Scott M. Laster

Works (25)

Updated: September 26th, 2023 05:01
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2022 journal article

Chalcones from Angelica keiskei (ashitaba) inhibit key Zika virus replication proteins

BIOORGANIC CHEMISTRY, 120.

By: M. Mottin *, L. Caesar*, D. Brodsky n, N. Mesquita*, K. Oliveira*, G. Noske  n, B. Sousa*, P. Ramos* ...

co-author countries: Brazil 🇧🇷 United States of America 🇺🇸
author keywords: Angelica keiskei; Ashitaba; Chalcones; Zika virus; Polymerase; Protease
MeSH headings : Angelica / chemistry; Animals; Chalcone / pharmacology; Chalcones / chemistry; Chalcones / pharmacology; Chlorocebus aethiops; Humans; RNA; RNA-Dependent RNA Polymerase; Vero Cells; Virus Replication; Zika Virus; Zika Virus Infection
Source: Web Of Science
Added: July 18, 2022

2022 journal article

Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis

FRONTIERS IN ALLERGY, 3.

By: L. Cortes n, D. Brodsky n, C. Chen, T. Pridgen n, J. Odle n , D. Snider n, G. Cruse n , A. Putikova* ...

co-author countries: United States of America 🇺🇸
author keywords: pig; food allergy; animal model; immunology; gastrointestinal; eosinophilic esophagitis
Sources: Web Of Science, ORCID
Added: September 25, 2023

2018 journal article

Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E,4E-dienoic acid isobutylamide

Journal of Ethnopharmacology, 212, 166–174.

By: T. Gulledge n, N. Collette n, E. Mackey *, S. Johnstone n, Y. Moazami n, D. Todd*, A. Moeser *, J. Pierce n , N. Cech *, S. Laster n

co-author countries: United States of America 🇺🇸
author keywords: Alkylamide; Echinacea purpurea; Allergies; Inflammation; Mast cell
MeSH headings : Amides / chemistry; Amides / pharmacology; Animals; Calcium / metabolism; Cell Line; Dinoprostone / genetics; Dinoprostone / metabolism; Echinacea / chemistry; Female; Gene Expression Regulation / drug effects; Humans; Male; Mast Cells / drug effects; Mice; Plant Extracts / chemistry; Plant Extracts / pharmacology; Rats; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism
Sources: Crossref, ORCID
Added: February 21, 2020

2017 journal article

Il-10 deficient mice express IFN-gamma mRNA and clear Leptospira interrogans from their kidneys more rapidly than normal C57BL/6 mice

IMMUNOBIOLOGY, 222(5), 768–777.

By: A. Devlin*, P. Halvorsen*, J. Miller * & S. Laster n

co-author countries: United States of America 🇺🇸
author keywords: Leptospira interrogans; Leptospirosis; Innate immunity; IL-10
MeSH headings : Animals; Antibodies, Bacterial / immunology; Cytokines / genetics; Cytokines / metabolism; Disease Models, Animal; Gene Expression; Immunoglobulin M / immunology; Interferon-gamma / genetics; Interleukin-10 / deficiency; Kidney / immunology; Kidney / metabolism; Kidney / microbiology; Leptospira interrogans / immunology; Leptospirosis / genetics; Leptospirosis / immunology; Leptospirosis / microbiology; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Polyphenol-enriched berry extracts naturally modulate reactive proteins in model foods

Food & Function, 8(12), 4760–4767.

By: M. Lila n , M. Schneider n, A. Devlin n, N. Plundrich  n, S. Laster n & E. Foegeding n

co-author countries: Belgium 🇧🇪 United States of America 🇺🇸
MeSH headings : Animals; Dendritic Cells / immunology; Food Hypersensitivity / prevention & control; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Functional Food / analysis; Humans; Macrophages / immunology; Ovalbumin / chemistry; Ovalbumin / immunology; Plant Extracts / chemistry; Polyphenols / chemistry; Swine; Tumor Necrosis Factor-alpha / immunology; Whey Proteins / chemistry; Whey Proteins / immunology
Sources: Crossref, ORCID
Added: February 17, 2020

2016 journal article

Secondary metabolites from fungal endophytes of Echinacea purpurea suppress cytokine secretion by macrophage-type cells

Natural Product Communications, 11(8), 1143–1146.

By: A. Kaur *, M. Oberhofer*, M. Juzumaite n, H. Raja *, T. Gulledge n, D. Kao *, S. Faeth*, S. Laster n, N. Oberlies*, N. Cech *

co-author countries: United States of America 🇺🇸
Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Cytokine-Suppressive Activity of a Hydroxylated Alkylamide from Echinacea purpurea

Planta Medica Letters, 2(01), e25–e27.

