Works Published in 2010
Displaying works 21 - 40 of 183 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2010 chapter
Elimination of Toxicants
In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 213–222). Hoboken, NJ: Wiley.
Ed(s): E. Hodgson
Source: NC State University Libraries
Added: March 8, 2021
2010 chapter
Introduction to Biochemical and Molecular Methods in Toxicology
In E. Hodgson (Ed.), A Textbook of Modern Toxicology (4th ed., pp. 15–28). Hoboken, NJ: Wiley.
Ed(s): E. Hodgson
Source: NC State University Libraries
Added: March 8, 2021
2010 journal article
Flawed experimental design reveals the need for guidelines requiring appropriate positive controls in endocrine disruption research
Toxicological Sciences, 115(2), 612–613.
Contributors: F. Saal *, B. Akingbemi *, S. Belcher* , D. Crain*, D. Crews*, L. Guidice*, P. Hunt*, C. Leranth*
MeSH headings : Animals; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Estrogens, Non-Steroidal / toxicity; Ethinyl Estradiol / toxicity; Female; Fertility / drug effects; Genitalia, Female / abnormalities; Genitalia, Female / drug effects; Guidelines as Topic; Male; Maternal Exposure; No-Observed-Adverse-Effect Level; Pregnancy; Rats; Rats, Long-Evans; Research Design / standards; Toxicity Tests / methods; Toxicity Tests / standards
TL;DR:
This dissertation aims to provide a history of tennis in China from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which the sport was introduced to China.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
Source: ORCID
Added: March 5, 2021
2010 journal article
Rapid signaling actions of environmental estrogens in developing granule cell neurons are mediated by estrogen receptor β
Endocrinology, 151(12), 5689–5699.
Contributors: H. Le* & S. Belcher*
MeSH headings : Animals; Cell Death; Endocrine Disruptors / chemistry; Endocrine Disruptors / pharmacology; Environmental Pollutants; Estrogen Receptor beta / metabolism; Estrogens / chemistry; Estrogens / pharmacology; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; Molecular Structure; Neurons / cytology; Neurons / drug effects; Neurons / physiology; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction
TL;DR:
The utility of estrogen sensitive developing granule cells as an in vitro assay for elucidating rapid estrogen-signaling mechanisms and to detect EDCs that act at ERβ to rapidly regulate intracellular signaling is demonstrated.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2010 journal article
Defining hormesis: Evaluation of a complex concentration response phenomenon
International Journal of Toxicology, 29(3), 235–246.
Contributors: E. Kendig*, H. Le* & S. Belcher*
author keywords: hormesis; dose-response relationship; threshold model; beta-curve; biphasic effects; nonmonotonic; low-dose effects; subthreshold response
MeSH headings : Animals; Dose-Response Relationship, Drug; History, 16th Century; History, 19th Century; History, Ancient; Humans; Models, Biological; Nonlinear Dynamics; Pharmacokinetics; Pharmacology / methods; Terminology as Topic; Toxicology / history; Toxicology / methods
TL;DR:
By examining the history of this dose-response theory, it is clear that both pharmacological and toxicological studies provide evidence for hormetic dose responses, but retrospective examination of studies can be problematic at best.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2010 journal article
Framework for traits-based assessment in ecotoxicology
Integrated Environmental Assessment and Management, 7(2), 172–186.
MeSH headings : Animals; Ecotoxicology / methods; Environmental Pollutants; Risk Assessment / methods
TL;DR:
A framework for the application of traits‐based assessment based on the population vulnerability conceptual model of Van Straalen, in which vulnerability is determined by traits that can be grouped into 3 major categories, i.e., external exposure, intrinsic sensitivity, and population sustainability is developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2010 journal article
Interspecies differences in metabolism of arsenic by cultured primary hepatocytes
Toxicology and Applied Pharmacology, 245(1), 47–56.
author keywords: Arsenic; Primary hepatocytes; Metabolism; As3mt; Mammalian species
MeSH headings : Animals; Arsenic / metabolism; Arsenic / toxicity; Cells, Cultured; Dogs; Female; Glutathione / metabolism; Hepatocytes / drug effects; Hepatocytes / enzymology; Hepatocytes / metabolism; Humans; Macaca mulatta; Male; Methylation; Methyltransferases / metabolism; Mice; Middle Aged; Rabbits; Rats; Species Specificity
TL;DR:
Immunoblot analyses indicate that the superior arsenic methylation capacities of dog, rat and monkey hepatocytes examined in this study may be associated with a higher As3mt expression, which may also contribute to the interspecies differences in the hepatocyte capacity to methylate iAs.
(via Semantic Scholar)
Source: Crossref
Added: January 21, 2021
2010 journal article
Presentation Skills for Scientists. E. Zanders & L. MacLeod. Cambridge University Press. 2010. 80 pages. ISBN 9780521741033. Price £19.99 (paperback with DVD-ROM).
