Works Published in 2012
Displaying works 61 - 80 of 221 in total
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2012 journal article
Running-induced epigenetic and gene expression changes in the adolescent brain
International Journal of Developmental Neuroscience, 31(6), 382–390.
author keywords: Epigenetic; Exercise; Puberty; Adolescent; Cerebellum; BDNF
MeSH headings : Animals; Animals, Newborn; Brain / physiology; Epigenesis, Genetic / physiology; Epigenomics; Gene Expression / physiology; Histones; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins / metabolism; Neuronal Plasticity / physiology; Physical Conditioning, Animal; Signal Transduction / physiology
TL;DR:
After 1 week of exercise, global acetylation of histone 3 was increased in both brain regions, Interestingly this was correlated with increased brain derived neural growth factor in the hippocampus, as noted in many other studies, but only a trend was found in cerebellum.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Resetting for the Next Generation
Molecular Cell, 48(6), 819–821.
TL;DR:
In this issue of Molecular Cell, Seisenberger et al. (2012) refine DNA methylation mapping to interrogate the epigenetic reprogramming of primordial germ cells, defining the timings of methylation loss, linking to pluripotency, and identifying potential routes to transgenerational epigenetic inheritance.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2012 journal article
Protection against De Novo Methylation Is Instrumental in Maintaining Parent-of-Origin Methylation Inherited from the Gametes
Molecular Cell, 47(6), 909–920.
MeSH headings : Animals; Blastocyst / metabolism; Cadherins / genetics; DNA Methylation; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Fertilization; Genetic Testing; Genomic Imprinting; Germ Cells / metabolism; Mice; Oocytes / metabolism; Pseudogenes; Sequence Analysis, DNA
TL;DR:
Evidence is provided that protection against de novo methylation acts as an equal major pivot, at implantation and throughout life.
(via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2012 journal article
341 ANDROGENETIC ALOPECIA AT VARIOUS AGES AND PROSTATE CANCER RISK IN AN EQUAL ACCESS MULTIETHNIC CASE CONTROL SERIES OF VETERANS
Journal of Urology, 187(4S).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Insulin-Like Growth Factor 2/H19 Methylation at Birth and Risk of Overweight and Obesity in Children
The Journal of Pediatrics, 161(1), 31–39.
MeSH headings : DNA Methylation; Female; Humans; Infant; Insulin-Like Growth Factor II / genetics; Male; Obesity / genetics; Overweight / genetics; Prospective Studies; Risk
TL;DR:
The findings suggest that IGF2 plasticity may be mechanistically important in early childhood overweight or obese status and suggest aberrant DNA methylation at sequences regulating imprinted genes may be useful identifiers of children at risk for the development of early obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke
Gene, 494(1), 36–43.
author keywords: Sex-specific methylation effects; Imprinted gene; Pyrosequencing; Early origins hypothesis
MeSH headings : Adult; Birth Weight; DNA Methylation; Female; Fetal Blood / chemistry; Genomic Imprinting; Humans; Insulin-Like Growth Factor II / genetics; Male; Maternal-Fetal Exchange; Pregnancy; RNA, Long Noncoding; RNA, Untranslated; Sex Characteristics; Smoking / genetics
TL;DR:
The findings suggest that IGF2 DMR plasticity is an important mechanism by which in utero adjustments to environmental toxicants are conferred.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites
Cancer Causes & Control, 23(7), 1127–1138.
author keywords: Insulin; IGF; Polymorphism; Colon cancer; African Americans
MeSH headings : Adiponectin / genetics; Adiponectin / metabolism; Black or African American / genetics; Aged; C-Peptide / blood; Colonic Neoplasms / blood; Colonic Neoplasms / ethnology; Colonic Neoplasms / genetics; Female; Gene Frequency; Genetic Predisposition to Disease / ethnology; Genetic Predisposition to Disease / genetics; Genotype; Genotyping Techniques / methods; Humans; Insulin-Like Growth Factor Binding Protein 3 / genetics; Insulin-Like Growth Factor Binding Protein 3 / metabolism; Insulin-Like Growth Factor I / genetics; Insulin-Like Growth Factor I / metabolism; Insulin-Like Growth Factor II / genetics; Insulin-Like Growth Factor II / metabolism; Logistic Models; Male; Middle Aged; Polymorphism, Genetic; Risk Factors; White People / genetics
TL;DR:
An association between insulin pathway-related genes and elevated colon cancer risk in Whites but not in African Americans is supported, and carrying the IGF BP-3 variant alleles was associated with lower IGFBP-3 protein levels, a difference most pronounced in Whites.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Association of cord blood methylation fractions at imprinted insulin-like growth factor 2 (IGF2), plasma IGF2, and birth weight
Cancer Causes & Control, 23(4), 635–645.
