Center for Environmental and Health Effects of PFAS

Works Published in 2012

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Displaying works 61 - 80 of 115 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2012 journal article

Fungal and atopic sensitization are low among farmers in the Agricultural Health Study

Journal of Allergy and Clinical Immunology, 130(1), 267–270.e1.

By: S. Endres*, B. Green*, P. Henneberger*, D. Germolec*, T. Bledsoe*, D. Beezhold*, S. London*, M. Alavanja*, L. Beane Freeman*, J. Hoppin*

Contributors: S. Endres*, B. Green*, P. Henneberger*, D. Germolec*, T. Bledsoe*, D. Beezhold*, S. London*, M. Alavanja*, L. Beane Freeman*, J. Hoppin*

MeSH headings : Agricultural Workers' Diseases / diagnosis; Agricultural Workers' Diseases / epidemiology; Agricultural Workers' Diseases / etiology; Agricultural Workers' Diseases / immunology; Agriculture; Fungi / classification; Fungi / immunology; Humans; Hypersensitivity, Immediate / diagnosis; Hypersensitivity, Immediate / epidemiology; Hypersensitivity, Immediate / etiology; Hypersensitivity, Immediate / immunology; Immunoglobulin E / blood; Male; Prevalence; Surveys and Questionnaires
TL;DR: Prevalence of fungal sensitization and atopy was lower among farmers than the US population and related to growing specific agricultural commodities. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 13, 2019

2012 journal article

Consumer product exposures associated with urinary phthalate levels in pregnant women

Journal of Exposure Science & Environmental Epidemiology, 22(5), 468–475.

By: J. Buckley*, R. Palmieri*, J. Matuszewski*, A. Herring*, D. Baird*, K. Hartmann*, J. Hoppin*

Contributors: J. Buckley*, R. Palmieri*, J. Matuszewski*, A. Herring*, D. Baird*, K. Hartmann*, J. Hoppin*

author keywords: phthalates; pregnancy; biomonitoring; urine; personal care products
MeSH headings : Adolescent; Adult; Cosmetics / adverse effects; Female; Household Articles; Household Products / adverse effects; Humans; Perfume / adverse effects; Phthalic Acids / metabolism; Phthalic Acids / urine; Pregnancy; Surveys and Questionnaires; Young Adult
TL;DR: Although personal care product use may be an important predictor of urinaryphthalate levels, most of the variability in phthalate exposure was not captured by the relatively comprehensive set of questionnaire items. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 13, 2019

2012 journal article

Exposure to Tobacco Smoke in Utero and Subsequent Plasma Lipids, ApoB, and CRP among Adult Women in the MoBa Cohort

Environmental Health Perspectives, 120(11), 1532–1537.

By: L. Cupul-Uicab*, R. Skjaerven*, K. Haug*, G. Travlos*, R. Wilson*, M. Eggesbø*, J. Hoppin*, K. Whitworth*, M. Longnecker*

Contributors: L. Cupul-Uicab*, R. Skjaerven*, K. Haug*, G. Travlos*, R. Wilson*, M. Eggesbø*, J. Hoppin*, K. Whitworth*, M. Longnecker*

author keywords: clinical chemistry; C-reactive protein; metabolic syndrome; plasma lipids; prenatal exposure delayed effects; smoking; women
MeSH headings : Adolescent; Adult; Biomarkers / blood; C-Reactive Protein / metabolism; Cohort Studies; Female; Humans; Lipids / blood; Metabolic Syndrome / blood; Metabolic Syndrome / chemically induced; Metabolic Syndrome / epidemiology; Norway / epidemiology; Pregnancy; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / epidemiology; Risk Factors; Smoking / adverse effects; Smoking / epidemiology; Tobacco Smoke Pollution / adverse effects; Young Adult
TL;DR: In this population of pregnant women, in utero exposure to tobacco smoke was associated with high triglycerides and low HDL in adulthood, 18–44 years after exposure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref
Added: September 13, 2019

2012 journal article

Lifetime organophosphorous insecticide use among private pesticide applicators in the Agricultural Health Study

Journal of Exposure Science & Environmental Epidemiology, 22(6), 584–592.

By: J. Hoppin*, S. Long*, D. Umbach*, J. Lubin*, S. Starks*, F. Gerr*, K. Thomas*, C. Hines* ...

