Hongyu Ru

Works (30)

Updated: July 16th, 2023 21:15

2020 journal article

International lineages of Salmonella enterica serovars isolated from chicken farms, Wakiso District, Uganda

PLOS ONE, 15(1), e0220484.

By: T. Ball  n, D. Monte *, A. Aidara-Kane*, J. Matheu*, H. Ru n, S. Thakur n , F. Ejobi*, P. Fedorka-Cray n

Ed(s): F. Gao

MeSH headings : Animals; Anti-Bacterial Agents / classification; Anti-Bacterial Agents / pharmacology; Chickens / microbiology; Drug Resistance, Multiple, Bacterial / genetics; Farms; Genes, Bacterial; Humans; Immunologic Surveillance; Plasmids / chemistry; Plasmids / metabolism; Poultry Diseases / epidemiology; Poultry Diseases / microbiology; Poultry Diseases / transmission; Prevalence; Replicon; Salmonella Infections / epidemiology; Salmonella Infections / microbiology; Salmonella Infections / transmission; Salmonella enterica / drug effects; Salmonella enterica / genetics; Salmonella enterica / isolation & purification; Seasons; Uganda / epidemiology; Whole Genome Sequencing
topics (OpenAlex): Salmonella and Campylobacter epidemiology; Antibiotic Resistance in Bacteria; Bacteriophages and microbial interactions
TL;DR: It is concluded that MDR Salmonella highlights the risks posed to the animals, environment, and humans for infection and implementing a robust integrated surveillance system in Uganda will help monitor MDR to help control infectious threats. (via Semantic Scholar)
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Added: June 15, 2020

2020 article

Metabolite Profiling of the Gut Microbiome in Mice with Dietary Administration of Black Raspberries

Tu, P., Bian, X., Chi, L., Xue, J., Gao, B., Lai, Y., … Lu, K. (2020, January 17). ACS Omega.

By: P. Tu *, X. Bian*, L. Chi *, J. Xue *, B. Gao *, Y. Lai *, H. Ru n, K. Lu *

topics (OpenAlex): Gut microbiota and health; Biochemical Analysis and Sensing Techniques; Ginseng Biological Effects and Applications
TL;DR: A number of functional metabolites, such as tetrahydrobiopterin and butyrate that were significantly increased in the gut microbiome may be linked to the beneficial health effects of BRB consumption. (via Semantic Scholar)
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Added: February 27, 2020

2019 article

A preoperative bupivacaine retrobulbar block offers superior antinociception compared with an intraoperative splash block in dogs undergoing enucleation

Zibura, A. E., Posner, L. P., Ru, H., & Westermeyer, H. D. (2019, September 30). Veterinary Ophthalmology.

By: A. Zibura n, L. Posner n, H. Ru* & H. Westermeyer n 

author keywords: analgesia; bupivacaine; dogs; enucleation; retrobulbar block; splash block
MeSH headings : Anesthetics, Local / administration & dosage; Anesthetics, Local / pharmacology; Animals; Bupivacaine / administration & dosage; Bupivacaine / pharmacology; Dog Diseases / surgery; Dogs; Double-Blind Method; Eye Enucleation / veterinary; Female; Intraoperative Care; Male; Nerve Block / methods; Nerve Block / veterinary; Pain, Postoperative / prevention & control; Preoperative Care
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Anesthesia and Pain Management; Pain Mechanisms and Treatments
TL;DR: Preoperative retrobulbar block bupvacaine is more effective than an iSB bupivacaine at controlling both intraoperative and postoperative nociception in dogs undergoing enucleation. (via Semantic Scholar)
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Added: October 21, 2019

2019 article

Biomechanical Function and Size of the Anteromedial and Posterolateral Bundles of the ACL Change Differently with Skeletal Growth in the Pig Model

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, Vol. 477, pp. 2161–2174.

By: S. Cone, E. Lambeth, H. Ru, L. Fordham, J. Piedrahita , J. Spang, M. Fisher 

MeSH headings : Aging / physiology; Animals; Anterior Cruciate Ligament / physiology; Biomechanical Phenomena; Cadaver; Models, Animal; Musculoskeletal Development / physiology; Range of Motion, Articular / physiology; Rotation; Swine; Tibia / physiology; Torque
topics (OpenAlex):
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5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 17, 2020

2019 article

Chronic Arsenic Exposure Induces Oxidative Stress and Perturbs Serum Lysolipids and Fecal Unsaturated Fatty Acid Metabolism

Chi, L., Tu, P., Liu, C.-wei, Lai, Y., Xue, J., Ru, H., & Lu, K. (2019, April 30). Chemical Research in Toxicology.

