Immunology

Recent Works

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Sorted by most recent date added to the index first, which may not be the same as publication date order.

2021 journal article

Modified-Live Feline Calicivirus Vaccination Elicits Cellular Immunity against a Current Feline Calicivirus Field Strain in an Experimental Feline Challenge Study

VIRUSES-BASEL, 13(9).

By: A. Spiri *, M. Novacco *, M. Meli *, M. Stirn*, B. Riond *, J. Fogle n, F. Boretti *, I. Herbert*, M. Hosie *, R. Hofmann-Lehmann *

co-author countries: Switzerland 🇨🇭 United Kingdom of Great Britain and Northern Ireland 🇬🇧
author keywords: crossneutralisation; crossimmunity; lymphocyte subsets; neutralising antibodies; cytokines; IFN-gamma; perforin; granzyme B; antiviral factor MX1; ELISpot
MeSH headings : Animals; Antibodies, Viral / blood; Calicivirus, Feline; Cat Diseases / prevention & control; Cats; Cytokines; Granzymes; Immunity, Cellular / immunology; Immunity, Humoral; Leukocytes, Mononuclear / immunology; Perforin; Specific Pathogen-Free Organisms; Vaccination / veterinary; Vaccines, Attenuated; Viral Vaccines / immunology
topics (OpenAlex): Viral gastroenteritis research and epidemiology; Animal Virus Infections Studies; Viral Infections and Immunology Research
TL;DR: Investigating the cellular and humoral immune response of specified pathogen-free (SPF) cats after modified-live FCV F9 vaccinations and two heterologous FCV challenges induced cellular but not humoral crossimmunity in SPF cats finds innate immune mechanisms, secretory and membranolytic pathways, and IFN-γ-releasing PBMCs seem to be important in the host immune defence against FCV. (via Semantic Scholar)
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Source: Web Of Science
Added: October 4, 2021

2021 journal article

Sex Differences in Pulmonary Eicosanoids and Specialized Pro-Resolving Mediators in Response to Ozone Exposure

TOXICOLOGICAL SCIENCES, 183(1), 170–183.

By: M. Yaeger *, S. Reece *, B. Kilburg-Basnyat *, M. Hodge*, A. Pal *, K. Dunigan-Russell, B. Luo *, D. You n ...

author keywords: air pollution; lipids; lung; inflammation; sex differences
MeSH headings : Animals; Eicosanoids; Female; Lung; Male; Mice; Mice, Inbred C57BL; Ozone / toxicity; Sex Characteristics
topics (OpenAlex): Eicosanoids and Hypertension Pharmacology; Fatty Acid Research and Health; Sulfur Compounds in Biology
TL;DR: Data indicate that O3 drives an increased pulmonary inflammatory and bioactive lipid mediator response in females, and ovariectomy increases susceptibility to O3-induced pulmonary inflammation and injury, as well as decreases pulmonary DHA concentrations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2021 journal article

Retrospective and prospective assessment of butorphanol, azaperone and medetomidine (BAM™) for immobilisation of feral horses (<i>Equus ferus caballus</i>)

Equine Veterinary Journal, 54(3), 549–555.

By: J. Balko n, C. Fogle n , S. Stuska, J. Fogle n & L. Posner n

author keywords: azaperone; BAM; butorphanol; castration; horse; immobilisation; medetomidine
MeSH headings : Animals; Azaperone / pharmacology; Butorphanol / pharmacology; Horses; Hypnotics and Sedatives / pharmacology; Immobilization / veterinary; Ketamine; Male; Medetomidine / pharmacology; Prospective Studies; Retrospective Studies
topics (OpenAlex): Veterinary Pharmacology and Anesthesia; Veterinary Equine Medical Research; Pharmacological Effects and Assays
TL;DR: Intramuscular BAM™ with IV ketamine provided chemical restraint suitable for field castration of feral horses with no mortality. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 9, 2021

2021 journal article

Scavenger Receptor BI Attenuates IL-17A-Dependent Neutrophilic Inflammation in Asthma

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 64(6), 698–708.

