Works (20)
Updated: August 23rd, 2023 21:19
2021 article
Transient and reversible reduction of stratum corneum filaggrin degradation products after allergen challenge in experimentally mite-sensitised atopic dogs
Olivry, T., Paps, J. S., & Amalric, N. (2021, September 14). VETERINARY DERMATOLOGY, Vol. 33.
MeSH headings : Allergens; Animals; Dermatitis, Atopic / veterinary; Dog Diseases; Dogs; Epidermis; Filaggrin Proteins; Mites; Skin
TL;DR:
In this experimental model, a single epicutaneous allergen challenge led to a transient and reversible decrease in skin surface NMF and its components, and concentrations were negatively correlated with skin lesion scores.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 15, 2021
2020 journal article
Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
CELL REPORTS, 31(1).
Contributors: S. Mishra n, J. Wheeler n, S. Pitake n, H. Ding *, C. Jiang *, T. Fukuyama n, n, P. Ralph n
MeSH headings : Animals; Cell Adhesion Molecules / metabolism; Cell Adhesion Molecules / physiology; Dermatitis, Atopic / etiology; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dogs; Female; Hypersensitivity / physiopathology; Integrin alpha5 / metabolism; Integrin beta3 / metabolism; Integrins / metabolism; Keratinocytes / metabolism; Male; Mice; Primates; Pruritus / metabolism; Pruritus / pathology; Sensory Receptor Cells / metabolism; Skin / metabolism
TL;DR:
A TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons is identified and the non-canonical functional role of an integrin in itch is characterized.
(via Semantic Scholar)
open access via doi.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 27, 2020
2019 journal article
Proactive maintenance therapy of canine atopic dermatitis with the anti‐ IL ‐31 lokivetmab. Can a monoclonal antibody blocking a single cytokine prevent allergy flares?
Veterinary Dermatology, 30(2), 98–e26.
Contributors: C. Tamamoto-Mochizuki n, n & T. Olivry n
TL;DR:
Although lokivetmab seems more effective to prevent pruritus than skin lesions in dogs with experimental AD' it also can delay disease flares in some dogs with the spontaneous disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: April 2, 2019
2018 journal article
Glucocorticosteroids and ciclosporin do not significantly impact canine cutaneous microbiota
BMC VETERINARY RESEARCH, 14(1).
Contributors: G. Widmer *, L. Ferrer *, C. Favrot *, n, K. Huynh* & T. Olivry n
author keywords: Prednisone; Ciclosporin; 16S amplicon sequencing; Microbiota; Malassezia; Papillomavirus; Principal coordinates analysis
MeSH headings : Animals; Cyclosporine / pharmacology; Dermatomycoses / chemically induced; Dermatomycoses / veterinary; Dog Diseases / chemically induced; Dog Diseases / microbiology; Dog Diseases / virology; Dogs / microbiology; Female; Immunosuppressive Agents / pharmacology; Malassezia / metabolism; Male; Microbiota / drug effects; Papillomaviridae / metabolism; Papillomavirus Infections / chemically induced; Papillomavirus Infections / veterinary; Prednisone / pharmacology; Skin / drug effects; Skin / microbiology; Skin / virology
TL;DR:
Ciclosporin and prednisone at doses used for the treatment of atopic dermatitis do not impact the canine cutaneous microbiota in a detectable manner.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 article
Diluted sodium hypochlorite (bleach) in dogs: antiseptic efficacy, local tolerability and in vitro effect on skin barrier function and inflammation
Banovic, F., Olivry, T., Baumer, W., Paps, J., Stahl, J., Rogers, A., & Jacob, M. (2018, February). VETERINARY DERMATOLOGY, Vol. 29.
Contributors: F. Banovic n, T. Olivry n , W. Bäumer n, n, J. Stahl*, A. Rogers n, M. Jacob n
MeSH headings : Administration, Cutaneous; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacology; Anti-Infective Agents, Local / administration & dosage; Anti-Infective Agents, Local / pharmacology; Cell Survival / drug effects; Dogs; Inflammation / drug therapy; Keratinocytes / drug effects; Male; Skin / drug effects; Sodium Hypochlorite / administration & dosage; Sodium Hypochlorite / pharmacology
TL;DR:
The results indicate that a topical diluted bleach solution, at either 0.05 or 0.005% hypochlorite concentrations, is a well-tolerated antiseptic that also exhibits anti-inflammatory properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Early Activation of Th2/Th22 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(10), 1961–1969.
