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Works (25)
Updated: August 16th, 2024 13:38
2022 journal article
Chalcones from Angelica keiskei (ashitaba) inhibit key Zika virus replication proteins
BIOORGANIC CHEMISTRY, 120.
author keywords: Angelica keiskei; Ashitaba; Chalcones; Zika virus; Polymerase; Protease
MeSH headings : Angelica / chemistry; Animals; Chalcone / pharmacology; Chalcones / chemistry; Chalcones / pharmacology; Chlorocebus aethiops; Humans; RNA; RNA-Dependent RNA Polymerase; Vero Cells; Virus Replication; Zika Virus; Zika Virus Infection
TL;DR:
With their simple structures and relative ease of modification, the chalcones represent attractive candidates for hit-to-lead optimization in the search of new anti-ZIKV therapeutics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 18, 2022
2022 journal article
Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis
FRONTIERS IN ALLERGY, 3.
author keywords: pig; food allergy; animal model; immunology; gastrointestinal; eosinophilic esophagitis
TL;DR:
Swine is established as a relevant large animal model for translational biomedical research in EoE with the potential to facilitate development of therapeutics and it is demonstrated that the sensitization and oral challenge protocol not only induces the underlying immune markers but also the micro- and macro-pathological hallmarks of human EiE.
(via Semantic Scholar)
open access via www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 25, 2023
2017 journal article
Il-10 deficient mice express IFN-gamma mRNA and clear Leptospira interrogans from their kidneys more rapidly than normal C57BL/6 mice
IMMUNOBIOLOGY, 222(5), 768–777.
author keywords: Leptospira interrogans; Leptospirosis; Innate immunity; IL-10
MeSH headings : Animals; Antibodies, Bacterial / immunology; Cytokines / genetics; Cytokines / metabolism; Disease Models, Animal; Gene Expression; Immunoglobulin M / immunology; Interferon-gamma / genetics; Interleukin-10 / deficiency; Kidney / immunology; Kidney / metabolism; Kidney / microbiology; Leptospira interrogans / immunology; Leptospirosis / genetics; Leptospirosis / immunology; Leptospirosis / microbiology; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger
TL;DR:
The hypothesis that L. interrogans ability to induce IL-10, which in turn prevents production of IFN-γ and inhibits T cell immunity, may contribute to the persistent growth of this microorganism in the murine kidney is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide
Journal of Ethnopharmacology, 212, 166–174.
author keywords: Alkylamide; Echinacea purpurea; Allergies; Inflammation; Mast cell
MeSH headings : Amides / chemistry; Amides / pharmacology; Animals; Calcium / metabolism; Cell Line; Dinoprostone / genetics; Dinoprostone / metabolism; Echinacea / chemistry; Female; Gene Expression Regulation / drug effects; Humans; Male; Mast Cells / drug effects; Mice; Plant Extracts / chemistry; Plant Extracts / pharmacology; Rats; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
It is suggested that Echinacea extracts and alkylamides may be useful for treating allergic and inflammatory responses mediated by mast cells and the inhibitory effects of alkyamides on calcium uptake would be predicted to dampen a variety of pathological responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 21, 2020
2017 journal article
Polyphenol-enriched berry extracts naturally modulate reactive proteins in model foods
Food & Function, 8(12), 4760–4767.
MeSH headings : Animals; Dendritic Cells / immunology; Food Hypersensitivity / prevention & control; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Functional Food / analysis; Humans; Macrophages / immunology; Ovalbumin / chemistry; Ovalbumin / immunology; Plant Extracts / chemistry; Polyphenols / chemistry; Swine; Tumor Necrosis Factor-alpha / immunology; Whey Proteins / chemistry; Whey Proteins / immunology
TL;DR:
The reactive allergenic epitopes of certain proteins were effectively blunted by binding with polyphenols, attenuating the allergenicity of the food proteins, allowing for the potential creation of hypoallergenic protein-berry polyphenol enriched foods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries
Added: February 17, 2020
2016 journal article
Secondary metabolites from fungal endophytes of Echinacea purpurea suppress cytokine secretion by macrophage-type cells
Natural Product Communications, 11(8), 1143–1146.
TL;DR:
The results of this study are particularly interesting given that they show the presence of compounds with cytokine-suppressive activity in endophytes from a botanical used to treat inflammation.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Cytokine-Suppressive Activity of a Hydroxylated Alkylamide from Echinacea purpurea
Planta Medica Letters, 2(01), e25–e27.