By: M. Leyte-Lugo *, D. Todd*, T. Gulledge n, M. Juzumaite n, F. Carter*, S. Laster n, N. Cech *

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: February 24, 2020

2015 journal article

Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria

PLOS ONE, 10(5).

By: D. Todd*, T. Gulledge n, E. Britton *, M. Oberhofer*, M. Leyte-Lugo *, A. Moody*, T. Shymanovich *, L. Grubbs* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Amides / pharmacology; Animals; Bacteria / chemistry; Cell Death / drug effects; Chemical Fractionation; Chemokines / metabolism; Cytokines / metabolism; Echinacea / chemistry; Echinacea / growth & development; Endophytes / chemistry; Ethanol / chemistry; Mice; Plant Extracts / pharmacology; Pyrans / chemistry; Pyrans / pharmacology; RAW 264.7 Cells; Seeds / drug effects; Structure-Activity Relationship; Tumor Necrosis Factor-alpha / biosynthesis; Xanthines / chemistry; Xanthines / pharmacology
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Synthesis and biological evaluation of a series of fatty acid amides from Echinacea

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(16), 3091–3094.

By: Y. Moazami n, T. Gulledge n, S. Laster n & J. Pierce n 

co-author countries: United States of America 🇺🇸
author keywords: Echinacea; Alkylamide; TNF-alpha; Anti-inflammatory; Cytokine
MeSH headings : Amides / chemical synthesis; Amides / chemistry; Amides / pharmacology; Animals; Cell Line; Echinacea / chemistry; Echinacea / metabolism; Fatty Acids / chemistry; Lipopolysaccharides / toxicity; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Mice; Plant Extracts / chemistry; Tumor Necrosis Factor-alpha / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Chemical investigation of fungal endophytes from Echinacea purpurea

Planta Medica, 80(10).

By: D. Kao, A. Kaur, H. Raja, T. El-Elimat, M. Oberhofer, M. Juzumaite, T. Gulledge, S. Laster* ...

Source: Crossref
Added: February 24, 2020

2014 journal article

Unraveling immunomodulatory activities of complex Echinacea purpurea extracts

Planta Medica, 80(10).

By: E. Britton, D. Todd, M. Leyte-Lugo, T. Gulledge, L. Grubbs, M. Oberhofer, S. Faeth, S. Laster*, N. Cech

Source: Crossref
Added: February 24, 2020

2012 journal article

Production of prostaglandin E-2 in response to infection with modified vaccinia Ankara virus

VIROLOGY, 428(2), 146–155.

By: J. Pollara*, A. Spesock, D. Pickup, S. Laster* & I. Petty

author keywords: Poxvirus; Vaccine; Lipid mediator; Cyclooxygenase-2; Cytosolic phospholipase A(2); NF-kappa B
MeSH headings : Animals; Arachidonic Acid / metabolism; Cell Line; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Dinoprostone / metabolism; Humans; Mice; Vaccinia / enzymology; Vaccinia / metabolism; Vaccinia / virology; Vaccinia virus / genetics; Vaccinia virus / physiology; Viral Proteins / genetics; Viral Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis)

International Immunopharmacology, 11(11), 1706–1714.

By: C. Cecil n, J. Davis n , N. Cech * & S. Laster n

co-author countries: United States of America 🇺🇸
author keywords: Goldenseal; Berberine; Cytokines; Lipid mediators; H1N1 influenza A; Anti-viral
MeSH headings : Animals; Antiviral Agents / chemistry; Antiviral Agents / isolation & purification; Antiviral Agents / pharmacology; Berberine / chemistry; Berberine / pharmacology; Cell Culture Techniques; Cell Line; Cell Survival / drug effects; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Hydrastis / chemistry; Immunoblotting; Immunologic Factors / antagonists & inhibitors; Immunologic Factors / biosynthesis; Influenza A Virus, H1N1 Subtype / drug effects; Influenza A Virus, H1N1 Subtype / growth & development; Influenza A Virus, H1N1 Subtype / metabolism; Macrophages / drug effects; Macrophages / virology; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Plant Extracts / chemistry; Plant Extracts / isolation & purification; Plant Extracts / pharmacology; Viral Proteins / biosynthesis
Sources: Crossref, ORCID
Added: February 12, 2020

2010 journal article

Echinacea and its alkylamides: Effects on the influenza A-induced secretion of cytokines, chemokines, and PGE(2) from RAW 264.7 macrophage-like cells

INTERNATIONAL IMMUNOPHARMACOLOGY, 10(10), 1268–1278.