Contributors: T. Olivry n , D. Mayhew*, n, K. Linder n, C. Peredo *, D. Rajpal *, H. Hofland *, J. Cote-Sierra*
MeSH headings : Adaptive Immunity / immunology; Animals; Cytokines / genetics; Cytokines / immunology; Dermatitis, Atopic / immunology; Dermatophagoides farinae / immunology; Disease Models, Animal; Dogs; Female; Immunity, Innate / immunology; Inflammation / immunology; Interleukin-9 / genetics; Interleukin-9 / immunology; Interleukins / genetics; Interleukins / immunology; Male; Pruritus / immunology; Skin / immunology; Skin / pathology; Species Specificity; Th2 Cells / immunology; Time Factors; Up-Regulation / genetics
TL;DR:
Experimental acute canine house dust mite-induced AD lesions exhibit an activation of innate and adaptive immune responses and pruritogenic pathways similar to those seen in humans with acute AD, thereby validating this model to test innovative therapeutics modalities for this disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
The skin microbiome in allergen-induced canine atopic dermatitis
VETERINARY DERMATOLOGY, 27(5), 332-+.
Contributors: F. Pierezan *, T. Olivry n , n, S. Lawhon *, J. Wu *, J. Steiner*, J. Suchodolski *, A. Rodrigues Hoffmann *
MeSH headings : Animals; Antigens, Dermatophagoides / immunology; Bacteria / classification; Bacteria / genetics; Dermatitis, Atopic / microbiology; Dermatitis, Atopic / veterinary; Dog Diseases / microbiology; Dog Diseases / pathology; Dogs; Female; Male; Pyroglyphidae / microbiology; RNA, Bacterial / genetics; RNA, Ribosomal, 16S / genetics; Skin / microbiology
TL;DR:
It is demonstrated that an allergen challenge in sensitized dogs leads to bacterial dysbiosis with increased abundance of S. pseudintermedius at the site of lesion induction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 article
Development of an Allergen-induced Atopic Itch Model in Dogs: A Preliminary Report
ACTA DERMATO-VENEREOLOGICA, Vol. 96, pp. 400–401.
Contributors: n, W. Bäumer & T. Olivry*
MeSH headings : Animals; Anti-Allergic Agents / pharmacology; Antigens, Dermatophagoides; Behavior, Animal; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / immunology; Dermatitis, Atopic / psychology; Disease Models, Animal; Dogs; Glucocorticoids / pharmacology; Motor Activity; Prednisolone / pharmacology; Pruritus / drug therapy; Pruritus / immunology; Pruritus / psychology; Reproducibility of Results; Time Factors
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Cowhage can induce itch in the atopic dog
EXPERIMENTAL DERMATOLOGY, 22(6), 435–437.
Contributors: T. Olivry n , P. Bizikova n, n, S. Dunston n, E. Lerner * & G. Yosipovitch *
author keywords: canine; dog; itch; model; pruritus
MeSH headings : Animals; Dermatitis, Atopic / etiology; Dermatitis, Atopic / physiopathology; Dogs; Hot Temperature; Inflammation; Mucuna / metabolism; Peptide Hydrolases / chemistry; Protein Denaturation; Pruritus / etiology; Pruritus / physiopathology; Random Allocation; Recombinant Proteins / chemistry; Skin / drug effects; Skin Tests / methods
TL;DR:
Cowhage spicules, protein‐rich extracts and mucunain can all inducePruritus and inflammation in dogs as in other species, but the inconsistency of provocation is currently a limitation of this challenge type for future studies of pruritus in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Deficient plakophilin-1 expression due to a mutation in PKP1 causes ectodermal dysplasia-skin fragility syndrome in Chesapeake Bay Retriever dogs
PLoS One, 7(2).
