Works Published in 2014
Displaying works 101 - 120 of 270 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
The cranial morphology of large captive versus wild felids
Faseb Journal, 28(1). http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000346651003383&KeyUID=WOS:000346651003383
Contributors: A. Hartstone-Rose , H. Selvey, B. Boyde & J. Villari
Source: ORCID
Added: September 12, 2019
2014 article
Results of in vitro experiments, including pH, methane, fiber disappearance, and short chain fatty acid (SCFA) profiles
Figshare.
Contributors: E. McKenney, A. Hartstone-Rose , J. Lambert & V. Fellner
doi.org (publisher)
Source: ORCID
Added: September 12, 2019
2014 article
Macronutrient content of Arctictis binturong and Potos flavus diet, including extruded diet and the vegetative parts (leaves, petioles), reproductive parts (fruits, seeds), and modified roots (tubers) of domesticated plant species
Figshare.
Contributors: E. McKenney, A. Hartstone-Rose , J. Lambert & V. Fellner
Source: ORCID
Added: September 12, 2019
2014 journal article
Binturong (Arctictis binturong) and Kinkajou (Potos flavus) Digestive Strategy: Implications for Interpreting Frugivory in Carnivora and Primates
Plos One, 9(8).
Contributors: J. Lambert*, V. Fellner n, E. McKenney * & A. Hartstone-Rose*
MeSH headings : Animals; Carnivora / physiology; Diet, Vegetarian; Dietary Fiber / analysis; Digestion; Fatty Acids / analysis; Feces / chemistry; Fruit / chemistry; Herbivory; Hydrogen-Ion Concentration; Polysaccharides / analysis; Primates; Species Specificity
TL;DR:
Evaluating the digestive physiology of two frugivorous Carnivora species that converge with primates in a diversity of ecological and anatomical traits related to fruit consumption indicates that both carnivoran species have rapid digestive passage for mammals that consume a predominantly plant-based diet.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: ORCID
Added: September 12, 2019
2014 journal article
Anatomy and Adaptations of the Chewing Muscles in Daubentonia (Lemuriformes)
Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology, 297(2), 308–316.
Contributors: J. Perry*, K. Macneill*, A. Heckler*, G. Rakotoarisoa* & A. Hartstone-Rose*
author keywords: Daubentonia; chewing; muscle; architecture; primate
MeSH headings : Adaptation, Physiological / physiology; Aging / pathology; Aging / physiology; Animals; Body Size; Female; Jaw / anatomy & histology; Jaw / physiology; Mastication / physiology; Masticatory Muscles / anatomy & histology; Masticatory Muscles / physiology; Models, Biological; Phylogeny; Regression Analysis; Strepsirhini / anatomy & histology; Strepsirhini / physiology
TL;DR:
It may be that great jaw adductor PCSA in the adult aye‐aye, as compared to the juvenile, is a means of increasing foraging efficiency in the absence of parental assistance.
(via Semantic Scholar)
Source: ORCID
Added: September 12, 2019
2014 journal article
Local adaptation of a marine invertebrate with a high dispersal potential: evidence from a reciprocal transplant experiment of the eastern oyster Crassostrea virginica
Marine Ecology Progress Series, 505, 161–175.
author keywords: Reciprocal transplant; Local adaptation; Crassostrea virginica; Growth rate; Survivorship; Reproductive maturation; Genetic cline; Life history; Marine invertebrate
TL;DR:
The results of this study suggest that small environmental changes may have significant effects on conservation of the eastern oyster, particularly in the northern genetic lineage, and the potential role of temperature and phytoplankton community composition between the northern and southern regions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Source: ORCID
Added: September 11, 2019
2014 journal article
Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging
Acta Neuropathologica Communications, 2(1).
