Works Published in 2012
Displaying works 41 - 60 of 221 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Estrogen-like disruptive effects of dietary exposure to bisphenol A or 17α-ethinyl estradiol in CD1 mice
International Journal of Toxicology, 31(6), 537–550.
Contributors: E. Kendig*, D. Buesing*, S. Christie*, C. Cookman*, R. Gear*, E. Hugo*, S. Kasper*, J. Kendziorski*
author keywords: Bisphenol A; diabetes; endocrine disruptor; estrogen; metabolic effects; obesity; prolactin
MeSH headings : Animal Feed; Animals; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Environmental Pollutants / toxicity; Estrogens / toxicity; Ethinyl Estradiol / toxicity; Female; Glucose Tolerance Test; Male; Maternal Exposure; Mice; Mice, Inbred Strains; No-Observed-Adverse-Effect Level; Obesity / chemically induced; Organ Size / drug effects; Paternal Exposure; Phenols / toxicity; Reproduction / drug effects; Sex Factors; Sexual Maturation / drug effects; Sperm Count; Spermatozoa / drug effects; Uterus / drug effects
TL;DR:
Overall, BPA was found to have modest, sex specific endocrine disruptive effects on a variety of end points below the established no observed adverse effect level, and the dose response characteristics for many of the effects were nonmonotonic and not predictable from high-dose extrapolations.
(via Semantic Scholar)
citeseerx.ist.psu.edu (repository)
Source: ORCID
Added: March 5, 2021
2012 journal article
Rapid estrogen receptor-mediated mechanisms determine the sexually dimorphic sensitivity of ventricular myocytes to 17β-estradiol and the environmental endocrine disruptor bispheno A
Endocrinology, 153(2), 712–720.
Contributors: S. Belcher* , Y. Chen *, S. Yan * & H. Wang *
MeSH headings : Animals; Benzhydryl Compounds; Calcium / metabolism; Calcium Signaling / physiology; Cells, Cultured; Dose-Response Relationship, Drug; Endocrine Disruptors / pharmacology; Estradiol / administration & dosage; Estradiol / pharmacology; Female; Male; Mice; Mice, Knockout; Myocardial Contraction / drug effects; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Phenols / administration & dosage; Phenols / pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Receptors, Estrogen / metabolism; Sex Characteristics
TL;DR:
The sex-specific sensitivity of myocytes to estrogens and the rapid arrhythmogenic effects of BPA and estradiol in the female heart are regulated by the balance between ERα and ERβ signaling.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2012 journal article
Inhibition of stathmin1 accelerates the metastatic process
Cancer Research, 72(20), 5407–5417.
Contributors: K. Williams *, R. Ghosh *, P. Giridhar*, G. Gu*, T. Case *, S. Belcher* , S. Kasper*
MeSH headings : Base Sequence; Cells, Cultured; DNA Primers; Down-Regulation; Humans; Male; Neoplasm Metastasis; Signal Transduction; Stathmin / antagonists & inhibitors
TL;DR:
It is reported for the first time that STMN1 strongly inhibits metastatic behavior in both normal epithelial and cancerous epithelial cells, suggesting that there may be a tumor stage-specific window-of-opportunity in which conserving ST MN1 expression is required to inhibit emergence of metastatic disease.
(via Semantic Scholar)
Source: ORCID
Added: March 5, 2021
2012 journal article
Polyubiquitin Is Required for Growth, Development and Pathogenicity in the Rice Blast Fungus Magnaporthe oryzae
PLoS ONE, 7(8), e42868.
Ed(s): K. Nielsen
MeSH headings : Boronic Acids / pharmacology; Bortezomib; Cluster Analysis; Fungal Proteins / genetics; Fungal Proteins / metabolism; Gene Expression Profiling; Gene Expression Regulation, Fungal; Germination / genetics; Magnaporthe / genetics; Magnaporthe / growth & development; Magnaporthe / pathogenicity; Mutation; Nitrogen / metabolism; Oryza / microbiology; Plant Diseases / microbiology; Polyubiquitin / genetics; Polyubiquitin / metabolism; Proteasome Inhibitors / pharmacology; Proteolysis / drug effects; Proteomics; Pyrazines / pharmacology; Ubiquitination
TL;DR:
This study suggests that ubiquitination of target proteins plays an important role in nutrient assimilation, development and pathogenicity of M. oryzae.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: February 27, 2021
2012 journal article
Poly Specific trans-Acyltransferase Machinery Revealed via Engineered Acyl-CoA Synthetases
ACS Chemical Biology, 8(1), 200–208.
MeSH headings : Acyltransferases / chemistry; Acyltransferases / genetics; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Chromatography, Liquid; Coenzyme A Ligases / chemistry; Coenzyme A Ligases / genetics; Crystallography, X-Ray; Genetic Variation; Models, Molecular; Substrate Specificity
TL;DR:
Results reveal that polyketide biosynthetic machinery might be more tolerant to non-natural substrates than previously established, and that mutant synthetases are valuable tools for probing the specificity of biosynthetics machinery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 18, 2021
2012 journal article
Alexander R. Ivanov, Alexander V. Lazarev (Eds): Sample preparation in biological mass spectrometry
Analytical and Bioanalytical Chemistry, 404(5), 1331–1332.