By: S. Reece *, S. Varikuti*, B. Kilburg-Basnyat *, K. Dunigan-Russell, M. Hodge *, B. Luo *, J. Madenspacher*, S. Thomas * ...

author keywords: asthma; IL-17A; SR-BI receptor; neutrophilia; adrenal insufficiency
MeSH headings : Adrenal Insufficiency / complications; Adrenal Insufficiency / immunology; Animals; Asthma / immunology; Asthma / metabolism; Asthma / parasitology; Asthma / pathology; CD36 Antigens / deficiency; CD36 Antigens / metabolism; Hypersensitivity / complications; Inflammation / pathology; Interleukin-17 / metabolism; Lung / parasitology; Lung / pathology; Male; Mice, Inbred C57BL; Neutrophils / immunology; Neutrophils / pathology; Ovalbumin / immunology; Pyroglyphidae / physiology; Th17 Cells / immunology
topics (OpenAlex): Asthma and respiratory diseases; Receptor Mechanisms and Signaling; Allergic Rhinitis and Sensitization
TL;DR: Data indicate that SR-BI dampens pulmonary neutrophilic inflammation and IL-17A production in allergic asthma at least in part by maintaining adrenal function. (via Semantic Scholar)
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Source: Web Of Science
Added: June 28, 2021

2021 journal article

Multi-omic analyses in Abyssinian cats with primary renal amyloid deposits

Scientific Reports, 11(1).

By: F. Genova *, S. Nonnis *, E. Maffioli *, G. Tedeschi *, M. Strillacci *, M. Carisetti *, G. Sironi *, F. Cupaioli * ...

co-author countries: Australia 🇦🇺 Switzerland 🇨🇭 Germany 🇩🇪 Finland 🇫🇮 France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Italy 🇮🇹 Japan 🇯🇵 Netherlands 🇳🇱 New Zealand 🇳🇿 Portugal 🇵🇹 Sweden 🇸🇪
MeSH headings : Amyloidogenic Proteins / metabolism; Amyloidosis, Familial / genetics; Amyloidosis, Familial / metabolism; Amyloidosis, Familial / veterinary; Animals; Cat Diseases / genetics; Cat Diseases / metabolism; Cats / genetics; Cats / metabolism; Genetic Variation / genetics; Kidney / metabolism; Kidney Diseases / genetics; Kidney Diseases / metabolism; Kidney Diseases / veterinary; MicroRNAs; Proteomics; Whole Genome Sequencing
topics (OpenAlex): Amyloidosis: Diagnosis, Treatment, Outcomes; Genetic and Kidney Cyst Diseases; Renal Diseases and Glomerulopathies
TL;DR: The general conclusions are that the familial amyloid renal form in Abyssinians is not a simple monogenic trait and is a mix of proteins codified by wild-type genes, and the form is biochemically classifiable as AA amyloidsosis. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: May 24, 2021

2021 journal article

Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31

JOURNAL OF NEUROVIROLOGY, 27(2), 302–324.

By: J. Fogle n, L. Hudson n, A. Thomson n, B. Sherman n, M. Gruen n , B. Lacelles n, B. Colby n, G. Clary*, F. Longo *, R. Meeker*

author keywords: Human immunodeficiency virus; Neurocognitive; Neurotrophin; Therapy; Behavior; Neuroprotection
MeSH headings : Animals; Cats; Cognition Disorders / virology; Feline Acquired Immunodeficiency Syndrome / complications; Immunodeficiency Virus, Feline; Isoleucine / analogs & derivatives; Isoleucine / pharmacology; Morpholines / pharmacology; Neuroprotective Agents / pharmacology; Receptor, Nerve Growth Factor / agonists
topics (OpenAlex): Nerve injury and regeneration; HIV Research and Treatment; Neuroinflammation and Neurodegeneration Mechanisms
TL;DR: The data indicate that LM11A-31 is likely to be a potent adjunctive treatment for the control of neurodegeneration in HIV infected individuals. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021

2021 journal article

The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus

Frontiers in Immunology, 12.

