Works Published in 2014
Displaying works 41 - 60 of 270 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Signatures of sex-antagonistic selection on recombining sex chromosomes.
Genetics, 6.
MeSH headings : Animals; Biological Evolution; Female; Genetic Variation; Linkage Disequilibrium; Male; Models, Genetic; Selection, Genetic; Sex Chromosomes / genetics; Silene / genetics
TL;DR:
This work uses coalescent models to characterize the patterns of polymorphism expected within and divergence between recombining X and Y (or Z and W) sex chromosomes and shows how the pattern of divergence is altered when the SA polymorphism or the sex-determining region was recently established.
(via Semantic Scholar)
www.genetics.org (publisher PDF)
Source: ORCID
Added: September 15, 2020
2014 journal article
LOCAL ADAPTATION AND THE EVOLUTION OF CHROMOSOME FUSIONS
Evolution, 68(10), 2747–2756.
author keywords: Coalescent; population divergence; rearrangements; recombination; Robertsonian translocations; selection
MeSH headings : Adaptation, Physiological / genetics; Alleles; Biological Evolution; Chromosomes / genetics; Genetic Fitness; Genetics, Population; Models, Genetic; Recombination, Genetic; Selection, Genetic
TL;DR:
Local adaptation could explain the evolution of many of chromosome fusions, which are some of the most common chromosome rearrangements in nature.
(via Semantic Scholar)
Source: ORCID
Added: September 15, 2020
2014 journal article
Matrix inversions for chromosomal inversions: A method to construct summary statistics in complex coalescent models
Theoretical Population Biology.
author keywords: Chromosomal inversions; Coalescent models; Local adaptation; Gametic disequilibrium; Approximate Bayesian computation
MeSH headings : Animals; Bayes Theorem; Chromosome Inversion / statistics & numerical data; Linkage Disequilibrium; Models, Genetic; Models, Statistical
TL;DR:
A method to construct summary statistics in such complex population structure models by analyzing the disequilibrium between two sites within an inversion and providing an estimator of the distinct recombination rate between these two sites in homokaryotype and heterokaryotypes is defined.
(via Semantic Scholar)
Source: ORCID
Added: September 15, 2020
2014 journal article
Efficient Use of Information in Adaptive Management with an Application to Managing Recreation near Golden Eagle Nesting Sites
PLoS ONE, 9(8), e102434.
Ed(s): A. Margalida
MeSH headings : Animals; Eagles / physiology; Female; Humans; Male; Models, Biological; Nesting Behavior / physiology
TL;DR:
This paper uses an extension of the Partial Observable Markov Decision Process (POMDP) framework to expand the information set used to update belief in competing models and applies this framework to a case study wherein interest lies in managing recreational restrictions around golden eagle nesting sites.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 15, 2020
2014 journal article
Reducing fatigue damage for ships in transit through structured decision making
Marine Structures, 38, 18–43.
author keywords: Structured Decision Making; Fatigue damage; Structural reliability
TL;DR:
This work describes a structured decision making (SDM) process for taking available information and producing a plan of action for maintaining the structure and shows the benefit of SDM over heuristic approaches to maintaining the vessel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 15, 2020
2014 journal article
Loss of estrogen-mediated immunoprotection underlies female gender bias in experimental Crohn’s-like ileitis
Mucosal Immunology, 7(5), 1255–1265.
MeSH headings : Animals; Crohn Disease / drug therapy; Crohn Disease / immunology; Crohn Disease / physiopathology; Disease Models, Animal; Estrogens / pharmacology; Female; Flow Cytometry; Ileitis / drug therapy; Ileitis / physiopathology; Male; Mice; Sex Factors; T-Lymphocytes, Regulatory / drug effects
TL;DR:
Hormone signaling influences the expansion and function of GALT Tregs in an ER-dependent manner and contributes to gender-based differences in experimental CD.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Reprint of: Policy decisions on endocrine disruptors should be based on science across disciplines: A response to Dietrich et al.
Hormones and Behavior, 65(2), 190–193.
