Center for Human Health and the Environment

Works Published in 2015

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Displaying works 61 - 80 of 327 in total

Sorted by most recent date added to the index first, which may not be the same as publication date order.

2015 chapter

Trichomonosis

In F. Beugnet & L. Halos (Eds.), Parasitoses and Vector Borne Diseases of Cats. Lyon, France: Merial.

By: J. Gookin & M. Levy

Ed(s): F. Beugnet & L. Halos

Source: NC State University Libraries
Added: October 21, 2020

2015 report

Semiparametric estimation of spectral density function for irregular spatial data

https://arxiv.org/abs/1508.06886

By: S. Yang & Z. Zhu

Source: NC State University Libraries
Added: September 27, 2020

2015 journal article

Erratum: Gene expression in major depressive disorder

Molecular Psychiatry, 21(3), 444–444.

By: R. Jansen, B. Penninx*, V. Madar, K. Xia, Y. Milaneschi*, J. Hottenga, A. Hammerschlag*, A. Beekman ...

TL;DR: The authors noticed that the Supplementary Figure legends were not published with the paper, and the legends accompany this erratum. (via Semantic Scholar)
Source: Crossref
Added: August 28, 2020

2015 journal article

Gene expression in major depressive disorder

Molecular Psychiatry, 21(3), 339–347.

By: R. Jansen*, B. Penninx*, V. Madar*, K. Xia*, Y. Milaneschi*, J. Hottenga*, A. Hammerschlag*, A. Beekman* ...

MeSH headings : Adult; Anxiety Disorders / genetics; Cross-Sectional Studies; Depressive Disorder, Major / diagnosis; Depressive Disorder, Major / genetics; Female; Gene Expression / genetics; Gene Expression Regulation / genetics; Genetic Predisposition to Disease / genetics; Genome-Wide Association Study; Humans; Interleukin-6 / genetics; Interleukin-6 / metabolism; Killer Cells, Natural / metabolism; Longitudinal Studies; Male; Middle Aged; Polymorphism, Single Nucleotide / genetics; Signal Transduction / genetics
TL;DR: Multiple gene expression associations with MDD were identified and a measurable impact of current MDD state on gene expression is suggested, in line with the immune suppression and immune activation hypothesis of MDD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: August 28, 2020

2015 journal article

New Master of Science program emphasizing Safety Pharmacology—Results to date

Journal of Pharmacological and Toxicological Methods, 75, 191–192.

By: A. Matlib*, S. Belcher*, R. Rapoport*, R. Millard*, H. Wang* & J. Maggio*

Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2015 journal article

Effects of whole life exposure to Bisphenol A or 17α-ethinyl estradiol in uterus of nulligravida CD1 mice

Data in Brief, 5, 948–953.

By: J. Kendziorski* & S. Belcher*

Contributors: J. Kendziorski* & S. Belcher*

author keywords: BPA; Estrogen; EDC; endocrine disruption; Collagen; Fibrosis; Immune; Macrophage
TL;DR: Uterine histopathology findings from CD1 mice exposed to BPA or 17α-ethinyl estradiol at multiple doses from conception through postnatal day 90 are reported, along with uterine pathology, impacts of exposure on collagen accumulation and F4/80 positive macrophage numbers, as an indicator of immune response in the endometrium and myometrium are presented. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

2015 journal article

Phosphorylation is an on/off switch for 5-hydroxyconiferaldehyde O-methyltransferase activity in poplar monolignol biosynthesis

Proceedings of the National Academy of Sciences, 112(27), 8481–8486.