By: A. Kick  n, A. Amaral n, A. Frias-De-Diego  n, L. Cortes n, J. Fogle n, E. Crisci n , G. Almond n , T. Käser n

author keywords: adaptive immunity; humoral immunity; neutralizing antibodies; IgA; IgG; porcine reproductive and respiratory syndrome virus
MeSH headings : Animals; Antibodies, Neutralizing / blood; Flow Cytometry / methods; Immunity, Humoral / immunology; Immunoglobulin A / analysis; Immunoglobulin A / immunology; Immunoglobulin G / blood; Nasal Mucosa / immunology; Nasal Mucosa / virology; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine respiratory and reproductive syndrome virus / immunology; Swine; Vaccination; Viral Vaccines / immunology; Viremia / immunology; Viremia / virology
topics (OpenAlex): Animal Virus Infections Studies; Viral gastroenteritis research and epidemiology; Virus-based gene therapy research
TL;DR: This study improves the understanding of the relationship between local and systemic infections and the humoral immune response induced by PRRSV-2 infection or MLV vaccination and provides novel insights into the timeline of the development of homologous and heterologous NA levels – by bothMLV vaccination or infection with two strains from the currently prevalent PRRSv-2 lineage 1. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: March 29, 2021

2020 journal article

Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort

PEDIATRIC OBESITY, 16(7).

By: R. Maguire n, J. House n , D. Lloyd n, H. Skinner n, T. Allen *, A. Raffi n, D. Skaar n , S. Park n ...

Contributors: R. Maguire n, J. House n , D. Lloyd n, H. Skinner n, T. Allen *, A. Raffi n, D. Skaar n , S. Park n ...

author keywords: cytokines; maternal obesity; childhood obesity
MeSH headings : Black or African American; Body Mass Index; Child; Child, Preschool; Cohort Studies; Cytokines / blood; Female; Humans; Obesity, Maternal / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; White People
topics (OpenAlex): Reproductive System and Pregnancy; Gestational Diabetes Research and Management; Adipokines, Inflammation, and Metabolic Diseases
TL;DR: Although maternal systemic inflammation is hypothesized to link maternal pre‐pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 19, 2021

2020 journal article

Detection of circulating anti-retinal antibodies in dogs with sudden acquired retinal degeneration syndrome using indirect immunofluorescence: A case control study

EXPERIMENTAL EYE RESEARCH, 193.

By: F. Mowat n, J. Avelino n, A. Bowyer n, V. Parslow n, H. Westermeyer n , M. Foster n, J. Fogle n, P. Bizikova n 

author keywords: SARDS; Dog; Retina; Immune-mediated; IgG; IgM
MeSH headings : Animals; Autoantibodies / immunology; Blotting, Western; Case-Control Studies; Disease Models, Animal; Dogs; Fluorescent Antibody Technique, Indirect / methods; Retina / immunology; Retina / metabolism; Retina / pathology; Retinal Degeneration / diagnosis; Retinal Degeneration / immunology; Retinal Degeneration / metabolism; Syndrome
topics (OpenAlex): Virus-based gene therapy research; Retinal and Optic Conditions; Virology and Viral Diseases
TL;DR: Despite having decreased serum IgG compared with healthy controls, circulating IgG in dogs with SARDS binds photoreceptor outer segments to a greater extent than matched healthy controls. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2020 journal article

Multicenter flow cytometry proficiency testing of canine blood and lymph node samples

Veterinary Clinical Pathology, 49(2), 249–257.

By: K. Meichner*, T. Stokol *, J. Tarigo*, A. Avery, M. Burkhard*, S. Comazzi *, J. Fogle n, D. Stowe n  ...

co-author countries: Austria 🇦🇹 Canada 🇨🇦 Italy 🇮🇹
author keywords: assay performance; dog; external laboratory quality assessment; immunophenotyping
MeSH headings : Animals; Cross-Sectional Studies; Dog Diseases / blood; Dog Diseases / diagnosis; Dog Diseases / pathology; Dogs; Flow Cytometry / standards; Flow Cytometry / veterinary; Hematologic Neoplasms / diagnosis; Hematologic Neoplasms / pathology; Hematologic Neoplasms / veterinary; Immunophenotyping / veterinary; Laboratory Proficiency Testing / standards; Lymph Nodes / pathology; Lymphoproliferative Disorders / diagnosis; Lymphoproliferative Disorders / pathology; Lymphoproliferative Disorders / veterinary
topics (OpenAlex): Veterinary Oncology Research; Mycobacterium research and diagnosis; Microbial infections and disease research
TL;DR: Lymphoproliferations were readily identified by FC, but identification of the categories of hematolymphoid neoplasia in fresh samples or archived files was variable, indicating a need for a more standardized approach to maximize the enormous potential of FC in veterinary medicine. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: April 20, 2020