MeSH headings : Animals; Endocrine Disruptors / toxicity; Humans
Source: Crossref
Added: August 28, 2020
2014 journal article
Mouse model systems to study sex chromosome genes and behavior: Relevance to humans
Frontiers in Neuroendocrinology, 35(4), 405–419.
author keywords: Klinefelter syndrome; Turner syndrome; Four core genotypes; Sex differences; Behavior; Sexual differentiation
MeSH headings : Animals; Behavior, Animal / physiology; Disease Models, Animal; Genes, sry / genetics; Humans; Mice; Sex Characteristics; Sex Chromosomes / genetics; Y Chromosome / genetics
TL;DR:
It is concluded that many social and cognitive behaviors are modified by sex chromosome complement, and the implications for human research are discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
Reprint of: Policy decisions on endocrine disruptors should be based on science across disciplines: A response to Dietrich, et al.
Frontiers in Neuroendocrinology, 35(1), 2–5.
Source: Crossref
Added: August 28, 2020
2014 journal article
Dietary phytoestrogens inhibit experimental aneurysm formation in male mice
Journal of Surgical Research, 188(1), 326–338.
author keywords: Phytoestrogen; Aortic aneurysm; Mouse AAA model; Aneurysm phenotype; Inflammatory cytokine; MMP
MeSH headings : Animals; Aorta, Abdominal / metabolism; Aorta, Abdominal / pathology; Aortic Aneurysm, Abdominal / pathology; Aortic Aneurysm, Abdominal / prevention & control; Cytokines / metabolism; Dietary Supplements; Female; Inflammation / diet therapy; Male; Matrix Metalloproteinase 9 / metabolism; Mice; Mice, Inbred C57BL; Phytoestrogens / blood; Phytoestrogens / therapeutic use
TL;DR:
The results suggest that dietary phytoestrogens inhibit experimental aortic aneurysm formation in male mice via a reduction of the inflammatory response in the aorta wall.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Do early paternal exposures to lifestyle factors such as smoking increase the risk of chronic diseases in the offspring?
European Journal of Human Genetics, 22(12), 1341–1342.
MeSH headings : Adiposity; Female; Humans; Male; Paternal Exposure; Puberty; Smoking / adverse effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
PD31-11 CARBOHYDRATE INTAKE, GLYCEMIC INDEX AND PROSTATE CANCER RISK
Journal of Urology, 191(4S).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
The association between race and prostate cancer risk on initial biopsy in an equal access, multiethnic cohort
Cancer Causes & Control, 25(8), 1029–1035.
author keywords: Prostate cancer; Risk; Initial biopsy; Race; Equal access
MeSH headings : Aged; Biopsy, Needle; Black People / statistics & numerical data; Cohort Studies; Health Services Accessibility; Humans; Male; Middle Aged; North Carolina; Prostatic Neoplasms / ethnology; Prostatic Neoplasms / pathology; Retrospective Studies; Veterans / statistics & numerical data; White People / statistics & numerical data
TL;DR:
In an equal access healthcare facility, black race was associated with greater risk of PC detection on initial biopsy and of high-grade PC after adjusting for clinical characteristics and mechanisms linking black race and PC risk and PC aggressiveness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
A paternal environmental legacy: Evidence for epigenetic inheritance through the male germ line
BioEssays, 36(4), 359–371.
author keywords: developmental origins of health and disease (DOHaD); environment; epigenetics; imprinted genes; offspring; paternal exposures; spermatogenesis; transgenerational effects
MeSH headings : Animals; DNA Methylation; Diet; Epigenesis, Genetic; Gene-Environment Interaction; Genomic Imprinting; Histones / metabolism; Humans; Life Style; Male; Obesity / genetics; Paternal Exposure; RNA, Untranslated; Radiation, Ionizing; Spermatogenesis / physiology; Spermatozoa / physiology; Zygote
TL;DR:
This essay suggests the existence of epigenetic windows of susceptibility to environmental insults during sperm development and suggests changes in DNA methylation, histone modification, and non‐coding RNAs are viable mechanistic candidates for a non‐genetic transfer of paternal environmental information, from maturing germ cell to zygote.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Bisphenol A and cardiometabolic risk factors in obese children
Science of The Total Environment, 470-471, 726–732.