Contributors: J. Hoppin*, S. Long*, D. Umbach*, J. Lubin*, S. Starks*, F. Gerr*, K. Thomas*, C. Hines* ...

author keywords: pesticide use; farming; organophosphorous insecticide
MeSH headings : Aged; Aged, 80 and over; Humans; Insecticides; Middle Aged; North Carolina; Organophosphorus Compounds; Private Sector
TL;DR: Information on farmers’ OP use enhances the ability to characterize and understand the potential health effects of multiple OP exposures, and much of the variability in OP use was associated with the choice of OP, rather than the frequency or duration of application. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 13, 2019

2012 journal article

Genetic modification of the association of paraquat and Parkinson's disease

Movement Disorders, 27(13), 1652–1658.

By: S. Goldman*, F. Kamel*, G. Ross*, G. Bhudhikanok*, J. Hoppin*, M. Korell*, C. Marras*, C. Meng* ...

Contributors: S. Goldman*, F. Kamel*, G. Ross*, G. Bhudhikanok*, J. Hoppin*, M. Korell*, C. Marras*, C. Meng* ...

author keywords: Parkinson's disease; paraquat; glutathione transferase; pesticide; gene-environment interaction
MeSH headings : Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Cohort Studies; Diagnosis, Computer-Assisted; Disease Susceptibility / chemically induced; Disease Susceptibility / epidemiology; Female; Gene Deletion; Genetic Association Studies; Genotype; Glutathione Transferase / genetics; Herbicides / toxicity; Humans; Male; Middle Aged; Occupational Exposure; Paraquat / toxicity; Parkinson Disease, Secondary / chemically induced; Parkinson Disease, Secondary / epidemiology; Parkinson Disease, Secondary / genetics; Risk Factors; Surveys and Questionnaires
TL;DR: The results suggest that PD risk from paraquat exposure might be particularly high in individuals lacking GSTT1, which is common and could potentially identify a large subpopulation at high risk of PD from oxidative stressors such as paraquats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref
Added: September 13, 2019

2012 journal article

Collaborative biocuration--text-mining development task for document prioritization for curation

Database, 2012(0), bas037–bas037.

By: T. Wiegers n, A. Davis n & C. Mattingly n

MeSH headings : Cooperative Behavior; Data Mining / methods; Databases, Genetic; Disease; Documentation / methods; Genes; Humans; Internet; Toxicogenetics; User-Computer Interface
TL;DR: A detailed description of the Critical Assessment of Information Extraction systems in Biology (BioCreAtIvE) challenge evaluation is presented and a summary of the results are presented. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 7, 2019

2012 journal article

MEDIC: a practical disease vocabulary used at the Comparative Toxicogenomics Database

Database, 2012(0), bar065–bar065.

By: A. Davis*, T. Wiegers*, M. Rosenstein* & C. Mattingly*

MeSH headings : Databases, Factual; Disease / classification; Humans; Subject Headings; Toxicogenetics
TL;DR: The construction, implementation, maintenance and use of MEDIC is described to raise awareness of this resource and to offer it as a putative scaffold in the formal construction of an official disease ontology. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 7, 2019

2012 journal article

Aquatic models, genomics and chemical risk management

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 155(1), 169–173.

By: K. Cheng*, D. Hinton*, C. Mattingly* & A. Planchart*

Contributors: K. Cheng*, D. Hinton*, C. Mattingly* & A. Planchart*

author keywords: Aquatic toxicology; Phenome project; Zebrafish; Genomics; Atlas
MeSH headings : Animals; Computational Biology / methods; Databases, Factual; Ecotoxicology; Environmental Exposure / analysis; Environmental Monitoring / methods; Fishes / anatomy & histology; Fishes / genetics; Fishes / physiology; Gene-Environment Interaction; Genomics / methods; Internet; Models, Animal; Risk Factors; User-Computer Interface
TL;DR: It is concluded that automation, database generation, and web-based accessibility, facilitated by genomic/transcriptomic data and high-performance and cloud computing, will potentiate the unique and potentially key roles that aquatic models play in advancing systems biology, drug development, and environmental risk management. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 7, 2019

2012 journal article

Disease model curation improvements at Mouse Genome Informatics

Database, 2012(0), bar063–bar063.

By: S. Bello*, J. Richardson*, A. Davis*, T. Wiegers*, C. Mattingly*, M. Dolan*, C. Smith*, J. Blake*, J. Eppig*

MeSH headings : Animals; Database Management Systems; Databases, Factual; Disease Models, Animal; Genome; Humans; Mice / genetics; Molecular Sequence Annotation; User-Computer Interface
TL;DR: The merged Medical Subject Headings (MeSH) and OMIM disease vocabulary created by the Comparative Toxicogenomics Database (CTD) project is evaluated and an extended version of the vocabulary is created to meet the genetic disease-specific curation needs at MGI. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: August 7, 2019

2012 journal article

The Comparative Toxicogenomics Database: update 2013

Nucleic Acids Research, 41(D1), D1104–D1114.