2019 book

Juvenile polyarteritis

In Clinical Veterinary Advisor (4th ed.). Elsevier.

By: J. Fogle

Source: NC State University Libraries
Added: September 8, 2019

2019 chapter

Neonatal Isoerythrolysis

In Clinical Veterinary Advisor (4th ed.). Elsevier.

By: J. Fogle

Source: NC State University Libraries
Added: September 8, 2019

2019 journal article

ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(2), 313–334.

By: O. Garden *, L. Kidd*, A. Mexas*, Y. Chang *, U. Jeffery *, S. Blois *, J. Fogle n, A. MacNeill * ...

co-author countries: Australia 🇦🇺 Canada 🇨🇦 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Italy 🇮🇹
author keywords: comorbidity; Delphi survey; direct antiglobulin test; erythrocyte; evidence; flow cytometry; hemolysis; iceberg model; spherocyte; veterinary and comparative clinical immunology society
MeSH headings : Anemia, Hemolytic, Autoimmune / diagnosis; Anemia, Hemolytic, Autoimmune / etiology; Anemia, Hemolytic, Autoimmune / veterinary; Animals; Cat Diseases / diagnosis; Cat Diseases / etiology; Cats; Comorbidity; Consensus; Dog Diseases / diagnosis; Dog Diseases / etiology; Dogs; Societies, Veterinary
topics (OpenAlex): Blood groups and transfusion; Erythrocyte Function and Pathophysiology; Hepatitis B Virus Studies
TL;DR: Clinical guidelines for diagnosis of, and underlying disease screening for, IMHA in dogs and cats are provided, which should be implemented with consideration of animal, owner, and geographical factors. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 22, 2019

2018 journal article

Precision medicine validation: identifying the MYBPC3 A31P variant with whole-genome sequencing in two Maine Coon cats with hypertrophic cardiomyopathy

JOURNAL OF FELINE MEDICINE AND SURGERY, 21(12), 1086–1093.

By: E. Ontiveros*, Y. Ueda *, S. Harris *, J. Stern* , L. Lyons, B. Gandolfi, D. Aberdein, D. Garrick ...

author keywords: HCM; WGS; individualized medicine; next-generation sequencing
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Carrier Proteins / genetics; Cat Diseases / genetics; Cats; Genetic Predisposition to Disease; Mutation; Precision Medicine / instrumentation; Precision Medicine / methods; Precision Medicine / veterinary; Whole Genome Sequencing / veterinary
topics (OpenAlex): Cardiovascular Conditions and Treatments; Congenital heart defects research; Cardiomyopathy and Myosin Studies
TL;DR: This proof-of-concept experiment identified the previously reported MYBPC3 A31P Maine Coon variant in two HCM-affected cases and highlights the power of whole-genome sequencing for feline precision medicine. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: December 16, 2019

2018 journal article

Enrichment Preferences of FIV-Infected and Uninfected Laboratory-Housed Cats

Viruses, 10(7), 353.

By: C. Kennedy n, A. Thomson*, E. Griffith n , J. Fogle n, B. Lascelles* , R. Meeker*, B. Sherman*, M. Gruen* 

author keywords: FIV; enrichment; welfare; feline; laboratory animal
MeSH headings : Animals; Animals, Laboratory; Cats; Feline Acquired Immunodeficiency Syndrome / virology; Immunodeficiency Virus, Feline / physiology
topics (OpenAlex): Animal Behavior and Welfare Studies; Human-Animal Interaction Studies; Primate Behavior and Ecology
TL;DR: Cats used in a longitudinal study of the effects of chronic feline immunodeficiency virus (FIV) infection were used and it was found that cats elected to be brushed, preferred social interaction and play with the laser to the ball, and preferred to scratch on an inclined-box toenail conditioning object compared to a horizontal, circular toenails conditioning object. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 16, 2018

2018 review

Epigenetic Modulation of CD8(+) T Cell Function in Lentivirus Infections: A Review

[Review of ]. VIRUSES-BASEL, 10(5).