TL;DR:
Bioassay-guided fractionation of hexane and ethanol extracts of this plant yielded 4[(2-methylbutyl)amino]-4-oxo-2-butenoic acid and 8,11-dihidroxy-dodeca-2E,4E,9E-trienoic acid isobutylamide, both of which are new to Echinacea.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria
PLOS ONE, 10(5).
MeSH headings : Amides / pharmacology; Animals; Bacteria / chemistry; Cell Death / drug effects; Chemical Fractionation; Chemokines / metabolism; Cytokines / metabolism; Echinacea / chemistry; Echinacea / growth & development; Endophytes / chemistry; Ethanol / chemistry; Mice; Plant Extracts / pharmacology; Pyrans / chemistry; Pyrans / pharmacology; RAW 264.7 Cells; Seeds / drug effects; Structure-Activity Relationship; Tumor Necrosis Factor-alpha / biosynthesis; Xanthines / chemistry; Xanthines / pharmacology
TL;DR:
It is shown that ethanolic extracts prepared from E. purpurea plants grown under sterile conditions and from sterilized seeds, do not contain LPS and do not stimulate Macrophage production of TNF-α, supporting the hypothesis that the macrophage-stimulating activity in E. Purpurea extracts can originate from endophytic bacteria.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Synthesis and biological evaluation of a series of fatty acid amides from Echinacea
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(16), 3091–3094.
author keywords: Echinacea; Alkylamide; TNF-alpha; Anti-inflammatory; Cytokine
MeSH headings : Amides / chemical synthesis; Amides / chemistry; Amides / pharmacology; Animals; Cell Line; Echinacea / chemistry; Echinacea / metabolism; Fatty Acids / chemistry; Lipopolysaccharides / toxicity; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Mice; Plant Extracts / chemistry; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
The SAR of simple alkylamides found in Echinacea extracts with respect to their ability to decrease the production of the pro-inflammatory mediator TNF-α is explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Chemical investigation of fungal endophytes from Echinacea purpurea
Planta Medica, 80(10).
Source: Crossref
Added: February 24, 2020
2014 journal article
Unraveling immunomodulatory activities of complex Echinacea purpurea extracts
Planta Medica, 80(10).
Source: Crossref
Added: February 24, 2020
2012 journal article
Production of prostaglandin E-2 in response to infection with modified vaccinia Ankara virus
VIROLOGY, 428(2), 146–155.
author keywords: Poxvirus; Vaccine; Lipid mediator; Cyclooxygenase-2; Cytosolic phospholipase A(2); NF-kappa B
MeSH headings : Animals; Arachidonic Acid / metabolism; Cell Line; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Dinoprostone / metabolism; Humans; Mice; Vaccinia / enzymology; Vaccinia / metabolism; Vaccinia / virology; Vaccinia virus / genetics; Vaccinia virus / physiology; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR:
In this study, PGE₂ production in vitro by cells infected with the poxvirus vaccine strain, modified vaccinia Ankara virus (MVA), is investigated and it is demonstrated that MVA induced the release of AA from infected cells, and this was, most unusually, independent of host cytosolic phospholipase A₁ activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis)
International Immunopharmacology, 11(11), 1706–1714.
author keywords: Goldenseal; Berberine; Cytokines; Lipid mediators; H1N1 influenza A; Anti-viral
MeSH headings : Animals; Antiviral Agents / chemistry; Antiviral Agents / isolation & purification; Antiviral Agents / pharmacology; Berberine / chemistry; Berberine / pharmacology; Cell Culture Techniques; Cell Line; Cell Survival / drug effects; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Hydrastis / chemistry; Immunoblotting; Immunologic Factors / antagonists & inhibitors; Immunologic Factors / biosynthesis; Influenza A Virus, H1N1 Subtype / drug effects; Influenza A Virus, H1N1 Subtype / growth & development; Influenza A Virus, H1N1 Subtype / metabolism; Macrophages / drug effects; Macrophages / virology; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Viral Proteins / biosynthesis
TL;DR:
The results suggest that berberine may indeed be useful for the treatment of infections with influenza A and strong inhibition of production of both mediators is revealed, suggesting that this effect is distinct from the anti-viral effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 12, 2020
2010 journal article
Echinacea and its alkylamides: Effects on the influenza A-induced secretion of cytokines, chemokines, and PGE(2) from RAW 264.7 macrophage-like cells
INTERNATIONAL IMMUNOPHARMACOLOGY, 10(10), 1268–1278.
author keywords: Echinacea; H1N1 influenza; Alkylamide; Isobutylamide; Plant extracts; Anti-inflammatory
TL;DR:
In vitro experiments suggest that E. purpurea extracts have the potential for use in alleviating the symptoms and pathology associated with infections with influenza A; however, further study will be necessary to define procedures necessary to unmask the alkylamide activity in crude extracts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid
ANTIVIRAL RESEARCH, 88(3), 287–295.