By: L. Chi *, P. Tu *, C. Liu *, Y. Lai *, J. Xue *, H. Ru n, K. Lu *

MeSH headings : Administration, Oral; Animals; Arsenic / administration & dosage; Arsenic / metabolism; Arsenic / toxicity; Fatty Acids, Unsaturated / metabolism; Feces / chemistry; Female; Lipids / blood; Metabolomics; Mice; Mice, Inbred C57BL; Oxidative Stress / drug effects
topics (OpenAlex): Arsenic contamination and mitigation; Fluoride Effects and Removal; Vitamin C and Antioxidants Research
TL;DR: Investigating the impact of arsenic exposure on the metabolic profiles of female C57BL/6J mice found decreased levels of serum compounds with antioxidative activities in arsenic-treated mice, in accordance with elevated oxidative stress indicated by higher urinary 8-oxo-2'-deoxyguanosine (8-oxO-dG) levels. (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 8, 2019

2019 article

Comparison of oral, intravenous, and subcutaneous fluid therapy for resuscitation of calves with diarrhea

Doré, V., Foster, D. M., Ru, H., & Smith, G. W. (2019, October 9). Journal of Dairy Science, Vol. 102, pp. 11337–11348.

By: V. Doré n, D. Foster n , H. Ru n & G. Smith n 

author keywords: dehydration; acidosis; osmotic diarrhea; oral electrolyte solution (OES); subcutaneous fluid therapy
MeSH headings : Administration, Intravenous; Animals; Animals, Newborn; Body Weight; Cattle; Cattle Diseases / drug therapy; Cattle Diseases / therapy; Dehydration / therapy; Dehydration / veterinary; Diarrhea / therapy; Diarrhea / veterinary; Electrolytes / administration & dosage; Feces; Fluid Therapy / veterinary; Infusions, Subcutaneous; Osmolar Concentration; Plasma Volume; Saline Solution, Hypertonic / administration & dosage; Saline Solution, Hypertonic / therapeutic use
topics (OpenAlex): Animal health and immunology; Viral gastroenteritis research and epidemiology; Congenital Anomalies and Fetal Surgery
TL;DR: In conclusion, oral electrolyte products remain the gold standard for resuscitating diarrheic calves with moderate dehydration and acidemia and will likely perform better than small volumes of IV lactated Ringer's solution. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 journal article

Diagnostic utility of clinical and laboratory test parameters for differentiating between sudden acquired retinal degeneration syndrome and pituitary‐dependent hyperadrenocorticism in dogs

Veterinary Ophthalmology, 22(6), 842–858.

By: A. Oh n , M. Foster n, J. Williams n, C. Zheng n, H. Ru n, K. Lunn n , F. Mowat n

author keywords: biomarker; dog; hyperadrenocorticism; retina; sudden acquired retinal degeneration syndrome
MeSH headings : Animals; Case-Control Studies; Dog Diseases / diagnosis; Dogs; Electroretinography / veterinary; Female; Male; Pituitary ACTH Hypersecretion / diagnosis; Pituitary ACTH Hypersecretion / veterinary; Retina / pathology; Retinal Degeneration / diagnosis; Retinal Degeneration / veterinary; Tomography, Optical Coherence / veterinary
topics (OpenAlex): Retinal Development and Disorders; Glaucoma and retinal disorders; Retinal Diseases and Treatments
TL;DR: This work provides the basis for future studies that could identify and examine dogs with SARDS prior to vision loss, which may extend the potential therapeutic window for SARDS. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: December 16, 2019

2019 article

Dietary administration of black raspberries modulates arsenic biotransformation and reduces urinary 8-oxo-2′-deoxyguanosine in mice

Tu, P., Xue, J., Bian, X., Chi, L., Gao, B., Leng, J., … Lu, K. (2019, June 20). Toxicology and Applied Pharmacology.