By: M. Nag  n, K. De Paris * & J. Fogle n

author keywords: CD8(+) T cells; T regulatory cells; CD8(+) T cell dysfunction; epigenetics; lentiviral infections; feline immunodeficiency virus; simian immunodeficiency virus; human immunodeficiency virus
MeSH headings : Animals; CD8-Positive T-Lymphocytes / immunology; Cats; Cytokines / immunology; Epigenesis, Genetic; HIV Infections / immunology; Humans; Immunodeficiency Virus, Feline; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Lymphocyte Activation; Simian Immunodeficiency Virus; T-Lymphocytes, Regulatory / immunology; Viremia / veterinary
topics (OpenAlex): HIV Research and Treatment; Immune Cell Function and Interaction; Epigenetics and DNA Methylation
TL;DR: Using the feline immunodeficiency virus (FIV) model for lentiviral persistence, it is demonstrated that CD8+ T cells exhibit epigenetic changes such as DNA demethylation during the course of infection as compared to uninfected cats and epigenetic modulation reduces Foxp3 binding to these promoter regions. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2018 journal article

Histone Modulation Blocks Treg-Induced Foxp3 Binding to the IL-2 Promoter of Virus-Specific CD8(+) T Cells from Feline Immunodeficiency Virus-Infected Cats

VIRUSES-BASEL, 10(6).

By: M. Nag  n, Y. Wang *, K. De Paris * & J. Fogle n

author keywords: Feline Immunodeficiency Virus; CD8(+) T cells; CD8(+) T cell dysfunction; T regulatory cells; Treg suppression; Foxp3; IL-2 suppression; epigenetics; histone acetylation
MeSH headings : Acetylation; Anacardic Acids / pharmacology; Animals; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / virology; Cats; Coculture Techniques; Epigenesis, Genetic; Feline Acquired Immunodeficiency Syndrome / immunology; Forkhead Transcription Factors / metabolism; Histones / metabolism; Immunodeficiency Virus, Feline; Interferon-gamma / immunology; Interleukin-2 / genetics; Promoter Regions, Genetic; T-Lymphocytes, Regulatory / immunology
topics (OpenAlex): HIV Research and Treatment; Immunotherapy and Immune Responses; T-cell and B-cell Immunology
TL;DR: Using anacardic acid (AA), a known histone acetyl transferase (HAT) inhibitor, a reduction in Foxp3 binding to the IL-2 promoter in virus-specific CD8+ T cells co-cultured with autologous Treg cells is demonstrated. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2017 journal article

Micro-RNA 10a Is Increased in Feline T Regulatory Cells and Increases Foxp3 Protein Expression Following In Vitro Transfection

Veterinary Sciences, 4(4), 12.

By: Y. Wang  n, M. Nag  n, J. Tuohy  n & J. Fogle n

topics (OpenAlex): Immune Cell Function and Interaction; interferon and immune responses; Cancer-related molecular mechanisms research
TL;DR: It is demonstrated that CD4+CD25+ T cells from both feline immunodeficiency virus infected (FIV+) cats and uninfected control cats exhibit increased miRNA 10a and 21 levels compared to autologous CD4-CD25− T cells but there was no difference in the levels of these miRNAs when T Reg cells from FIV+ cats were compared to Treg cells from unin infected controls. (via Semantic Scholar)
Source: Crossref
Added: July 20, 2019

2017 journal article

T Regulatory Cell Induced Foxp3 Binds the IL2, IFNγ, and TNFα Promoters in Virus-Specific CD8+ T Cells from Feline Immunodeficiency Virus Infected Cats

AIDS Research and Human Retroviruses, 34(3), 269–276.

