Works Published in 2014
Displaying all 4 works
Sorted by most recent date added to the index first, which may not be the same as publication date order.
2014 journal article
Modulating DNA Methylation in Activated CD8+ T Cells Inhibits Regulatory T Cell–Induced Binding of Foxp3 to the CD8+ T Cell IL-2 Promoter
The Journal of Immunology, 194(3), 990–998.
MeSH headings : Animals; Base Sequence; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Cats; Chromatin Assembly and Disassembly; Coculture Techniques; DNA Methylation; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Gene Expression Regulation; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / chemistry; Interleukin-2 / genetics; Lentivirus / immunology; Lymphocyte Activation; Models, Biological; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / metabolism
TL;DR:
Using the FIV model for lentiviral persistence, these studies provide a framework for understanding how immune activation combined with Treg-mediated suppression may affect CD8+ T cell IL-2 transcription, maturation, and antiviral function.
(via Semantic Scholar)
www.jimmunol.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: July 20, 2019
2014 journal article
Vaginal Microbiota of Spayed Dogs with or without Recurrent Urinary Tract Infections
JOURNAL OF VETERINARY INTERNAL MEDICINE, 28(2), 300–304.
author keywords: Recurrent urinary tract infection; Lactic acid-producing bacteria
MeSH headings : Animals; Dog Diseases / microbiology; Dogs / microbiology; Female; Microbiota; Ovariectomy / veterinary; Recurrence; Urinary Tract Infections / microbiology; Urinary Tract Infections / veterinary; Vagina / microbiology
TL;DR:
The vaginal microbiota of spayed female dogs with recurrent UTI was similar to the control population of normal, spayed male dogs and vaginal bacteria isolate from vaginal swabs obtained from each dog.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ / GARP-mediated mechanism
Virology Journal, 11(1), 7.
author keywords: FIV; HIV; AIDS; Lentivirus; Treg cells; mTGF beta; GARP
MeSH headings : Animals; CD4-Positive T-Lymphocytes / chemistry; CD4-Positive T-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Immune Tolerance; Immunodeficiency Virus, Feline / immunology; Interleukin-2 Receptor alpha Subunit / analysis; Membrane Proteins / metabolism; Signal Transduction; T-Lymphocytes, Regulatory / chemistry; T-Lymphocytes, Regulatory / immunology; Transforming Growth Factor beta / metabolism
TL;DR:
Th to Treg conversion may initiate a cascade of events that contributes to the maintenance of virus reservoirs, progressive Th cell immunosuppression, and the development of immunodeficiency, all of which are central to the pathogenesis of AIDS lentivirus infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2014 journal article
Lentivirus-Activated T Regulatory Cells Suppress T Helper Cell Interleukin-2 Production by Inhibiting Nuclear Factor of Activated T Cells 2 Binding to the Interleukin-2 Promoter
AIDS RESEARCH AND HUMAN RETROVIRUSES, 30(1), 58–66.
MeSH headings : Amino Acid Sequence; Animals; Cats; Cell Proliferation; Cells, Cultured; Coculture Techniques; Immunodeficiency Virus, Feline / immunology; Interleukin-2 / biosynthesis; Interleukin-2 / genetics; Lentivirus Infections / immunology; Lentivirus Infections / pathology; Lentivirus Infections / virology; Lymph Nodes / cytology; Lymph Nodes / virology; Lymphocyte Activation / immunology; Molecular Sequence Data; NFATC Transcription Factors / antagonists & inhibitors; NFATC Transcription Factors / genetics; Promoter Regions, Genetic / immunology; Protein Binding / immunology; RNA, Messenger / biosynthesis; Receptors, Transforming Growth Factor beta / biosynthesis; Sequence Alignment; T-Lymphocytes, Helper-Inducer / immunology; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / virology; Transforming Growth Factor beta / biosynthesis; Transforming Growth Factor beta / pharmacology; Up-Regulation
TL;DR:
Data suggest that TGF-β-mediated Treg cell suppression of IL-2 transcription is modulated through alterations in NFAT2 binding to the IL-1 promoter in suppressed Th cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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