author keywords: IGF2; H19; ELISA; DNA methylation; Epigenetics; Epidemiology
MeSH headings : Birth Weight / genetics; DNA Methylation / genetics; Enzyme-Linked Immunosorbent Assay; Female; Fetal Blood; Genomic Imprinting; Humans; Infant, Newborn; Insulin-Like Growth Factor II / analysis; Insulin-Like Growth Factor II / genetics; Male
TL;DR:
Variation in IGF2 DMR methylation is an important mechanism by which circulating IGF2 concentrations, a putative risk factor for obesity and cancers of the colon, esophagus, and prostate, are modulated; associations that may depend on pre-pregnancy obesity are suggested.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2012 journal article
Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis
Nature Genetics, 44(8), 886–889.
MeSH headings : Adolescent; Age of Onset; Child; Child, Preschool; Cystic Fibrosis / complications; Cystic Fibrosis / genetics; Dynactin Complex; Exome; Gene Frequency; Humans; Infant; Infant, Newborn; Linkage Disequilibrium; Microtubule-Associated Proteins / genetics; Phenotype; Polymorphism, Single Nucleotide; Pseudomonas Infections / etiology; Pseudomonas Infections / genetics; Pseudomonas aeruginosa
TL;DR:
An extreme phenotype study design is used to discover that variants in DCTN4, encoding a dynactin protein, are associated with time to first P. aeruginosa airway infection, chronic P.aerug inosa infection and mucoid P. AerugInosa in individuals with cystic fibrosis.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis
Nature Genetics, 44(5), 562–569.
MeSH headings : Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral / genetics; Antiporters / genetics; Cell Membrane / metabolism; Cystic Fibrosis / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Ileus / genetics; Intestinal Obstruction / etiology; Meconium; Polymorphism, Single Nucleotide / genetics; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers / genetics; Sulfate Transporters
TL;DR:
It is suggested that modulating activities of apical membrane constituents could complement current therapeutic paradigms for cystic fibrosis and provide evidence of association between meconium ileus and multiple genes encoding constituents of the apical plasma membrane where CFTR resides.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Strain specific induction of pyometra and differences in immune responsiveness in mice exposed to 17α-ethinyl estradiol or the endocrine disrupting chemical bisphenol A
Reproductive Toxicology, 34(1), 22–30.
Contributors: J. Kendziorski*, E. Kendig*, R. Gear* & S. Belcher*
author keywords: Bisphenol A; Macrophage; Pyometra; Uterus; Mouse; Estrogen; Endocrine disruptor; Immune response
MeSH headings : Animals; Benzhydryl Compounds; Cell Count; Endocrine Disruptors / toxicity; Estrogens, Non-Steroidal / toxicity; Ethinyl Estradiol / toxicity; Female; Fertility / drug effects; Macrophages / cytology; Macrophages / drug effects; Macrophages / immunology; Male; Mice; Mice, Inbred C57BL; Phenols / toxicity; Pyometra / chemically induced; Pyometra / immunology; Pyometra / pathology; Species Specificity; Uterus / drug effects; Uterus / immunology; Uterus / pathology
TL;DR:
It is suggested that BPA enhances immune responsiveness of the uterus and that heightened responsiveness in C57BL/6 females is related to increased susceptibility to pyometra.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020
2012 journal article
Epithelial transforming growth factor -activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species
Proceedings of the National Academy of Sciences, 109(9), 3365–3370.
MeSH headings : Adaptor Proteins, Signal Transducing / deficiency; Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Enzyme Activation; Epidermis / enzymology; Epithelial Cells / enzymology; Intestinal Mucosa / enzymology; Keratinocytes / enzymology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Phenotype; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species / metabolism; Signal Transduction
TL;DR:
It is demonstrated that epithelial TAK1 activity is regulated through two unique, TAB1-dependent basal and TAB2-mediated stimuli-dependent mechanisms, which are dependent on each other.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2012 journal article
Neurological impacts from inhalation of pollutants and the nose–brain connection
NeuroToxicology, 33(4), 838–841.
author keywords: Air pollution; Neurotoxicity; Olfactory tract
MeSH headings : Air Pollutants / adverse effects; Animals; Body Burden; Environmental Monitoring; Humans; Inhalation Exposure / adverse effects; Nervous System / drug effects; Nervous System / physiopathology; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / physiopathology; Nose / drug effects; Nose / physiopathology; Olfactory Pathways / drug effects; Olfactory Pathways / physiopathology; Risk Assessment; Risk Factors
TL;DR:
The key available literature on nanoparticle uptake and transport through the olfactory pathway, the experimental data from animal and in vitro studies, and human epidemiological observations are reviewed to provide an increased understanding of the neurotoxicity associated with air pollution exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Source: Crossref
Added: August 28, 2020
2012 journal article
Effects of an Acute Hypoxic Event on Microplankton Community Structure in a Coastal Harbor of Southern California
Estuaries and Coasts, 36(1), 135–148.