By: P. Tu *, J. Xue *, X. Bian*, L. Chi *, B. Gao *, J. Leng *, H. Ru n, T. Knobloch *, C. Weghorst *, K. Lu *

author keywords: Black raspberry; Arsenic; Oxidative stress; Biotransformation; Diet
MeSH headings : 8-Hydroxy-2'-Deoxyguanosine / urine; Animals; Arsenic Poisoning; Arsenicals / metabolism; Biotransformation; Carrier Proteins / metabolism; Diet; Glutathione Transferase / metabolism; Liver / enzymology; Liver / metabolism; Methylation; Mice; Mice, Inbred C57BL; Polyphenols / pharmacology; Rubus / chemistry
topics (OpenAlex): Arsenic contamination and mitigation; Acne and Rosacea Treatments and Effects; Vitamin C and Antioxidants Research
TL;DR: Data indicate that BRB consumption affected arsenic biotransformation in vivo likely via alterations in related metabolic enzymes and cofactors, providing evidence on reduction of arsenic toxicity by consumption of BRBs. (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 12, 2019

2019 article

Lipid and Cholesterol Homeostasis after Arsenic Exposure and Antibiotic Treatment in Mice: Potential Role of the Microbiota

Chi, L., Lai, Y., Tu, P., Liu, C.-W., Xue, J., Ru, H., & Lu, K. (2019, September 1). Environmental Health Perspectives.

By: L. Chi *, Y. Lai *, P. Tu *, C. Liu *, J. Xue *, H. Ru n, K. Lu *

MeSH headings : Animals; Anti-Bacterial Agents / toxicity; Arsenic / toxicity; Cholesterol / blood; Gastrointestinal Microbiome / drug effects; Homeostasis / drug effects; Lipid Metabolism / drug effects; Mice
topics (OpenAlex): Retinoids in leukemia and cellular processes; Drug Transport and Resistance Mechanisms; Genomics, phytochemicals, and oxidative stress
TL;DR: The results suggest that in mice, the Gut microbiota may be a critical factor regulating arsenic-induced LXR/RXR signaling perturbation, suggesting that modulation of the gut microbiota might be an intervention strategy to reduce the toxic effects of arsenic on lipid and cholesterol homeostasis. (via Semantic Scholar)
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Added: October 21, 2019

2019 article

Quantitative proteomics reveals systematic dysregulations of liver protein metabolism in sucralose-treated mice

Liu, C.-W., Chi, L., Tu, P., Xue, J., Ru, H., & Lu, K. (2019, January 17). Journal of Proteomics.

By: C. Liu *, L. Chi *, P. Tu *, J. Xue *, H. Ru n & K. Lu *

author keywords: Artificial sweetener; Sucralose; Liver proteome; Tandem mass tags; Quantitative proteomics
MeSH headings : Animals; Gastrointestinal Microbiome / drug effects; Liver / metabolism; Male; Mice; Proteome / metabolism; Proteomics; Sucrose / analogs & derivatives; Sucrose / pharmacology
topics (OpenAlex): Gut microbiota and health; Biochemical Analysis and Sensing Techniques; Tryptophan and brain disorders
TL;DR: The first quantitative proteomics for mice liver proteome was demonstrated, proposed that enhanced inflammation may be triggered by ribosomal inactivation in sucralose treated mice liver, and revealed the systematic dysregulations of protein metabolism after Sucralose treatment. (via Semantic Scholar)
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Added: March 25, 2019

2019 journal article

Risk factors associated with progressive myelomalacia in dogs with complete sensorimotor loss following intervertebral disc extrusion: a retrospective case-control study

BMC Veterinary Research, 15(1).

By: A. Castel*, N. Olby n , H. Ru n, C. Mariani n , K. Muñana n  & P. Early n

author keywords: Ascending-descending myelomalacia; Spinal cord injury; Intervertebral disk disease; Paraplegia
MeSH headings : Animals; Case-Control Studies; Dog Diseases / etiology; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / veterinary; Logistic Models; Male; Multivariate Analysis; Paraplegia / etiology; Paraplegia / physiopathology; Paraplegia / veterinary; Retrospective Studies; Risk Factors; Spinal Cord Diseases / etiology; Spinal Cord Diseases / pathology; Spinal Cord Diseases / physiopathology; Spinal Cord Diseases / veterinary
topics (OpenAlex): Veterinary Orthopedics and Neurology; Veterinary Oncology Research; Human-Animal Interaction Studies
TL;DR: Dogs with lumbar intumescence IVDE are at increased risk of progressive myelomalacia and timing of surgery and corticosteroid use warrant further investigations. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: February 10, 2020

2019 article

Serum Metabolomics Identifies Altered Bioenergetics, Signaling Cascades in Parallel with Exposome Markers in Crohn’s Disease

Lai, Y., Xue, J., Liu, C.-W., Gao, B., Chi, L., Tu, P., … Ru, H. (2019, January 27). Molecules.

