Works Published in 2011
Displaying works 41 - 60 of 225 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2011 journal article
Re-engineering multicloning sites for function and convenience
Nucleic Acids Research, 39(14), e92–e92.
MeSH headings : 5' Untranslated Regions; Cloning, Molecular / methods; Codon; Genetic Vectors / chemistry; Promoter Regions, Genetic; Protein Biosynthesis; Saccharomyces cerevisiae / genetics
TL;DR:
This work develops and applies a novel predictive model of structure-based translation inhibition to design improved MCSs for significantly higher and more consistent protein expression, and was able to minimize the inhibitory effects of M CSs with the yeast TEF, CYC and GPD promoters.
(via Semantic Scholar)
academic.oup.com (publisher PDF)
Source: ORCID
Added: May 6, 2021
2011 article
Using Flux Balance Analysis to Guide Microbial Metabolic Engineering
Curran, K. A., Crook, N. C., & Alper, H. S. (2011, November). Microbial Metabolic Engineering, pp. 197–216.
author keywords: Flux balance analysis; MOMA; Genomic-scale metabolic model; Metabolic engineering; Strain engineering
MeSH headings : Algorithms; Computational Biology / methods; Internet; Metabolic Engineering / methods; Metabolic Networks and Pathways / genetics; Models, Biological; Reproducibility of Results; Software
TL;DR:
Fux balance analysis (FBA) is a mathematical approach that uses a genomic-scale metabolic network models to afford in silico prediction and optimization of metabolic changes.
(via Semantic Scholar)
Source: ORCID
Added: May 6, 2021
2011 chapter
Bivalves
In Invertebrate Medicine (pp. 127–151).
Sources: Crossref, NC State University Libraries
Added: April 23, 2021
2011 journal article
Integration of Environmental Stewardship and Local Economic Development to Enhance Community Health
North Carolina Medical Journal, 72(2), 141–144.
Sources: Crossref, NC State University Libraries
Added: April 23, 2021
2011 report
St. Louis speaks about Open Streets
http://activelivingresearch.org/files/Hipp_GranteeUpdate_OpenStreets2011_PolicyBrief2.pdf
Source: NC State University Libraries
Added: March 12, 2021
2011 report
Open and shut: the case for Open Streets in St. Louis
http://activelivingresearch.org/files/Hipp_GranteeUpdate_OpenStreets2011_PolicyBrief.pdf
Source: NC State University Libraries
Added: March 12, 2021
2011 report
Social ecological constraints to park use in communities with quality access
(CSD Working Paper No. 11-36). St. Louis, MO: Washington University, Center for Social Development.
Source: NC State University Libraries
Added: March 12, 2021
2011 journal article
Bisphenol A and 17β-estradiol promote arrhythmia in the female heart via alteration of calcium handling
PLoS ONE, 6(9).
MeSH headings : Animals; Arrhythmias, Cardiac / chemically induced; Arrhythmias, Cardiac / metabolism; Arrhythmias, Cardiac / pathology; Benzhydryl Compounds; Calcium Signaling / drug effects; Dose-Response Relationship, Drug; Endocrine Disruptors / pharmacology; Estradiol / pharmacology; Estrogen Receptor beta / deficiency; Estrogen Receptor beta / genetics; Estrogens / pharmacology; Female; Gene Knockout Techniques; Heart / drug effects; Heart Ventricles / drug effects; Heart Ventricles / pathology; Male; Mice; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / pathology; Phenols / pharmacology; Rats; Sarcoplasmic Reticulum / drug effects; Sarcoplasmic Reticulum / metabolism; Sex Characteristics; Time Factors
TL;DR:
Physiologically-relevant concentrations of BPA and E2 promote arrhythmias in a female-specific manner in rat hearts; the pro-arrhythmic actions of estrogens are mediated by ERβ-signaling through alterations of myocyte Ca2- handling, particularly increases in SR Ca2+ leak.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: March 5, 2021
2011 journal article
Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies
International Journal of Epidemiology, 40(5), 1314–1328.
author keywords: Data synthesis; data quality; data pooling; harmonization; meta-analysis; DataSHaPER; retrospective harmonization
MeSH headings : Chronic Disease / epidemiology; Cohort Studies; Data Collection / methods; Data Interpretation, Statistical; Databases, Factual; Epidemiologic Methods; Humans; Retrospective Studies; Risk Factors; Surveys and Questionnaires
TL;DR:
The current article shows that the DataSHaPER provides an effective and flexible approach for the retrospective harmonization of information across studies and offers the promise of enhanced research potential generated through synthesized databases.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 28, 2021
2011 chapter
N-Linked Global Glycan Profiling by NanoLC Mass Spectrometry
In Methods in Molecular Biology (pp. 87–97).