By: A. Davis, C. Murphy, R. Johnson, J. Lay, K. Lennon-Hopkins, C. Saraceni-Richards, D. Sciaky, B. King ...

MeSH headings : Computer Graphics; Databases, Chemical; Disease / genetics; Internet; Software; Toxicogenetics
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Crossref, ORCID
Added: August 7, 2019

2012 journal article

Aggregating Data for Computational Toxicology Applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System.

International Journal of Molecular Sciences, 13(2), 1805–1831.

By: R. Judson*, M. Martin*, P. Egeghy*, S. Gangwal*, D. Reif*, P. Kothiya*, M. Wolf*, T. Cathey* ...

Contributors: R. Judson*, M. Martin*, P. Egeghy*, S. Gangwal*, D. Reif*, P. Kothiya*, M. Wolf*, T. Cathey* ...

author keywords: computational toxicology; database; hazard; exposure; high-throughput screening; ACToR; ToxCastDB; ExpoCastDB; ToxRefDB; DSSTox
MeSH headings : Algorithms; Computational Biology / methods; Databases, Factual / standards; Databases, Factual / supply & distribution; Ecotoxicology / methods; Ecotoxicology / organization & administration; Environmental Pollutants / toxicity; Humans; Software; United States; United States Environmental Protection Agency / organization & administration
TL;DR: The organization of the ACToR data repository is described and selected examples of use cases are provided, including links to underlying biological information related to genes and pathways. (via Semantic Scholar)
Source: ORCID
Added: May 14, 2019

2012 journal article

Zebrafish developmental screening of the ToxCast™ Phase I chemical library.

Reproductive Toxicology, 33(2), 174–187.

By: S. Padilla*, D. Corum*, B. Padnos*, D. Hunter*, A. Beam*, K. Houck*, N. Sipes*, N. Kleinstreuer* ...

Contributors: S. Padilla*, D. Corum*, B. Padnos*, D. Hunter*, A. Beam*, K. Houck*, N. Sipes*, N. Kleinstreuer* ...

author keywords: Zebrafish; Development; Concentration-response; ToxCast (TM); Octanol-water partition coefficient; Chemical class
MeSH headings : Animals; Embryo, Nonmammalian / drug effects; Environmental Pollutants / toxicity; Models, Animal; Pesticides / toxicity; Small Molecule Libraries; Teratogens / toxicity; Toxicity Tests / methods; Zebrafish
TL;DR: The zebrafish embryo screen, by providing an integrated model of the developing vertebrate, compliments the ToxCast assay portfolio and has the potential to provide information relative to overt and organismal toxicity. (via Semantic Scholar)
Source: ORCID
Added: May 14, 2019

2012 journal article

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

Chem. Res. Toxicol., 25(7), 1287–1302.

By: R. Kavlock*, K. Chandler*, K. Houck*, S. Hunter*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin* ...

Contributors: R. Kavlock*, K. Chandler*, K. Houck*, S. Hunter*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin* ...

MeSH headings : Biological Assay; Decision Support Techniques; Environmental Pollutants / chemistry; Environmental Pollutants / toxicity; Humans; Program Development; Risk Management; United States; United States Environmental Protection Agency
TL;DR: A summary of the initial, proof of concept, Phase I of ToxCast that has laid the groundwork for the next phases and future directions of the program is provided. (via Semantic Scholar)
Source: ORCID
Added: May 14, 2019

2012 journal article

Incorporating exposure information into the toxicological prioritization index decision support framework

Science of The Total Environment, 435-436, 316–325.

By: S. Gangwal*, D. Reif*, S. Mosher*, P. Egeghy*, J. Wambaugh*, R. Judson*, E. Hubal*

Contributors: S. Gangwal*, D. Reif*, S. Mosher*, P. Egeghy*, J. Wambaugh*, R. Judson*, E. Hubal*

author keywords: ExpoCast; Exposure assessment; ToxCast; Exposure metrics; Exposure prioritization; Pesticides
MeSH headings : Adolescent; Adult; Child; Child, Preschool; Decision Support Techniques; Environmental Exposure; Fruit / chemistry; Hazardous Substances / analysis; Humans; Infant; Male; Middle Aged; Models, Biological; Nutrition Surveys / statistics & numerical data; Pesticide Residues / adverse effects; Pesticide Residues / analysis; Risk Assessment / methods; Vegetables / chemistry; Young Adult
TL;DR: The goal of this analysis is to demonstrate the utility of the ToxPi framework for incorporating exposure information to rank chemicals and improve understanding of key exposure surrogates and build confidence in exposure-based chemical prioritization. (via Semantic Scholar)
Source: ORCID
Added: May 14, 2019

2012 journal article

Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity.

