Audrey T. O'Nan

Works (8)

Updated: August 5th, 2023 21:15

2018 journal article

Articular cartilage gene expression patterns in the tissue surrounding the impact site following applications of shear and axial loads

BMC Musculoskeletal Disorders, 19(1).

By: R. McCulloch n, P. Mente n, A. O’Nan n & M. Ashwell n 

author keywords: Osteoarthritis; Porcine; Articular injury
MeSH headings : Animals; Cartilage, Articular / metabolism; Cartilage, Articular / pathology; Collagen Type II / genetics; Collagen Type II / metabolism; Gene Expression Profiling / methods; Gene Expression Regulation, Enzymologic; Osteoarthritis, Knee / genetics; Osteoarthritis, Knee / metabolism; Osteoarthritis, Knee / pathology; Patella / metabolism; Patella / pathology; Stress, Mechanical; Sus scrofa; Time Factors; Tissue Culture Techniques; Transcriptome; fas Receptor / genetics; fas Receptor / metabolism
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Knee injuries and reconstruction techniques; Tendon Structure and Treatment
TL;DR: The results suggest that a more physiologically valid shear load may induce more damage to surrounding articular cartilage than a normal load alone. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: January 14, 2019

2018 journal article

Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain

The Veterinary Journal, 243, 42–47.

By: M. Ashwell n , M. Freire n , A. O’Nan n, J. Benito n , J. Hash n, R. McCulloch*, B. Lascelles n 

author keywords: Cat; Degenerative joint disease; Neurobiological signature; Osteoarthritis; Pain
MeSH headings : Animals; Cat Diseases / genetics; Cats; Female; Ganglia, Spinal / metabolism; Ganglia, Spinal / physiopathology; Gene Expression; Gene Expression Profiling; Lumbosacral Region / physiopathology; Male; Osteoarthritis, Spine / veterinary; Pain / genetics; Pain / veterinary; Spinal Cord Dorsal Horn / metabolism; Spinal Cord Dorsal Horn / physiopathology
topics (OpenAlex): Veterinary Orthopedics and Neurology; Veterinary Equine Medical Research; Osteoarthritis Treatment and Mechanisms
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Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: February 11, 2019

2014 article

The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine

Howard, J. T., Baynes, R. E., Brooks, J. D., Yeatts, J. L., Bellis, B., Ashwell, M. S., … Maltecca, C. (2014, April 15). Journal of Veterinary Pharmacology and Therapeutics, Vol. 37, pp. 531–541.

By: J. Howard  n, R. Baynes n , J. Brooks n, J. Yeatts n, B. Bellis n, M. Ashwell n , P. Routh n, A. O'Nan n, C. Maltecca n 

Contributors: J. Howard  n, R. Baynes n , J. Brooks n, J. Yeatts n, B. Bellis n, M. Ashwell n , P. Routh n, . A.T. O'Nan n, C. Maltecca n 

MeSH headings : Animals; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Antinematodal Agents / blood; Antinematodal Agents / pharmacokinetics; Benzimidazoles / blood; Ciprofloxacin / blood; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Enrofloxacin; Female; Fenbendazole / blood; Fenbendazole / pharmacokinetics; Fluoroquinolones / blood; Fluoroquinolones / pharmacokinetics; Male; Sex Factors; Species Specificity; Sulfamethazine / analogs & derivatives; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / metabolism
topics (OpenAlex): Antibiotics Pharmacokinetics and Efficacy; Drug Transport and Resistance Mechanisms; Pharmacogenetics and Drug Metabolism
TL;DR: Whether drug clearance differs across genetic backgrounds and sex for sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine is determined to determine the degree of additive genetic variation utilizing a larger population. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 article

Amount and source of dietary copper affects small intestine morphology, duodenal lipid peroxidation, hepatic oxidative stress,and mRNA expression of hepatic copper regulatory proteins in weanling pigs1,2

Fry, R. S., Ashwell, M. S., Lloyd, K. E., O'Nan, A. T., Flowers, W. L., Stewart, K. R., & Spears, J. W. (2012, May 15). Journal of Animal Science, Vol. 90, pp. 3112–3119.

By: R. Fry n, M. Ashwell n , K. Lloyd n, A. O'Nan n, W. Flowers n , K. Stewart n, J. Spears n

author keywords: copper; copper proteins; mucosal histology; oxidative stress; pigs
MeSH headings : Animals; Copper / metabolism; Copper / pharmacology; Duodenum / drug effects; Duodenum / metabolism; Gene Expression Regulation / drug effects; Intestinal Mucosa / drug effects; Lipid Peroxidation / drug effects; Liver / metabolism; Male; Malondialdehyde / metabolism; Oxidative Stress / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Real-Time Polymerase Chain Reaction / veterinary; Swine / blood; Swine / metabolism
topics (OpenAlex): Trace Elements in Health; Heavy Metal Exposure and Toxicity; Plant Micronutrient Interactions and Effects
TL;DR: Results of this study indicated that, when fed at 225 mg Cu/kg diet, TBCC may cause less oxidative stress in the duodenum than CuSO(4), and feeding weanling pigs increased Cu resulted in modulation of certain Cu transporters and chaperones at the transcription level. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Changes in chondrocyte gene expression following in vitro impaction of porcine articular cartilage in an impact injury model

Ashwell, M. S., Gonda, M. G., Gray, K., Maltecca, C., O'Nan, A. T., Cassady, J. P., & Mente, P. L. (2012, October 1). Journal of Orthopaedic Research®, Vol. 31, pp. 385–391.