author keywords: N-linked glycans; NanoLC mass spectrometry; Glycoproteins; Glycosylation; Glycan profiling; Hydrophilic interaction chromatography; Glycobiology; Glycan algorithms
MeSH headings : Acetylglucosamine / metabolism; Asparagine; Blood Proteins / chemistry; Blood Proteins / metabolism; Chromatography, Liquid / methods; Glycoproteins / metabolism; Glycoside Hydrolases / metabolism; Hydrophobic and Hydrophilic Interactions; Mannose / metabolism; Mass Spectrometry / methods; Nanotechnology / methods; Nitrogen / chemistry; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase / metabolism; Polysaccharides / analysis; Polysaccharides / chemistry; Polysaccharides / isolation & purification; Polysaccharides / metabolism; Protein Denaturation; Solid Phase Extraction; Substrate Specificity; Tandem Mass Spectrometry
TL;DR:
Material, methods, and algorithms for the identification of both glycan composition and structure are summarized and potential problems and their resolutions are addressed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 12, 2021
2011 journal article
Absolute quantification of free glutathione and cysteine in aquatic insects using isotope dilution and selected reaction monitoring
Analytical and Bioanalytical Chemistry, 402(1), 357–366.
author keywords: Glutathione; Cysteine; Selected reaction monitoring; Absolute quantification; Isotope dilution
MeSH headings : Animals; Aquatic Organisms / chemistry; Carbon Isotopes / analysis; Chromatography, High Pressure Liquid / methods; Cysteine / analysis; Glutathione / analysis; Indicator Dilution Techniques; Insecta / chemistry; Nitrogen Isotopes / analysis
TL;DR:
A simple and robust isotope dilution mass spectrometry-based assay was developed for the determination of free cysteine and glutathione in aquatic insects and was demonstrated to have a quantitative dynamic range spanning nearly three orders of magnitude.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 21, 2021
2011 journal article
Nuclear Factor κ-Light Chain-Enhancer of Activated B Cells is Activated by Radiotherapy and is Prognostic for Overall Survival in Patients With Rectal Cancer Treated With Preoperative Fluorouracil-Based Chemoradiotheraphy
International Journal of Radiation Oncology*Biology*Physics, 80(3), 705–711.
author keywords: Chemoradiotherapy; NF-kappa B; rectal cancer; prognostic markers; inducible resistance genes; TRAF1; Bcl-2; cIAP-2; interleukin 8
MeSH headings : Adult; Aged; Aged, 80 and over; Combined Modality Therapy / methods; Female; Genes, bcl-2 / genetics; Humans; Inhibitor of Apoptosis Proteins / genetics; Interleukin-8 / genetics; Male; Middle Aged; NF-kappa B / metabolism; Neoplasm Proteins / metabolism; Prognosis; Prospective Studies; Radiation Tolerance / genetics; Rectal Neoplasms / drug therapy; Rectal Neoplasms / genetics; Rectal Neoplasms / metabolism; Rectal Neoplasms / mortality; Rectal Neoplasms / radiotherapy; Retrospective Studies; TNF Receptor-Associated Factor 1 / genetics; Treatment Outcome
TL;DR:
NF-κB might play an important role in tumor metastasis but not to the resistance to chemoradiotherapy, and nuclear expression at baseline in rectal cancer was prognostic for overall survival but not predictive of the response to RT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: January 4, 2021
2011 conference paper
Genetic analysis of bed bug infestations and populations
In W. Robinson & A. E. Carvalho Campos (Eds.), Proceedings of the Seventh International Conference on Urban Pests (pp. 319–323). Sao Paulo, Brazil: Instituto Biologico.
Ed(s): W. Robinson & A. Carvalho Campos
Source: NC State University Libraries
Added: November 20, 2020
2011 journal article
Advanced Structural Mass Spectrometry for Systems Biology: Pulling the Needles from Haystacks
Current Trends in Mass Spectrometry, 9(3), 18–23.
Source: NC State University Libraries
Added: November 16, 2020
2011 chapter
Public Health and Social Work
In S. Gehlert & T. A. Browne (Eds.), Handbook of Health Social Work (pp. 64–99). Hoboken, New Jersey: John Wiley & Sons.