By: Y. Lai *, J. Xue *, C. Liu *, B. Gao *, L. Chi *, P. Tu *, K. Lu *, H. Ru n

author keywords: Inflammatory Bowel Disease; Crohn's Disease; Serum Metabolomics; docosahexaenoic acid; Tryptophan Metabolism; ergothioneine; gut microbiota; Exposome
MeSH headings : Amino Acids / metabolism; Biomarkers; Crohn Disease / blood; Crohn Disease / metabolism; Energy Metabolism; Fatty Acids / metabolism; Humans; Lipid Metabolism; Metabolome; Metabolomics; Oxidation-Reduction; Signal Transduction
topics (OpenAlex): Gut microbiota and health; Health, Environment, Cognitive Aging; Chronic Obstructive Pulmonary Disease (COPD) Research
TL;DR: This study endorses the analytical capacity of untargeted metabolomics for biomarker development, cohort stratification, and mechanistic interpretation in IBD, and the findings might be valuable for advancing biomarker research and etiologic inquiry in Crohn’s disease. (via Semantic Scholar)
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Added: March 4, 2019

2019 article

Serum Metabolomics Reveals That Gut Microbiome Perturbation Mediates Metabolic Disruption Induced by Arsenic Exposure in Mice

Xue, J., Lai, Y., Chi, L., Tu, P., Leng, J., Liu, C.-W., … Lu, K. (2019, January 10). Journal of Proteome Research.

By: J. Xue *, Y. Lai *, L. Chi *, P. Tu *, J. Leng *, C. Liu *, H. Ru n, K. Lu *

author keywords: arsenic; metabolomics; mouse model; bacterial infection; gut microbiome
MeSH headings : Animals; Arsenic / pharmacology; Bacterial Infections / complications; Gastrointestinal Microbiome / physiology; Mass Spectrometry; Metabolic Diseases / etiology; Metabolome / drug effects; Metabolomics / methods; Mice; Serum / metabolism
topics (OpenAlex): Gut microbiota and health; Metabolomics and Mass Spectrometry Studies; Nutritional Studies and Diet
TL;DR: It is suggested that gut microbiome perturbation can exacerbate or cause metabolic disorders induced by arsenic exposure, including fatty acid metabolism, phospholipids, sphingolIPids, cholesterols, and tryptophan metabolism. (via Semantic Scholar)
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Added: March 25, 2019

2019 article

Stifle joint osteoarthritis at the time of diagnosis of cranial cruciate ligament injury is higher in Boxers and in dogs weighing more than 35 kilograms

Gilbert, S., Langenbach, A., Marcellin‐Little, D. J., Pease, A. P., & Ru, H. (2019, February 15). Veterinary Radiology & Ultrasound.

By: S. Gilbert *, A. Langenbach*, D. Marcellin‐Little *, A. Pease* & H. Ru n

author keywords: cranial cruciate ligament; dog; osteoarthritis; osteophytes
MeSH headings : Animals; Anterior Cruciate Ligament Injuries / diagnosis; Anterior Cruciate Ligament Injuries / diagnostic imaging; Anterior Cruciate Ligament Injuries / veterinary; Body Weight; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dogs; Female; Male; Osteoarthritis / diagnosis; Osteoarthritis / diagnostic imaging; Osteoarthritis / veterinary; Prevalence; Radiography / veterinary; Retrospective Studies; Species Specificity; Stifle
topics (OpenAlex): Veterinary Orthopedics and Neurology; Knee injuries and reconstruction techniques; Tendon Structure and Treatment
TL;DR: It is concluded that dogs have a consistent distribution pattern of OA within the stifle joint after CCL injury and Boxers had more severe OA than the other breeds evaluated in the study. (via Semantic Scholar)
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Added: May 20, 2019

2019 journal article

Tissue-specific changes in size and shape of the ligaments and tendons of the porcine knee during post-natal growth

PLOS ONE, 14(10), e0219637.

By: S. Cone  n, H. Piercy n, E. Lambeth  n, H. Ru n, J. Piedrahita n , J. Spang *, L. Fordham *, M. Fisher n 

Ed(s): A. Almarza

MeSH headings : Animals; Anterior Cruciate Ligament / diagnostic imaging; Anterior Cruciate Ligament / growth & development; Female; Knee Joint / diagnostic imaging; Knee Joint / growth & development; Magnetic Resonance Imaging; Organ Specificity; Patellar Ligament / diagnostic imaging; Patellar Ligament / growth & development; Swine
topics (OpenAlex): Knee injuries and reconstruction techniques; Lower Extremity Biomechanics and Pathologies; Tendon Structure and Treatment
TL;DR: The findings suggest that musculoskeletal soft tissue morphometry can vary within tissues of similar structure and within a single joint during post-natal growth. (via Semantic Scholar)
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Added: June 8, 2020

2019 article

Towards Mass Spectrometry-Based Chemical Exposome: Current Approaches, Challenges, and Future Directions

Xue, J., Lai, Y., Liu, C.-W., & Ru, H. (2019, August 18). Toxics.