author keywords: AldOMT; COMT; lignin; phosphoproteomics; phosphoregulation
MeSH headings : Acrolein / analogs & derivatives; Acrolein / metabolism; Amino Acid Sequence; Binding Sites / genetics; Biocatalysis; Catechols / metabolism; Chromatography, Liquid; Electrophoresis, Polyacrylamide Gel; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Isoenzymes / genetics; Isoenzymes / metabolism; Lignin / biosynthesis; Methyltransferases / genetics; Methyltransferases / metabolism; Microscopy, Confocal; Molecular Sequence Data; Mutation; Phosphoproteins / metabolism; Phosphorylation; Plant Proteins / genetics; Plant Proteins / metabolism; Populus / enzymology; Populus / genetics; Populus / metabolism; Proteomics / methods; Protoplasts / enzymology; Protoplasts / metabolism; Sequence Homology, Amino Acid; Tandem Mass Spectrometry
TL;DR: It is shown that reversible monophosphorylation at Ser123 or Ser125 acts as an on/off switch for the activity of 5-hydroxyconiferaldehyde O-methyltransferase 2 (PtrAldOMT2), an enzyme central to monolignol biosynthesis for lignification in stem-differentiating xylem of Populus trichocarpa. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2015 journal article

Select nutrients and their effects on conceptus development in mammals

Animal Nutrition, 1(3), 85–95.

By: F. Bazer*, X. Wang*, G. Johnson* & G. Wu

author keywords: Amino acids; Secreted phosphoprotein 1; Pregnancy; Interferon tau; Conceptus development; Trophectoderm
TL;DR: Mechanisms whereby arginine regulates expression of genes via the mechanistic target of rapamycin cell signaling pathways critical to conceptus development, implantation and placentation are discussed in detail in this review. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020

2015 journal article

Uterine Histotroph and Conceptus Development. I. Cooperative Effects of Arginine and Secreted Phosphoprotein 1 on Proliferation of Ovine Trophectoderm Cells via Activation of the PDK1-Akt/PKB-TSC2-MTORC1 Signaling Cascade

Biology of Reproduction, 92(2).

By: X. Wang*, G. Johnson*, R. Burghardt*, G. Wu* & F. Bazer

author keywords: arginine; MTORC1; sheep; SPP1; trophectoderm
MeSH headings : Animals; Arginine / pharmacology; Cell Line; Cell Proliferation / drug effects; Cell Proliferation / physiology; Embryonic Development / drug effects; Female; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes / metabolism; Osteopontin / pharmacology; Pregnancy; Protein Serine-Threonine Kinases / metabolism; Proto-Oncogene Proteins c-akt / metabolism; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Sheep; Signal Transduction / drug effects; Signal Transduction / physiology; TOR Serine-Threonine Kinases / metabolism; Uterus / drug effects; Uterus / metabolism
TL;DR: Results suggest that arginine and SPP1 in histotroph act cooperatively to enhance survival, growth, and development of ovine conceptuses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020

2015 journal article

Functional Roles of Arginine During the Peri-Implantation Period of Pregnancy. III. Arginine Stimulates Proliferation and Interferon Tau Production by Ovine Trophectoderm Cells via Nitric Oxide and Polyamine-TSC2-MTOR Signaling Pathways

Biology of Reproduction, 92(3).

author keywords: arginine; interferon tau; mechanistic target of rapamycin; trophectoderm; tuberous sclerosis protein 2
MeSH headings : Animals; Arginine / pharmacology; Arginine / physiology; Cell Proliferation / drug effects; Cell Proliferation / physiology; Cells, Cultured; Dose-Response Relationship, Drug; Ectoderm / cytology; Ectoderm / drug effects; Ectoderm / metabolism; Embryo Implantation / physiology; Female; Interferon Type I / metabolism; Models, Animal; Nitric Oxide / metabolism; Phosphorylation; Polyamines / metabolism; Pregnancy; Pregnancy Proteins / metabolism; Pregnancy, Animal / physiology; Putrescine / metabolism; Repressor Proteins / metabolism; Sheep / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; TOR Serine-Threonine Kinases / metabolism
TL;DR: It is indicated that arginine is essential for oTr1 cell proliferation and IFNT production via the NO/polyamine-TSC2-MTOR signaling pathways, particularly the pathway involving polyamine biosynthesis. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020

2015 journal article

The many faces of interferon tau

Amino Acids, 47(3), 449–460.