Ed(s): S. Gehlert & T. Browne
Source: NC State University Libraries
Added: November 3, 2020
2011 journal article
Unusual macrocyclic lactone sex pheromone of Parcoblatta lata, a primary food source of the endangered red-cockaded woodpecker
Proceedings of the National Academy of Sciences, 109(8), E490–E496.
author keywords: pheromone monitoring; surveillance; wildlife conservation
MeSH headings : Animals; Arthropod Antennae / physiology; Birds / physiology; Chromatography, Gas; Cockroaches / metabolism; Endangered Species; Female; Food; Lactones / metabolism; Macrocyclic Compounds / metabolism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Sex Attractants / analysis; Sex Attractants / chemistry
TL;DR:
Parcoblattalactone was biologically active in electrophysiological assays and attracted not only P. lata but also several other Parcoblatta species in pine forests, underscoring its utility in monitoring several endemic wood cockroach species in red-cockaded woodpecker habitats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: Crossref
Added: September 5, 2020
2011 journal article
High pesticide exposure events and central nervous system function among pesticide applicators in the Agricultural Health Study
International Archives of Occupational and Environmental Health, 85(5), 505–515.
author keywords: Agricultural workers; Epidemiology; Neurobehavioral testing; Pesticide exposure; High pesticide exposure event
MeSH headings : Aged; Aged, 80 and over; Agriculture; Central Nervous System / drug effects; Humans; Iowa; Linear Models; Male; Middle Aged; North Carolina; Occupational Diseases / chemically induced; Occupational Diseases / diagnosis; Occupational Exposure / adverse effects; Occupational Exposure / analysis; Pesticides / poisoning; Prospective Studies; Surveys and Questionnaires
TL;DR:
One or more HPEE may contribute to adverse CNS outcomes independent of diagnosed pesticide poisoning, and no significant associations were observed between participants who ever had an HPEE and the remaining neurobehavioral tests.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 2, 2020
2011 journal article
Enzymatic Defects Underlying Hereditary Glutamate Cysteine Ligase Deficiency Are Mitigated by Association of the Catalytic and Regulatory Subunits
Biochemistry, 50(29), 6508–6517.
MeSH headings : Animals; Catalytic Domain; Enzyme Stability; Glutamate-Cysteine Ligase / chemistry; Glutamate-Cysteine Ligase / deficiency; Glutamate-Cysteine Ligase / metabolism; Glutathione / biosynthesis; Homozygote; Humans; Kinetics; Mice; Models, Biological; Mutant Proteins / metabolism; Mutation / genetics; Protein Binding; Protein Structure, Secondary; Recombinant Proteins / metabolism; Saccharomyces cerevisiae / metabolism; Structural Homology, Protein; Temperature
TL;DR:
Kinetic characterizations of the recombinant GCLC mutants indicated that the Arg127Cys, His370Leu, and Pro414Leu mutants have compromised enzymatic activity that can largely be rescued by the addition of GCLM, suggesting that heterodimer formation is needed for stability in vivo.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
An Evolved Adeno-associated Viral Variant Enhances Gene Delivery and Gene Targeting in Neural Stem Cells
Molecular Therapy, 19(4), 667–675.
MeSH headings : Animals; Cells, Cultured; Chromatography; Dependovirus / genetics; Female; Fluorescent Antibody Technique; Gene Transfer Techniques; Neural Stem Cells / virology; Polymerase Chain Reaction; Rats; Rats, Inbred F344
TL;DR:
This work applied directed evolution to create a "designer" AAV vector with enhanced delivery efficiency for neural stem cells (NSCs), and a novel AAV variant, carrying an insertion of a selected peptide sequence on the surface of the threefold spike within the heparin-binding site, emerged from this evolution.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Rho GTPases Mediate the Mechanosensitive Lineage Commitment of Neural Stem Cells
STEM CELLS, 29(11), 1886–1897.
author keywords: Neural stem cells; Cellular mechanotransduction; Rho GTP-binding proteins; Adipose stem cells; Extracellular matrix; Elastic modulus
MeSH headings : Animals; Apoptosis / genetics; Apoptosis / physiology; Cell Differentiation / genetics; Cell Differentiation / physiology; Cell Proliferation; Cells, Cultured; Extracellular Matrix / metabolism; Female; Fluorescent Antibody Technique; Mechanotransduction, Cellular / genetics; Mechanotransduction, Cellular / physiology; Microscopy, Atomic Force; Neural Stem Cells / cytology; Neural Stem Cells / metabolism; Neurogenesis / genetics; Neurogenesis / physiology; Rats; Rats, Inbred F344; cdc42 GTP-Binding Protein / genetics; cdc42 GTP-Binding Protein / metabolism; rho GTP-Binding Proteins / genetics; rho GTP-Binding Proteins / metabolism; rhoA GTP-Binding Protein / genetics; rhoA GTP-Binding Protein / metabolism
TL;DR:
These results establish Rho GTPase‐based mechanotransduction and cellular stiffness as biophysical regulators of NSC fate in vitro and RhoA as an important regulatory protein in the hippocampal stem cell niche.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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