Jennifer Holmes

Works (8)

Updated: November 25th, 2025 13:25

2025 article

Assessing mutation-origin neopeptide prediction tools in canine cancer using the model MHC class Ia allomorphs, DLA-88*508:01 and *034:01 9302

Hess, P. R., Lee, C.-Y., Holmes, J., & Zaharoff, D. (2025, November 1). The Journal of Immunology.

By: P. Hess n , C. Lee n, J. Holmes n & D. Zaharoff n

topics (OpenAlex): vaccines and immunoinformatics approaches; Veterinary Oncology Research; Immunotherapy and Immune Responses
Sources: NC State University Libraries, NC State University Libraries
Added: November 23, 2025

2025 article

Optimizing canine T cell activation, expansion, and transduction

Davis, T. W., Holmes, J. C., He, A., Hess, P. R., Mariani, C. L., & Brudno, Y. (2025, September 11). (X. Tan, Ed.). PLoS ONE, Vol. 9.

By: T. Davis n, J. Holmes n, A. He n, P. Hess n , C. Mariani n  & Y. Brudno n 

Ed(s): X. Tan n

topics (OpenAlex): CAR-T cell therapy research; Virus-based gene therapy research; T-cell and B-cell Immunology
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 11, 2025

2024 journal article

Acquired dysfunction of CFTR underlies cystic fibrosis-like disease of the canine gallbladder

American Journal of Physiology-Gastrointestinal and Liver Physiology, 327(4), G513–G530.

By: J. Gookin n , J. Holmes n, L. Clarke *, S. Stauffer n, B. Meredith n, M. Vandewege n, N. Torres-Machado n, S. Friedenberg* ...

author keywords: comparative; electrogenic ion transport; epithelium; immunofluorescence; mucus
MeSH headings : Animals; Dogs; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / metabolism; Cystic Fibrosis / metabolism; Cystic Fibrosis / genetics; Cystic Fibrosis / veterinary; Gallbladder / metabolism; Gallbladder / pathology; Dog Diseases / metabolism; Dog Diseases / genetics; Mucocele / metabolism; Mucocele / genetics; Mucocele / veterinary; Gallbladder Diseases / veterinary; Gallbladder Diseases / metabolism; Gallbladder Diseases / genetics; Gallbladder Diseases / pathology
topics (OpenAlex): Cystic Fibrosis Research Advances; Tracheal and airway disorders; Neonatal Respiratory Health Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: October 28, 2024

2024 article

Immunization of turkeys with Clostridium septicum alpha toxin-based recombinant subunit proteins can confer protection against experimental Clostridial dermatitis

John, F. A., Criollo, V., Gaghan, C., Armwood, A., Holmes, J., Thachil, A. J., … Kulkarni, R. R. (2024, April 29). (Y.-F. Chang, Ed.). PLoS ONE, Vol. 19.

By: F. John n, V. Criollo n, C. Gaghan n, A. Armwood n , J. Holmes n, A. Thachil*, R. Crespo n , R. Kulkarni n 

Ed(s): Y. Chang

MeSH headings : Animals; Turkeys / immunology; Clostridium septicum / immunology; Clostridium Infections / prevention & control; Clostridium Infections / immunology; Clostridium Infections / veterinary; Poultry Diseases / prevention & control; Poultry Diseases / immunology; Poultry Diseases / microbiology; Bacterial Toxins / immunology; Recombinant Proteins / immunology; Recombinant Proteins / administration & dosage; Dermatitis / prevention & control; Dermatitis / immunology; Dermatitis / veterinary; Bacterial Vaccines / immunology; Bacterial Vaccines / administration & dosage; Immunization
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Toxin Mechanisms and Immunotoxins; Streptococcal Infections and Treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 1, 2024

2024 article

Myeloid cell MHC I expression drives CD8+ T cell activation in nonalcoholic steatohepatitis

Adams, V. R., Collins, L. B., Williams, T. I., Holmes, J., Hess, P., Atkins, H. M., … Kennedy, A. (2024, January 11). (T. I. Williams, L. B. Collins, & A. Kennedy, Eds.). Frontiers in Immunology, Vol. 14.