Contributors: A. Motsinger-Reif n, H. Zhu *, M. Kling*, W. Matson*, S. Sharma *, O. Fiehn *, D. Reif n , D. Appleby *
author keywords: Alzheimer's disease; Dementias; Metabolomics; Cerebrospinal fluid biomarkers; Stepwise logistic regression
MeSH headings : Aged; Aging / cerebrospinal fluid; Aging / drug effects; Aging / pathology; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / diagnosis; Alzheimer Disease / drug therapy; Alzheimer Disease / pathology; Amyloid beta-Peptides / cerebrospinal fluid; Area Under Curve; Biomarkers / cerebrospinal fluid; Chromatography, Liquid; Cognition; Diagnosis, Differential; Female; Gas Chromatography-Mass Spectrometry; Humans; Logistic Models; Male; Metabolomics / methods; Neuropsychological Tests; tau Proteins / cerebrospinal fluid
TL;DR:
Several CSF small-molecule metabolites that discriminated especially well between clinically diagnosed AD and control groups appear to be suitable for further confirmatory and validation studies, and show the potential to provide predictive performance for AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Source: ORCID
Added: May 14, 2019
2014 journal article
Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
Scientific Reports, 4.
Contributors: R. Huang *, S. Sakamuru *, M. Martin*, D. Reif* , R. Judson *, K. Houck *, W. Casey *, J. Hsieh *
MeSH headings : Cell Line; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Genes, Reporter / drug effects; HEK293 Cells; High-Throughput Screening Assays / methods; Humans; Ligands; Protein Binding / drug effects; Signal Transduction / drug effects; Small Molecule Libraries / pharmacology; Structure-Activity Relationship
TL;DR:
The results demonstrate the feasibility of qHTS to identify environmental chemicals with the potential to interact with the ERα signaling pathway and the two different assay formats improve the confidence in correctly identifying these chemicals.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses
Environmental Science and Technology, 48(15), 8706–8716.
Contributors: D. Rotroff *, M. Martin*, D. Dix*, D. Filer*, K. Houck *, T. Knudsen *, N. Sipes *, D. Reif*
MeSH headings : Algorithms; Animals; Biological Assay; Endocrine Disruptors / analysis; Estrogen Antagonists / analysis; Estrogen Receptor alpha / agonists; Estrogen Receptor alpha / antagonists & inhibitors; Estrogen Receptor beta / agonists; Estrogen Receptor beta / antagonists & inhibitors; Estrogens / analysis; High-Throughput Screening Assays; Humans; MCF-7 Cells; Models, Chemical; Pesticides; Signal Transduction
TL;DR:
A novel method for combining in vitro concentration response data from multiple assays and, when applied to a large set of ER data, accurately predicted estrogenic responses and demonstrated its utility for chemical prioritization is provided.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
Nature Biotechnology, 32(6), 583–591.
Contributors: N. Kleinstreuer *, J. Yang *, E. Berg*, T. Knudsen *, A. Richard *, M. Martin*, D. Reif* , R. Judson *
MeSH headings : Animal Testing Alternatives / methods; Animals; Computer Simulation; High-Throughput Screening Assays / methods; Humans; Mice; Models, Biological; Phenotype; Rats; Small Molecule Libraries; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
The results demonstrate that assaying complex biological pathways in primary human cells can identify potential chemical targets, toxicological liabilities and mechanisms useful for elucidating adverse outcome pathways.
(via Semantic Scholar)
Source: ORCID
Added: May 14, 2019
2014 journal article
Multidimensional in vivo hazard assessment using zebrafish.
Toxicological Sciences, 137(1), 212–233.
Contributors: L. Truong *, D. Reif n , L. Mary *, M. Geier*, H. Truong* & R. Tanguay *
MeSH headings : Animals; Cluster Analysis; Computational Biology; Dose-Response Relationship, Drug; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Embryo, Nonmammalian / pathology; Embryonic Development / drug effects; Environmental Pollutants / toxicity; High-Throughput Screening Assays; Humans; Motor Activity / drug effects; Notochord / drug effects; Notochord / pathology; Reproducibility of Results; Risk Assessment; Toxicity Tests / methods; Zebrafish / embryology
TL;DR:
An experimental design for high-throughput characterization of multidimensional in vivo effects with the power to evaluate trends relating to commonly cited chemical predictors is described and it is demonstrated that the developmental zebrafish detects adverse responses that would be missed by less comprehensive testing strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 14, 2019
2014 journal article
Hierarchical dose-response modeling for high-throughput toxicity screening of environmental chemicals
Biom, 70(1), 237â246.