By: F. Bazer*, W. Ying*, X. Wang*, K. Dunlap*, B. Zhou*, G. Johnson*, G. Wu*

author keywords: Uterus; Amino acids; Proteins; Pregnancy; Uteroferrin; Interferon tau
MeSH headings : Animals; Arginine / metabolism; Biological Transport, Active / physiology; Embryo, Mammalian / metabolism; Female; Interferon Type I / metabolism; Pregnancy / metabolism; Pregnancy Proteins / metabolism; Ruminants / metabolism; Uterus / metabolism
TL;DR: Interferon tau (IFNT) was discovered as the pregnancy recognition signal in ruminants, but is now known to have a plethora of physiological functions in the mammalian uterus, contributing to survival, growth and development of the ruminant conceptus. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020

2015 journal article

Exosomes, endogenous retroviruses and toll-like receptors: pregnancy recognition in ewes

REPRODUCTION, 149(3), 281–291.

By: I. Ruiz-González, J. Xu, X. Wang*, R. Burghardt*, K. Dunlap & F. Bazer

MeSH headings : Animals; Cytokines / metabolism; Embryo Implantation / physiology; Endogenous Retroviruses / metabolism; Endometrium / metabolism; Exosomes / metabolism; Female; Pregnancy; Pregnancy, Animal / physiology; Sheep / physiology; Signal Transduction / physiology; Toll-Like Receptors / genetics; Toll-Like Receptors / metabolism; Uterus / metabolism
TL;DR: The hypothesis that free and/or exosomal enJSRV act on the trophectoderm via TLR to induce the secretion of IFNT in a manner similar to that for innate immune responses of macrophages and plasmacytoid dendritic cells to viral pathogens is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020

2015 journal article

Involvement of TLR7 and TLR8 in conceptus development and establishment of pregnancy in sheep

REPRODUCTION, 149(4), 305–316.

By: I. Ruiz-González*, M. Minten*, X. Wang*, K. Dunlap* & F. Bazer*

MeSH headings : Animals; Cells, Cultured; Embryo Implantation / drug effects; Embryo, Mammalian / cytology; Embryo, Mammalian / drug effects; Embryo, Mammalian / metabolism; Embryonic Development / drug effects; Endometrium / cytology; Endometrium / drug effects; Endometrium / metabolism; Estrous Cycle; Female; Fetal Development / drug effects; Immunoenzyme Techniques; Oligonucleotides, Antisense / pharmacology; Pregnancy; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sheep; Toll-Like Receptor 7 / antagonists & inhibitors; Toll-Like Receptor 7 / metabolism; Toll-Like Receptor 8 / antagonists & inhibitors; Toll-Like Receptor 8 / metabolism; Uterus / cytology; Uterus / drug effects; Uterus / metabolism
TL;DR: Findings corroborate the hypothesis that TLR7 and TLR8 mediate pathways whereby enJSRV-Env regulates key peri-implantation events in conceptus development and differentiated functions of trophectoderm cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: May 4, 2020

2015 journal article

Evolution of the indoor biome

Trends in Ecology & Evolution, 30(4), 223–232.

By: L. Martin*, R. Adams*, A. Bateman*, H. Bik*, J. Hawks*, S. Hird*, D. Hughes*, S. Kembel* ...

author keywords: urban ecology; anthrome; microbiome; phylogeography; built environment
MeSH headings : Animals; Biological Evolution; Ecosystem; Housing; Humans; Microbiota / physiology; Plant Physiological Phenomena
TL;DR: The emerging subfield of 'indoor biome' studies, situated at the intersection of evolutionary ecology, anthropology, architecture, and human ecology, is reviewed and some of its evolutionary dimensions are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: March 8, 2020

2015 journal article

Cytosolic Fe-S Cluster Protein Maturation and Iron Regulation Are Independent of the Mitochondrial Erv1/Mia40 Import System

Journal of Biological Chemistry, 290(46), 27829–27840.