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Dermatophagoides farinae house dust mite allergen challenges reduce stratum corneum ceramides in an experimental dog model of acute atopic dermatitis
Veterinary Dermatology, 23(6), 497–e97.
Contributors: J. Stahl*, n, W. Bäumer * & T. Olivry n
MeSH headings : Animals; Antigens, Dermatophagoides / toxicity; Ceramides / chemistry; Ceramides / metabolism; Dermatitis, Atopic / immunology; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Dermatitis, Atopic / veterinary; Dog Diseases / immunology; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Epidermis / metabolism; Fatty Acids, Nonesterified / metabolism
TL;DR:
The findings suggest that the allergic reactions caused by Df-HDM allergens lead to a selective reduction of SC ceramides, not only at sites of inflammation but also at sites away from those of allergen application.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
Validation of a novel epicutaneous delivery system for patch testing of house dust mite-hypersensitive dogs
Veterinary Dermatology, 23(6).
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Lack of preventing effect of systemically and topically administered histamine H-1 or H-4 receptor antagonists in a dog model of acute atopic dermatitis
EXPERIMENTAL DERMATOLOGY, 20(7), 577–581.
Contributors: W. Bäumer n, J. Stahl *, K. Sander *, L. Petersen *, n, H. Stark *, M. Kietzmann *, T. Olivry n
author keywords: canine atopic dermatitis; histamine H4 receptor; microdialysis; JNJ28307474; JNJ7777120
MeSH headings : Aging / physiology; Animals; Antigens, Dermatophagoides / administration & dosage; Antigens, Dermatophagoides / immunology; Antigens, Dermatophagoides / metabolism; Cetirizine / administration & dosage; Cetirizine / therapeutic use; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / complications; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / immunology; Dermatitis, Atopic / pathology; Dermatophagoides farinae / immunology; Disease Models, Animal; Dogs; Erythema / etiology; Erythema / pathology; Erythema / prevention & control; Female; Histamine / metabolism; Histamine Antagonists / administration & dosage; Histamine Antagonists / metabolism; Histamine Antagonists / therapeutic use; Histamine H1 Antagonists / administration & dosage; Histamine H1 Antagonists / therapeutic use; Hydroxyzine / administration & dosage; Hydroxyzine / therapeutic use; Indoles / administration & dosage; Indoles / metabolism; Indoles / therapeutic use; Male; Permeability; Piperazines / administration & dosage; Piperazines / metabolism; Piperazines / therapeutic use; Skin / metabolism; Skin / pathology; Skin Absorption / physiology; Triamcinolone / administration & dosage; Triamcinolone / therapeutic use
TL;DR:
The preventive administration of H1R or H4R antagonists has no impact on the development of acute skin lesions in this experimental canine atopic dermatitis model and determined that only during the initiation increased concentrations of histamine were detected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
A comparison of the clinical manifestations of feeding whole and hydrolysed chicken to dogs with hypersensitivity to the native protein
VETERINARY DERMATOLOGY, 21(4), 358–366.
MeSH headings : Animal Feed; Animals; Chickens; Cross-Over Studies; Dermatitis / immunology; Dermatitis / pathology; Dermatitis / veterinary; Diet; Dog Diseases / immunology; Dogs; Double-Blind Method; Female; Food Hypersensitivity / immunology; Food Hypersensitivity / veterinary; Hydrolysis; Male; Meat / adverse effects; Proteins / immunology
TL;DR:
Assessment of a CADESI (Canine Atopic Dermatitis Extent and Severity Index) score and pruritus were performed throughout the entire study, and combined in a global score (GS).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Effect of a novel topical diester glucocorticoid spray on immediate- and late-phase cutaneous allergic reactions in Maltese-beagle atopic dogs: a placebo-controlled study
Veterinary Dermatology, 21(1), 70–79.
Source: NC State University Libraries
Added: August 6, 2018
2010 personal communication
Evaluation of the agreement between allergen-specific intradermal or IgE serological tests and a point-of-care immunodot assay in dogs with atopic dermatitis
Olivry, T., & Paps, J. (2011, June).