author keywords: Poxvirus; Cowpox virus; Vaccinia virus; Terameprocol; Antiviral agent; Cell-to-cell spread
MeSH headings : Actins / chemistry; Actins / metabolism; Antiviral Agents / pharmacology; Bioterrorism / prevention & control; Cell Line; Clinical Trials, Phase I as Topic; Cowpox virus / drug effects; Cowpox virus / physiology; Humans; Masoprocol / analogs & derivatives; Masoprocol / pharmacology; Poxviridae Infections / drug therapy; Poxviridae Infections / virology; Vaccinia virus / drug effects; Vaccinia virus / physiology; Virus Attachment / drug effects; Virus Replication / drug effects
TL;DR:
The ability of TMP to inhibit poxvirus growth in vitro was examined, and it was found that TMP potently inhibited the growth of both cowpox virus and vaccinia virus in a variety of cell lines.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-kappa B-dependent transcription of TNF-alpha and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA
JOURNAL OF INFLAMMATION-LONDON, 7.
TL;DR:
TMP acts indirectly as an inhibitor of NF-κB-dependent transcription by preventing RelA from binding the promoters of certain key cytokine and chemokine genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines
JOURNAL OF INFLAMMATION-LONDON, 6.
TL;DR:
TMP inhibited the LPS-induced production of lipid mediators and several key inflammatory cytokines and chemokines, both in vitro and in vivo, raising the possibility that TMP might be useful as a treatment for a variety of inflammatory disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Adenovirus type 5 exerts multiple effects on the expression and activity of cytosolic phospholipase A(2), cyclooxygenase-2, and prostaglandin synthesis
JOURNAL OF IMMUNOLOGY, 179(6), 4170–4179.
MeSH headings : Adenoviruses, Human / genetics; Adenoviruses, Human / immunology; Animals; Arachidonic Acid / antagonists & inhibitors; Arachidonic Acid / metabolism; Cell Line; Cell Line, Tumor; Cyclooxygenase 2 / biosynthesis; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Dinoprostone / antagonists & inhibitors; Dinoprostone / biosynthesis; Enzyme Activation / immunology; Epoprostenol / antagonists & inhibitors; Epoprostenol / biosynthesis; Fibroblasts / enzymology; Fibroblasts / metabolism; Fibroblasts / virology; Group IV Phospholipases A2; Humans; Intracellular Fluid / enzymology; Intracellular Fluid / virology; Mice; Phospholipases A / biosynthesis; Phospholipases A / genetics; Phospholipases A / metabolism; Phospholipases A2; Prostaglandins / biosynthesis; Protein Transport / immunology; Tritium
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Evidence against calcium as a mediator of mitochondrial dysfunction during apoptosis induced by arachidonic acid and other free fatty acids
JOURNAL OF IMMUNOLOGY, 177(9), 6398–6404.
MeSH headings : Animals; Apoptosis; Arachidonic Acid / pharmacology; Autocrine Communication; Calcium / metabolism; Cell Line; Fatty Acids, Nonesterified / pharmacology; Fibroblasts / drug effects; Fibroblasts / metabolism; Membrane Potential, Mitochondrial / drug effects; Mice; Mitochondria / drug effects; Mitochondria / metabolism
TL;DR:
It is found that cyclosporine A could inhibit the AA-induced loss of Δψm with both whole cells and isolated mitochondria, confirming that the antimitochondrial effects of FFA can stem from direct effects on the mitochondrial permeability transition pore.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
The anti-apoptotic effects of nordihydroguaiaretic acid: Inhibition of cPLA(2) activation during TNF-induced apoptosis arises from inhibition of calcium signaling
LIFE SCIENCES, 77(19), 2457–2470.
author keywords: apoptosis; NDGA; cPLA(2)
MeSH headings : Animals; Antioxidants / pharmacology; Apoptosis / drug effects; Arachidonic Acid / metabolism; Blotting, Western; Butylated Hydroxyanisole / pharmacology; Calcium Signaling / drug effects; Caspases / metabolism; Cell Line; Chromium Radioisotopes; Enzyme Activation / drug effects; Fibroblasts / drug effects; Fibroblasts / metabolism; Immunoprecipitation; Male; Masoprocol / pharmacology; Mice; Microscopy, Phase-Contrast; Phosphates / metabolism; Phospholipases A / antagonists & inhibitors; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
The mechanism underlying the ability of NDGA to inhibit TNF-induced apoptosis is examined and it is shown that NDGA blocks many key indicators of apoptosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Calcium and its role in the nuclear translocation and activation of cytosolic phospholipase A(2) in cells rendered sensitive to TNF-induced apoptosis by cycloheximide
JOURNAL OF IMMUNOLOGY, 172(4), 2416–2423.