By: Y. Wang  n, M. Nag  n, J. Tuohy  n, K. De Paris * & J. Fogle n

author keywords: animal models; T cell immunity; cell mediated immunity; T regulatory cell; polyfunctional T cell; CD8(+) T cell
MeSH headings : Animals; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / virology; Cats; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Forkhead Transcription Factors / biosynthesis; Forkhead Transcription Factors / metabolism; Immunodeficiency Virus, Feline; Interferon-gamma / genetics; Interleukin-2 / genetics; Lymphocyte Activation; Promoter Regions, Genetic; T-Lymphocytes, Regulatory / immunology; Tumor Necrosis Factor-alpha / genetics; Viremia / immunology; Viremia / virology
topics (OpenAlex): HIV Research and Treatment; T-cell and B-cell Immunology; Immune Cell Function and Interaction
TL;DR: It is shown that Foxp3 inhibits IL2, TNFα, and IFNγ transcription by binding to their promoter regions in lentivirus-specific CD8+ T cells, the first description of this process during the course of AIDS lentiviral infection. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: July 20, 2019

2017 journal article

Disruption of Trim9 function abrogates macrophage motility in vivo

Journal of Leukocyte Biology, 102(6), 1371–1380.

By: D. Tokarz n, A. Heffelfinger n, D. Jima n, J. Gerlach n, R. Shah n, I. Rodriguez-Nunez  n, A. Kortum n, A. Fletcher  n ...

author keywords: chemotaxis; zebrafish; leukocyte; ubiquitin
MeSH headings : Animals; Cell Movement / genetics; Cell Shape; Chemotaxis; Humans; Macrophages / cytology; Macrophages / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tripartite Motif Proteins / genetics; Tripartite Motif Proteins / metabolism; U937 Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
topics (OpenAlex): Immune cells in cancer; Neuroinflammation and Neurodegeneration Mechanisms; interferon and immune responses
TL;DR: It is demonstrated that Trim9 mediates cellular movement and migration in Mϕs as well as neurons, and is implicated in axonal migration, and found that M ϕ chemotaxis and cellular architecture are subsequently impaired in vivo. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Association of Canine Osteosarcoma and Monocyte Phenotype and Chemotactic Function

Journal of Veterinary Internal Medicine, 30(4), 1167–1178.

By: J. Tuohy n, B. Lascelles  n, E. Griffith n  & J. Fogle n

author keywords: Bone tumor; Chemoreceptors; Chemotaxis; Immunoregulation
MeSH headings : Animals; Bone Neoplasms / blood; Bone Neoplasms / veterinary; Case-Control Studies; Chemotaxis; Cytokines / metabolism; Disease-Free Survival; Dog Diseases / blood; Dogs; Female; Flow Cytometry / veterinary; Gene Expression Regulation; Male; Monocytes / metabolism; Monocytes / physiology; Osteosarcoma / blood; Osteosarcoma / veterinary; RNA, Messenger / analysis
topics (OpenAlex): Veterinary Oncology Research; Chemokine receptors and signaling; Immune cells in cancer
TL;DR: Dogs with OSA have decreased monocyte chemokine receptor expression and monocytes chemotaxis, potential mechanisms by which OSA might evade the immune response, and reversal of monocyte dysfunction using immunotherapy could improve survival in dogs with Osa. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Comparison of lipopolysaccharides and soluble CD14 measurement between clinically endotoxaemic and nonendotoxaemic horses

Equine Veterinary Journal, 49(2), 155–159.

By: J. Fogle n, M. Jacob n, A. Blikslager n , A. Edwards  n, B. Wagner *, K. Dean n, C. Fogle n 

Contributors: J. Fogle n, M. Jacob n, A. Blikslager n , A. Edwards  n, B. Wagner *, K. Dean n, C. Fogle n 

author keywords: horse; soluble CD14; endotoxin; sepsis; inflammation; colic
MeSH headings : Animals; Biomarkers / blood; Endotoxemia / blood; Endotoxemia / veterinary; Horse Diseases / blood; Horse Diseases / diagnosis; Horses; Lipopolysaccharide Receptors / blood; Lipopolysaccharides
topics (OpenAlex): Immune Response and Inflammation; Veterinary Equine Medical Research; Immune Cell Function and Interaction
TL;DR: It is suggested that sCD14 and LPS were poor predictors of clinical endotoxaemia for the horses in this study, and further investigation is warranted to assess the utility of s CD14 measurement as a clinically useful biomarker to identify endotox aemia in horses. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Efficacy of various Marek's disease vaccines protocols for prevention of Marek's disease virus-induced immunosuppression

VACCINE, 34(35), 4180–4187.