Contributors: T. Olivry n & n
MeSH headings : Allergens / immunology; Animals; Dermatitis, Atopic / blood; Dermatitis, Atopic / diagnosis; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dog Diseases / blood; Dog Diseases / diagnosis; Dog Diseases / immunology; Dogs; Immunoblotting / methods; Immunoblotting / veterinary; Immunoglobulin E / blood; Intradermal Tests / veterinary; Predictive Value of Tests; Serologic Tests / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Stratum corneum removal facilitates experimental sensitization to mite allergens in atopic dogs
VETERINARY DERMATOLOGY, 22(2), 188–196.
Contributors: T. Olivry n , J. Wofford n, n & S. Dunston n
MeSH headings : Allergens / administration & dosage; Allergens / immunology; Animals; Antigens, Dermatophagoides / immunology; CD4-Positive T-Lymphocytes / metabolism; Dermatitis, Atopic / immunology; Dermatitis, Atopic / veterinary; Dermatophagoides farinae / immunology; Dog Diseases / immunology; Dogs; Epidermis / immunology; Female; Immunoglobulin E / blood; Interleukin-2 Receptor alpha Subunit / biosynthesis; Intradermal Tests; Ki-1 Antigen / biosynthesis; Lymphocyte Activation; Male; Pilot Projects
TL;DR:
Observations implicate a role of the SC as a barrier limiting sensitization to exogenous allergens in this experimental atopic dog model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
A blinded randomized controlled trial evaluating the usefulness of a novel diet (Aminoprotect Care) in dogs with spontaneous food allergy
JOURNAL OF VETERINARY MEDICAL SCIENCE, 69(10), 1025–1031.
Contributors: T. Olivry* , K. Kurata*, * & K. Masuda *
author keywords: atopy; canine; food allergy; hypoallergenic diet
MeSH headings : Animal Feed; Animals; Cross-Over Studies; Diet / veterinary; Dog Diseases / diet therapy; Dogs; Female; Food Hypersensitivity / therapy; Food Hypersensitivity / veterinary; Lymphocyte Activation; Male; Pruritus; Skin Diseases; T-Lymphocytes, Helper-Inducer; Zea mays
TL;DR:
Even though APC contains corn starch to which corn-sensitive MBA dogs often react, the ingestion of APC did not lead to significant increases in skin lesions or pruritus, and Aminoprotect Care might prove valuable for management of food allergies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 personal communication
A pilot open trial evaluating the efficacy of low-dose aminopterin in the canine homologue of human atopic dermatitis
Olivry, T., Paps, J. S., Bizikova, P., Murphy, K. M., Jackson, H. A., & Zebala, J. (2007, November).
Contributors: T. Olivry n , n, P. Bizikova n, K. Murphy n, H. Jackson n & J. Zebala *
MeSH headings : Aminopterin / therapeutic use; Animals; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / veterinary; Dog Diseases / drug therapy; Dogs; Folic Acid Antagonists / therapeutic use; Humans; Models, Animal; Pilot Projects; Treatment Outcome
TL;DR:
The efficacy of AMT in the spontaneous canine model of human AD, where methotrexate appears to be more potent and to have a higher bioavailability and lower toxic effects, is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Effects of routine prophylactic vaccination or administration of aluminum adjuvant alone on allergen-specific serum IgE and IgG responses in allergic dogs
AMERICAN JOURNAL OF VETERINARY RESEARCH, 66(9), 1572–1577.
MeSH headings : Adjuvants, Immunologic / pharmacology; Aluminum; Analysis of Variance; Animals; Dog Diseases / immunology; Dogs; Enzyme-Linked Immunosorbent Assay / veterinary; Food Hypersensitivity / immunology; Food Hypersensitivity / veterinary; Immunoglobulin E / blood; Immunoglobulin G / blood; Time Factors; Vaccination / veterinary; Zea mays / adverse effects
TL;DR:
Allergen-specific IgE and IgG concentrations increase after prophylactic vaccination in allergic dogs but not in clinically normal dogs, while control dogs did not have a significant change in serum immunoglobulin concentrations after vaccination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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