By: N. Cech *, V. Kandhi*, J. Davis n , A. Hamilton n, D. Eads n & S. Laster n

co-author countries: United States of America 🇺🇸
author keywords: Echinacea; H1N1 influenza; Alkylamide; Isobutylamide; Plant extracts; Anti-inflammatory
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid

ANTIVIRAL RESEARCH, 88(3), 287–295.

By: J. Pollara*, S. Laster* & I. Petty

author keywords: Poxvirus; Cowpox virus; Vaccinia virus; Terameprocol; Antiviral agent; Cell-to-cell spread
MeSH headings : Actins / chemistry; Actins / metabolism; Antiviral Agents / pharmacology; Bioterrorism / prevention & control; Cell Line; Clinical Trials, Phase I as Topic; Cowpox virus / drug effects; Cowpox virus / physiology; Humans; Masoprocol / analogs & derivatives; Masoprocol / pharmacology; Poxviridae Infections / drug therapy; Poxviridae Infections / virology; Vaccinia virus / drug effects; Vaccinia virus / physiology; Virus Attachment / drug effects; Virus Replication / drug effects
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Tetra-O-methyl nordihydroguaiaretic acid (Terameprocol) inhibits the NF-kappa B-dependent transcription of TNF-alpha and MCP-1/CCL2 genes by preventing RelA from binding its cognate sites on DNA

JOURNAL OF INFLAMMATION-LONDON, 7.

By: A. Oyegunwa n, M. Sikes n, J. Wilson n, F. Scholle n & S. Laster n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines

JOURNAL OF INFLAMMATION-LONDON, 6.

By: D. Eads n, R. Hansen n, A. Oyegunwa n, C. Cecil n, C. Culver n, F. Scholle n, I. Petty n, S. Laster n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Adenovirus type 5 exerts multiple effects on the expression and activity of cytosolic phospholipase A(2), cyclooxygenase-2, and prostaglandin synthesis

JOURNAL OF IMMUNOLOGY, 179(6), 4170–4179.

By: C. Culver n & S. Laster n

co-author countries: United States of America 🇺🇸
MeSH headings : Adenoviruses, Human / genetics; Adenoviruses, Human / immunology; Animals; Arachidonic Acid / antagonists & inhibitors; Arachidonic Acid / metabolism; Cell Line; Cell Line, Tumor; Cyclooxygenase 2 / biosynthesis; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Dinoprostone / antagonists & inhibitors; Dinoprostone / biosynthesis; Enzyme Activation / immunology; Epoprostenol / antagonists & inhibitors; Epoprostenol / biosynthesis; Fibroblasts / enzymology; Fibroblasts / metabolism; Fibroblasts / virology; Group IV Phospholipases A2; Humans; Intracellular Fluid / enzymology; Intracellular Fluid / virology; Mice; Phospholipases A / biosynthesis; Phospholipases A / genetics; Phospholipases A / metabolism; Phospholipases A2; Prostaglandins / biosynthesis; Protein Transport / immunology; Tritium
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Evidence against calcium as a mediator of mitochondrial dysfunction during apoptosis induced by arachidonic acid and other free fatty acids

JOURNAL OF IMMUNOLOGY, 177(9), 6398–6404.

By: R. Maia n, C. Culver n & S. Laster n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Apoptosis; Arachidonic Acid / pharmacology; Autocrine Communication; Calcium / metabolism; Cell Line; Fatty Acids, Nonesterified / pharmacology; Fibroblasts / drug effects; Fibroblasts / metabolism; Membrane Potential, Mitochondrial / drug effects; Mice; Mitochondria / drug effects; Mitochondria / metabolism
Source: Web Of Science
Added: August 6, 2018

2005 journal article

The anti-apoptotic effects of nordihydroguaiaretic acid: Inhibition of cPLA(2) activation during TNF-induced apoptosis arises from inhibition of calcium signaling

LIFE SCIENCES, 77(19), 2457–2470.

By: C. Culver*, S. Michalowski*, R. Maia* & S. Laster*

author keywords: apoptosis; NDGA; cPLA(2)
MeSH headings : Animals; Antioxidants / pharmacology; Apoptosis / drug effects; Arachidonic Acid / metabolism; Blotting, Western; Butylated Hydroxyanisole / pharmacology; Calcium Signaling / drug effects; Caspases / metabolism; Cell Line; Chromium Radioisotopes; Enzyme Activation / drug effects; Fibroblasts / drug effects; Fibroblasts / metabolism; Immunoprecipitation; Male; Masoprocol / pharmacology; Mice; Microscopy, Phase-Contrast; Phosphates / metabolism; Phospholipases A / antagonists & inhibitors; Tumor Necrosis Factor-alpha / pharmacology
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Calcium and its role in the nuclear translocation and activation of cytosolic phospholipase A(2) in cells rendered sensitive to TNF-induced apoptosis by cycloheximide

JOURNAL OF IMMUNOLOGY, 172(4), 2416–2423.

