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Works (20)
Updated: April 5th, 2024 05:58
2022 journal article
Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish
JOURNAL OF HAZARDOUS MATERIALS, 431.
author keywords: PFAS; Developmental toxicity; Structure-activity relationship; Abnormal behavior; Zebrafish
MeSH headings : Animals; Fluorocarbons / analysis; Larva; Teratogens; Zebrafish
TL;DR:
The results illustrate the power of a multi-dimensional in vivo platform to assess the developmental (neuro)toxicity of diverse PFAS and in the acceleration of PFAS safety research.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 8, 2022
2022 article
ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS
Fleming, J., Marvel, S. W., Supak, S., Motsinger-Reif, A. A., & Reif, D. M. (2022, April 26). JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, Vol. 4.
author keywords: Visual analytics; Geographic information systems; Data integration
MeSH headings : Humans; Geographic Information Systems; COVID-19
TL;DR:
The integration of ToxPi profiles with ArcGIS provides new avenues for geospatial analysis, visualization, and public sharing of multi-factor data that can support decisions that help address issues such as disease prevention, environmental health, natural disaster prevention, chemical risk, and many others.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 10, 2022
2021 personal communication
The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning
Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January).
Contributors: n, J. House* , M. Wheeler *, K. Song n, Y. Zhou n , F. Wright n, W. Chiu *, I. Rusyn *, A. Motsinger-Reif*, D. Reif n
MeSH headings : COVID-19 / epidemiology; Data Visualization; Health Status Indicators; Humans; Machine Learning; Models, Statistical; Vulnerable Populations
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 22, 2021
2020 journal article
Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function
ARCHIVES OF TOXICOLOGY, 94(2), 469–484.
author keywords: Neurotoxicity; Screening; ToxCast
MeSH headings : Animals; Cell Culture Techniques / instrumentation; Cell Culture Techniques / methods; Databases, Chemical; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical / methods; Machine Learning; Microelectrodes; Nerve Net / drug effects; Neural Networks, Computer; Neurons / drug effects; Neurotoxicity Syndromes / pathology; Rats, Long-Evans; Toxicity Tests / methods
TL;DR:
It is demonstrated that multivariate MEA activity patterns can efficiently screen for diverse chemical activities relevant to neurotoxicity, and that response patterns may have predictive value related to chemical structural features.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020
2020 journal article
The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity
REPRODUCTIVE TOXICOLOGY, 96, 359–369.
author keywords: Developmental toxicity; Flame retardants; Benchmark dose; Lowest effect concentration; Neurotoxicity; Classification model
MeSH headings : Animals; Embryo, Nonmammalian; Embryonic Development / drug effects; Flame Retardants / toxicity; Models, Animal; Neurotoxicity Syndromes; Risk Assessment; Structure-Activity Relationship; Teratogens / chemistry; Teratogens / toxicity; Zebrafish
TL;DR:
Developmental zebrafish were sufficiently sensitive at detecting FRC structure-bioactivity impacts that this work illustrates the power of a multi-dimensional in vivo platform to expand the ability to predict the hazard potential of new compounds based on structural relatedness, ultimately leading to reliable toxicity predictions based on chemical structure.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 30, 2020
2018 journal article
Genetic variants in CPA6 and PRPF31 are associated with variation in response to metformin in individuals with type 2 diabetes
Diabetes, 67(7), 1428–1440.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models
BMC Bioinformatics, 19.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial
PeerJ, 5.
Source: NC State University Libraries
Added: August 6, 2018
2017 article
Common genetic variants in neurobeachin (nbea) are associated with metformin drug response in individuals with type 2 diabetes in the accord clinical trial
Clinical Pharmacology & Therapeutics, Vol. 101, pp. S9–9.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish
TOXICOLOGY AND APPLIED PHARMACOLOGY, 329, 148–157.
Contributors: A. Knecht*, L. Truong *, n, D. Reif n , A. Garcia*, C. Lu *, M. Simonich*, J. Teeguarden *, R. Tanguay *
author keywords: Zebrafish Benzo[a]pyrene; Transgenerational; Neurobehavioral; Developmental toxicity; Physiological deficits; Aryl hydrocarbon receptor
MeSH headings : Animals; Animals, Genetically Modified; Behavior, Animal / drug effects; Benzo(a)pyrene / toxicity; DNA Methylation / drug effects; DNA Modification Methylases / metabolism; Dose-Response Relationship, Drug; Epigenesis, Genetic / drug effects; Genotype; Heart Rate / drug effects; Heredity; Inheritance Patterns / drug effects; Learning / drug effects; Mitochondria / drug effects; Mitochondria / metabolism; Motor Activity / drug effects; Neurotoxicity Syndromes / genetics; Neurotoxicity Syndromes / metabolism; Neurotoxicity Syndromes / physiopathology; Phenotype; Repressor Proteins / agonists; Repressor Proteins / deficiency; Repressor Proteins / genetics; Respiration / drug effects; Risk Assessment; Social Behavior; Time Factors; Water Pollutants, Chemical / toxicity; Zebrafish / genetics; Zebrafish / growth & development; Zebrafish / metabolism; Zebrafish Proteins / agonists; Zebrafish Proteins / deficiency; Zebrafish Proteins / genetics
TL;DR:
Exposure to benzo[a]pyrene during development resulted in transgenerational inheritance of neurobehavioral and physiological deficiencies, and indirect evidence suggested the potential for an AHR2‐dependent epigenetic route.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
A genome-wide study of lipid response to fenofibrate in Caucasians: A combined analysis of the GOLDN and ACCORD studies
Pharmacogenetics and Genomics, 26(7), 324–333.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure
REPRODUCTIVE TOXICOLOGY, 62, 92–99.
