug effects; Neurons / physiology; Photoperiod; Seasons; Songbirds; Statistics as Topic; Testosterone / blood; Testosterone / pharmacology; Time Factors; Vocalization, Animal / drug effects; Vocalization, Animal / physiology
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2005 journal article
Differing Roles of Inhibition in Hierarchical Processing of Species-Specific Calls in Auditory Brainstem Nuclei
Journal of Neurophysiology, 94(6), 4019–4037.
MeSH headings : Acoustic Stimulation / methods; Action Potentials / drug effects; Action Potentials / physiology; Animals; Auditory Pathways / physiology; Bicuculline / pharmacology; Brain Stem / cytology; Brain Stem / physiology; Cell Count / methods; Chiroptera; Dose-Response Relationship, Radiation; Drug Interactions; Echolocation / drug effects; Echolocation / physiology; Electrodes; Functional Laterality; GABA Antagonists / pharmacology; Glycine Agents / pharmacology; Neural Inhibition / drug effects; Neural Inhibition / physiology; Neurons / classification; Neurons / drug effects; Neurons / physiology; Sound Localization; Species Specificity; Strychnine / pharmacology; gamma-Aminobutyric Acid / pharmacology
TL;DR:
It is shown that inhibition plays only limited roles in the DNLL and INLL but dominates in the IC, where the various patterns of inhibition sculpt a wide variety of emergent response properties from the backdrop of more expansive and far less specific excitatory innervation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2005 chapter
THE MOUSE IN BIOMEDICAL RESEARCH
In The Mouse in Animal Genetics and Breeding Research (pp. 319–340).
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2005 journal article
Masking in Waved‐2 Mice: EGF Receptor Control of Locomotion Questioned
Chronobiology International, 22(6), 963–974.
author keywords: circadian rhythm; epidermal growth factor; locomotion; masking; subparaventricular zone; waved-2; mutants
MeSH headings : Animals; Circadian Rhythm / genetics; DNA Primers; ErbB Receptors / genetics; Lighting; Mice; Mice, Mutant Strains; Motor Activity / physiology; Polymerase Chain Reaction
TL;DR:
Study of the responses to light over a large range in illumination levels, in a variety of tests, with pulses of light and with ultradian light‐dark cycles in Egfrwa2 mutant mice suggested that normal functioning of epidermal growth factor receptors was required, or even involved, in masking.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2005 journal article
Re: "Cancer incidence among pesticide applicators exposed to alachlor in the agricultural health study" [2] (multiple letters)
American Journal of Epidemiology, 161(1), 101–103.
Contributors: C. Poole*, M. Cullen *, R. Irons*, J. Acquavella *, W. Lee, J. Hoppin , A. Blair, J. Lubin
MeSH headings : Acetamides; Adult; Agricultural Workers' Diseases / epidemiology; Causality; Female; Herbicides; Humans; Incidence; Iowa / epidemiology; Male; Middle Aged; Neoplasms / epidemiology; North Carolina / epidemiology; Occupational Exposure / statistics & numerical data; Reference Values
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: September 13, 2019
2005 journal article
Pesticide Use and Breast Cancer Risk among Farmers' Wives in the Agricultural Health Study
American Journal of Epidemiology, 161(2), 121–135.
Contributors: L. Engel *, D. Hill*, J. Hoppin* , J. Lubin*, C. Lynch *, J. Pierce, C. Samanic*, D. Sandler *, A. Blair*, M. Alavanja*
author keywords: agriculture; agrochemicals; breast neoplasms; fungicides; industrial; herbicides; insecticides; pesticides; risk
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / chemically induced; Breast Neoplasms / chemically induced; Female; Follow-Up Studies; Humans; Iowa; Life Style; Male; Middle Aged; North Carolina; Occupational Exposure / adverse effects; Pesticides / adverse effects; Prospective Studies; Reproductive History; Risk Factors; Spouses
TL;DR:
The authors found no clear association of breast cancer risk with farm size or washing of clothes worn during pesticide application, but risk was modestly elevated among women whose homes were closest to areas of pesticide application.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 13, 2019
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