By: M. Ashwell n , M. Gonda n, K. Gray n, C. Maltecca n , A. O'Nan n, J. Cassady n, P. Mente n

Contributors: M. Ashwell n , M. Gonda n, K. Gray n, C. Maltecca n , . A.T. O'Nan n, J. Cassady n, P. Mente n

author keywords: articular cartilage; chondrocyte; gene expression; joint injury; osteoarthritis
MeSH headings : Animals; Cartilage, Articular / cytology; Cartilage, Articular / physiology; Chondrocytes / physiology; Female; Knee Injuries / genetics; Knee Injuries / physiopathology; Knee Joint / cytology; Knee Joint / physiology; Models, Genetic; Organ Culture Techniques; Osteoarthritis, Knee / genetics; Osteoarthritis, Knee / physiopathology; Patella / cytology; Patella / physiology; Real-Time Polymerase Chain Reaction; Sus scrofa; Transcriptome / physiology
topics (OpenAlex): Lower Extremity Biomechanics and Pathologies; Tendon Structure and Treatment; Osteoarthritis Treatment and Mechanisms
TL;DR: Ten of the 17 genes were differentially expressed with col1a1 most significantly up‐regulated in the impacted samples, suggesting impacted chondrocytes may have reverted to a fibroblast‐like phenotype. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 article

Effect of dietary copper and breed on gene products involved in copper acquisition, distribution, and use in Angus and Simmental cows and fetuses1,2

Fry, R. S., Spears, J. W., Lloyd, K. E., O'Nan, A. T., & Ashwell, M. S. (2012, November 13). Journal of Animal Science, Vol. 91, pp. 861–871.

By: R. Fry n, J. Spears n, K. Lloyd n, A. O'Nan n & M. Ashwell n 

author keywords: breed; cattle; copper; deficiency; fetus; placentome
MeSH headings : Animals; Cattle / genetics; Cattle / metabolism; Copper / blood; Copper / pharmacokinetics; Copper / pharmacology; Female; Fetus / metabolism; Gene Expression Regulation / drug effects; Liver / metabolism; Minerals; Pregnancy
topics (OpenAlex): Trace Elements in Health; Plant Micronutrient Interactions and Effects
TL;DR: Less expression of duodenal Ctr1 and a tendency for less CTR1 suggest that Simmentals have a lesser ability to absorb and utilize dietary Cu, and may explain why Simmental are more prone to Cu deficiency than Angus. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 article

Investigation of breed and sex effects on cytochrome P450 gene expression in cattle liver

Ashwell, M. S., Fry, R. S., Spears, J. W., O’Nan, A. T., & Maltecca, C. (2010, June 17). Research in Veterinary Science, Vol. 90, pp. 235–237.

By: M. Ashwell n , R. Fry n, J. Spears n, A. O’Nan n & C. Maltecca n 

Contributors: M. Ashwell n , R. Fry n, J. Spears n, . A.T. O'Nan n & C. Maltecca n 

author keywords: Cytochrome P450; Cattle; Gene expression; Liver
MeSH headings : Animals; Cattle / genetics; Cattle / metabolism; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Female; Gene Expression Regulation, Enzymologic / genetics; Gene Expression Regulation, Enzymologic / physiology; Liver / enzymology; Male; Sex Characteristics
topics (OpenAlex): Molecular Biology Techniques and Applications; Genetic and phenotypic traits in livestock; Pharmacogenetics and Drug Metabolism
TL;DR: Breed and/or sex of an animal may need to be considered before administering a dose of a xenobiotic due to the potential for harmful drug residues in foodstuffs as well as improper treatment of disease conditions. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 article

Gene expression profiling of chondrocytes from a porcine impact injury model

Ashwell, M. S., O'Nan, A. T., Gonda, M. G., & Mente, P. L. (2008, February 15). Osteoarthritis and Cartilage, Vol. 16, pp. 936–946.

By: M. Ashwell n , A. O'Nan n, M. Gonda n & P. Mente n

author keywords: gene expression; chondrocyte; impact injury model; osteoarthritis
MeSH headings : Animals; Cells, Cultured / metabolism; Chondrocytes / metabolism; Disease Models, Animal; Gene Expression; Gene Expression Profiling / methods; Knee Joint / metabolism; Osteoarthritis / genetics; Osteoarthritis / metabolism; Phenotype; Polymerase Chain Reaction; Swine; Wounds, Nonpenetrating / genetics; Wounds, Nonpenetrating / metabolism
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Knee injuries and reconstruction techniques; Lower Extremity Biomechanics and Pathologies
TL;DR: Results using this porcine impact injury model have contributed further evidence that damaged chondrocytes may de-differentiate into fibroblast-like cells and proliferate in an attempt to repair themselves and provide a more complete story about the fate of chondROcytes in articular cartilage following an injury. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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