Presentation Skills for Scientists. E. Zanders & L. MacLeod. Cambridge University Press. 2010. 80 pages. ISBN 9780521741033. Price £19.99 (paperback with DVD-ROM). Genetics Research, 92(4), 323–324.
TL;DR:
The Elements of Evolutionary Genetics by Brian and Deborah Charlesworth is a work of biblical proportions for the age of genetics, and in a fast-moving field, I anticipate that this book will be a key textbook for many years to come.
(via Semantic Scholar)
Source: Crossref
Added: January 5, 2021
2010 journal article
Polysaccharide Capsule and Sialic Acid-Mediated Regulation Promote Biofilm-Like Intracellular Bacterial Communities during Cystitis
Infection and Immunity, 78(3), 963–975.
MeSH headings : Animals; Bacterial Capsules / metabolism; Biofilms / growth & development; Colony Count, Microbial; Cystitis / immunology; Cystitis / microbiology; Cystitis / pathology; Disease Models, Animal; Mice; Mice, Knockout; N-Acetylneuraminic Acid / metabolism; Signal Transduction; Toll-Like Receptor 4 / deficiency; Urinary Tract Infections / microbiology; Uropathogenic Escherichia coli / pathogenicity; Virulence
TL;DR:
It is suggested that capsule is necessary for efficient IBC formation and that aberrant sialic acid accumulation, resulting from disruption of K1 capsule assembly, produces a NanR-mediated defect in intracellular proliferation and IBC development.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 30, 2020
2010 journal article
Revisiting the Escherichia coli polysaccharide capsule as a virulence factor during urinary tract infection: Contribution to intracellular biofilm development
Virulence, 1(4), 333–337.
author keywords: Escherichia coli; polysaccharide; capsule; sialic acid; urinary tract infection; biofilm; IBC; virulence; intra-cellularbacterial communities
MeSH headings : Animals; Bacterial Capsules / metabolism; Biofilms / growth & development; Cytosol / microbiology; Escherichia coli Infections / microbiology; Humans; Mice; N-Acetylneuraminic Acid / metabolism; Urinary Tract Infections / microbiology; Uropathogenic Escherichia coli / growth & development; Uropathogenic Escherichia coli / pathogenicity; Virulence; Virulence Factors / metabolism
TL;DR:
Evidence is provided for an expanded role for K capsule in the intracellular and extracellular pathogenesis of UTI, and additional rationale for the development of small molecule inhibitors of capsule biogenesis as anti-virulence therapeutics is provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 30, 2020
2010 journal article
High-Throughput Identification of Chemical Inhibitors of E. coli Group 2 Capsule Biogenesis as Anti-Virulence Agents
PLoS ONE, 5(7), e11642.
Ed(s): D. Ojcius
MeSH headings : Anti-Bacterial Agents / pharmacology; Antigens, Bacterial / drug effects; Antigens, Bacterial / metabolism; Antigens, Surface / drug effects; Antigens, Surface / metabolism; Bacterial Capsules / drug effects; Bacterial Capsules / metabolism; Escherichia coli / drug effects; Escherichia coli / metabolism; Escherichia coli / pathogenicity; Humans; Virulence / drug effects
TL;DR:
A screen for anti-capsular small molecules was conducted and an agent designated “C7” was identified that blocks the production of K1 and K5 capsules, unrelated polysaccharide types among the Group 2–3 capsules.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 30, 2020
2010 journal article
Discovery of a minimal form of RNase P in Pyrobaculum
Proceedings of the National Academy of Sciences, 107(52), 22493–22498.
author keywords: catalytic RNA; gene finding; RNA processing
MeSH headings : Archaeal Proteins / genetics; Archaeal Proteins / isolation & purification; Archaeal Proteins / metabolism; Base Sequence; Biocatalysis; Computational Biology / methods; Electrophoresis, Polyacrylamide Gel; Genome, Archaeal / genetics; Molecular Sequence Data; Nucleic Acid Conformation; Pyrobaculum / classification; Pyrobaculum / enzymology; Pyrobaculum / genetics; RNA Precursors / chemistry; RNA Precursors / genetics; RNA Precursors / metabolism; RNA, Archaeal / genetics; RNA, Archaeal / metabolism; RNA, Catalytic / genetics; RNA, Catalytic / metabolism; RNA, Transfer / chemistry; RNA, Transfer / genetics; RNA, Transfer / metabolism; Ribonuclease P / genetics; Ribonuclease P / isolation & purification; Ribonuclease P / metabolism; Sequence Homology, Nucleic Acid; Species Specificity; Substrate Specificity
TL;DR:
An effective combination of next-generation RNA sequencing, computational genomics, and biochemistry is illustrated to identify a divergent, formerly undetectable variant of an essential noncoding RNA gene.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: December 8, 2020
2010 journal article
Species interactions along a continuum: The fig wasp mutualism
EcoEdNet.
Source: NC State University Libraries
Added: November 5, 2020
2010 journal article
Patterns of neutral genetic variation on recombining sex chromosomes.
Genetics, 4.