Sources: Crossref, NC State University Libraries
Added: January 18, 2021
2012 journal article
Seasonal Synechococcus and Thaumarchaeal population dynamics examined with high resolution with remote in situ instrumentation
The ISME Journal, 6(3), 513–523.
author keywords: Crenarchaeota; Environmental Sample Processor; Monterey Bay; Synechococcus; Thaumarchaeota; time series
MeSH headings : Archaea / genetics; Archaea / growth & development; Bays / microbiology; California; Chlorophyll / analysis; Chlorophyll A; Ecosystem; Nitrates / analysis; Pacific Ocean; Phytoplankton / classification; Polymerase Chain Reaction; Population Dynamics; RNA, Ribosomal, 16S / genetics; Remote Sensing Technology; Seasons; Synechococcus / genetics; Synechococcus / growth & development
TL;DR:
It is concluded that controls on these ecosystems change on smaller scales than are routinely assessed, and that more predictable trends will be uncovered if they are evaluated within seasonal (monthly) rather than on annual or interannual scales.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: December 26, 2020
2012 journal article
Location, location, location: Genetic regulation of neural sex differences
Reviews in Endocrine and Metabolic Disorders, 13(3), 151–161.
author keywords: Sex chromosomes; Estrogen receptors; Calbindin-D28k; Tyrosine hydroxylase; Dopamine; Vasopressin; Sexually dimorphic; Cerebellum; Frontal cortex; Epigenetic
MeSH headings : Animals; Arginine Vasopressin / physiology; Calbindin 1; Calbindins; Epigenesis, Genetic; Estrogen Receptor alpha / physiology; Female; Humans; Male; Mice; Midline Thalamic Nuclei / physiology; Preoptic Area / physiology; Rats; Receptors, Steroid / genetics; S100 Calcium Binding Protein G / genetics; Septal Nuclei / physiology; Sex Characteristics; Sex Chromosomes / physiology; Sexual Behavior, Animal / physiology; Tyrosine 3-Monooxygenase / genetics; Vasopressins / genetics
TL;DR:
The thrust is to examine genetic bases of sex differences and how the use of genetically modified models has advanced understanding of this topic, focusing on three proteins that have well described sexual dimorphisms; calbindin-D28k, a calcium binding protein, tyrosine hydroxylase, the rate limiting enzyme involved in dopamine synthesis and vasopressin, a neuropeptide with central and peripheral sites of action.
(via Semantic Scholar)
Source: Crossref
Added: October 29, 2020
2012 chapter
Trichomoniasis
In C. E. Green (Ed.), Infectious Diseases of the Dog and Cat (4th ed., pp. 797–801). St. Louis, MO: Elsevier Saunder.
Ed(s): C. Green
Source: NC State University Libraries
Added: October 21, 2020
2012 journal article
P60—Preliminary results on subfecundity and plasma concentrations of perfluorinated compounds during pregnancy in the Norwegian Mother and Child Cohort Study, 2002–2004
Reproductive Toxicology, 33(4), 620–621.
Sources: Crossref, NC State University Libraries
Added: September 10, 2020
2012 journal article
Evaluating temporally weighted kernel density methods for predicting the next event location in a series
Annals of GIS, 18(3), 225–240.
TL;DR:
Results of applying the methodology to identify the optimal parameters and test the performance of temporally weighted kernel density estimation models for predicting the next event in a criminal or terrorist event series indicate that performance can vary greatly by crime type and little by series length and is fairly robust to choice of bandwidth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 8, 2020
2012 journal article
Functional data analysis of mandibular movement using third-degree b-spline basis functions and self-modeling regression
Orthodontic Waves, 71(1), 17–25.
author keywords: Mandibular movement; Functional data analysis; Spline function; Self-modeling regression; Finite helical axis
TL;DR:
The results of this study demonstrated that the calculation of population average curves is effective for clarifying the characteristics of functional data, such as in mandibular movement.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 8, 2020
2012 journal article
Lethal ovitraps and dengue prevention: report from Iquitos, Peru
International Journal of Infectious Diseases, 16, e473.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: September 6, 2020
2012 chapter
Pheromone Production
In Insect Endocrinology (pp. 523–567).
TL;DR:
There is much better understanding of how pheromones are made, and in some systems the authors are developing an understanding of their regulation at the molecular level, and the continued application of the powerful tools of molecular biology along with studies using genomics and proteomics will only increase the rate at which researchers increase the understanding of phersomone production.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 5, 2020
2012 chapter
Evaluating Collective Effects: A Participatory Approach to Mapping Public Information About Water Issues in an Uncertain and Politicized Context
In Geospatial Tools for Urban Water Resources (pp. 37–60).