Contributors: G. Zhang n, n, L. Truong *, R. Tanguay * & D. Reif n
author keywords: Developmental neurotoxicology; Chemical biology; Morphology; Zebrafish; High throughput screening; ToxCast; Multiplexed assays
MeSH headings : Animals; Embryo, Nonmammalian; Entropy; Flame Retardants / toxicity; High-Throughput Screening Assays; Models, Theoretical; Phenotype; Teratogens / toxicity; Zebrafish / embryology
TL;DR:
An information-theoretic method named Aggregate Entropy (AggE) is proposed and applied to scoring multiplexed, phenotypic endpoints measured in developing zebrafish across a broad concentration-response profile for a diverse set of 1060 chemicals, identifying chemicals with significant morphological effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Genetic predictors of cardiovascular mortality during intensive glycemic control in type 2 diabetes: Findings from the ACCORD clinical trial
Diabetes Care, 39(11), 1915–1924.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes
ARCHIVES OF TOXICOLOGY, 90(6), 1459–1470.
Contributors: D. Reif n , L. Truong *, D. Mandrell*, n, G. Zhang n & R. Tanguay *
author keywords: Developmental neurotoxicology; Alternative testing; Chemical biology; Behavior; Zebrafish; High-throughput screening; Bioinformatics; Data integration; ToxCast; Bioactivity
MeSH headings : Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / physiopathology; Hazardous Substances / toxicity; High-Throughput Screening Assays; Predictive Value of Tests; Teratogens / toxicity; Zebrafish / abnormalities; Zebrafish / embryology
TL;DR:
This high-throughput screening system using a vertebrate organism can provide rapid characterization of chemical-elicited behavioral responses at an early developmental stage that are predictive of observable adverse effects later in life.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Incorporating concomitant medications into genome-wide analyses for the study of complex disease and drug response
Frontiers in Genetics, 7.
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero
BMC Genomics, 17.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Set membership experimental design for biological systems
BMC SYSTEMS BIOLOGY, 6.
MeSH headings : Models, Biological; Research Design; Uncertainty
TL;DR:
A bounded-error experimental design framework for nonlinear continuous-time systems when few data measurements are available that is able to identify candidate measurement time points that maximize information corresponding to biologically relevant metrics and determine the number at which additional measurements begin to provide insignificant information.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 conference paper
Set membership state and parameter estimation for nonlinear differential equations with sparse discrete measurements
Ieee international conference on systems man and cybernetics conference, 72–77.
TL;DR:
This paper presents a method to perform parameter and state estimation in a bounded-error context for nonlinear continuous-time systems with sparse, discrete measurements and demonstrates how preprocessing the measurements through the addition of application specific stabilizing bounds vastly improves bounded parameters and state estimations.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2010 journal article
The Development and Validation of a LIPUS System With Preliminary Observations of Ultrasonic Effects on Human Adult Stem Cells
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 57(9), 1977–1984.
MeSH headings : Adipose Tissue / cytology; Adult; Adult Stem Cells / cytology; Adult Stem Cells / diagnostic imaging; Bone Marrow Cells / cytology; Calcium / analysis; Calcium / metabolism; Cell Growth Processes / physiology; Cells, Cultured; DNA / chemistry; Humans; Reproducibility of Results; Ultrasonics / instrumentation; Ultrasonics / methods; Ultrasonography
TL;DR:
The custom LIPUS system designed and validated by exploring the effects of using different pulse repetition frequency (PRF) parameters on human adipose derived adult stem cells and bone marrow derived mesenchymal stem cells was successfully designed to allow extreme parameter variation, specifically PRF, and encourages further studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Osteogenic Effects of Rest Inserted and Continuous Cyclic Tensile Strain on hASC Lines with Disparate Osteodifferentiation Capabilities
ANNALS OF BIOMEDICAL ENGINEERING, 37(5), 955–965.
author keywords: Adipose derived stem cells; Mesenchymal stem cells; Osteogenesis; Mechanical effects on cells and tissues; Tissue engineering
MeSH headings : Adipose Tissue / cytology; Adult Stem Cells; Calcium / metabolism; Cell Differentiation; Cell Proliferation; Cells, Cultured; Humans; Mesenchymal Stem Cells; Models, Biological; Osteogenesis / physiology; Stress, Mechanical; Tensile Strength; Tissue Engineering / methods
TL;DR:
Results showed that both continuous and rest inserted cyclic tensile strain increased the amount and rate of calcium deposition for both high and low calcium depositing hASC lines as compared to unstrained controls, suggesting that mechanical loading has a greater effect on cell lines that already have an innate ability to produce bone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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