Contributors: A. Wilson n, D. Reif n & B. Reich n
author keywords: Bayesian; Computational toxicology; Dose-response; MCMC; Monotonicity; Semiparametric; ToxCast
MeSH headings : Algorithms; Bayes Theorem; Computer Simulation; Dose-Response Relationship, Drug; Environmental Pollutants / toxicity; Estrogen Receptor alpha / metabolism; Humans; Markov Chains; Models, Statistical; Monte Carlo Method; PPAR gamma / metabolism; Toxicity Tests / methods; United States; United States Environmental Protection Agency
TL;DR:
This work proposes a semiparametric Bayesian model that borrows strength across chemicals and assays and demonstrates that the hierarchical method provides more accurate estimates of the probability of response, efficacy, and potency than separate curve estimation in a simulation study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: ORCID
Added: May 14, 2019
2014 journal article
Erratum to Incorporating human dosimetry and exposure into High-throughput in Vitro Toxicity Screening [Toxicological sciences 137, 2, (2014), 499]
Toxicological Sciences, 137(2).
Contributors: D. Rotroff, B. Wetmore, D. Dix, S. Ferguson, H. Clewell, K. Houck, E. LeCluyse, M. Andersen
Source: ORCID
Added: May 14, 2019
2014 journal article
Sampling and summary statistics of endpoint-conditioned paths in DNA sequence evolution
Bayesian Phylogenetics: Methods, Algorithms, and Applications, 247–275.
Source: NC State University Libraries
Added: August 6, 2018
2014 chapter
Changing the game: Multidimensional mentoring and partnerships in the recruitment of underrepresented students in fisheries
In Future of Fisheries: Perspectives for Emerging Professionals (pp. 193–200).
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Too big to be noticed: cryptic invasion of Asian camel crickets in North American houses
PEERJ, 2.
author keywords: Rhaphidophoridae; Diestrammena; Invasive species; Urban ecology; Citizen science
TL;DR:
A continental-scale citizen science campaign is launched to better understand the relative distributions and frequency of native and nonnative camel crickets in human homes across North America and reports the establishment in the northeastern United States of a second exotic species, putatively Diestrammena japanica Blatchley, which was previously undocumented in the literature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Human-caused habitat fragmentation can drive rapid divergence of male genitalia
EVOLUTIONARY APPLICATIONS, 7(10), 1252–1267.
author keywords: anthropogenic environmental change; genital evolution; gonopodium; human-induced phenotypic change; natural selection; Poeciliidae; sexual selection
TL;DR:
It is found that genital shape and allometry consistently and repeatedly diverged in fragmented systems across all species and islands, demonstrating that human modifications to the environment can drive rapid and predictable divergence in male genitalia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
C/EBP alpha regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G(1)/S checkpoint
CELL CYCLE, 13(22), 3602–3610.
author keywords: C/EBP alpha; CRL4(Cdt2); G(1)/S DNA damage checkpoint; keratinocytes; p21
MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / genetics; CCAAT-Enhancer-Binding Protein-alpha / metabolism; Cell Cycle Checkpoints / genetics; Cell Cycle Checkpoints / radiation effects; Cyclin-Dependent Kinase Inhibitor p21 / metabolism; DNA Damage / genetics; DNA Damage / radiation effects; G1 Phase Cell Cycle Checkpoints / genetics; Keratinocytes / metabolism; Keratinocytes / radiation effects; Mice; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Proteolysis; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Ultraviolet Rays; p21-Activated Kinases / genetics; p21-Activated Kinases / metabolism
TL;DR:
Findings reveal C/EBPα regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4Cdt2 mediated degradation of p21.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II
CURRENT OPINION IN PHARMACOLOGY, 19, 145–152.
Contributors: D. Filer*, H. Patisaul n , T. Schug*, D. Reif n & K. Thayer *
MeSH headings : Animals; Databases, Factual; Endocrine Disruptors / toxicity; High-Throughput Screening Assays; Humans; Models, Theoretical; Risk Assessment; United States; United States Environmental Protection Agency
TL;DR:
Results from this exercise suggest the spectrum of environmental chemicals with potential endocrine activity is much broader than indicated, and that some aspects of endocrine disruption are not fully covered in ToxCast.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Minimal detection of nuclear mutations in XP-V and normal cells treated with oxidative stress inducing agents
Journal of Biochemical and Molecular Toxicology, 28(12), 568–577.
Source: NC State University Libraries
Added: August 6, 2018
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