By: J. Xue *, Y. Lai *, C. Liu * & H. Ru n

author keywords: chemical exposome; biomonitoring; environmental monitoring; mass spectrometry; disease; bioinformatics
topics (OpenAlex): Health, Environment, Cognitive Aging; Nutritional Studies and Diet
TL;DR: In conclusion, efforts towards chemical exposome have only uncovered the tip of the iceberg, and further advancement in measurement techniques, computational tools, high-throughput data analysis, and standardization may allow more exciting discoveries concerning the role of exposomes in human health and disease. (via Semantic Scholar)
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Added: October 21, 2019

2018 article

Detection of skin temperature differences using palpation by manual physical therapists and lay individuals

Levine, D., Walker, J. R., Marcellin-Little, D. J., Goulet, R., & Ru, H. (2018, January 22). Journal of Manual & Manipulative Therapy.

By: D. Levine *, J. Walker*, D. Marcellin-Little *, R. Goulet* & H. Ru n

author keywords: Skin temperature; palpation; manual therapy; physical therapist
topics (OpenAlex): Infrared Thermography in Medicine; Thermoregulation and physiological responses; Thermal Regulation in Medicine
TL;DR: Palpation can be used to accurately detecting temperature differences between sites and is more accurately performed by an experienced practitioner than lay individuals. (via Semantic Scholar)
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Added: August 6, 2018

2018 article

Effects of the Artificial Sweetener Neotame on the Gut Microbiome and Fecal Metabolites in Mice

Chi, L., Bian, X., Gao, B., Tu, P., Lai, Y., Ru, H., & Lu, K. (2018, February 9). Molecules.

By: L. Chi *, X. Bian*, B. Gao *, P. Tu *, Y. Lai *, H. Ru n, K. Lu *

author keywords: neotame; gut microbiome; metabolomics; artificial sweeteners
MeSH headings : Animals; Butyrates / metabolism; Cholesterol / metabolism; Dipeptides / pharmacology; Fatty Acids / metabolism; Feces / chemistry; Food Additives / pharmacology; Gastrointestinal Microbiome / drug effects; Glyceric Acids / metabolism; Lipid Metabolism; Malates / metabolism; Male; Metabolome / physiology; Mice; Sweetening Agents / pharmacology
topics (OpenAlex): Biochemical Analysis and Sensing Techniques; Gut microbiota and health; Advanced Chemical Sensor Technologies
TL;DR: The study first explored the specific effects of neotame on mouse gut microbiota and the results may improve the understanding of the interaction between gut microbiome and neotome and how this interaction could influence the normal metabolism of host bodies. (via Semantic Scholar)
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Added: August 6, 2018

2018 article

Gut microbiome disruption altered the biotransformation and liver toxicity of arsenic in mice

Chi, L., Xue, J., Tu, P., Lai, Y., Ru, H., & Lu, K. (2018, October 24). Archives of Toxicology.

By: L. Chi *, J. Xue *, P. Tu *, Y. Lai *, H. Ru n & K. Lu *

author keywords: Gut bacteria; Microbiome; Arsenic biotransformation; Methylation; One-carbon metabolism
MeSH headings : Animals; Arsenic / metabolism; Arsenic / toxicity; Arsenites; Dysbiosis / physiopathology; Female; Gastrointestinal Microbiome; Inactivation, Metabolic; Liver / metabolism; Mice, Inbred C57BL; Signal Transduction; Sodium Compounds; Tumor Suppressor Protein p53
topics (OpenAlex): Arsenic contamination and mitigation; Heavy Metal Exposure and Toxicity; Environmental Justice and Health Disparities
TL;DR: Investigation of the role of the gut microbiota in As biotransformation and its toxicity in mice found that the urinary total As levels of GM-disrupted mice were much higher, but the fecaltotal As levels were lower, than the levels in the conventionally raised mice. (via Semantic Scholar)
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Added: February 11, 2019

2018 article

Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome

Chi, L., Gao, B., Tu, P., Liu, C.-W., Xue, J., Lai, Y., … Lu, K. (2018, February 1). Mammalian Genome.

