Jennifer Holmes

Works (4)

Updated: April 5th, 2024 13:33

2024 journal article

Myeloid cell MHC I expression drives CD8<SUP>+</SUP> T cell activation in nonalcoholic steatohepatitis

FRONTIERS IN IMMUNOLOGY, 14.

By: V. Adams n, L. Collins n , T. Williams n , J. Holmes n, P. Hess n , H. Atkins n, G. Scheidemantle n, X. Liu n ...

Contributors: T. Williams n , V. Adams n, L. Collins n , J. Holmes n, P. Hess n , H. Atkins n, G. Scheidemantle n, X. Liu n ...

Ed(s): T. Williams n , L. Collins n  & A. Kennedy n 

author keywords: liver; NASH; fibrosis; H2Kb; CD8(+) T cells; immunopeptidome
TL;DR: Activated hepatic CD8+ T cells are dependent on myeloid cell MHC class I expression in diet induced NASH to promote inflammation and fibrosis and a role of NADPH oxidase in the production of Ncf2 peptide generation is suggested. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 28, 2024

2022 article

Long-term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T-cells, IL-10 and TGF-beta, in dogs with atopic dermatitis

Herrmann, I., Mamo, L. B., Holmes, J., Mohammed, J. P., Murphy, K. M., & Bizikova, P. (2022, December 8). VETERINARY DERMATOLOGY.

By: I. Herrmann n, L. Mamo n, J. Holmes n, J. Mohammed n, K. Murphy n & P. Bizikova n

author keywords: canine atopic dermatitis; ciclosporin; oclacitinib; T regulatory cell
MeSH headings : Dogs; Animals; Cyclosporine / therapeutic use; T-Lymphocytes, Regulatory; Interleukin-10; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / veterinary; Transforming Growth Factor beta1 / therapeutic use; Transforming Growth Factor beta / therapeutic use; Immune Tolerance; Dog Diseases / drug therapy
TL;DR: Lower Treg cell percentages in the CSA-treated dogs suggest an impact of this drug on this cell population; however, it does not necessarily mean that it diminishes tolerance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 3, 2023

2021 journal article

Dog leukocyte antigen-88*034:01 presents nonamer peptides from canine distemper virus hemagglutinin, large polymerase, and matrix proteins

HLA, 97(5), 428–434.

By: P. Nemec n, J. Holmes n & P. Hess n 

author keywords: distemper virus; canine; dogs; epitopes; major histocompatibility complex; peptides; T-lymphocytes; cytotoxic
MeSH headings : Alleles; Animals; Distemper Virus, Canine / genetics; Dogs; Hemagglutinins; Leukocytes; Peptides
TL;DR: The allomorph's binding motif is experimentally confirmed by developing an MHC surface stabilization assay, which adds new tools for studying neoepitope‐specific CTL in Boxers to foster canine comparative oncology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 4, 2021

2021 article

High-resolution characterization of the structural features and genetic variation of six feline leukocyte antigen class I loci via single molecule, real-time (SMRT) sequencing

Holmes, J. C., Scholl, E. H., Dickey, A. N., & Hess, P. R. (2021, June 27). IMMUNOGENETICS, Vol. 6.

By: J. Holmes n, E. Scholl n, A. Dickey n & P. Hess n 

author keywords: Cats; Class I genes; High-throughput DNA sequencing; Major histocompatibility complex; Polymorphism
MeSH headings : Animals; Cats; Exons; Genes, MHC Class I / genetics; Genetic Variation; Haplotypes; High-Throughput Nucleotide Sequencing; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Sequence Analysis, DNA / methods
TL;DR: A targeted approach to FLAI genotyping, using the single-molecule real-time (SMRT) platform, which allows full-length (3.4-kb) reads without assembly, is developed, which could allow highly accurate allele surveys in large cat cohorts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

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