By: N. Faiz  n, A. Cortes n, J. Guy n , J. Fogle n & I. Gimeno n 

author keywords: MDV; Control; ILTV; Immunosuppression; Immune system; Vaccine
MeSH headings : Animals; Chickens; Female; Immune Tolerance; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / adverse effects; Neoplasms / virology; Poultry Diseases / prevention & control; Vaccination / methods; Vaccination / veterinary
topics (OpenAlex): Herpesvirus Infections and Treatments; Cytomegalovirus and herpesvirus research; Hepatitis B Virus Studies
TL;DR: It is demonstrated that currently used vaccine protocols confer high levels of protection against MDV-induced tumors (protection index=100), but do not protect against late-MDV-IS; thus, commercial poultry flocks could suffer late- MDv-IS even in complete absence of tumors. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Expression of Apoptosis-regulating Proteins Bcl-2 and Bax in Lymph Node Aspirates from Dogs with Lymphoma

JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(3), 819–826.

By: K. Meichner n, J. Fogle n, L. English n & S. Suter n

author keywords: Canine; Flow cytometry; Lymphosarcoma; Programmed cell death
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Apoptosis; Case-Control Studies; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Female; Flow Cytometry / veterinary; Gene Expression Regulation, Neoplastic; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphoma, B-Cell / drug therapy; Lymphoma, B-Cell / pathology; Lymphoma, B-Cell / veterinary; Lymphoma, T-Cell / drug therapy; Lymphoma, T-Cell / pathology; Lymphoma, T-Cell / veterinary; Male; Prospective Studies; Proto-Oncogene Proteins c-bcl-2 / genetics; Proto-Oncogene Proteins c-bcl-2 / metabolism; Systole; Treatment Outcome; bcl-2-Associated X Protein / genetics; bcl-2-Associated X Protein / metabolism
topics (OpenAlex): Immunotherapy and Immune Responses; Veterinary Oncology Research; Immune Response and Inflammation
TL;DR: Whether Bcl‐2/Bax will be helpful to identify canine BCL and TCL with more aggressive and more indolent behavior, respectively, should be evaluated in larger prospective clinical studies. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Extreme lymphocytosis with myelomonocytic morphology in a horse with diffuse large B-cell lymphoma

Veterinary Clinical Pathology, 46(1), 64–71.

By: K. Meichner *, B. Kraszeski n, J. Durrant n, C. Grindem n, B. Breuhaus n , P. Moore*, J. Neel n , K. Linder  n ...

Contributors: K. Meichner *, B. Kraszeski n, J. Durrant n, C. Grindem n, B. Breuhaus n , P. Moore*, J. Neel n , K. Linder  n ...

author keywords: Clonality; equine; leukemia; leukocytosis; lymphoid
MeSH headings : Animals; Female; Horse Diseases / diagnostic imaging; Horse Diseases / pathology; Horses; Immunohistochemistry / veterinary; Lymphocytosis / diagnostic imaging; Lymphocytosis / pathology; Lymphocytosis / veterinary; Lymphoma, B-Cell / diagnostic imaging; Lymphoma, B-Cell / pathology; Lymphoma, B-Cell / veterinary; Microscopy, Electron, Transmission / veterinary; T-Lymphocytes / pathology
topics (OpenAlex): T-cell and Retrovirus Studies; Veterinary Oncology Research; T-cell and B-cell Immunology
TL;DR: An 11-year-old Haflinger mare presented to the North Carolina State University Veterinary Teaching Hospital with a 2-week history of lethargy and a 3-day duration of anorexia, pyrexia, tachycardia, and ventral edema was diagnosed with diffuse large B-cell lymphoma with a marked hematogenous component. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

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