By: D. Draper n, V. Harris*, C. Culver n & S. Laster n

co-author countries: United States of America 🇺🇸
MeSH headings : Active Transport, Cell Nucleus / drug effects; Active Transport, Cell Nucleus / immunology; Animals; Apoptosis / drug effects; Apoptosis / immunology; Arachidonic Acid / antagonists & inhibitors; Arachidonic Acid / metabolism; Calcium / metabolism; Calcium / physiology; Caspases / metabolism; Cell Line; Cell Nucleus / drug effects; Cell Nucleus / enzymology; Cell Nucleus / immunology; Cycloheximide / pharmacology; Cytosol / drug effects; Cytosol / enzymology; Cytosol / immunology; Enzyme Activation / drug effects; Enzyme Activation / immunology; Hydrolysis / drug effects; Intracellular Fluid / drug effects; Intracellular Fluid / immunology; Intracellular Fluid / metabolism; Mice; Mice, Inbred C3H; Phosphatidylserines / metabolism; Phospholipases A / metabolism; Phospholipases A2; Tritium; Tumor Necrosis Factor-alpha / pharmacology; Up-Regulation / drug effects; Up-Regulation / immunology; Verapamil / pharmacology
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Thymocyte and peripheral blood T lymphocyte subpopulation changes in piglets following in utero infection with porcine reproductive and respiratory syndrome virus

VIROLOGY, 302(2), 363–372.

By: W. Feng n, M. Tompkins n, J. Xu n, T. Brown n, S. Laster n, H. Zhang*, M. McCaw n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: PRRSV; thymus; thymocyte; T lymphocyte
MeSH headings : Animals; Animals, Newborn; Female; Infectious Disease Transmission, Vertical; Leukocytes, Mononuclear / immunology; Lymphocyte Count; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / virology; Porcine respiratory and reproductive syndrome virus / immunology; Pregnancy; Pregnancy, Animal; Swine; Swine Diseases / immunology; Swine Diseases / virology; T-Lymphocyte Subsets / immunology; Thymus Gland / cytology; Thymus Gland / immunology; Uterus / virology
Source: Web Of Science
Added: August 6, 2018

2001 journal article

In utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility of piglets to challenge by Streptococcus suis type II

JOURNAL OF VIROLOGY, 75(10), 4889–4895.

By: W. Feng *, S. Laster*, M. Tompkins*, T. Brown*, J. Xu*, C. Altier*, W. Gomez n, D. Benfield *, M. McCaw*

co-author countries: France 🇫🇷 United States of America 🇺🇸
MeSH headings : Animals; Cell Differentiation; Disease Susceptibility / immunology; Female; Infectious Disease Transmission, Vertical; Leukocyte Count; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine Reproductive and Respiratory Syndrome / physiopathology; Porcine Reproductive and Respiratory Syndrome / transmission; Porcine respiratory and reproductive syndrome virus / immunology; Porcine respiratory and reproductive syndrome virus / isolation & purification; Pregnancy; Pregnancy, Animal; Streptococcal Infections / complications; Streptococcal Infections / immunology; Streptococcal Infections / microbiology; Streptococcal Infections / pathology; Streptococcus suis / immunology; Streptococcus suis / isolation & purification; Streptococcus suis / physiology; Swine; Uterus / virology
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Characterization of arachidonic acid-induced apoptosis

Cell Biochemistry and Biophysics, 30(3), 353–368.

By: L. Wolf n & S. Laster n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Apoptosis / drug effects; Arachidonic Acid / metabolism; Arachidonic Acid / pharmacology; Blotting, Western; Cell Line; Ceramides / pharmacology; Chromium Radioisotopes / metabolism; Dose-Response Relationship, Drug; Fatty Acids / metabolism; Fibroblasts / drug effects; Humans; Melanoma / physiopathology; Mice; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha / metabolism
Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Sustained phosphorylation of cytosolic phospholipase A(2) accompanies cycloheximide- and adenovirus-induced susceptibility to TNF

Journal of Immunology, 161(3), 1525–1532.

By: J. O'Brien, D. Piddington, C. Voelkel-Johnson, D. Richards, L. Hadley & S. Laster

Source: NC State University Libraries
Added: August 6, 2018