By: L. Chi *, B. Gao *, P. Tu *, C. Liu *, J. Xue *, Y. Lai *, H. Ru n, K. Lu *

MeSH headings : Animals; Arsenic / toxicity; Carcinogens / toxicity; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / genetics; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / microbiology; Gastrointestinal Tract / pathology; Genetic Predisposition to Disease; Humans; Nutrigenomics; Water Pollutants, Chemical / toxicity
topics (OpenAlex): Arsenic contamination and mitigation; Fluoride Effects and Removal; Gut microbiota and health
TL;DR: Key factors, such as host genetics and nutritional status, that influence As susceptibility are summarized and potential mechanisms of how the gut microbiome may influence As metabolism and its toxic effects on the host are presented to induce variations in As susceptibility. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
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Added: August 6, 2018

2018 article

Isobaric Labeling Quantitative Metaproteomics for the Study of Gut Microbiome Response to Arsenic

Liu, C.-W., Chi, L., Tu, P., Xue, J., Ru, H., & Lu, K. (2018, December 14). Journal of Proteome Research.

By: C. Liu *, L. Chi *, P. Tu *, J. Xue *, H. Ru n & K. Lu *

author keywords: metaproteomics; gut microbiome; arsenic; isobaric labeling; tandem mass tags; label free; MetaPro-IQ
MeSH headings : Arsenic / pharmacology; Feces / microbiology; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / genetics; Humans; Proteome / analysis; Proteome / drug effects; Proteomics / methods; Proteomics / standards; RNA, Ribosomal, 16S / analysis
topics (OpenAlex): Advanced Proteomics Techniques and Applications; Gut microbiota and health; Microbial Community Ecology and Physiology
TL;DR: A new experimental workflow coupled to isobaric labeling and MetaPro-IQ was demonstrated for the metaproteomics study of arsenic-induced gut microbiome perturbations, demonstrating the significant improvement of quantitative metAProteomics for gut microbiome study. (via Semantic Scholar)
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Added: March 25, 2019

2017 article

Editor’s Highlight: Organophosphate Diazinon Altered Quorum Sensing, Cell Motility, Stress Response, and Carbohydrate Metabolism of Gut Microbiome

Gao, B., Bian, X., Chi, L., Tu, P., Ru, H., & Lu, K. (2017, March 21). Toxicological Sciences.

By: B. Gao *, X. Bian*, L. Chi *, P. Tu *, H. Ru n & K. Lu *

author keywords: organophosphate; gut microbiome; metatranscriptomics; quorum sensing
MeSH headings : Animals; Bacterial Translocation / drug effects; Bacterial Translocation / genetics; Carbohydrate Metabolism / drug effects; Carbohydrate Metabolism / genetics; Diazinon / toxicity; Down-Regulation; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / genetics; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / microbiology; Genes, Bacterial; Insecticides / toxicity; Male; Metagenome; Mice, Inbred C57BL; Quorum Sensing / drug effects; Quorum Sensing / genetics; Stress, Physiological / drug effects; Stress, Physiological / genetics; Up-Regulation
topics (OpenAlex): Pharmaceutical and Antibiotic Environmental Impacts; Indoor Air Quality and Microbial Exposure; bioluminescence and chemiluminescence research
TL;DR: It is demonstrated for the first time that organophosphate diazinon modulated quorum sensing, which may serve as a key mechanism to regulate bacterial population, composition, and more importantly, their functional genes, which provides new understandings of the functional interplay between the gut microbiome and environmental chemicals, such as organoph phosphates. (via Semantic Scholar)
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Added: August 6, 2018

2017 article

Gut Microbiome Response to Sucralose and Its Potential Role in Inducing Liver Inflammation in Mice

Bian, X., Chi, L., Gao, B., Tu, P., Ru, H., & Lu, K. (2017, July 23). Frontiers in Physiology.

By: X. Bian*, L. Chi *, B. Gao *, P. Tu *, H. Ru n & K. Lu *

author keywords: artificial sweetener; sucralose; gut microbiota; metabolomics; inflammation
topics (OpenAlex): Gut microbiota and health; Diet and metabolism studies; Diet, Metabolism, and Disease
TL;DR: Enrichment of bacterial pro-inflammatory genes and disruption in fecal metabolites suggest that 6-month sucralose consumption at the human acceptable daily intake (ADI) may increase the risk of developing tissue inflammation by disrupting the gut microbiota, which is supported by elevated pro- inflammatory gene expression in the liver of Sucralose-treated mice. (via Semantic Scholar)
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Added: August 6, 2018

2017 article

Manganese-induced sex-specific gut microbiome perturbations in C57BL/6 mice

Chi, L., Gao, B., Bian, X., Tu, P., Ru, H., & Lu, K. (2017, June 11). Toxicology and Applied Pharmacology.