Toxicological Sciences, 130(2), 440–441.

By: D. Dix*, K. Houck*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin*, D. Reif*, A. Richard* ...

Contributors: D. Dix*, K. Houck*, R. Judson*, N. Kleinstreuer*, T. Knudsen*, M. Martin*, D. Reif*, A. Richard* ...

MeSH headings : Animals; Hazardous Substances / toxicity
TL;DR: An evaluation of statistical models for classifying in vivo toxicity endpoints from ToxRefDB using ToxCast in vitro bioactivity data and chemical structure descriptors concluded that the current Tox cast phase I assays and chemicals have limited applicability for predicting in vivo chemical hazards. (via Semantic Scholar)
Source: ORCID
Added: May 14, 2019

2012 journal article

A comparison of internal model validation methods for multifactor dimensionality reduction in the case of genetic heterogeneity

BMC Research Notes, 5(1), 623.

By: J. Gory n, H. Sweeney n, D. Reif n & A. Motsinger-Reif n

Contributors: J. Gory n, H. Sweeney n, D. Reif n & A. Motsinger-Reif n

MeSH headings : Algorithms; Computer Simulation; Epistasis, Genetic; Genetic Heterogeneity; Humans; Models, Genetic; Multifactor Dimensionality Reduction / standards; Research Design; Validation Studies as Topic
TL;DR: Results show that the cross-validation approach greatly outperformed the three-way split approach in detecting heterogeneity and emphasize the challenge of detecting heterogeneity models and the need for further methods development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: ORCID
Added: May 14, 2019

2012 conference paper

A comparison of GE optimized neural networks and decision trees

Proceedings of the fourteenth international conference on Genetic and evolutionary computation conference companion - GECCO Companion '12, 611–614.

By: K. Hoover, R. Marceau n, T. Harris n, D. Reif n & A. Motsinger-Reif n

Contributors: K. Hoover, D. Reif n, R. Marceau n, T. Harris n & A. Motsinger-Reif n

TL;DR: Grammatical evolution of decision trees (GEDT) is shown to be not as effective as GENN at detecting disease causing polymorphisms especially in more difficult to detect models, but this power trade off may be worth it for interpretability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions (OpenAlex)
Source: ORCID
Added: May 14, 2019

2012 journal article

Development and Characterization of Anti-Nitr9 Antibodies

Advances in Hematology, 2012, 1–9.

By: R. Shah n, I. Rodriguez-Nunez n, D. Eason*, R. Haire*, J. Bertrand*, V. Wittamer*, D. Traver*, S. Nordone n ...

TL;DR: Anti-Nitr9 monoclonal antibodies were generated and evaluated for the ability to recognize the three Nitr9 isoforms and should prove to be useful for identifying the specific lymphocyte lineages that express Nitr9 and may permit the isolation of Nitr9-expressing cells that can be directly assessed for cytotoxic function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: ORCID, Crossref
Added: February 13, 2019

2012 conference paper

Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) Protein Plays A Critical Role In Production Of Proinflammatory Cytokines By Isolated Canine Neutrophils

A67. ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS SYNDROME: BIOLOGICAL MECHANISMS.

By: S. Nordone, J. Li, M. D’Annibale, A. Birkenheuer, M. Levy, J. Yoder*, S. Jones, K. Adler

Source: ORCID
Added: February 13, 2019

2012 journal article

Targeted Proteomics of the Secretory Pathway Reveals the Secretome of Mouse Embryonic Fibroblasts and Human Embryonic Stem Cells

MOLECULAR & CELLULAR PROTEOMICS, 11(12), 1829–1839.

By: P. Sarkar n, S. Randall n, D. Muddiman n & B. Rao n

MeSH headings : Animals; Cell Differentiation; Cells, Cultured; Culture Media, Conditioned / analysis; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; Mice; Proteins / analysis; Secretory Pathway; Subcellular Fractions / chemistry
TL;DR: Targeted proteomics of secretory pathway organelles is shown to be a powerful alternate approach for interrogating the cellular secretome and expected to be particularly valuable in two contexts highly relevant to hESC biology: obtaining a temporal snapshot of proteins secreted in response to a differentiation trigger, and identifying proteinssecreted by cells that are isolated from a heterogeneous population. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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