Contributors: N. Khalil *, J. Ebert *, L. Wang *, S. Belcher* , M. Lee *, S. Czerwinski*, K. Kannan *
author keywords: Bisphenol A; Endocrine disruptor; Non-monotonic dose response; Childhood obesity; Nonalcoholic fatty liver disease; Spline analysis
MeSH headings : Anthropometry; Aspartate Aminotransferases / blood; Benzhydryl Compounds / blood; Body Mass Index; Child; Endocrine Disruptors / blood; Fatty Liver / blood; Fatty Liver / epidemiology; Female; Humans; Insulin Resistance; Male; Non-alcoholic Fatty Liver Disease; Obesity / blood; Obesity / epidemiology; Ohio / epidemiology; Phenols / blood; Risk Factors
TL;DR:
Urinary BPA in obese children, at least in males is associated with adverse liver and metabolic effects, and high diastolic blood pressure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2014 journal article
Classical nuclear hormone receptor activity as a mediator of complex concentration response relationships for endocrine active compounds
Current Opinion in Pharmacology, 19, 112–119.
Contributors: C. Cookman & S. Belcher*
MeSH headings : Animals; Cell Survival / drug effects; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Humans; Receptors, Cytoplasmic and Nuclear / metabolism
TL;DR:
Evidence suggests that ligand selectivity, activation of multiple molecular targets, concerted regulation of multiple opposing endpoints, and multiple ligand binding sites within nuclear receptors also contribute to nonmonotonic concentration response relationships of endocrine active ligands.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2014 journal article
Zebrafish: A Marvel of High-Throughput Biology for 21st Century Toxicology
Current Environmental Health Reports, 1(4), 341–352.
TL;DR:
Advances in automation, high-throughput screening, and analysis that leverage the power of the zebrafish embryo model for unparalleled advances in the authors' understanding of how chemicals in their environment affect their health and wellbeing are highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2014 journal article
Evidence of the Biochemical Basis of Host Virulence in the Greenbug Aphid,Schizaphis graminum(Homoptera: Aphididae)
Journal of Proteome Research, 13(4), 2094–2108.
author keywords: aphid; biotype; vector biology; insect-plant interactions; host virulence; Schizaphis graminum; greenbug; DIGE; LC-MS/MS
MeSH headings : Animals; Aphids / genetics; Aphids / microbiology; Aphids / pathogenicity; Aphids / physiology; Buchnera; Host-Parasite Interactions; Insect Proteins / analysis; Insect Proteins / classification; Insect Proteins / genetics; Insect Proteins / metabolism; Poaceae / parasitology; Proteome / analysis; Proteome / genetics; Proteome / metabolism; Proteome / physiology; Symbiosis
Source: Crossref
Added: August 28, 2020
2014 journal article
Synchrotron Chemical and Structural Analysis of Tyrannosaurus rex Blood Vessels: The Contribution of Collagen Hypercrosslinking to Tissue Longevity
Microscopy and Microanalysis, 20(S3), 1430–1431.
TL;DR:
Non-enzymatic intermolecular crosslinking of fibrillar collagen supermolescular networks in fossil blood vessels has been suggested as a possible contributor to tissue longevity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2014 journal article
Mercury bioaccumulation in Southern Appalachian birds, assessed through feather concentrations
Ecotoxicology, 23(2), 304–316.
author keywords: Mercury; Songbirds; Appalachian Mountains; Nitrogen-15 stable isotope; Trophic position; Terrestrial
MeSH headings : Animals; Birds; Environmental Monitoring / methods; Environmental Pollutants / analysis; Feathers / chemistry; Female; Linear Models; Male; Mercury / analysis
TL;DR:
It is demonstrated that mercury is biomagnifying in birds within this terrestrial mountainous system, and further research is warranted for animals foraging at higher trophic levels, particularly those associated with aquatic environments downslope from montane areas receiving high mercury deposition.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
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