By: L. Chi *, B. Gao *, X. Bian*, P. Tu *, H. Ru n & K. Lu *

author keywords: Manganese exposure; Gut microbiome; Sex-specific toxicity; Gut-brain axis; Metabolome; Metagenomics
MeSH headings : Animals; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / physiology; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / physiology; Male; Manganese / administration & dosage; Manganese / toxicity; Mice; Mice, Inbred C57BL; Sex Characteristics
topics (OpenAlex): Gut microbiota and health; Child Nutrition and Water Access
TL;DR: Taken together, this study has demonstrated that Mn2+ exposure perturbs the gut microbiome and its metabolic functions, which highlights the potential role of the Gut microbiome in Mn2- toxicity, particularly its sex‐specific toxic effects. (via Semantic Scholar)
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Added: August 6, 2018

2017 article

Multi-Omics Reveals that Lead Exposure Disturbs Gut Microbiome Development, Key Metabolites, and Metabolic Pathways

Gao, B., Chi, L., Mahbub, R., Bian, X., Tu, P., Ru, H., & Lu, K. (2017, February 24). Chemical Research in Toxicology.

By: B. Gao *, L. Chi *, R. Mahbub*, X. Bian*, P. Tu *, H. Ru n, K. Lu *

MeSH headings : Animals; Bacteria / genetics; Bacteria / isolation & purification; Bacteria / metabolism; Bacterial Proteins / metabolism; Bile Acids and Salts / metabolism; Carrier Proteins / metabolism; Energy Metabolism / drug effects; Female; Gas Chromatography-Mass Spectrometry; Gastrointestinal Microbiome / drug effects; Gastrointestinal Tract / microbiology; Lead / toxicity; Metabolic Networks and Pathways / drug effects; Metabolome / drug effects; Metabolomics; Mice; Mice, Inbred C57BL; Nitrite Reductases / metabolism; Oxidative Stress / drug effects; RNA, Ribosomal, 16S / chemistry; RNA, Ribosomal, 16S / genetics; RNA, Ribosomal, 16S / metabolism; Sequence Analysis, DNA; Vitamin E / metabolism
topics (OpenAlex): Gut microbiota and health; Child Nutrition and Water Access; Nutritional Studies and Diet
TL;DR: Gut microbiome toxicity induced by lead exposure in C57BL/6 mice was defined using multiomics approaches, which demonstrated that lead exposure not only altered the gut microbiome community structures/diversity but also greatly affected metabolic functions, leading to gut microbiome toxicity. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 article

Profound perturbation induced by triclosan exposure in mouse gut microbiome: a less resilient microbial community with elevated antibiotic and metal resistomes

Gao, B., Tu, P., Bian, X., Chi, L., Ru, H., & Lu, K. (2017, June 12). BMC Pharmacology and Toxicology.

By: B. Gao *, P. Tu *, X. Bian*, L. Chi *, H. Ru n & K. Lu *

author keywords: Triclosan; Gut microbiome; Antibiotic resistance; Metal resistance; Resistome; Triclosan resistance
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents, Local / pharmacology; Drinking Water; Drug Resistance, Microbial / genetics; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / genetics; Metagenomics; Metals, Heavy / toxicity; Mice, Inbred C57BL; RNA, Bacterial / genetics; RNA, Ribosomal, 16S / genetics; Triclosan / pharmacology
topics (OpenAlex): Gut microbiota and health; Probiotics and Fermented Foods; Advanced Chemical Sensor Technologies
TL;DR: To the best knowledge, this is the first evidence regarding the functional alterations of gut microbiome induced by triclosan exposure, which may provide novel mechanistic insights into tricrosan exposure and associated diseases. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 article

Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions

Bian, X., Tu, P., Chi, L., Gao, B., Ru, H., & Lu, K. (2017, May 1). Food and Chemical Toxicology.