By: H. Ozer*, A. Dlouhy*, J. Thornton*, J. Hu*, Y. Liu*, J. Barycki*, J. Balk*, C. Outten*

MeSH headings : Amino Acid Sequence; Cytosol / metabolism; Glutamate-Cysteine Ligase / metabolism; Glutathione / deficiency; Glutathione / metabolism; Iron / metabolism; Iron-Sulfur Proteins / metabolism; Mitochondria / metabolism; Mitochondrial Membrane Transport Proteins / genetics; Mitochondrial Membrane Transport Proteins / metabolism; Mitochondrial Precursor Protein Import Complex Proteins; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Molecular Sequence Data; Mutation; Oxidation-Reduction; Oxidoreductases / metabolism; Oxidoreductases Acting on Sulfur Group Donors / genetics; Oxidoreductases Acting on Sulfur Group Donors / metabolism; Protein Transport; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae / ultrastructure; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism
TL;DR: These results confirm that GSH is critical for cytosolic Fe-S protein biogenesis and iron regulation, whereas ruling out significant roles for Erv1 or Mia40 in these pathways. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking

Journal of Biological Chemistry, 290(21), 13144–13156.

By: C. McAtee*, A. Berkebile*, C. Elowsky*, T. Fangman*, J. Barycki*, J. Wahl*, O. Khalimonchuk*, N. Naslavsky*, S. Caplan*, M. Simpson*

MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Antigens, Neoplasm / metabolism; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Endocytosis / physiology; Endosomes / metabolism; Histone Acetyltransferases / metabolism; Humans; Hyaluronic Acid / metabolism; Hyaluronoglucosaminidase / metabolism; Male; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology; Protein Transport; Subcellular Fractions; Transferrin / metabolism; Transport Vesicles / metabolism; Tumor Cells, Cultured
TL;DR: Overall, excess Hyal1 secretion accelerates endocytic vesicle trafficking in a substrate-dependent manner, promoting aggressive tumor cell behavior. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Chromatin regulation at the frontier of synthetic biology

Nature Reviews Genetics, 16(3), 159–171.

MeSH headings : Animals; Cell Engineering / methods; Chromatin / chemistry; Chromatin / metabolism; Epigenesis, Genetic; Genome; Histones / chemistry; Histones / metabolism; Humans; Plants / genetics; Plants / metabolism; RNA, Untranslated / chemistry; RNA, Untranslated / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Synthetic Biology; Systems Biology
TL;DR: These studies lay the foundation for biomedical and biotechnological engineering applications that could take advantage of the unique combinatorial and spatiotemporal layers of chromatin regulation to create synthetic systems of unprecedented sophistication. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Number of X-chromosome genes influences social behavior and vasopressin gene expression in mice

Psychoneuroendocrinology, 51, 271–281.

By: K. Cox*, K. Quinnies*, A. Eschendroeder*, P. Didrick*, E. Eugster* & E. Rissman*

author keywords: Turner syndrome; Klinefelter syndrome; Sexual differentiation; Sex differences; Social behavior; Anxiety; Social anxiety
MeSH headings : Amygdala / metabolism; Animals; Behavior, Animal / physiology; Child; Female; Gene Dosage; Gene Expression Regulation / genetics; Genes, X-Linked; Humans; Male; Mice; Social Behavior; Turner Syndrome / blood; Turner Syndrome / genetics; Vasopressins / genetics; Vasopressins / metabolism; X Chromosome / genetics
TL;DR: Novel findings link sex chromosome genes with social behavior via concentrations of AVP in brain, adding to the understanding of sex differences in neurobehavioral disorders. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

MP14-11 IS BMI THE BEST ADIPOSITY MEASURE FOR PROSTATE CANCER RISK?

Journal of Urology, 193(4S).

By: L. Guerrios, L. Howard, K. Sourbeer, E. Arulraja, D. Beverly, D. Grant, C. Hoyo, S. Freedland

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

MP14-06 SELF-REPORTED SEXUAL FUNCTION IS ASSOCIATED WITH PROSTATE CANCER RISK

Journal of Urology, 193(4S).

By: D. Zapata, L. Howard, J. Frank, S. Ross, C. Hoyo, D. Grant, S. Freedland, A. Vidal

Source: Crossref
Added: February 24, 2020

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