MeSH headings : Animals; Evolution, Molecular; Female; Genetic Variation / genetics; Male; Models, Genetic; Mutation; Polymorphism, Genetic / genetics; Recombination, Genetic / genetics; Sex Chromosomes / genetics
TL;DR:
This work develops coalescent models for neutral sites on sex chromosomes that recombine over much of their length and analyzes the standard neutral model, a model with polymorphic Y chromosomes under balancing selection, and the invasion of a neo-Y chromosome.
(via Semantic Scholar)
Source: ORCID
Added: September 15, 2020
2010 journal article
Pesticide Exposures and Uterine Fibroid Risk Among Farming Women
Annals of Epidemiology, 20(9), 707.
Sources: Crossref, NC State University Libraries
Added: September 10, 2020
2010 journal article
Mortality in the Agricultural Health Study, 1993-2007
American Journal of Epidemiology, 173(1), 71–83.
author keywords: agriculture; healthy worker effect; mortality; neoplasms; pesticides; wounds and injuries
MeSH headings : Adult; Aged; Aged, 80 and over; Agricultural Workers' Diseases / mortality; Cause of Death / trends; Female; Humans; Iowa / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Occupational Exposure / adverse effects; Pesticides / adverse effects; Retrospective Studies; Survival Rate / trends
TL;DR:
Using data from the Agricultural Health Study, a cohort of 89,656 pesticide applicators and their spouses in North Carolina and Iowa, standardized mortality ratios (SMRs) were computed comparing deaths from time of the enrollment through 2007 to state-specific rates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 2, 2020
2010 journal article
Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice
Hormones and Behavior, 58(5), 754–761.
author keywords: Endocrine disruptive compounds; Estrogens; Epigenetic; Environment; Methylation; Sex differences; Bisphenol A
MeSH headings : Air Pollutants / toxicity; Animal Husbandry; Animals; Animals, Newborn; Anxiety / chemically induced; Behavior, Animal / drug effects; Behavior, Animal / physiology; Benzhydryl Compounds; Exploratory Behavior / drug effects; Exploratory Behavior / physiology; Female; Male; Maternal Deprivation; Maternal Exposure / adverse effects; Maze Learning / drug effects; Maze Learning / physiology; Mice; Mice, Inbred C57BL; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / physiopathology; Prenatal Exposure Delayed Effects / psychology
TL;DR:
The results show that prenatal BPA exposure affects social behavior and anxiety in the EPM, and some facet(s) of the infant-maternal interaction may modify these effects.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Of mice and rats: Key species variations in the sexual differentiation of brain and behavior
Frontiers in Neuroendocrinology, 31(3), 341–358.
author keywords: Hypothalamus; Calbindin D28k; Progestin receptor; Estrogen receptor; Nitric oxide; Sexual dimorphism
MeSH headings : Animals; Behavior, Animal / physiology; Brain / growth & development; Brain / physiology; Humans; Mice; Models, Animal; Rats; Sex Differentiation / physiology; Sexual Behavior, Animal / physiology; Species Specificity
TL;DR:
Neural and behavioral sexual dimorphisms in rats and mice are reviewed, which highlight species differences and experimental gaps in the literature, that are needed for direct species comparisons.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Critical periods of susceptibility to short-term energy challenge during pregnancy: Impact on fertility and offspring development
Physiology & Behavior, 99(1), 100–108.
author keywords: Reproduction; Pregnancy; Fertility; Gestation; Delayed implantation; Energy balance; Food restriction; Sexual behavior; Development
MeSH headings : Analysis of Variance; Animals; Body Weight; Disease Susceptibility; Eating / physiology; Fasting / physiology; Female; Fertility / physiology; Fetal Development / physiology; Litter Size; Male; Nutritional Status; Pregnancy / physiology; Pregnancy Outcome; Pregnancy, Animal; Sexual Behavior, Animal; Shrews; Time Factors
TL;DR:
There are critical periods of pregnancy, particularly after implantation, when short-term, mild energetic challenges have significant impacts on fertility and offspring postnatal development, and delayed implantation may have evolved, in part, as a buffering mechanism to prevent pregnancy failure during impaired energy balance in early gestation.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Maternally-inherited Grb10 reduces placental size and efficiency
Developmental Biology, 337(1), 1–8.
author keywords: Adapter protein; Cell signalling; Epigenetics; Genomic imprinting; Growth factor receptor-bound protein; Growth regulation; IGF; Insulin-like growth factor; Mouse; Placenta
MeSH headings : Alleles; Animals; Endothelium / metabolism; Female; GRB10 Adaptor Protein / analysis; GRB10 Adaptor Protein / genetics; GRB10 Adaptor Protein / physiology; Genomic Imprinting; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Placenta / pathology; Placenta / physiology; Pregnancy
TL;DR:
It is shown that following disruption of the maternal allele in mice, the labyrinthine volume was increased in a manner consistent with a cell-autonomous function of Grb10 and the enlarged placenta was more efficient in supporting foetal growth, becoming the first example of a gene that acts to limit placental size and efficiency.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
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