By: X. Bian*, P. Tu *, L. Chi *, B. Gao *, H. Ru n & K. Lu *

author keywords: Saccharin; Artificial sweetener; Gut microbiota; Inflammation; Metabolite
MeSH headings : Animals; Gastrointestinal Microbiome / drug effects; Gastrointestinal Tract / drug effects; Gastrointestinal Tract / metabolism; Gastrointestinal Tract / microbiology; Humans; Liver / drug effects; Liver / immunology; Liver Diseases / etiology; Liver Diseases / genetics; Liver Diseases / immunology; Liver Diseases / microbiology; Male; Mice; Mice, Inbred C57BL; Saccharin / adverse effects; Sweetening Agents / adverse effects; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / immunology
topics (OpenAlex): Gut microbiota and health; Biochemical Analysis and Sensing Techniques; Probiotics and Fermented Foods
TL;DR: The altered gut bacterial genera, enriched orthologs of pathogen-associated molecular patterns, in concert with increased pro-inflammatory metabolites suggested that the saccharin-induced liver inflammation could be associated with the perturbation of the gut microbiota and its metabolic functions. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 article

The Effects of an Environmentally Relevant Level of Arsenic on the Gut Microbiome and Its Functional Metagenome

Chi, L., Bian, X., Gao, B., Tu, P., Ru, H., & Lu, K. (2017, August 29). Toxicological Sciences.

By: L. Chi *, X. Bian*, B. Gao *, P. Tu *, H. Ru n & K. Lu *

author keywords: arsenic; gut microbiome; metagenomics; functional pathways
MeSH headings : Animals; Arsenites / toxicity; Bacteria / classification; Bacteria / drug effects; Bacteria / genetics; Dysbiosis; Environmental Pollutants / toxicity; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / genetics; Gene Expression Regulation, Bacterial; Intestines / drug effects; Intestines / microbiology; Metagenome / drug effects; Metagenome / genetics; Mice, Inbred C57BL; Ribotyping; Sodium Compounds / toxicity; Time Factors
topics (OpenAlex): Arsenic contamination and mitigation; Gut microbiota and health; Folate and B Vitamins Research
TL;DR: It is demonstrated that arsenic exposure, at an environmentally relevant dose, not only perturbed the communal composition of the gut microbiome but also profoundly altered a variety of important bacterial functional pathways. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 article

The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice

Bian, X., Chi, L., Gao, B., Tu, P., Ru, H., & Lu, K. (2017, June 8). PLoS ONE.

By: X. Bian*, L. Chi *, B. Gao *, P. Tu *, H. Ru n & K. Lu *

MeSH headings : Animals; Body Weight / drug effects; Body Weight / genetics; Energy Metabolism / drug effects; Energy Metabolism / genetics; Female; Gastrointestinal Microbiome / drug effects; Lipopolysaccharides / metabolism; Male; Metabolomics / methods; Mice; RNA, Ribosomal, 16S / genetics; Sex Factors; Sweetening Agents / pharmacology; Thiazines / pharmacology; Weight Gain / drug effects
topics (OpenAlex): Biochemical Analysis and Sensing Techniques; Gut microbiota and health; Diet and metabolism studies
TL;DR: It is found that Ace-K consumption perturbed the gut microbiome of CD-1 mice after a 4-week treatment, and the observed body weight gain, shifts in the gut bacterial community composition, enrichment of functional bacterial genes related to energy metabolism, and fecal metabolomic changes were highly gender-specific, with differential effects observed for males and females. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 article

The organophosphate malathion disturbs gut microbiome development and the quorum-Sensing system

Gao, B., Chi, L., Tu, P., Bian, X., Thomas, J., Ru, H., & Lu, K. (2017, October 31). Toxicology Letters.

By: B. Gao *, L. Chi *, P. Tu *, X. Bian*, J. Thomas *, H. Ru n, K. Lu *

author keywords: Quorum sensing; Gut microbiome toxicity; Malathion
MeSH headings : Animals; Bacteria / genetics; Bacteria / pathogenicity; Cell Wall / drug effects; Gastrointestinal Microbiome / drug effects; Genome; Genomics; Insecticides / toxicity; Malathion / toxicity; Male; Mice; Mice, Inbred C57BL; Quorum Sensing / drug effects; Quorum Sensing / genetics; RNA, Ribosomal, 16S / biosynthesis; RNA, Ribosomal, 16S / genetics
topics (OpenAlex): Gut microbiota and health; Inhalation and Respiratory Drug Delivery; Bacterial biofilms and quorum sensing
TL;DR: This work uses a combination of Illumina-based 16S rRNA gene amplicon and shotgun metagenome sequencing to examine the impacts of a widely used organophosphate insecticide, malathion, on the gut microbiome trajectory, quorum sensing system and behaviors related toQuorum sensing, such as motility and pathogenicity. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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