MeSH headings : Active Transport, Cell Nucleus / drug effects; Active Transport, Cell Nucleus / immunology; Animals; Apoptosis / drug effects; Apoptosis / immunology; Arachidonic Acid / antagonists & inhibitors; Arachidonic Acid / metabolism; Calcium / metabolism; Calcium / physiology; Caspases / metabolism; Cell Line; Cell Nucleus / drug effects; Cell Nucleus / enzymology; Cell Nucleus / immunology; Cycloheximide / pharmacology; Cytosol / drug effects; Cytosol / enzymology; Cytosol / immunology; Enzyme Activation / drug effects; Enzyme Activation / immunology; Hydrolysis / drug effects; Intracellular Fluid / drug effects; Intracellular Fluid / immunology; Intracellular Fluid / metabolism; Mice; Mice, Inbred C3H; Phosphatidylserines / metabolism; Phospholipases A / metabolism; Phospholipases A2; Tritium; Tumor Necrosis Factor-alpha / pharmacology; Up-Regulation / drug effects; Up-Regulation / immunology; Verapamil / pharmacology
TL;DR:
Data suggest that calcium is important for cPLA2 activation by diverse apoptotic stimuli, and verapamil prevented the release of [3H]arachidonic acid from C3HA cells induced to undergo apoptosis by the chemotherapeutic agents vinblastine, melphalan, and cis-platinum.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Thymocyte and peripheral blood T lymphocyte subpopulation changes in piglets following in utero infection with porcine reproductive and respiratory syndrome virus
VIROLOGY, 302(2), 363–372.
author keywords: PRRSV; thymus; thymocyte; T lymphocyte
MeSH headings : Animals; Animals, Newborn; Female; Infectious Disease Transmission, Vertical; Leukocytes, Mononuclear / immunology; Lymphocyte Count; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / immunology; Pregnancy; Pregnancy, Animal; Swine; Swine Diseases / immunology; Swine Diseases / virology; T-Lymphocyte Subsets / immunology; Thymus Gland / cytology; Thymus Gland / immunology; Uterus / virology
TL;DR:
It is shown that the number of thymocytes undergoing apoptosis was increased twofold in piglets infected with PRRSV and this results help explain the dramatic immunosuppression observed in neonatal animals infected in utero withPRRSV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
In utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility of piglets to challenge by Streptococcus suis type II
JOURNAL OF VIROLOGY, 75(10), 4889–4895.
MeSH headings : Animals; Cell Differentiation; Disease Susceptibility / immunology; Female; Infectious Disease Transmission, Vertical; Leukocyte Count; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / physiopathology; Porcine Reproductive and Respiratory Syndrome / transmission; Porcine respiratory and reproductive syndrome virus / immunology; Porcine respiratory and reproductive syndrome virus / isolation & purification; Pregnancy; Pregnancy, Animal; Streptococcal Infections / complications; Streptococcal Infections / immunology; Streptococcal Infections / microbiology; Streptococcal Infections / pathology; Streptococcus suis / immunology; Streptococcus suis / isolation & purification; Streptococcus suis / physiology; Swine; Uterus / virology
TL;DR:
In utero infection by PRRSV makes piglets more susceptible to infection and disease following challenge by S. suis type II, and this model may provide a useful model to study the interaction betweenPRRSV and bacterial coinfections in piglets.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Characterization of arachidonic acid-induced apoptosis
Cell Biochemistry and Biophysics, 30(3), 353–368.
MeSH headings : Animals; Apoptosis / drug effects; Arachidonic Acid / metabolism; Arachidonic Acid / pharmacology; Blotting, Western; Cell Line; Ceramides / pharmacology; Chromium Radioisotopes / metabolism; Dose-Response Relationship, Drug; Fatty Acids / metabolism; Fibroblasts / drug effects; Humans; Melanoma / physiopathology; Mice; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
It is shown that arachidonic acid is unique among 20 carbon fatty acids for its ability to induce apoptosis and that several other unsaturated, but not saturated fatty acids can also inducing apoptosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Sustained phosphorylation of cytosolic phospholipase A(2) accompanies cycloheximide- and adenovirus-induced susceptibility to TNF
Journal of Immunology, 161(3), 1525–1532.
Source: NC State University Libraries
Added: August 6, 2018
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