author keywords: Hypoxia; Microplankton; Trophic shifts; Mortality event
TL;DR:
Significant changes in community structure were observed together with dramatically reduced photosynthetic yield of the remaining phytoplankton, indicating severe physiological stress during the extreme hypoxia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 14, 2020
2012 journal article
Algal toxins and reverse osmosis desalination operations: Laboratory bench testing and field monitoring of domoic acid, saxitoxin, brevetoxin and okadaic acid
Water Research, 46(19), 6563–6573.
author keywords: Reverse osmosis; Desalination; Harmful algal blooms; Algal toxins
MeSH headings : California; Environmental Monitoring; Harmful Algal Bloom; Kainic Acid / analogs & derivatives; Kainic Acid / analysis; Kainic Acid / chemistry; Marine Toxins / analysis; Marine Toxins / chemistry; Okadaic Acid / analysis; Okadaic Acid / chemistry; Osmosis; Oxocins / analysis; Oxocins / chemistry; Pilot Projects; Saxitoxin / analysis; Saxitoxin / chemistry; Seawater / chemistry; Water Purification / methods
TL;DR:
The results of this study demonstrate the potential for HAB toxins to be inducted into coastal RO intake facilities, and the ability of typical RO operations to effectively remove these toxins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: June 14, 2020
2012 journal article
Public attitudes toward biofuels: Effects of knowledge, political partisanship, and media use
Politics and the Life Sciences, 31(1-2), 36–51.
Sources: Crossref, NC State University Libraries
Added: June 6, 2020
2012 journal article
Variation in Synechococcus sp. CC9311 narB mRNA abundance relative to changes in light, nitrogen growth conditions and nitrate assimilation.
Journal of Phycology, 48(4), 1028–1039.
author keywords: diel light; irradiance; mRNA; narB; nitrate assimilation; nitrate reductase; qPCR; Synechococcus; transcript abundance
TL;DR:
Environmental sampling for narB transcripts should consider time, irradiance, and the growth status of cells to ecologically interpret narB transcript abundances, as changes in narB mRNA levels in nitrogen‐deprived CC9311 cultures following nitrate amendment were distinct from cultures grown solely on nitrate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2012 journal article
Can publicly available webcameras and mechanical Turks be used to evaluate physical activity policy and built environment change?
Journal of Science and Medicine in Sport, 15, S33.
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2012 journal article
Comprehensive Quantification of Monolignol-Pathway Enzymes in Populus trichocarpa by Protein Cleavage Isotope Dilution Mass Spectrometry
Journal of Proteome Research, 11(6), 3390–3404.
author keywords: quantification; isotope dilution mass spectrometry; selected reaction monitoring; filter-aided sample preparation; monolignol biosynthesis
MeSH headings : Amino Acid Sequence; Biosynthetic Pathways; Isotope Labeling; Molecular Sequence Data; Plant Proteins / chemistry; Plant Proteins / metabolism; Populus / enzymology; Proteome / chemistry; Proteome / metabolism; Reference Standards; Spectrometry, Mass, Electrospray Ionization / standards; Xylem / enzymology
TL;DR:
This represents the most comprehensive assay for quantification of proteins regulating monolignol biosynthesis and will lead to a better understanding of lignin formation at a systems level.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2012 journal article
The outdoor air pollution and brain health workshop
NeuroToxicology, 33(5), 972–984.
author keywords: Air pollution; Brain; Particulate matter; Ozone; Central nervous system; Susceptibility; Epidemiology; Neuroinflammation; Neurotoxicity; Behavior
MeSH headings : Air Pollutants / poisoning; Air Pollution / adverse effects; Brain / pathology; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / pathology; Disease Susceptibility; Encephalitis / etiology; Encephalitis / pathology; Humans; Lung Diseases / chemically induced; Lung Diseases / pathology; Neurotoxicity Syndromes / epidemiology; Neurotoxicity Syndromes / etiology; Neurotoxicity Syndromes / pathology
TL;DR:
Recent findings that have established the effects of inhaled air pollutants in the brain, explore the potential mechanisms driving these phenomena, and discuss the recommended research priorities/approaches that were identified by the panel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Crossref
Added: February 24, 2020
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