By: V. Adams n, L. Collins n , T. Williams n , J. Holmes n, P. Hess n , H. Atkins n, G. Scheidemantle n, X. Liu n ...

Contributors: T. Williams n , V. Adams n, L. Collins n , J. Holmes n, P. Hess n , H. Atkins n, G. Scheidemantle n, X. Liu n ...

Ed(s): T. Williams n , L. Collins n  & A. Kennedy n 

author keywords: liver; NASH; fibrosis; H2Kb; CD8(+) T cells; immunopeptidome
MeSH headings : Animals; Mice; Non-alcoholic Fatty Liver Disease / pathology; CD8-Positive T-Lymphocytes; Inflammation; Myeloid Cells / metabolism; Mice, Transgenic; Fibrosis; Cytokines / metabolism
topics (OpenAlex): Immune Cell Function and Interaction; Liver Disease Diagnosis and Treatment; Immune cells in cancer
TL;DR: Activated hepatic CD8+ T cells are dependent on myeloid cell MHC class I expression in diet induced NASH to promote inflammation and fibrosis and a role of NADPH oxidase in the production of Ncf2 peptide generation is suggested. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 28, 2024

2022 journal article

Long‐term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T‐cells, IL‐10 and TGF‐β, in dogs with atopic dermatitis

Veterinary Dermatology, 34(2), 107–114.

By: I. Herrmann n , L. Mamo n, J. Holmes n, J. Mohammed n, K. Murphy n  & P. Bizikova n 

author keywords: canine atopic dermatitis; ciclosporin; oclacitinib; T regulatory cell
MeSH headings : Dogs; Animals; Cyclosporine / therapeutic use; T-Lymphocytes, Regulatory; Interleukin-10; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / veterinary; Transforming Growth Factor beta1 / therapeutic use; Transforming Growth Factor beta / therapeutic use; Immune Tolerance; Dog Diseases / drug therapy
topics (OpenAlex): Dermatology and Skin Diseases; T-cell and B-cell Immunology; Asthma and respiratory diseases
TL;DR: Lower Treg cell percentages in the CSA-treated dogs suggest an impact of this drug on this cell population; however, it does not necessarily mean that it diminishes tolerance. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 3, 2023

2021 article

Dog leukocyte antigen‐88*034:01 presents nonamer peptides from canine distemper virus hemagglutinin, large polymerase, and matrix proteins

Nemec, P. S., Holmes, J. C., & Hess, P. R. (2021, February 3). HLA, Vol. 2.

By: P. Nemec n, J. Holmes n & P. Hess n 

author keywords: distemper virus; canine; dogs; epitopes; major histocompatibility complex; peptides; T-lymphocytes; cytotoxic
MeSH headings : Alleles; Animals; Distemper Virus, Canine / genetics; Dogs; Hemagglutinins; Leukocytes; Peptides
topics (OpenAlex): Virus-based gene therapy research; vaccines and immunoinformatics approaches; Virology and Viral Diseases
TL;DR: The allomorph's binding motif is experimentally confirmed by developing an MHC surface stabilization assay, which adds new tools for studying neoepitope‐specific CTL in Boxers to foster canine comparative oncology. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 4, 2021

2021 article

High-resolution characterization of the structural features and genetic variation of six feline leukocyte antigen class I loci via single molecule, real-time (SMRT) sequencing

Holmes, J. C., Scholl, E. H., Dickey, A. N., & Hess, P. R. (2021, June 26). Immunogenetics, Vol. 6.

By: J. Holmes n, E. Scholl n, A. Dickey n & P. Hess n 

author keywords: Cats; Class I genes; High-throughput DNA sequencing; Major histocompatibility complex; Polymorphism
MeSH headings : Animals; Cats; Exons; Genes, MHC Class I / genetics; Genetic Variation; Haplotypes; High-Throughput Nucleotide Sequencing; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Sequence Analysis, DNA / methods
topics (OpenAlex): T-cell and B-cell Immunology; Immune Cell Function and Interaction; Microbial infections and disease research
TL;DR: A targeted approach to FLAI genotyping, using the single-molecule real-time (SMRT) platform, which allows full-length (3.4-kb) reads without assembly, is developed, which could allow highly accurate allele surveys in large cat cohorts. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.