Sources: Crossref, NC State University Libraries
Added: September 3, 2020
2012 journal article
UDP-glucose Dehydrogenase Polymorphisms from Patients with Congenital Heart Valve Defects Disrupt Enzyme Stability and Quaternary Assembly
Journal of Biological Chemistry, 287(39), 32708–32716.
MeSH headings : Amino Acid Substitution; Animals; Animals, Genetically Modified / embryology; Animals, Genetically Modified / genetics; Enzyme Stability / genetics; Escherichia coli; Heart Defects, Congenital / embryology; Heart Defects, Congenital / enzymology; Heart Defects, Congenital / genetics; Heart Valve Diseases / embryology; Heart Valve Diseases / enzymology; Heart Valve Diseases / genetics; Heart Valves / embryology; Heart Valves / enzymology; Muscle Proteins / genetics; Muscle Proteins / metabolism; Mutation, Missense; Polymorphism, Genetic; Protein Structure, Quaternary; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Uridine Diphosphate Glucose Dehydrogenase; Zebrafish / embryology; Zebrafish / genetics; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
UGDH loss of function mutations result in a subset of human congenital cardiac valve defects caused by reduced enzyme activity during morphogenesis, consistent with the reduced function of both missense mutations significantly reducing the ability of UGDH to provide precursors for cardiac cushion formation, which is essential to subsequent valve formation.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells
Integrative Biology, 4(9), 1049–1058.
MeSH headings : Cell Culture Techniques / methods; Cell Differentiation / physiology; Dopaminergic Neurons / cytology; Extracellular Matrix / physiology; Flow Cytometry; Humans; Microscopy, Atomic Force; Microscopy, Phase-Contrast; Neurogenesis / physiology; Pluripotent Stem Cells / cytology; Stress, Mechanical
TL;DR:
It is found that increasing extracellular matrix stiffness in vitro increases hPSC cell and colony spread area but does not alter self-renewal, in contrast to past studies with mESCs, and softer ECMs with stiffnesses similar to that of neural tissue promote the generation of early neural ectoderm.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
A Genetic Strategy for the Dynamic and Graded Control of Cell Mechanics, Motility, and Matrix Remodeling
Biophysical Journal, 102(3), 434–442.
MeSH headings : Biomechanical Phenomena; Cell Line; Cell Movement / drug effects; Cell Movement / genetics; Collagen / metabolism; Extracellular Matrix / drug effects; Extracellular Matrix / genetics; Extracellular Matrix / metabolism; Gene Expression Regulation / drug effects; Gene Expression Regulation / genetics; Genetic Engineering / methods; Humans; Mechanical Phenomena; Mechanotransduction, Cellular / drug effects; Mechanotransduction, Cellular / genetics; Mutation; Promoter Regions, Genetic / genetics; Tetracycline / pharmacology
TL;DR:
It is demonstrated that soft ECMs render cells maximally sensitive to changes in RhoA activity, and that by modulating the ability of cells to engage and contract soft ECM, the strategy enables the physical interactions between cells and the ECM and thereby dictate how cells respond to matrix properties.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Experience-facilitated improvements in pup retrieval; evidence for an epigenetic effect
Hormones and Behavior, 62(2), 128–135.
author keywords: Maternal experience; Epigenetics; Sodium butyrate; HDAC inhibition; Oxytocin; CBP
MeSH headings : Animals; Animals, Newborn; Behavior, Animal / drug effects; Behavior, Animal / physiology; Butyrates / pharmacology; Epigenesis, Genetic / drug effects; Epigenesis, Genetic / physiology; Exploratory Behavior / drug effects; Exploratory Behavior / physiology; Female; Gene Expression Regulation / drug effects; Gene Expression Regulation / physiology; Histone Deacetylase Inhibitors / pharmacology; Learning / drug effects; Learning / physiology; Maternal Behavior / drug effects; Maternal Behavior / physiology; Mice; Mice, Inbred C57BL; Pregnancy
TL;DR:
Experiences with infants suggest that experience induces high levels of maternal care via epigenetic modifications, which in turn change expression of genes that promote maternal care.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
X-chromosome dosage affects male sexual behavior
Hormones and Behavior, 61(4), 565–572.
author keywords: Klinefelter's Syndrome; Sex Chromosomes; Sexual differentiation; Masculine behavior; Aneuploid
MeSH headings : Aggression / physiology; Animals; Aromatase / biosynthesis; Copulation / physiology; Ejaculation / physiology; Estrogen Receptor alpha / biosynthesis; Female; Gene Dosage; Genitalia, Male / anatomy & histology; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Orchiectomy; Radioimmunoassay; Real-Time Polymerase Chain Reaction; Receptors, Androgen / biosynthesis; Septum of Brain / metabolism; Sex Characteristics; Sexual Behavior, Animal / physiology; Vasopressins / blood; X Chromosome / physiology
TL;DR:
It is speculated that expression levels of a yet to be discovered gene(s) on the X-chromosome may affect sexual behavior in mice and perhaps in other mammals.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
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